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Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Saturday June 27, 2026 @09:36PM (#48703497)
>my body and mind are no longer is in starvation mode

What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body?

I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ceejayoz on Saturday June 27, 2026 @09:53PM (#48703604)
What if you could intentionally eat good food?

I've heard it widely described as reducing mental noise around food.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by mycall on Sunday June 28, 2026 @12:24AM (#48704331)
People can get fat by eating too much healthy food.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @12:38AM (#48704417)
true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense.

Eating healthy food alone isn't solution, you need to make your life active as well.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by theturtletalks on Sunday June 28, 2026 @12:55AM (#48704491)
The glycemic index also comes into play. It essentially measures how much certain foods keeps you full regardless of calories. So healthy food, even if you’re consuming the same calories as junk food, is going to keep you full longer.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by imajoo on Sunday June 28, 2026 @12:03PM (#48708583)
Sorry but isn’t GI about how “sugary” a food is…? I don’t believe it doesn’t measure to do how full you feel.

https://www.verywellhealth.com/glycemic-index-vs-load-521436...

Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @04:15PM (#48711155)
Not directly but they can be related. GI is about how quickly the carbs in food are metabolized and how quickly sugar is released into the blood.

Blood sugars spikes then drops can have different impacts on food appetite.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @02:11AM (#48704854)
This has never been my problem. I can easily eat 5k calories of whole foods
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @02:16AM (#48704884)
What do you eat in those 5000kcal calories? Genuinely curious.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by amanaplanacanal on Sunday June 28, 2026 @06:10AM (#48705998)
I don't think I could do it, but 3.5 cups of peanut butter would get you there. Or four 16 ounce ribeyes.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @04:30PM (#48711310)
It doesnt have to be one sitting. Eat 2500 diet and add a cup of roast nuts twice a day and you are basically there.

Moreover, you dont need to eat anywhere close to 5k to be morbidly obese.

1 cup of roast nuts over TDEE will gain you 100lbs in a couple short years

Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Monday June 29, 2026 @01:16PM (#48722049)
Assuming you maintain same activity level, the increase in weight wouldn't be that simple.

TDEE rises as body weight rises (heavier body burns more)

Overfeeding increases NEAT in some people (more fidgeting, movement)

Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Tuesday June 30, 2026 @03:26PM (#48737998)
I cup over TDEE will always be more as it raises
Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @10:23AM (#48707553)
as an aexample, I once ate a 5lb tritip over an afternoon, and that isnt counting breakfast or sides
Re:GLP-1 drugs led to weight loss and reversed depression-li... by giardini on Sunday June 28, 2026 @01:55PM (#48709715)
Get checked for parasites, seriously! It will save you $$
Re:GLP-1 drugs led to weight loss and reversed depression-li... by unparagoned on Sunday June 28, 2026 @11:20AM (#48708116)
Healthy and whole foods are a different thing. A healthy diet would have so much fiber that 5k Fritos be near impossible
Re:GLP-1 drugs led to weight loss and reversed depression-li... by chiply314 on Sunday June 28, 2026 @04:37AM (#48705517)
Some don't get at all what calories are.

In some video a woman was eating 8-10 Oranges a day just as a snack on the side.

No knowledge about sugar or calroies, just the thought "but its a fruit its health". No fruits are not healthy

Re:GLP-1 drugs led to weight loss and reversed depression-li... by Illotus on Sunday June 28, 2026 @05:05AM (#48705636)
8 to 10 oranges per day being healthy or not is largely dependent what else you eat. Biggest issue there is likely teeth decay due to acidity.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by chiply314 on Sunday June 28, 2026 @05:27AM (#48705778)
No its not. 8-10 Oranges is too much sugar. Too much sugar hurts your insulin reaction and can bring diabetes.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by Illotus on Sunday June 28, 2026 @06:08AM (#48705994)
Not really, healthy person can easily handle that amount of sugar. Has plenty of fiber to balance.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by chiply314 on Sunday June 28, 2026 @06:17AM (#48706055)
I rechecked it and you are right.

