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Re:WHO declares coronavirus outbreak a public health emergency by cheeseblubber on Thursday January 30, 2020 @03:50PM (#22195417)
For those who are referencing the flu and it's mortality rate here are estimates from the CDC for 2019

* 15,000,000 – 21,000,000 who had the flu

* 8,200 – 20,000 deaths from the flu

The morality rate ranges from 0.03% to 0.09% or 3/10000 9/10000

https://www.cdc.gov/flu/about/burden/preliminary-in-season-e...

Re:WHO declares coronavirus outbreak a public health emergency by hurricanetc on Thursday January 30, 2020 @09:10PM (#22198346)
Those are US numbers only. The CDC estimates that 291,000 to 646,000 people die worldwide every year. You cannot take the US mortality rate and assume it would apply to any other country and especially not China.

https://www.cdc.gov/media/releases/2017/p1213-flu-death-esti...

Re:WHO declares coronavirus outbreak a public health emergency by ttul on Thursday January 30, 2020 @10:10PM (#22198655)
Indeed. China’s medical system is primitive by comparison. They have shiny highways and trains, but hospitals are overcrowded and underfunded.
Re:WHO declares coronavirus outbreak a public health emergency by zhte415 on Friday January 31, 2020 @05:59AM (#22200684)
I wouldn't use the word primitive, but inconsistent, non-patient-focused and underfunded in many places.

Larger cities can have excellent treatment, smaller cities less so. After a car accident I had pin-hole surgery on a badly broken collar bone (three pieces and several fragments) and only afterwards discovered the lead surgeon was internationally published in leading journals for his work, and the second surgeon would soon be departing for Northern Europe for a 2 year secondment to complete his PhD. Physiotherapy with minimal but sufficient. After-patient care consisted of being invited to dinners with other ex-patients for sharing over dinner, which is very unlike the West.

Certainly I was fortunate and the vast majority of care is not like this, which is why I don't use the word 'primitive' but prefer 'inconsistent'. The doctors described hospitals more like factories: There's a lot of throughput. He chuckled "You get lots of practice, but the focus is on how to do things better."

Edit: When I say 'not patient focused' here's a typical process flow:

1. Go to ER. Have a friend, family member or colleague pay a fee for consultation for a General Practitioner, and specify Chinese Medicine or Western Medicine GP.

2. Wait to see the GP, usually in a queue or ticketing system. There's a nurse on front desk and if it's obvious and urgent you'll be fast-tracked.

3. See the GP. They'll have some idea and request further work, like an X-Ray, Blood Test, CT Scan, etc. That's all in ER. Have the friend, family member or colleague pay a fee for that and wait in a queue/ticketing system or get fast-tracked again.

4. Get the results and return to GP for further prognosis. They'll recommend medicine (go to the front desk, pay a fee, etc, then go to a separate part, typically a separate floor, for that), operation, or other work. At this point you're referred to a specialist department and need to make your own way there, or if urgent have a wheelchair or stretcher and nurse take you there.

5. Turn up at the specialist department. Now this varies. For urgent treatment you'll likely be seen immediately, better, larger hospitals work 24/7. For non-urgent there might be a ticketing system. For something like a bone operation as I had there'll be a junior doctor on front-desk who will make a further assessment. If non-urgent and they're busy, schedule a few days later.

6. A ward consists of several rooms, typical Marie-Curie design with a central lift block and wards coming off from that. Rooms are rarely individual, if fortunate you'll have 2 to a room, sometime 8 or more. Some pre-op, some post-op. Nurses don't do a lot other than administer drips, observe, and escalate to the doctor on-call. For stuff like getting in or out of bed when you can't walk, friends, family or colleagues are there for that. Often you'll see family members on rotation with a small chair or camper bed next to the patient. You can also hire private unskilled unqualified helpers.

How to choose a hospital: Always go with a Medical University. It's a rule-of-thumb the world over and especially true in China. They have the most experienced, best qualified, best paid (outside of a handful of private international hospitals in Shanghai/Beijing/etc) doctors. If there's a #1, #2, #3 etc affiliated hospital, go to the #1, if that's too far, go down the numbering system until distance/urgency tradeoff works best. If you're out in the countryside, the quality of the care isn't likely to be the best.

Sorry, wrote quite a lot there. Thought it would be interesting to share with Hacker News as most readers here probably won't have had experiences with hospitals in China.

In the crisis like Wuhan at the moment I imagine they'd be incredibly overworked.

Re:WHO declares coronavirus outbreak a public health emergency by me_me_me on Friday January 31, 2020 @07:17AM (#22201032)
Well it might be partially due to culture. Large parts of population is skeptical to the modern western medicine, and rather use traditional Chinese medicine practices.
Re:WHO declares coronavirus outbreak a public health emergency by hatenberg on Saturday February 01, 2020 @09:20AM (#22210616)
Yea those damn antivaxxers. Oh wait
Re:WHO declares coronavirus outbreak a public health emergency by teknologist on Friday January 31, 2020 @09:32PM (#22208198)
I have to wonder at what point "culture" becomes an excuse for being ignorant and/or under-educated about what science is.
Re:WHO declares coronavirus outbreak a public health emergency by ekianjo on Friday January 31, 2020 @12:15AM (#22199273)
Especially away from the large cities.
Re:WHO declares coronavirus outbreak a public health emergency by kabacha on Friday January 31, 2020 @05:11AM (#22200463)
> China’s medical system is primitive by comparison.

Comparison to what? Isn't US hostpitals notorious in that regard? Getting flu and either dying or being bankrupt.

Re:WHO declares coronavirus outbreak a public health emergency by ProZsolt on Friday January 31, 2020 @08:00AM (#22201258)
At least you have options. Some countries only have the first.
Re:WHO declares coronavirus outbreak a public health emergency by cambalache on Friday January 31, 2020 @09:27AM (#22201883)
Countries such as?
Re:WHO declares coronavirus outbreak a public health emergency by hatenberg on Thursday January 30, 2020 @11:05PM (#22198933)
...because they are not for profit so people can actually afford to get help even if they are poor
Re:WHO declares coronavirus outbreak a public health emergency by chaorace on Thursday January 30, 2020 @11:11PM (#22198965)
Well, yes... but that's not really the point. There's plenty of better hospital systems, socialized or not.
Re:WHO declares coronavirus outbreak a public health emergency by taneq on Friday January 31, 2020 @01:23AM (#22199561)
Large parts of the world have government-funded healthcare, including many countries where it's anything but "overcrowded and underfunded."
Re:WHO declares coronavirus outbreak a public health emergency by lopmotr on Friday January 31, 2020 @02:11AM (#22199752)
I think you're a bit off the mark. Healthcare is cheap in China, but people are even poorer. Only rich people can afford the important stuff. It's common for young people from poor families to work or forgo their education to pay their sick parent's medical costs. Usually old people just die because they can't afford medical care where in the west, they would be treated. Also doctors are poorly paid and commonly supplement their income with under the table drug sales. Oh, and most of them prescribe fake herbal medicines as if it was real and patients are fooled by it because their culture tells them it works. Imagine getting a vial of homeopathic diluted water and a sugar pill when you complain about a cough. I once knew someone who had TB and was recommended to treat it with an OTC sachet of herb from the pharmacy! It's common to find beggars outside hospitals with signs asking for money to continue their treatment. Insurance? Yes, that exists but the excess is often something like 1/3 the total cost so if you couldn't afford it yourself, you still can't afford it with insurance. That's if you have a high enough income to afford insurance in the first place.
Re:WHO declares coronavirus outbreak a public health emergency by new2628 on Friday January 31, 2020 @05:50AM (#22200656)
> Imagine getting a vial of homeopathic diluted water and a sugar pill when you complain about a cough.

This happens regularly in western europe, especially by pediatricians. The charitable interpretation is that the doctor knows the child will get better in a few days anyway, but has to give _something_ to soothe the parents. Giving the substance-free stuff is better than unnecessarily medicating the child, and placebo-effect can also play a positive role.

Re:WHO declares coronavirus outbreak a public health emergency by alisonatwork on Friday January 31, 2020 @06:12AM (#22200749)
In your subsequent comment you add the important point - this is Germany. Having lived both in Germany and (now) in China, i can confirm that both of these countries have a problem with quack medicine. I've never been anywhere else in the world where you need to argue with pharmacists to persuade them to sell you evidence-based medicine.

In China there is some historical reason for it - Mao needed something to placate the peasants while trying to figure out how to provide healthcare to rural areas[0]. Unfortunately the government is still trying to figure that out.

I don't know what the history is in Germany that caused it to be the way it is.

[0] https://respectfulinsolence.com/2019/05/29/mao-triumphant/

Re:WHO declares coronavirus outbreak a public health emergency by cygx on Friday January 31, 2020 @06:49AM (#22200908)
Note that homeopathy was invented by a German doctor, Samuel Hahnemann. It grew big at the turn of last century, with hundreds of homeopathic societies with their own apothecaries.

