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Re:GLP-1 drugs led to weight loss and reversed depression-li... by theshrike79 on Sunday June 28, 2026 @06:51AM (#48706212)
People are different. Weird, right?

I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

I'm not like that. Leaving half a burger that I paid for on the plate is something I've never done or even considered a possibility that any sane person would do.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @09:17AM (#48707020)
Same. College nutritionist: "I'm going to give you the opposite advice of everyone else. If you can add butter to something, do it."

Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

I guess the easiest way to describe my subjective experience is that the "You're hungry, eat" audio channel is turned waaay down in my brain, to the extent that anything moderately attention-capturing overrides it (a project, reading, hiking, tv, etc).

I'll feel the physical and psychological symptoms of hunger (body feels cold, irritable, low energy) before I'll feel the signal to eat.

I'd be fascinated to get my gut biome sequenced + see my natural GLP-1 levels, as I've always been like this.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:22AM (#48708137)
>Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

You probably move much less than you used to. Metabolism slowing down with age is already known.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @12:11PM (#48708653)
I'm not running cross country anymore, so that's about 10 miles less a week on my knees. ;)
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:21AM (#48708126)
>People are different. Weird, right?

How many people you see with 3 eyes and 4 on regular basis to claim people are different? I'd argue most people aren't that different.

Calorie balance works for majority of people.

>I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

Here's a thing, most of the underweight people tell me they are genetically predisposed to not gaining weight. When I calculate calories in their regular diet, what I notice is a very low-calorie diet.

After that, I put them on calorie-dense shakes and high-intensity workouts, with light movement, and their appetite quickly starts growing as they start consuming healthy fats.

The same engine which starts this appetite can also have a "thermal runway" kind of mechanism where your appetite just becomes very large and it becomes harder to dial down.

The question is why reach that point?