Its an issue if you drink orange juice not when you eat it. Eating takes longer and is getting balanced from the fiber.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by unparagoned on Sunday June 28, 2026 @11:17AM (#48708095)
No with the fiber that’s perfectly fine. The slow release of sugar is perfectly fine. Obesity is the main risk for insulin, fast release sugar is bad for insulin via obesity not on its own.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by 7bit on Sunday June 28, 2026 @04:52AM (#48705571)
Your first sent once and your last sentence don't align.

Yes. Fruits are healthy. One orange is healthy. 10 oranges are unhealthy. Same concept applies to water. Drinking too much can be unhealthy as well, but that doesn't change the fact that water is good.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by watwut on Sunday June 28, 2026 @09:35AM (#48707155)
> 10 oranges are unhealthy

You made that up tho.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by 7bit on Monday June 29, 2026 @02:39AM (#48715644)
I know Math is hard for you, so let me explain it:

10 oranges have a total of roughly 700 calories and 120 grams of sugar while only having 30 grams of fiber. It's mainly sugar. Eating 10 oranges per day crowds out protein, fat and other nutrients.

It's not a made up claim. You are a made up claim, troll.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by mathgeek on Monday June 29, 2026 @04:26AM (#48716377)
> Eating 10 oranges per day

I know it ends up as pedantry, but specifying the period with every post/restatement is so critical in these threads. 10 oranges a day is unhealthy, but so is 10 oranges a year to someone trying to make a counter point.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by 7bit on Monday June 29, 2026 @04:52AM (#48716584)
Not my responsibility to make sure people with read deficiencies are able to follow a discussion.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by butlike on Monday June 29, 2026 @03:22PM (#48723868)
I don't think you'll struggle to get tons of calories out of whole foods, but you'll be satiated faster eating whole foods, which will in all practicality, mean you ate less.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by fouc on Sunday June 28, 2026 @04:18AM (#48705426)
I think there's a bit of a caveat there, because that basically means eating reasonably high calorie food in sufficient quantities that starts violating the "healthy food" definition.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by babuskov on Sunday June 28, 2026 @05:43AM (#48705867)
That's the problem with the definition of "healthy". No single food is "healthy" on it's own. It's a wrong way to look at it and why most people fail at finding a good diet. There's no super food you can just eat unlimited amounts of.

A diet can be healthy if it's the nutrient combination of different foods that result in certain number of calories, protein, fat, carbs, minerals and vitamins per unit of time.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by mathgeek on Monday June 29, 2026 @04:18AM (#48716322)
You also have to adjust those numbers over time based on input and output. Your body’s energy system isn’t closed.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by butlike on Monday June 29, 2026 @03:20PM (#48723846)
The more colorful the plate, generally; the better it is for you.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by simiones on Thursday July 02, 2026 @05:01AM (#48758513)
That's why Skittles-based diets tend to perform so well!
Re:GLP-1 drugs led to weight loss and reversed depression-li... by Bombthecat on Sunday June 28, 2026 @06:00AM (#48705954)
Wasn't there just a study, that many fat kids are fat because of fruit juices?

Healthy in a way, but surprisingly a lot of sugar ( either added or from the fruits)

Re:GLP-1 drugs led to weight loss and reversed depression-li... by econ on Sunday June 28, 2026 @07:12AM (#48706342)
There was a study comparing big and small eaters with and without obesitas. Turns out that skinny people who eat a lot eat also eat a lot of fat and protein and that fat people who eat almost nothing eat mostly carbs and sugar.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by mathgeek on Monday June 29, 2026 @04:21AM (#48716342)
Link to the study would help that claim, when you have a chance.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by lotsofpulp on Sunday June 28, 2026 @09:18AM (#48707031)
Fruit juices are not healthy in any way, precisely because of the sugar density and lack of fiber which leads to easy overconsumption.

https://publications.aap.org/pediatrics/article/139/6/e20170...

>Pediatricians should support policies that seek to reduce the consumption of fruit juice and promote the consumption of whole fruit by toddlers and young children already exposed to juices.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by unparagoned on Sunday June 28, 2026 @11:14AM (#48708067)
Fruit juice isn’t considered healthy. It has worse health outcomes than soda
Re:GLP-1 drugs led to weight loss and reversed depression-li... by ThrowawayTestr on Sunday June 28, 2026 @06:12AM (#48706007)
You'd have to eat a lot of broccoli
Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @09:06AM (#48706950)
> People can get fat by eating too much healthy food.