Today, lobbying powers of a profitable industry also play into it.

Re:WHO declares coronavirus outbreak a public health emergency by new2628 on Friday January 31, 2020 @05:57AM (#22200674)
Curious about the downvotes -- this is common practice e.g. in Germany, and one that I consider largely beneficial to society.
Re:WHO declares coronavirus outbreak a public health emergency by stef25 on Friday January 31, 2020 @06:19AM (#22200780)
This probably only works with parents who're too dumb to comprehend what's being prescribed, or ones that are ok with homeopathics?

Here in Belgium all the doctors that have seen my kids have no problem saying paracetamol and they'll be fine in a few days.

W-Europe is particularly hostile to medical quackery IMHO.

Re:WHO declares coronavirus outbreak a public health emergency by dsfyu404ed on Friday January 31, 2020 @06:37AM (#22200852)
The parents that know they're gonna get a placebo because the kid will get better regardless probably aren't bringing their kids to the doctor for the kinds of ailments that result in a placebo.
Re:WHO declares coronavirus outbreak a public health emergency by stef25 on Friday January 31, 2020 @07:25AM (#22201061)
Anecdotally, 90% of the times I've taken my toddlers to the doctor I've gone home with advice to take paracetamol and wait it out.

Kids can get high fevers really fast and you just want to make sure their lungs & heart are ok, they don't have a throat / ear infection etc. A doc can verify that for you in 5 min so I rather be safe than sorry, an "OK" is all I need.

Re:WHO declares coronavirus outbreak a public health emergency by DailyHN on Friday January 31, 2020 @06:21AM (#22200798)
> Insurance? Yes, that exists but the excess is often something like 1/3 the total cost so if you couldn't afford it yourself, you still can't afford it with insurance.

In the USA or China?

Re:WHO declares coronavirus outbreak a public health emergency by skripp on Friday January 31, 2020 @08:53AM (#22201615)
China
Re:WHO declares coronavirus outbreak a public health emergency by vijaybritto on Thursday January 30, 2020 @11:52PM (#22199176)
yes, but still they are not as developed in human indices
Re:WHO declares coronavirus outbreak a public health emergency by sliken on Thursday January 30, 2020 @09:39PM (#22198490)
The scary part is that of the official 8,200 or so people that have been confirmed to have the virus there's been 171 deaths, and 143 recoveries. So more people dead than recovered, does make one wonder about the 8,200.

Seems few believe the official numbers, people visit numerous hospitals without being able to seen, and even those that get seen have problems getting tested, and people who posts about the situation get the post pulled or pressured to pulled themselves.

Here's an article describing the censorship (pulled posts), arrests for "rumor mongering", difficulty in getting tested, etc:

https://www.reuters.com/article/us-china-health-testing-insi...

This one documents 15% of 41 people getting hospitalized dying:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

Re:WHO declares coronavirus outbreak a public health emergency by bart_spoon on Thursday January 30, 2020 @10:13PM (#22198675)
Well there is something to be said for both potential biases in those counts. First of all, those being hospitalized are obviously among the most severe cases. And presumably people with the mildest cases will potentially not even be diagnosed, so the mortality rates would be skewed higher.

And secondly, that more people have died than have recovered doesn't say much other than that it takes longer to recover than to die. If you are going to die, it would appear that it would happen sooner rather than later. Whereas if you aren't going to die, you may take awhile before you've been officially cured.

That isn't to say that is absolutely what is happening here. But both scenarios are fairly likely, and therefore should mediate some of the bleakness of those numbers for the time being.

Re:WHO declares coronavirus outbreak a public health emergency by koheripbal on Thursday January 30, 2020 @10:36PM (#22198791)
The numbers we're getting out of China are a mess and almost entirely useless.

There are reports of hospitals turning people away unless they a very sick, and also not testing every ill patient because they're overwhelmed.

I've see death certificates posted online with "viral pneumonia" because they aren't able to test everyone - and certainly don't bother testing those who have already died.

The errors are both ways and huge.

The only thing we can conclude is that it's contagious, deadly, and more deadly than the seasonal flu.

Re:WHO declares coronavirus outbreak a public health emergency by dchichkov on Friday January 31, 2020 @02:21AM (#22199787)
There was one interesting number though. The Japanese had been evacuating 200 people from Wuhan and found 3 cases. Assume that a plane of evacuees like that is somewhat random sampling. And that evacuees have similar or better hygiene. This puts infection rate at 1% of the population. Official population of Wuhan is 11 million, it is possible that it is larger. This puts the number to 100k cases.
Re:WHO declares coronavirus outbreak a public health emergency by mantap on Friday January 31, 2020 @07:13AM (#22201018)
Isn't taking the population of Wuhan as 11 million cherry picking? You could choose the population of central Wuhan and get a higher estimate or the population of Hubei province and get a lower estimate. Presumably the distribution of Japanese people evacuated does not match the distribution of people in Hubei province, since many will be tourists (more likely to be in the city centre). Moreover their chance of being infected will depend on where they were staying: there is an epicenter.

But yes it does indicate that the real number is much higher than the confirmed cases. It's really hard to track an outbreak of this magnitude especially when many people are carriers showing mild symptoms. It's actually a good thing if cases are being severely underestimated as it implies a lower death rate (deaths are harder to fudge).

Re:WHO declares coronavirus outbreak a public health emergency by cannedslime on Friday January 31, 2020 @12:56PM (#22203782)
> deaths are harder to fudge

Are you sure about this? AFAIK, the Chinese government does not disclose someone as dead by this virus unless they tested the person positive. That means that if someone dies from respiratory complications on the street or in their home, they will write it off as pneumonia. Right now Wuhan city only has the capacity to screen roughly 6000 samples everyday. Add to this that many sick people are basically just told to go home. Not many cars are driving, city is shutdown so god knows how many are sitting lifeless in their livingroom. I have also seen much evidence that communities are barring the doors of infected households so they can't leave their apartments.

The death count can only be expected considerably higher than reported.

Re:WHO declares coronavirus outbreak a public health emergency by zhte415 on Friday January 31, 2020 @06:25AM (#22200809)
Korea evacuated 400 today, 1 couldn't board the plane because known infected, on arrival 4 were tested and found to be infected. This is consistent with the Japan flight from yesterday that you mention.
Re:WHO declares coronavirus outbreak a public health emergency by pabl0rg on Friday January 31, 2020 @06:49AM (#22200907)
So, you are infected? How does it compare to the flu? Are symptoms very different?

Best wishes for your recovery!

Re:WHO declares coronavirus outbreak a public health emergency by zhte415 on Friday January 31, 2020 @07:29AM (#22201077)
1, not I. I think you mis-read.
Re:WHO declares coronavirus outbreak a public health emergency by TotempaaltJ on Friday January 31, 2020 @07:23AM (#22201053)
GP didn't say anything about being infected.
Re:WHO declares coronavirus outbreak a public health emergency by brigandish on Friday January 31, 2020 @05:47AM (#22200640)
On top of that, 2 of the returnees refused to be tested. Who knows what they're up to… work? Seeing family? Hanging around in the park with a Strong Zero for a chat?
Re:WHO declares coronavirus outbreak a public health emergency by Double_a_92 on Friday January 31, 2020 @02:42AM (#22199869)
> I've see death certificates posted online with "viral pneumonia"

Would that not be a proper reason for a corona virus caused death? Or does it have to be specific if the exact cause is known?

Re:WHO declares coronavirus outbreak a public health emergency by mirimir on Friday January 31, 2020 @03:42AM (#22200098)
I'd expect that death certificates would specify the specific cause, if it's known. But I don't know if that's true.

Either way, it makes the data far less useful.

Re:WHO declares coronavirus outbreak a public health emergency by _-___________-_ on Friday January 31, 2020 @06:42AM (#22200872)
How is "viral pneumonia" not the specific cause of death?
Re:WHO declares coronavirus outbreak a public health emergency by Jamwinner on Friday January 31, 2020 @08:23PM (#22207834)
Thats like saying the person died form lack of blood after being shot. Its technically correct, but actually useless.
Re:WHO declares coronavirus outbreak a public health emergency by _-___________-_ on Saturday February 01, 2020 @04:23AM (#22209601)
Medically it seems much more specific though. You could die from numerous things after a gunshot wound, so naming the specific cause of death is more accurate.
Re:WHO declares coronavirus outbreak a public health emergency by mirimir on Friday January 31, 2020 @06:03PM (#22206865)
Doesn't say which virus.

If they don't know, fine. Albeit sloppy, given the context.

If they do know, and don't say, it's deceptive.

