GLP-1 drugs led to weight loss and reversed depression-like behavior in mice

Re:GLP-1 drugs led to weight loss and reversed depression-li... by gavinray on Sunday June 28, 2026 @12:00PM (#48708551)

I consumed +11lbs (5.1kg) of food yesterday for only 2,500kcal

If you have a stomach and appetite that are capable of consuming the 15 to 20 lb you need to eat 3,500 to 4,000 calories of similar foods, you ought to call a research lab

[ Parent | on HN ]

Re:GLP-1 drugs led to weight loss and reversed depression-li... by Jensson on Sunday June 28, 2026 @12:30PM (#48708872)

Nuts are healthy to eat, its easy to eat 4000 calories of nuts. Healthy doesn't mean low calories.

[ Parent | on HN ]

Re:GLP-1 drugs led to weight loss and reversed depression-li... by s1artibartfast on Sunday June 28, 2026 @04:08PM (#48711080)

In what world does that prove you cant get fat eating "healthy" or "whole" foods?

1) you didnt eat the most calorie dense foods

2) you dont need crazy calories to get fat, just above your burn rate.

What part are you confused about?

[ Parent | on HN ]

Re:GLP-1 drugs led to weight loss and reversed depression-li... by simiones on Thursday July 02, 2026 @05:05AM (#48758543)

2500 kcal is waaaayyy above the TDEE of most people (especially most women - who hover around 1200-1500 TDEE; but even for men, 2000 TDEE is quite common for a regular office worker lifestyle). So most people would get quite fat quite rapidly eating that.

[ Parent | on HN ]