It's a lot harder, as many of the comments mentioned, because of caloric density and lack of appetite hacks (sugar, salt).

A can of Mountain Dew is 170 kcal + 46g of sugar.

A navel orange is ~75 kcal + 13g of sugar + 3.2g of fiber + 1.25g of protein.

So take someone from Appalachia with a 4 can / day habit (modest), and that's ~10-12 oranges. That's a lot of oranges to not get sick of eating.

Which is where I think the sugar + salt difference comes in.

It's far easier to overload on the same food when it's stuffed with these appetite attractants than a caloric equivalent of healthy food, because the health food will taste more similar (read: like itself), which will eventually get boring.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by unparagoned on Sunday June 28, 2026 @11:13AM (#48708047)
Not really the fiber and stuff is normally too filling
Re:GLP-1 drugs led to weight loss and reversed depression-li... by bevesce- on Sunday June 28, 2026 @11:28AM (#48708214)
It is for some people, it's not for some other. I could get overweight overeating carrots and lettuce if I was not controlling myself constantly.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by Jensson on Sunday June 28, 2026 @12:28PM (#48708849)
Some fibers are not very filling, they just go through the guys quickly and you are hungry again a couple of hours later.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by GeoAtreides on Sunday June 28, 2026 @03:02PM (#48710370)
name the fibers, the meal and the quantity

if you one broccoli head with one pound of icecream then sure, you will feel hungry again quite soon

Re:GLP-1 drugs led to weight loss and reversed depression-li... by gavinray on Sunday June 28, 2026 @12:00PM (#48708551)
I consumed +11lbs (5.1kg) of food yesterday for only 2,500kcal

If you have a stomach and appetite that are capable of consuming the 15 to 20 lb you need to eat 3,500 to 4,000 calories of similar foods, you ought to call a research lab

Re:GLP-1 drugs led to weight loss and reversed depression-li... by Jensson on Sunday June 28, 2026 @12:30PM (#48708872)
Nuts are healthy to eat, its easy to eat 4000 calories of nuts. Healthy doesn't mean low calories.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @04:08PM (#48711080)
In what world does that prove you cant get fat eating "healthy" or "whole" foods?

1) you didnt eat the most calorie dense foods

2) you dont need crazy calories to get fat, just above your burn rate.

What part are you confused about?

Re:GLP-1 drugs led to weight loss and reversed depression-li... by simiones on Thursday July 02, 2026 @05:05AM (#48758543)
2500 kcal is waaaayyy above the TDEE of most people (especially most women - who hover around 1200-1500 TDEE; but even for men, 2000 TDEE is quite common for a regular office worker lifestyle). So most people would get quite fat quite rapidly eating that.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by testbjjl on Sunday June 28, 2026 @12:56AM (#48704498)
Intentionally eating good food is a lot more about where your head is at than what you’re eating, like any other devices. You can better understand the mentality of a person by their diet that they evolved through personal experience.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by sublinear on Saturday June 27, 2026 @11:36PM (#48704083)
If you want the real answer, people suck at shopping for groceries and don't know how or want to cook.

Long before LLMs, there was a different but similarly misguided hype around making food more convenient. Making money off ignorance is not "innovation", but we live in a world convinced by arrogant and pretentious fearmongering liars.

As always, just do it yourself. It's not that hard after all.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by rnewme on Saturday June 27, 2026 @11:51PM (#48704163)
Do you know what food noise is?
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @12:22AM (#48704319)
Does food noise exist in active tribal people (if so why they have less proportion of obese people?) or is it something which happens to sedentary people?
Re:GLP-1 drugs led to weight loss and reversed depression-li... by kube-system on Sunday June 28, 2026 @01:38AM (#48704697)
I suspect it does, but their ability to act upon it is significantly different. Perhaps if they had hot pockets and Taco Bell, they would have similar problems.

Addiction-like behaviors related to food transcend not only human culture but also even other species.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by solumunus on Sunday June 28, 2026 @01:23AM (#48704628)
Does drug addiction? Because food noise should be viewed through that lens, and I’m no expert but I suspect our modern non tribal life and culture is the root of our abundant addiction issues.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by sublinear on Sunday June 28, 2026 @01:36AM (#48704693)
Yes. I'm saying that it goes away when you fix your diet.