Re:WHO declares coronavirus outbreak a public health emergency by _-___________-_ on Saturday February 01, 2020 @04:24AM (#22209606)
I'm not sure that it's deceptive; generally the "cause of death" is just one part of a larger report that can give further detail.
Re:WHO declares coronavirus outbreak a public health emergency by explore on Friday January 31, 2020 @02:13AM (#22199758)
New data, based on "all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020": 11% "died of multiple organ failure" and 23% are in intensive care unit https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
Re:WHO declares coronavirus outbreak a public health emergency by peteretep on Friday January 31, 2020 @03:12AM (#22199970)
Interesting, however:

> Most patients were men, with a mean age of 55·5 years (SD 13·1; table 1). 50 (51%) patients had chronic diseases, including cardiovascular and cerebrovascular diseases, endocrine system disease [and some others]

The findings conclude:

> In general, the characteristics of patients who died were in line with the early warning model for predicting mortality in viral pneumonia

Also the group was self-selecting of people who went to hospital before Jan 20th.

In summary: old men with pre-existing health conditions are going to have a rough ride. Am yet to see this play out in 2020 Presidential Election odds though.

Re:WHO declares coronavirus outbreak a public health emergency by bra4you on Friday January 31, 2020 @03:36AM (#22200076)
>50 years is not old. I don't know what is considered old but I know that >75y has a two magnitudes higher mortality rate with the flu.

I doubt that the 50 years old Hospital doctor who died had any serious per-existing health condition. In fact, you could argue hat most doctors have a stronger immune system than average since they are exposed to more germs due to their profession. So this 50y old professional dropping dead is a bad sign! (and hands off to him for his bravery in doing his job).

You could only argue that he cough the strain very early. A virus jumping into a new species is more aggressive at the beginning, later it adopts more to the new host and becomes less aggressive.

Re:WHO declares coronavirus outbreak a public health emergency by ddeck on Friday January 31, 2020 @08:00AM (#22201251)
>I doubt that the 50 years old Hospital doctor who died had any serious per-existing health condition.

If you are referring to the doctor in Wuhan - Liang Wudong - he was 62-years old.

Re:WHO declares coronavirus outbreak a public health emergency by smileybarry on Friday January 31, 2020 @06:01AM (#22200696)
"Old" might be the wrong word, but the gist of it is that, like the flu, it's potentially worse around the 50-60+ age group.
Re:WHO declares coronavirus outbreak a public health emergency by fctorial on Thursday January 30, 2020 @10:24PM (#22198740)
> The scary part is that of the official 8,200 or so people that have been confirmed to have the virus there's been 171 deaths, and 143 recoveries.

It isn't that bad. It means that this virus won't kill more than 50% of population even if we were to shut down all research right now.

Re:WHO declares coronavirus outbreak a public health emergency by rurp on Friday January 31, 2020 @12:03AM (#22199222)
Uh, in what world is wiping out half a population not that bad??
Re:WHO declares coronavirus outbreak a public health emergency by flukus on Friday January 31, 2020 @12:24AM (#22199317)
The new world, post smallpox that wiped out up to 90% of the population. That's setting quite a low bar though, it would still be about on par with the black death.
Re:WHO declares coronavirus outbreak a public health emergency by Brave-Steak on Friday January 31, 2020 @05:24AM (#22200533)
One could argue that thinning the population of the older demographic with pre-existing (and expensive) conditions could be a net benefit to governments with socialized healthcare. See Taiwan which has repeatedly had to refund their system because of an aging population and the related growing costs.
Re:WHO declares coronavirus outbreak a public health emergency by ddeck on Friday January 31, 2020 @08:06AM (#22201317)
I'm not disputing your point, but with respect to Taiwan, the fact that visiting a doctor is almost a sport certainly doesn't help - An average of 14 visits per year per person:

>There is a high level of health seeking behaviour in Taiwan. It is part of the Taiwanese culture to take medicines or to seek medical help frequently, even for minor ailments.

>The average outpatient department visit rate is 14 times per year per person.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960712/

Re:WHO declares coronavirus outbreak a public health emergency by fctorial on Friday January 31, 2020 @09:52AM (#22202082)
That's not what I meant. I was saying that there's at least 50% chance that you might be immune to this virus. Who knows, there might be 1000 people who were infected but never went to hospital because they got better without medical care.
Re:WHO declares coronavirus outbreak a public health emergency by malka on Friday January 31, 2020 @04:33AM (#22200303)
It would be good for the environment
Re:WHO declares coronavirus outbreak a public health emergency by adventured on Friday January 31, 2020 @04:58AM (#22200406)
Humans are part of the environment. Every bit as much as a tree or a koala is. So it wouldn't be good for all of the environment.
Re:WHO declares coronavirus outbreak a public health emergency by rank0 on Friday January 31, 2020 @09:53AM (#22202089)
Christ. I can't imagine wanting half the population to die "for the greater good"...
Re:WHO declares coronavirus outbreak a public health emergency by brigandish on Friday January 31, 2020 @05:49AM (#22200649)
I've noticed it's never people in a vulnerable group that talk this way.
Re:WHO declares coronavirus outbreak a public health emergency by n0rbwah on Friday January 31, 2020 @10:28AM (#22202427)
If they really believed in it, they could start by giving the example and hope others follow.
Re:WHO declares coronavirus outbreak a public health emergency by bearburger on Friday January 31, 2020 @12:08AM (#22199249)
Thanos Did Nothing Wrong /s
Re:WHO declares coronavirus outbreak a public health emergency by mirimir on Friday January 31, 2020 @12:50AM (#22199425)
Sarcasm doesn't do well on HN. Maybe for good reason.
Re:WHO declares coronavirus outbreak a public health emergency by fctorial on Friday January 31, 2020 @09:48AM (#22202047)
There was no sarcasm here. The comment just states that the virus' 0 day fatality rate is at most 50%. Why are you offended by this fact? Obviously we might see some twists like the virus becoming more resiliant, and obviously we won't shut down all research. The actual death count of this disease will be much lower.

Trust me, I know what I'm talking about. I've played plague inc.

Re:WHO declares coronavirus outbreak a public health emergency by mirimir on Friday January 31, 2020 @06:11PM (#22206937)
I didn't mean that your comment is factually incorrect.

It's just that neutrally observing that 50% of a population would die is at least off-putting.

Given your explanation, maybe you were mocking the credulous. Mocking doesn't work well on HN either.

I've looked at comment histories for many shadowbanned users, and I'm just echoing commentary.

Re:WHO declares coronavirus outbreak a public health emergency by mrfusion on Thursday January 30, 2020 @04:41PM (#22196022)
Are the symptoms about the same as the flu? Does having it feel like a flu?
Re:WHO declares coronavirus outbreak a public health emergency by Medicalidiot on Thursday January 30, 2020 @07:37PM (#22197703)
It's like a worse version of the flu. The way that you'll die from the flu is getting a secondary pneumonia infection from Staph aureus or Steptococcus pneumonia, the virus just makes you more susceptible and weaker.

The major lethal consequence for this virus in the Coronavirus family is Acute Respiratory Distress Syndrome (ARDS). A strong outcome for this is we knock you out, put a tube down your throat, and have you breath via mechanical ventilator. It's intense to say the least.

Source: Medical student

Re:WHO declares coronavirus outbreak a public health emergency by lopmotr on Friday January 31, 2020 @02:23AM (#22199793)
If you have that ventilator, can you still die? How? Can the "respiratory distress" get worse without limit?
Re:WHO declares coronavirus outbreak a public health emergency by pfdietz on Friday January 31, 2020 @07:34AM (#22201102)
ECMO could be used in extreme cases, I imagine.

https://en.wikipedia.org/wiki/Extracorporeal_membrane_oxygen...

Re:WHO declares coronavirus outbreak a public health emergency by satanspastaroll on Friday January 31, 2020 @03:20AM (#22200001)
The lung's capacity to take oxygen from air decreases as the infection spreads
Re:WHO declares coronavirus outbreak a public health emergency by koheripbal on Thursday January 30, 2020 @07:49PM (#22197797)
Basically, yes - it's an upper respiratory infection. Indistinguishable from seasonal influenza or a cold, until symptoms are severe.

There may be some slight differences, but even seasonal influenza and a cold frequently present differently.

Re:WHO declares coronavirus outbreak a public health emergency by numpad0 on Thursday January 30, 2020 @09:49PM (#22198543)
Isn’t coronavirus itself a kind of common cold?

I’ve heard that “the common cold” is actually a few completely different infections that isn’t worth strictly classifying for the most, and that coronavirus is one of them. If so, this is “a common cold” except maybe death rates are statistically higher.

Re:WHO declares coronavirus outbreak a public health emergency by lubujackson on Thursday January 30, 2020 @10:02PM (#22198610)
Yes, coronavirus is a broad class of flus. SARS and MERS are both coronaviruses and there seems to be a lot of genetic similarity to SARS.
Re:WHO declares coronavirus outbreak a public health emergency by inferiorhuman on Thursday January 30, 2020 @11:09PM (#22198958)
The flu is the influenza virus, period. The common cold is typically caused by a rhinovirus, but coronaviruses, adenoviruses, and influenza viruses can cause colds too.
Re:WHO declares coronavirus outbreak a public health emergency by trevyn on Thursday January 30, 2020 @11:45PM (#22199142)
But note that “the influenza virus” is a term that includes many genetically distinct mutations.
Re:WHO declares coronavirus outbreak a public health emergency by inferiorhuman on Thursday January 30, 2020 @11:58PM (#22199200)
Sure, and there are around 160 known types of rhinovirus, 50 adenovirus types, and now 7 known forms of human corona viruses. Flu refers to a specific family of RNA viruses, common cold is a much more broad term.
Re:WHO declares coronavirus outbreak a public health emergency by hanniabu on Thursday January 30, 2020 @03:56PM (#22195480)
Any idea what the rates are for the corona virus?
Re:WHO declares coronavirus outbreak a public health emergency by mrtksn on Thursday January 30, 2020 @04:37PM (#22195973)
People mistakenly calculate %2 and %50 simultaneously because they assume that when a case is confirmed the death or cured status is also determined at that moment.

In reality, though, people who are going to die don't die at the moment of infection confirmation and people who are going to live do lag in the log because it takes time to confirm if someone has recovered and virus-free.

Some will suggest to simply compare the deaths to the confirmed case from a week? ago but this assumes that the patients are admitted at the same stage of their infection and all cases at the time are accounted for(deaths are probably much better tracked than the infection and the publicity has a huge impact on the reporting). It would be a guesstimate at best.

I would say, let's stick to official numbers since the calculation requires each patients timeline. Surely an educated guess can be constructed by modelling the patient prognosis and virus behaviour but that also requires much more data than what the public has.

Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @05:23PM (#22196484)
«assume that when a case is confirmed the death or cured status is also determined at that moment»

This is why epidemiologists (ref: https://pdfs.semanticscholar.org/ebf2/48c9fc0a1a23d1778b9408... or https://news.ycombinator.com/item?id=22195827 for my comment on the paper) prefer instead this formula which only counts patients for which the eventual outcome is already known:

deaths / (deaths + recoveries)

With this formula, there is no need to guess the "patient timeline". If you do the math right now for the largest case study known to date (published yesterday: https://www.thelancet.com/journals/lancet/article/PIIS0140-6... covering 99 patients, 11 dead, 31 recovered) you get:

11 / (11 + 31) = 26% case fatality rate

If you do the math on ALL data from mainland China (170 deads, 124 recovered as of 2020-01-29 http://www.nhc.gov.cn/xcs/yqtb/202001/e71bd2e7a0824ca69f87bb... or in english: https://en.wikipedia.org/wiki/Timeline_of_the_2019%E2%80%932...), you get:

170 / (170 + 124) = 58% case fatality rate

This formula gives a pretty good estimate of the eventual observed CFR according to the paper I referenced above. Of course, there are caveats, for one deaths or recoveries may not be properly tracked: there could be many patients with mild cases that are not even detected/confirmed and end up recovering on their own.

PS: I am not stating the lower bound CFR is 26%! Another method I applied (described in twitter thread https://twitter.com/zorinaq/status/1222427708723879936) suggest it could be as low as 9%.

Re:WHO declares coronavirus outbreak a public health emergency by BoiledCabbage on Thursday January 30, 2020 @10:04PM (#22198622)
The problem is that the method that you use and the paper referenced (https://pdfs.semanticscholar.org/ebf2/48c9fc0a1a23d1778b9408...) only applies the calculation on data 3 weeks, 4 weeks and 5 weeks after the epidemic has peaked. Of course you can get valid data once things have peaked and are slowing down. The issue is trying to get valid data while still in the exponential growth portion. And it seems like this method would have all the same flaws as other methods on rapidly changing data (if not worse due to the lag between recovery and deaths.).

I'm not an epidemiologist, but I believe I see flaws in your application of the methods from the paper.

[1] At the bottom page 481 it clearly say the virus peaked on March 27th. The first date they use data for the e2 calculation is April 6th. Two full weeks past the peak.

Re:WHO declares coronavirus outbreak a public health emergency by aqme28 on Thursday January 30, 2020 @07:36PM (#22197695)
Patient timelines still matter. It takes longer to recover than it does to die, so it would make sense to compare current recoveries with the number of deaths from several days ago. But without knowing the patient timeline, I couldn't tell you how many.
Re:WHO declares coronavirus outbreak a public health emergency by dumbfoundded on Thursday January 30, 2020 @09:43PM (#22198513)
This is a great point and we should also normalize it to similar flu's in the region. Quality of treatment will vary greatly.
Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @09:53PM (#22198560)
«It takes longer to recover than it does to die»

Citation needed. I am not aware of data supporting this (or the reverse.)

Re:WHO declares coronavirus outbreak a public health emergency by Double_a_92 on Friday January 31, 2020 @02:47AM (#22199889)
> deaths / (deaths + recoveries)

How does that produce a meaningful number? If you got 1000s of infected people, and 1 dies... The formula would be 1 / (1 + 0) = 100%. What does that mean?

Re:WHO declares coronavirus outbreak a public health emergency by acqq on Friday January 31, 2020 @04:40AM (#22200334)
You simply have to have the known numbers of confirmed dead and recovered patients.

The way you used it "1 / (1 + 0) = 100%" means just "the knowledge used in the formula is that one patient died, zero recovered." In that case, yes, the fatality rate is "everybody dies." But using the sample of 1 is of course not meaningful for any statistics, not only for that formula.

Re:WHO declares coronavirus outbreak a public health emergency by tremon on Friday January 31, 2020 @06:11AM (#22200747)
It means that nobody has succesfully recovered following a confirmed infection, which is exactly what your data suggests.
Re:WHO declares coronavirus outbreak a public health emergency by mrtksn on Thursday January 30, 2020 @05:31PM (#22196579)
What exactly a margin of %9 to %56 tells us anyway?
Re:WHO declares coronavirus outbreak a public health emergency by akiselev on Thursday January 30, 2020 @06:16PM (#22197033)
Nothing conclusive but if a new disease emerges has a mortality rate even approaching 9% and a basic reproduction number (R0) of 1 or greater, it's a significant cause for concern. Combined with the incubation period, asymptomatic transmission, and the population density in which the outbreaks occurred, in this case it's enough to declare a global public health emergency.
Re:WHO declares coronavirus outbreak a public health emergency by twelvechairs on Thursday January 30, 2020 @04:01PM (#22195533)
The official figures in China are 8,163 cases 171 deaths which is 2% right now, but take these with a big grain of salt. They could go up (some of those confirmed cases will be very recent and may get worse) or down (more cases might have happened but be unreported). Its really hard to tell what it will look like in a month or two.
Re:WHO declares coronavirus outbreak a public health emergency by Roritharr on Thursday January 30, 2020 @04:26PM (#22195839)
I recommend everyone to watch this on-site commentary from the chinese human rights lawyer Chen Qiushi: https://www.youtube.com/watch?v=7AI3R41dGnU

Any numbers we've seen so far seem very tame to me, compared to the pictures out of Wuhan.

Re:WHO declares coronavirus outbreak a public health emergency by colinprince on Thursday January 30, 2020 @07:34PM (#22197678)
I watched the whole thing. It was riveting. Don't forget to turn on CC if you need translation. It is a volunteer transalation.

The reporter, Chen Qiushi, describes his observations in Wuhan, a city of more than 10 million.

His preamble:

"My name has been flagged in China."

"If the content contains 'Chenqiushi' or 'CQS', or my face, it will not be sent on Wechat. ... if you [share on wechat], your wechat account will be deleted, like mine.""

He describes visits he made to hospitals in Wuhan and the general state in the city.

It is well worth listening to / reading.

Some points that stuck with me:

People cannot get to hospital because there is a critical lack of transportation.

There is a critical lack of test kits, so residents do not believe they will be diagnosed, so they stay home.

The original (not translated) is here: https://www.youtube.com/watch?v=iXozpbomAns

(thanks Roritharr)

Re:WHO declares coronavirus outbreak a public health emergency by Roritharr on Thursday January 30, 2020 @09:27PM (#22198439)
I really wonder if I made myself unemployable in China because I posted this.

How far does the censoring actually go?

Re:WHO declares coronavirus outbreak a public health emergency by iliketosleep on Thursday January 30, 2020 @10:15PM (#22198691)
It goes far enough that your concern is valid. Since HN is not exactly mainstream and many Chinese people are posting similar kinds of videos, you're probably okay in this case. However, if you want to make honest comments about China online and still want to travel there, I highly recommend that you post anonymously.
Re:WHO declares coronavirus outbreak a public health emergency by joejerryronnie on Friday January 31, 2020 @01:07AM (#22199496)
I’ve removed a couple HN posts that were super critical of China for fear of some type of online repercussions. You never know.
Re:WHO declares coronavirus outbreak a public health emergency by mantap on Thursday January 30, 2020 @09:44PM (#22198517)
China is an autocratic dictatorship so the rules can and do change at any time, retroactively and arbitrarily.