Do you know what nutrients are? Deficiencies are the cause of the noise. This is an evolutionary feature, not a bug. Your body is expecting you to keep eating alternatives until you eventually stumble onto the foods that make you feel better and then keep eating those. In severe cases you might need more patience with the right foods, but if you already feel like crap and you know you just started barely eating healthier, why stop now?

This search process has been somewhat disrupted by our modern environment, but it's not like the good food isn't right there. On the other hand, you don't need trial and error anymore. There's plenty of information available. You can even go see a doctor and get a blood test to confirm both your deficiencies and everything else I just said.

Does that answer your question?

EDIT: to reply to replies below and I am "posting too fast"...

TLDR: Y'all need to see a doctor.

I used to weigh 400 lbs, had a bad enough drinking problem to cause numbness in my legs (B12 deficiency to boot), and a sky high A1C. I recovered 100% after a decade of this self abuse. Doctor didn't bat an eye back then nor when I recovered a couple of years later. They see it all the time and my "success" story is very common. Most of us understandably find this all too embarrassing to shout about online. We'd get drowned out by influencers trying to sell you crap anyway.

Also, sorry not trying to be callous, but long term deficiencies can cause permanent damage. If you're still experiencing "food noise" after a serious attempt at a planned diet (and magically never had any other symptoms warning you of the impending damage) I have some doubts, but that's a whole different topic.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by tsimionescu on Sunday June 28, 2026 @01:54AM (#48704785)
It answers the question, but you are simply wrong, as anyone who has tried to lose significant weight knows from personal experience, and as countless studies have confirmed again and again.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @02:17AM (#48704889)
how many of those studies are designed to fail?
Re:GLP-1 drugs led to weight loss and reversed depression-li... by tsimionescu on Sunday June 28, 2026 @02:43AM (#48704988)
Badly designed? A lot of them, possibly. Designed to fail, intentionally? Few if any.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by crooked-v on Sunday June 28, 2026 @01:50AM (#48704764)
> it goes away when you fix your diet.

Anecdotally: no, it doesn't. Maybe it did for you. I spent most of a year once on a predesigned meal plan, and the only thing it changed about the low-key but constant food noise was better knowing when I had a safe margin to indulge a little bit.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by rnewme on Sunday June 28, 2026 @05:27AM (#48705779)
My wife saw many doctors. For her the food noise is related to PCOS and insuline resistance. Ozempic helped until it didn't. You are being callous even with your disclaimer.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by theshrike79 on Sunday June 28, 2026 @06:55AM (#48706235)
I eat a perfect diet of moslty vegetables, chicken and fish, I cook my own food and know what's in it.

I just eat too much of it, because food tastes good and it's a source of dopamine for me. Like most people with food noise.

Also when I get up and finish eating, within 30 minutes my brain is thinking what's going to be the next meal I eat. Food noise.

Yes, some people can lose massive amounts of weight by "just eting right", my brother in law lost 20kg by just not drinking beer anymore. I haven't had a beer in 3 years and didn't lose a single kg. Food noise.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by mcmoor on Monday June 29, 2026 @04:48AM (#48716557)
The beer part is relatable. I've seen people advising on cutting soda, beer, any sweety beverages. I've only consumed water for years now and here I am. Though i imagine if I do drink those beverages I'd be even bigger.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by grey-area on Sunday June 28, 2026 @02:16AM (#48704882)
The latest fad promoted by companies to sell you something?
Re:GLP-1 drugs led to weight loss and reversed depression-li... by rnewme on Sunday June 28, 2026 @05:25AM (#48705769)
Eating disorders are mental health condition. Just because there are a lot of visible "false" cases, it doesn't mean that someone else is not living it for real. Your comment is insensitive
Re:GLP-1 drugs led to weight loss and reversed depression-li... by grey-area on Sunday June 28, 2026 @07:03AM (#48706287)
> Eating disorders are mental health condition.

Agreed, and often the root cause is something else in a person’s life (stress, feelings of losing control etc ).