That said you aren't going to be blacklisted for a single comment on HN. That sounds like the kind of thing the US would do.

Re:WHO declares coronavirus outbreak a public health emergency by jdkee on Thursday January 30, 2020 @11:17PM (#22198992)
No, that sounds like the thing China would do once it has perfected pattern recognition in 2023 or so.
Re:WHO declares coronavirus outbreak a public health emergency by netsharc on Thursday January 30, 2020 @07:22PM (#22197588)
TL;DW/DR the subtitles: he saw a lot of chaos in Wuhan's hospitals. Not enough testing kits, not enough government-requisitioned emergency taxis. Taxi drivers were already talking to each other in December saying "avoid the market".

If you don't want to read subtitles for 26 minutes here's all the subtitles copy-pasted from the video: https://pastebin.com/6hJ4h4rm

(You can hit the "..." above the red subscribe button and select "open transcript", but it shows up in a tiny window).

I suppose the WHO saying they're very impressed with how China is handling the situation is because they felt the pressure to save China's face.

Re:WHO declares coronavirus outbreak a public health emergency by pmoriarty on Thursday January 30, 2020 @10:11PM (#22198666)
Thank you so much for this transcript.

Reading through it made it clear that:

1 - Wuhan's health care system is overwhelmed

2 - There's not enough transportation, test kits, masks, and hospital beds, or volunteers

3 - Many sick people are not even bothering to go to the hospital

4 - There's poor communication and rumors flying around

5 - People are frightened, panicking, and suspecting the worst

This tells me that:

A - there are likely way more people infected than there are confirmed cases, but possibly more deaths too of those who never made it in to hospitals

B - Many wouldn't have died had they had more adequate health care, better transportation and more test kits

So, for the rest of us who are sitting on our hands now, glued to social media or the television waiting to see how this will unfold, our time would be much more productively spent planning for when the outbreak hits our local area.

Volunteer. Get connected with volunteer organizations. Donate. See what you can do to ensure there's adequate transportation, communication and resources when the outbreak hits your area.

One thing I'm really curious about that I haven't heard covered yet is if people who get sick and recover become immune. If so, they should feel safe in volunteering to come in contact with the sick and help them directly after they've recovered themselves.

Cooperation, preparation, organization, and mutual aid are crucial.

Re:WHO declares coronavirus outbreak a public health emergency by mantap on Thursday January 30, 2020 @09:31PM (#22198453)
The way the central government is handling this is impressive, quarantining a city of that size is unprecedented and has bought the world extra time to prepare.

Yes the WHO are playing politics when they focus on the good things China is doing and ignore the bad. But personally I think they are closer to the truth than those who present an entirely negative version of events. China's response has been 70% good :)

Re:WHO declares coronavirus outbreak a public health emergency by heavyset_go on Friday January 31, 2020 @12:03AM (#22199221)
> The way the central government is handling this is impressive

Not really, they jailed the experts who told them that they needed to act quickly, sat on it for a month, and finally did something about it when it was already out of hand.

Re:WHO declares coronavirus outbreak a public health emergency by brigandish on Friday January 31, 2020 @06:06AM (#22200720)
> they jailed the experts who told them that they needed to act quickly

If you don't mind me asking, where did you see that info?

Re:WHO declares coronavirus outbreak a public health emergency by heavyset_go on Sunday February 02, 2020 @03:43AM (#22215921)
I don't have the exact articles on hand right now, but here is a newer article on the suppression: https://www.nytimes.com/2020/02/01/world/asia/china-coronavi...
Re:WHO declares coronavirus outbreak a public health emergency by sliken on Thursday January 30, 2020 @10:16PM (#22198695)
It would be more impressive if it wasn't a month after the problem started and after 5M people left.
Re:WHO declares coronavirus outbreak a public health emergency by netsharc on Friday January 31, 2020 @07:21AM (#22201045)
Huh, I would say you're in the wrong thread to claim it's "impressive", if this guy's video is to be believed, it's a whole lot of chaos and lack of supplies...
Re:WHO declares coronavirus outbreak a public health emergency by mantap on Friday January 31, 2020 @10:05PM (#22208353)
We have gone from the first confirmed human-to-human transmission to tens of thousands of cases in something like two weeks. No amount of preparation will prevent chaos and shortages in a situation like this.

I watched the CDC press conference today and saw nothing but fear written on their faces. And that is with far more advanced notice than the Chinese had.

Re:WHO declares coronavirus outbreak a public health emergency by pier25 on Thursday January 30, 2020 @11:56PM (#22199190)
Totally off topic but... Chinese seems like a very efficient language. The guy doesn't seem to be speaking so fast but the subtitles are conveying a lot of information really fast.
Re:WHO declares coronavirus outbreak a public health emergency by abj on Friday January 31, 2020 @03:08AM (#22199957)
Here's [1] a paper on information density vs speed of speech, done by the University of Lyon. I am not sure how accurate their methods are, but they seem to believe that some languages convey more information per syllable and for 5 out of 7 languages, that ones with lower information density are spoken faster. Note that the sample size was only 59 and only compared how fast 20 different texts were read out, all silences that lasted longer than 150 ms were edited out as well.

[1] http://www.ddl.ish-lyon.cnrs.fr/fulltext/pellegrino/Pellegri...

Re:WHO declares coronavirus outbreak a public health emergency by pier25 on Friday January 31, 2020 @10:15AM (#22202281)
Interesting. In that paper Mandarin has the lowest syllable rate and the highest information density.

https://imgur.com/4zwH1Ml

Re:WHO declares coronavirus outbreak a public health emergency by kordlessagain on Friday January 31, 2020 @12:21AM (#22199301)
It's a tonal language, which enables multiple use of a single letter/tone. Evidently English speakers have trouble detecting proper tone..
Re:WHO declares coronavirus outbreak a public health emergency by dredmorbius on Friday January 31, 2020 @01:51AM (#22199666)
Subtitles, slightly edited for reading:

https://pastebin.com/raw/VrLPVC2H

Re:WHO declares coronavirus outbreak a public health emergency by inferiorhuman on Thursday January 30, 2020 @10:59PM (#22198909)
The official figures in China are 8,163 cases 171 deaths which is 2% right now, but take these with a big grain of salt.

I wouldn't even go that far. I've been using this as an excuse to figure out the D3 v5 API using the Johns Hopkins data. Most provinces outside of Hubei are not reporting deaths yet. It's possible nobody's died outside of Hubei, but that seems suspect to me. There is almost certainly strong federal and local pressure to under report deaths, but this sort of thing is much harder to hide in Hubei because it's the epicenter.

I don't believe for a moment that China would've attempted to quarantine 60 million people so quickly if the case fatality rate were only 2%. 2% is bad but SARS saw around 15% in many countries and things weren't locked down this tightly.

More to the point, Hubei is reporting 204 deaths and 5,806 confirmed cases which works out to about 3.5%. This is compared to 76 deaths and 1,423 confirmed three days ago (or 5%). If you'd like to look at death compared to known outcomes you're looking at about 64% of the outcomes being death (204 deaths, 116 recoveries). It's not clear which part of the equation is lagging more in Hubei.

Re:WHO declares coronavirus outbreak a public health emergency by bosie on Friday January 31, 2020 @11:20AM (#22202844)
> I don't believe for a moment that China would've attempted to quarantine 60 million people so quickly if the case fatality rate were only 2%. 2% is bad but SARS saw around 15% in many countries and things weren't locked down this tightly.

presumably fatality is only one of many factors here. 15% of 100 infections is a different beast than 2% of 1M. And if it takes up to 14 days to see symptoms...

Re:WHO declares coronavirus outbreak a public health emergency by inferiorhuman on Friday January 31, 2020 @07:32PM (#22207493)
15% of 100 infections is a different beast than 2% of 1M.

There were roughly 8,000 SARS infections and currently about 10,000 nCoV infections so the comparisons aren't quite as absurd.

Re:WHO declares coronavirus outbreak a public health emergency by nabla9 on Thursday January 30, 2020 @04:06PM (#22195577)
That 2% is only among those confirmed. When most people get sick they just stay home, then get better and never visit hospital or get into confirmed cases. Those who die usually have some other disease as well.
Re:WHO declares coronavirus outbreak a public health emergency by jansan on Thursday January 30, 2020 @05:29PM (#22196554)
On April 1st 2003, when SARS was in full swing, the WHO reported 1622 cases and 58 deaths. That is a rate of 3.5%. In June 2003 (at the end of the SARS outbreak) the official figure was almost ten percent. From this comparison you can expect the mortality rate of the new corona virus to be at around 6 to 8%.

Source: https://www.who.int/csr/sars/press2003_04_01/en/ (search for "deaths")

Re:WHO declares coronavirus outbreak a public health emergency by lubujackson on Thursday January 30, 2020 @10:14PM (#22198682)
It is dangerous to extrapolate like this because the big differences are in incubation time and the fact that the novel coronavirus is likely spreadable before the carrier has a fever or other detectable sign. If that's the case, tracking the spread might as well be impossible because multiple people could be the potential source without a clear way to trace it, especially in a hospital setting.

On the flip side, the R0 (rate of transmission) and death rate might be a good clip lower than currently estimated. On the other hand, China walled off a city but part of their motivation might have been the flack they got for moving slowly with SARS.

Re:WHO declares coronavirus outbreak a public health emergency by hef19898 on Friday January 31, 2020 @08:42AM (#22201551)
I saw an interview with a German virologist. Her estimate was to have fatality rate of around 2%. Also stated the issues of calculating these number during the outbreak as not all cases are known, not everyone is either cured or dead. She also hinted at a bias towards the severe cases as most minor ones, symptoms like a cold, aren't reported yet and most likely not admitted to a hospital.

As she said, we will only know once the thing is over.

Re:WHO declares coronavirus outbreak a public health emergency by 2019-nCoV on Thursday January 30, 2020 @04:07PM (#22195599)
It's currently 171 deaths, 8,288 confirmed infected, which is 2% dead. However, what needs to be taken into consideration is that infected individuals don't die the day they are confirmed infected, there is a lag of several days.

Assuming the average time from symptom onset and diagnosis to death is 7 days, we're looking at at 20% death rate (830 confirmed infected 1 week ago). Even a 5 day lag between symptom onset to death is a ~9% death rate (1,975 confirmed infected 5 days ago).

This is exactly how the fatality rate of SARS played out.

Re:WHO declares coronavirus outbreak a public health emergency by jcfrei on Thursday January 30, 2020 @04:16PM (#22195710)
I'm not an expert on viruses by any means but that seems unnecessarily pessimistic. The number of infections is likely much much higher than the confirmed cases (laboratories have only so many test kits available per day) but most people stay asymptomatic. This would reduce the actual mortality rate, not increase it.
Re:WHO declares coronavirus outbreak a public health emergency by 2019-nCoV on Thursday January 30, 2020 @05:08PM (#22196322)
If indeed most people stay asymptomatic (but contagious), you're right that the actual mortality rate is lower. But this same outlook would translate to an increase in total fatalities as it greatly complicates containment.
Re:WHO declares coronavirus outbreak a public health emergency by btilly on Thursday January 30, 2020 @04:23PM (#22195809)
The number of infections is likely much much higher than the confirmed cases (laboratories have only so many test kits available per day) but most people stay asymptomatic.

Do you have evidence of that in this case?

Viruses vary widely on how many are asymptomatic. My understanding is that having people be infectious and asymptomatic only happens with diseases that are well-adapted to their hosts. Which this one, having recently crossed a species barrier, isn't. (Its fatality rate is also high for the same reason.)

However that is a general understanding and I don't have data to base it on on this case. Do you?

Re:WHO declares coronavirus outbreak a public health emergency by jcfrei on Thursday January 30, 2020 @04:35PM (#22195952)
There have been quite a few cases covered in the press about patients which carried the virus but didn't show any symptoms. Most recently: https://asia.nikkei.com/Spotlight/Coronavirus-outbreak/Three...
Re:WHO declares coronavirus outbreak a public health emergency by btilly on Thursday January 30, 2020 @04:41PM (#22196026)
Thanks.

If they in fact can't transmit, then this is OK. If they can or, even worse, have a long latency period and will show symptoms in 2 weeks, that is very, very scary.

Our best tool for diseases like this is contact tracing. And asymptomatic carriers make that very hard.

(Useless trivia, the first documented asymptomatic carrier who was infectious was a short order cook named Mary Mallon. She is better known as Typhoid Mary.)

Re:WHO declares coronavirus outbreak a public health emergency by underwater on Thursday January 30, 2020 @05:02PM (#22196252)
She wasn't a short order cook, she cooked for a number of families.
Re:WHO declares coronavirus outbreak a public health emergency by btilly on Thursday January 30, 2020 @05:35PM (#22196615)
She was both.

When she was first identified, she cooked for a number of families. The outbreak that got her put away for life was due to working as a cook at Sloane Hospital for Women.

I cannot immediately find record of her being a short order cook specifically. However that is my recollection from https://www.amazon.com/Betrayal-Trust-Collapse-Global-Public...

Re:WHO declares coronavirus outbreak a public health emergency by Zod666 on Thursday January 30, 2020 @06:54PM (#22197366)
There's a good docu on her story. It might be on YouTube.
Re:WHO declares coronavirus outbreak a public health emergency by merpnderp on Thursday January 30, 2020 @04:46PM (#22196087)
7 days is too short. In the 2 Lancet studies (the 41 person cohort and the 99 person cohort), the time from diagnosis to the first recorded death is 11 days later, but most happened sometime after that. It's likely safe to say that diagnosis to death is 2-3 weeks.
Re:WHO declares coronavirus outbreak a public health emergency by _-___________-_ on Friday January 31, 2020 @06:49AM (#22200911)
The number of deaths is likely to be much more accurate than the number of infections, which are likely much more than 8,288, leading to a much lower fatality rate.
Re:WHO declares coronavirus outbreak a public health emergency by yibg on Friday January 31, 2020 @12:39AM (#22199388)
Too many unknowns to say. We don’t know:

- how many infected but not confirmed. They could be asymptotic or mild enough not to seek medical treatment. This would increase the denominator.

- time between infection to first symptom to death. Therefore we don’t know which way the remaining confirmed cases will go. Probably increase the numerator over time but don’t know by how much.

- unclear how accurate the reported numbers are.

Re:WHO declares coronavirus outbreak a public health emergency by moralestapia on Thursday January 30, 2020 @04:27PM (#22195855)
IMHO assuming a 2% rate this early is a bit disingenuous. This due to the 8,288 confirmed cases not having registered an outcome yet. If you look at people cured vs. people dead, the picture looks much worse, but yeah a lot of variables still come into play (they were prob. the most vulnerable, they were the first ones so treatment may not have been the best, etc.).
Re:WHO declares coronavirus outbreak a public health emergency by fspeech on Thursday January 30, 2020 @06:54PM (#22197364)
Do a sanity check: does your 20% number make any sense based on what is known about the cases outside of China?
Re:WHO declares coronavirus outbreak a public health emergency by 2019-nCoV on Thursday January 30, 2020 @08:32PM (#22198126)
1 week ago there were only 6 confirmed cases outside of China.
Re:WHO declares coronavirus outbreak a public health emergency by threatripper on Thursday January 30, 2020 @05:25PM (#22196506)
We don't know.

We don't know how many people are infected. We only have numbers of confirmed cases and those numbers are heavily skewed because 1) people don't know they are sick 2) stay at home or 3) are not diagnosed properly. Those diagnosed in China are probably severe cases with a multiple not being diagnosed. Also, it is unclear how good the reporting is.

We don't know how many of those who are infected will die and how many will recover. We only know of deaths of confirmed patients in the hospital. Of roughly 10000 confirmed cases 200 are dead, 200 are recovered and 9600 are yet to be determined. From that you could deduce 2% or 50%, less than 2% or more than 50% or anything else. Right now we don't have good data. Also we don't know how long it takes to die or to recover and on most patients we will probably lose track.

Since the infection takes about 2 weeks, we have to wait a few weeks until the smoke starts clearing.

Re:WHO declares coronavirus outbreak a public health emergency by cheeseblubber on Thursday January 30, 2020 @03:58PM (#22195496)
It seems to be too early to tell. There are most likely a lot of undocumented infected cases as well as the incubation period for the virus might be different than the flu. Which can move mortality rate both ways.
Re:WHO declares coronavirus outbreak a public health emergency by zhte415 on Friday January 31, 2020 @06:34AM (#22200842)
Not being flippant, as you've had good answers already, I can tell you the rate of fear of this novel coronavirus:

100%

Streets are deserted. The few that go out all wear a mask. Restaurants, museums, cafes, bars have been demanded shut across the country, ostensibly until the end of the weekend but I can see this being extended. The first working day after the Chinese New Year was supposed to be February 3rd, but the city I'm in have extended this to February 9th - offices have been told not to open. Shops are open, there is food, and new fresh vegetables, fruits, meats are being stocked.

Re:WHO declares coronavirus outbreak a public health emergency by avip on Thursday January 30, 2020 @04:46PM (#22196088)
Short answer: seasonal flu << ncov < SARS.

Long answer: wait a week or two.