Adding new labels related to food doesn’t do anything to fix the underlying conditions and if anything distracts from them and points the blame at food and physiology, which is not often the root cause of over or under eating.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @10:31AM (#48707629)
yes, and many of those root causes are not addressable.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by serf on Sunday June 28, 2026 @12:31PM (#48708889)
these types of (modern) eating disorders are a product of our current market, and I think that blaming humans for eating wrong due to 'food noise' when many shelves have little else to offer is insensitive victim blaming.

the perpetrators are the people selling poison under false auspices.

we're not blaming people with pica for eating drywall.

We're blaming profiteers for shoveling garbage into the mouth of anyone with a buck while systematically lobbying to maximize garbage advertising and minimize actual food where feasible and simultaneously incentivizing sales groups as much as is profitable -- all the while trying to convince medical professionals and scientists to produce overtly narrow results to support the public consumption through bogus 'science' papers.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by grey-area on Sunday June 28, 2026 @01:31PM (#48709522)
> Many shelves have little else to offer

Go into any western supermarket and there are massive aisles of fruit and veg, along with various types of protein.

None of these eating disorders are new. If anything it is far easier to be healthy now.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by crooked-v on Sunday June 28, 2026 @01:39AM (#48704709)
If it "wasn't that hard", obesity rates would be much lower.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:23AM (#48708154)
obesity rates are lower in tribal population who still live active life.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by kube-system on Sunday June 28, 2026 @01:15AM (#48704594)
It does which is why medically supervised weight loss with GLP1s includes diet recommendations to mitigate this.

But in my experience, decreased cravings make it easier to choose food rationally. The food noise that causes people to overeat usually doesn’t cause them to overeat healthy foods anyway.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by Jensson on Sunday June 28, 2026 @12:47PM (#48709060)
> But in my experience, decreased cravings make it easier to choose food rationally. The food noise that causes people to overeat usually doesn’t cause them to overeat healthy foods anyway.

"Food noise" is much more than just craving calories, we have cravings for most of the different nutrients we need. That is how people ate a balanced diet in history even though it was much harder to do back then, peasants craved meat and vegetables even though it was easier to just eat potatoes for calories.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by kube-system on Sunday June 28, 2026 @03:18PM (#48710552)
My doctor explicitly does target my dosing to “make sure I don’t lose my appetite entirely, but just reduce the food noise”

I think there’s a distinct difference between what people are describing as “food noise” and a normal appetite.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by mathgeek on Monday June 29, 2026 @04:16AM (#48716300)
Anecdotal, but I think we need to consider that modern marketing and supply chains have a huge impact here. Without any cravings control, my mind was perfectly happy craving burgers, fries, and pizza 24/7 for thirty years. It hated every bite of veggies.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by solumunus on Sunday June 28, 2026 @01:19AM (#48704611)
Specifically for me it makes junk food unpleasant. My diet is now impeccable. I hardly ever have a takeaway and if I do it needs to be something that is not greasy and is good clean food.

I also find drinking alcohol much less pleasant. I still drink sometimes but after a few beers or glasses of wine it starts to become very unappealing and I stop.

I do bodybuilding and I’m still getting my 150g of protein in.

I’m barely overweight and I’m losing weight very slowly but I’ve decided I’m likely to stay on GLP’s long term, if not forever, just because the lifestyle changes have been so incredibly good.

Perhaps this helps dispel the myth that GLP drugs inherently = relentless starvation.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @04:32AM (#48705484)
All of what you've mentioned happens for me without any GLPs
Re:GLP-1 drugs led to weight loss and reversed depression-li... by theshrike79 on Sunday June 28, 2026 @06:51AM (#48706212)
People are different. Weird, right?

I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

I'm not like that. Leaving half a burger that I paid for on the plate is something I've never done or even considered a possibility that any sane person would do.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @09:17AM (#48707020)
Same. College nutritionist: "I'm going to give you the opposite advice of everyone else. If you can add butter to something, do it."

Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

I guess the easiest way to describe my subjective experience is that the "You're hungry, eat" audio channel is turned waaay down in my brain, to the extent that anything moderately attention-capturing overrides it (a project, reading, hiking, tv, etc).

I'll feel the physical and psychological symptoms of hunger (body feels cold, irritable, low energy) before I'll feel the signal to eat.