Re:WHO declares coronavirus outbreak a public health emergency by yibg on Friday January 31, 2020 @12:45AM (#22199404)
Even this we don’t know yet. Could be worse than SARS, although most likely not lower than flu. Not enough data to tell yet.
Re:WHO declares coronavirus outbreak a public health emergency by therealmarv on Thursday January 30, 2020 @04:31PM (#22195902)
NCOV (new corona) 2%, SARS (2012) around 10%, yearly normal flu around 0.01%-0.05% and Ebola 50-90%
Re:WHO declares coronavirus outbreak a public health emergency by jansan on Thursday January 30, 2020 @05:34PM (#22196602)
During the SARS outbreak in April 2003 the reported rate was around 3.5% (58 deaths on 1622 "probable cases").

Source: https://www.who.int/csr/sars/press2003_04_01/en/

Re:WHO declares coronavirus outbreak a public health emergency by _-___________-_ on Friday January 31, 2020 @06:52AM (#22200918)
What's your point? I don't think it obviously follows that the NCOV fatality rate is under-reported just because the SARS fatality rate was.
[dead]
Re:WHO declares coronavirus outbreak a public health emergency by dang on Friday January 31, 2020 @12:24AM (#22199321)
Please don't do this here.

We've fixed the typo in the GP comment.

Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @04:25PM (#22195827)
Ignore the people telling you it's 2-3%. The case fatality ratio is between 9 and 56% according to proper epidemiological methods, such as using the formula "deaths / (deaths + recoveries)": https://mobile.twitter.com/zorinaq/status/122242770872387993...

Disclosure: no I'm not an epidemiologist. But for a reference to a paper by actual epidemiologists see https://pdfs.semanticscholar.org/ebf2/48c9fc0a1a23d1778b9408... section Simple Estimators, specifically this formula:

e₂(s)=D(s)/{D(s)+R(s)} which is: deaths / (deaths + recoveries)

The paper concludes: "The second simple estimate based on the ratio of deaths of those for whom the outcome is known, e₂, is reasonable at most points in the epidemic" ie. produces a good estimate of the eventual observed case fatality rate (in fact in their example it slightly underestimates the actual case fatality rate)

Re:WHO declares coronavirus outbreak a public health emergency by goblin89 on Thursday January 30, 2020 @04:37PM (#22195974)
If hospitals err on safe side and do not report recoveries promptly (they probably have other business to deal with), applying this method at such early stage would not result in correct numbers, even supposing the virus is well-studied enough to tell when a patient has recovered.
Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @04:57PM (#22196205)
Agreed, when using the "deaths / (deaths + recoveries)" formula, recoveries being under-reported is possible and would skew the CFR upward. But also, if deaths are under-reported in the same proportion as recoveries, then it would not affect the CFR.

I suppose one way to reduce uncertainty is to examine a cohort of patients and follow it meticulously. To do that, we can look at the 99-patient case study published in The Lancet yesterday: https://www.thelancet.com/journals/lancet/article/PIIS0140-6... 11 died, 31 were discharged, and 57 remain in the hospital. This suggests a CFR of 11/(11+31) = 26% The assumption epidemiologists make when they use this formula is that the 57 still in the hospital have the same chance of dying as those who already died in the hospital.

Re:WHO declares coronavirus outbreak a public health emergency by Fomite on Thursday January 30, 2020 @06:54PM (#22197355)
...that's not the assumption epidemiologists make. For the very simple reason that there are many "just so" stories you can tell about those still in the hospital - are they sicker, and thus there longer? Are the secondary cases, which in the case of MERS had a much lower CFR?

This is a very straightforward application of survival analysis, and those still in the hospital are "censored" observations - we know their outcome takes place in the future, but we're not sure when.

There are methods for calculating things like CFR in the presence of censoring, which will change based on what type of model you're using.

Re:WHO declares coronavirus outbreak a public health emergency by goblin89 on Thursday January 30, 2020 @05:54PM (#22196827)
Assigning 50% chance of death to any patient remaining in the hospital when calculating mortality rate would be nuts, I can only thank the epidemiologists for not publishing the number.
Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @06:05PM (#22196944)
Not 50%, you misunderstand me. I edited my comment to clarify. What I meant is out of those who came out of the hospital (either dead or recovered), 26% died. So those remaining in the hospital are assumed to have a 26% chance of dying.

Another way of looking at probabilities, out of the 57 patients left in the hospital:

If 0 die (ie. all recover), the CFR is 11% (11 deads, 88 recovered)

If 15 die (26% of 57 still hospitalized), the CFR is 26% (11+15=26 deads, 73 recovered)

If 57 die, the CFR is 69% (11+57=68 deads, 31 recovered)

So the CFR bounds are 11-69% and if the trend on remaining patients continue it should be 26%.

Re:WHO declares coronavirus outbreak a public health emergency by nostrademons on Thursday January 30, 2020 @07:55PM (#22197848)
Looking only at hospitalized populations creates severe selection bias when applied to the question people want answered here, namely "If I get nCOV, what's my chance of dying?" Only the most severe cases a physician sees end up hospitalized, and only the most severe cases within the general population end up being seen by a physician and confirmed as nCOV. You've already got two levels of selection bias (with an unknown percentage passing through each filter) before reaching the denominator in your numbers.
Re:WHO declares coronavirus outbreak a public health emergency by pmoriarty on Thursday January 30, 2020 @10:35PM (#22198790)
Not only that, but Wuhan's hospitals and health care system in general seem to be overwhelmed.

In other places that are better prepared and which have more resources the outcomes will likely be better, in worse prepared places with fewer resources the outcomes will likely be worse.

Let's keep that in mind before we extrapolate from Wuhan to the rest of the world.

Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @09:59PM (#22198593)
Correct there is a bias. However even when comparing the coronavirus to the seasonal flu (hospitalized patients only), the coronavirus still looks much more severe:

Only 7% of hospitalized flu cases died in 2018-2019 (34 157 out of 490,561): https://www.cdc.gov/flu/about/burden/index.html The coronavirus would thus appear to be 4 times more deadly (26%.)

Re:WHO declares coronavirus outbreak a public health emergency by _-___________-_ on Friday January 31, 2020 @06:54AM (#22200931)
Or the hospitals are more overwhelmed now, so only the sickest patients are being admitted.
Re:WHO declares coronavirus outbreak a public health emergency by alasdair_ on Friday January 31, 2020 @02:05AM (#22199728)
I suspect that “chance of dying” varies based on treatment, and that treatment in an overwhelmed Wuhan hospital is likely not the same as treatment as, say, the first patient in France to get the disease.
Re:WHO declares coronavirus outbreak a public health emergency by bra4you on Friday January 31, 2020 @03:42AM (#22200101)
"I suspect that “chance of dying” varies based on treatment, "

I doubt this. WHile this may be true for a known disease, we have to ask, how much can the hospital do in this cases? It is a little bit like HIV in the beginning. Watch them die?

Interestingly, China is trying HIV medications on the infected.

Re:WHO declares coronavirus outbreak a public health emergency by hybrid_cluster on Friday January 31, 2020 @04:17AM (#22200237)
One of the main causes of death of the new coronavirus seems to be Acute Respiratory Distress Syndrome (ARDS). This can be treated fairly effectively with ventilation, but such treatment would obviously require a bed, ventilation system, and attentive nurses, at the very least. It's easy to imagine how these requirements may currently not be met for all patients with ARDS symptoms in Wuhan.

For more info on ARDS and treatment in the context of the current pandemic, see this informative explanation: https://www.youtube.com/watch?v=okg7uq_HrhQ

Re:WHO declares coronavirus outbreak a public health emergency by colinmegill on Thursday January 30, 2020 @04:35PM (#22195948)
That's you touting your own feed, and you don't appear to be an epi scientist
Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @05:43PM (#22196696)
I'm just applying the work of epi scientists. I'd love to get feedback from one. Your comment isn't useful.
Re:WHO declares coronavirus outbreak a public health emergency by Fomite on Thursday January 30, 2020 @06:55PM (#22197376)
Given you're posting on Twitter, adding the #epitwitter will get you plenty of exposure to ID epidemiologists, myself included.
Re:WHO declares coronavirus outbreak a public health emergency by baq on Thursday January 30, 2020 @04:32PM (#22195924)
couldn't believe these numbers, read the link. correctness is obvious in retrospect, numbers are trivial to calculate by hand by just looking at daily data.

still can't believe them.

Re:WHO declares coronavirus outbreak a public health emergency by mrb on Thursday January 30, 2020 @05:08PM (#22196320)
"Just looking at daily data" is your mistake. Essentially, it takes N days for the virus to kill, so deaths will lag confirmed cases by N days, and thus the calculated case fatality rate using this method is incorrect. This is why epidemiologists call it a "naïve esimator" (see section 3.1 in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540071/).
Re:WHO declares coronavirus outbreak a public health emergency by AlayaMatrix on Friday January 31, 2020 @08:33AM (#22201491)
It taks longer time to confirm recoveries than death.
Re:WHO declares coronavirus outbreak a public health emergency by explore on Friday January 31, 2020 @02:18AM (#22199775)
Based on "all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020": 11% "died of multiple organ failure" and 23% are in intensive care unit https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
Re:WHO declares coronavirus outbreak a public health emergency by peteretep on Friday January 31, 2020 @03:14AM (#22199979)
You've quoted this deeply misleading statistic without context more than once. Please desist!
Re:WHO declares coronavirus outbreak a public health emergency by explore on Friday January 31, 2020 @03:35AM (#22200074)
This is not statistics, these are all confirmed local cases of a 20 days period. However, the future distribution may not follow this pattern.
Re:WHO declares coronavirus outbreak a public health emergency by yelnatz on Thursday January 30, 2020 @04:00PM (#22195522)
Well 170/~7000 is ~2.4% which is about 8x deadlier.
Re:WHO declares coronavirus outbreak a public health emergency by Waterluvian on Thursday January 30, 2020 @04:04PM (#22195558)
I think you're off by a few orders.
Re:WHO declares coronavirus outbreak a public health emergency by postalrat on Thursday January 30, 2020 @04:22PM (#22195791)
Like one order? You might be more wrong than him.
Re:WHO declares coronavirus outbreak a public health emergency by Waterluvian on Thursday January 30, 2020 @04:30PM (#22195899)
Isn't it like 0.09% of deaths vs 2% of deaths? I certainly could be misunderstanding the data!
Re:WHO declares coronavirus outbreak a public health emergency by sudosysgen on Thursday January 30, 2020 @10:30PM (#22198767)
0.1 vs 2 is slightly over one order of magnitude.
Re:WHO declares coronavirus outbreak a public health emergency by Waterluvian on Saturday February 01, 2020 @01:16PM (#22212091)
Oh my. Yes. My bad.
Re:WHO declares coronavirus outbreak a public health emergency by ryanwaggoner on Thursday January 30, 2020 @04:04PM (#22195560)
It’s actually about 27x - 80x deadlier than 0.03% - 0.09%
Re:WHO declares coronavirus outbreak a public health emergency by snnn on Friday January 31, 2020 @02:51AM (#22199901)
In 2018, China had 600k flu cases and 153 deaths. So the new virus has caused 10 times more deaths in this Jan. Is it serve?

See: http://www.nhc.gov.cn/jkj/s3578/201904/050427ff32704a5db64f4...

Re:WHO declares coronavirus outbreak a public health emergency by DoctorOetker on Friday January 31, 2020 @04:37AM (#22200324)
I would like the WHO to be as transparent as we demand China to be (and perhaps they are):

At

https://www.who.int/emergencies/diseases/novel-coronavirus-2...

, you can see the standardized protocols for the hospitals dealing with 2019-nCov, such as the anonymizing CRF (Case Record Form):

https://www.who.int/docs/default-source/coronaviruse/who-nco...

Which describes both the CORE and DAILY forms for an electronic database.

Some selected sentences from the pdf:

===

* The CRF is designed to collect data obtained through examination, interview and review of hospital notes. Data may be collected retrospectively if the patient is enrolled after the admission date.

* DO NOT INPUT ANY PATIENT IDENTIFIERS: THIS INCLUDES NAMES, ADDRESSES, DATE OF BIRTH OR PLACE OF BIRTH.

* Step 1: Contact [email protected] to become a contributor to the nCoV global platform.

* Step 2: You will be contacted by ISARIC, platform manager, for assignment informational pack and instructions on how to use the REDCap nCoV platform.

[...]

* If your site would like to collect data independently, establishment of locally hosted database is possible.

* Standard reports will be provided on regular basis to all contributors. Additional analysis for operational public health purposes will be determined by an independent WHO clinical advisory group.

===

As you can see, the only way to get this anonymized data, is to be a contributor, and to be a contributor, you'd have to be a hospital, or somehow be granted access by WHO.

Remember the live outbreak map by John Hopkins? It also displays the number of people that recovered, the dates and definition of recovery duration are helpful in estimating mortality. Note that the other maps and graphs online only publish contaminations and deaths, which is not useful for calculating mortality. Why does John Hopkins deserve access, and why can I not get access, if I wish to fit a statistical model to the epidemic observations?

Re:WHO declares coronavirus outbreak a public health emergency by Accujack on Friday January 31, 2020 @09:36AM (#22201953)
You can. See this page:

https://www.who.int/healthinfo/statistics/en/

Use their API or the web search, however you like.

If you're going to complain about not having up to the minute data available for 2019-nCov, keep in mind that they're not getting the data submitted regularly from China, it's all in daily reports rather than from hospitals.

Re:WHO declares coronavirus outbreak a public health emergency by DoctorOetker on Friday January 31, 2020 @02:10PM (#22204558)
would you mind sharing a more precise link to the actual 2019-nCoV CRF database? I want to independently recalculate mortalities
Re:WHO declares coronavirus outbreak a public health emergency by Accujack on Monday February 03, 2020 @10:42AM (#22225081)
There's not much point, because the data WHO has on the outbreak is being collated from Chinese sources who probably aren't telling the truth. WHO doesn't have a lot of people on the ground in Wuhan and the rest of China feeding them information.

I'm sure there's a database for this outbreak in there somewhere, but I'm also sure the data presently in it is useless. It's likely that at this point the Chinese government doesn't even have accurate data.

Re:WHO declares coronavirus outbreak a public health emergency by DoctorOetker on Monday February 03, 2020 @07:15PM (#22230898)
>There's not much point, because the data WHO has on the outbreak is being collated from Chinese sources who probably aren't telling the truth.

1) No dataset is perfect, and everything leaves traces, so clever people can and do constantly deduce insights from apparently worthless data.

2) It is in the interest of the Chinese to cooperate with submitting these CRF's to their best ability.

3) The little data the WHO does release to the public seems quite accurate for an outbreak, if you look at the log-linear plots and so on. (I am not saying the "known infections" represent the actual number of infections, just that it looks like accurate reporting of exactly that "known infections", and if one reads the forms you see it was designed to take into account overcapacity effects, like sending a patient back home, forwarding to a different hospital, etc...).

>I'm sure there's a database for this outbreak in there somewhere, but I'm also sure the data presently in it is useless.

What do you mean with "in there somewhere" ?

1) If you mean the WHO has the database, then of course the WHO has the CRF database, that's what my original message pointed out.

2) If with "in there somewhere" you meant that it's publically available on their website, then no, it isn't it explicitly states it isn't:

" State Parties are invited to contribute Anonymized nCoV Data to the nCoV Data Platform. State Parties should please contact WHO at [email protected] to obtain more information about, including log-in credentials for, the nCoV Platform.

To preserve the security and confidentiality of the Anonymized nCoV Data, State Parties are respectfully requested to take all necessary measures to protect their respective log-in credentials and passwords to the nCoV Data Platform. "

So they are sitting on the data as I originally claimed. On some of the clearly popularity boosted "contra-infodemic" threads, they even openly admit they can't give more detailed information even though they have access, when people ask them what they base their numbers on. [throughout the rest of the threads they typically go to great lengths to give the impression they work on the same aggregate numbers you and I can publically see, as if there is no censorship on the anonymized CRF data]

Also, why would I care about live to the minute data? I am looking for the actual data (noisy or not), and I don't care if it's delayed by a few days.

As I said, I am would like to build a statistical model.

As a lesson, perhaps not for this epidemic, but then the next: if the average chinese person can afford a smartphone, then surely they can afford a couple of UV-C LED's with a battery pack, with the LED's shining through a reflective manifold (think a pipe bent back and forth with U-bends), then breathing airflow together with proper dose (X mJ per square cm) should sterilize microbes, viruses in the air. Then it just needs to be recharged, instead of trying to manufacture 61Mega masks a day. The air sterilizer (to be attached to a face mask) could be reused for new epidemics every 5 or 10 years (in which time they might have bought 3 or 4 cell phones...)

EDIT: I see on change.org that there have been petitions towards the WHO on other issues before, perhaps someone should submit a petition to release the CRF database to the public domain. And it's not a question of hosting bandwidth, since the WHO can publish cryptographic hashes, and put up torrent magnets...

Re:WHO declares coronavirus outbreak a public health emergency by erikbye on Thursday January 30, 2020 @04:02PM (#22195538)
Global numbers are more interesting.
Re:WHO declares coronavirus outbreak a public health emergency by fb1994 on Friday January 31, 2020 @01:27AM (#22199572)
Re:WHO declares coronavirus outbreak a public health emergency by kohtatsu on Friday January 31, 2020 @01:53AM (#22199673)
It's too early for data on this coronavirus. There isn't enough organizational capacity in Wuhan to properly capture the numbers; to start with it's difficult for people to get to the hospitals because transit is shutdown, and if they get there it's often pointless because there are very few test kits and no free beds. How many have been infected is impossible to determine.

https://www.youtube.com/watch?v=7AI3R41dGnU

Edit: removed remark