I'd be fascinated to get my gut biome sequenced + see my natural GLP-1 levels, as I've always been like this.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:22AM (#48708137)
>Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

You probably move much less than you used to. Metabolism slowing down with age is already known.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @12:11PM (#48708653)
I'm not running cross country anymore, so that's about 10 miles less a week on my knees. ;)
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:21AM (#48708126)
>People are different. Weird, right?

How many people you see with 3 eyes and 4 on regular basis to claim people are different? I'd argue most people aren't that different.

Calorie balance works for majority of people.

>I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

Here's a thing, most of the underweight people tell me they are genetically predisposed to not gaining weight. When I calculate calories in their regular diet, what I notice is a very low-calorie diet.

After that, I put them on calorie-dense shakes and high-intensity workouts, with light movement, and their appetite quickly starts growing as they start consuming healthy fats.

The same engine which starts this appetite can also have a "thermal runway" kind of mechanism where your appetite just becomes very large and it becomes harder to dial down.

The question is why reach that point?

Re:GLP-1 drugs led to weight loss and reversed depression-li... by chiply314 on Sunday June 28, 2026 @05:26AM (#48705774)
WOW good for you! Man if everyone would just be like you. That would mean no one would need something like GLPs eh?
Re:GLP-1 drugs led to weight loss and reversed depression-li... by StefanBatory on Sunday June 28, 2026 @10:42AM (#48707741)
"People say they need glasses to see. Why? I can see perfectly without them, have they even tried to actually be looking harder?"
Re:GLP-1 drugs led to weight loss and reversed depression-li... by planckscnst on Sunday June 28, 2026 @01:40AM (#48704710)
You don't desire to brush your teeth (at least not in the way that you desire to consume calorie-dense foods). But you manage to still do it anyway. (maybe not you specifically, but people in general) You can make the same choice about nutrition. The lowered desire makes it easier/possible to do this
Re:GLP-1 drugs led to weight loss and reversed depression-li... by lrasinen on Sunday June 28, 2026 @01:41AM (#48704717)
My personal experience is like getting eye glasses for your appetite. Easier to eat reasonably sized portions and they're nutritionally well-balanced.

Also the late night cravings are more specific: instead of vague "need to eat something", it's "I'd love a tomato" or "mmm yogurt" or "actually a load of carbs would hit the spot".

Re:GLP-1 drugs led to weight loss and reversed depression-li... by seanmcdirmid on Sunday June 28, 2026 @04:56AM (#48705586)
You lose your appetite but can still shove things in your pie hole. You just have to make an effort to shove vegetables and protein in, rather than making an effort resist eating junk food.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by raffael_de on Sunday June 28, 2026 @06:56AM (#48706247)
considering what we have been learning about the importance of a working gut brain axis I'd be highly worried about Ozempic harming this connection.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by fragmede on Sunday June 28, 2026 @07:47AM (#48706512)
whatever we learned about gut brain axis dysfunctionality? I thought most of the biggest findings were in that it exists in the first place.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by raffael_de on Sunday June 28, 2026 @02:34PM (#48710101)
the term "gut feeling" exists for a reason. the findings substantiated this colloquial wisdom and its relevance ... the article hints at it by associating mental disorders with gut microbiome. I wouldn't be surprised at all if it turns out that Ozempic et al. harm this gut/brain cooperation ... I'd bet on it.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by fragmede on Sunday June 28, 2026 @03:23PM (#48710608)
How much and how long do you want the bet you go for? How do you even want to define "harms". Let's say there's a road from the gut to the brain. If today's ultra processed food is motorcycles ripping down the road as fast as possible, and Ozempic is the police, saying whoa there, slow down, buddy, then from the POV of the motorcyclists that's harmful, but for everyone else around them, that's good.
Re:GLP-1 drugs led to weight loss and reversed depression-li... by raffael_de on Sunday June 28, 2026 @03:25PM (#48710633)
Re:GLP-1 drugs led to weight loss and reversed depression-li... by fragmede on Monday June 29, 2026 @01:18AM (#48715104)
https://en.wikipedia.org/wiki/List_of_fallacies

I can link to Wikipedia too. Which part is the straw man?