Re:GLP-1 drugs led to weight loss and reversed depression-li...
by faangguyindia on Sunday June 28, 2026 @11:21AM
(#48708126)
>People are different. Weird, right?
How many people you see with 3 eyes and 4 on regular basis to claim people are different? I'd argue most people aren't that different.
Calorie balance works for majority of people.
>I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".
Here's a thing, most of the underweight people tell me they are genetically predisposed to not gaining weight. When I calculate calories in their regular diet, what I notice is a very low-calorie diet.
After that, I put them on calorie-dense shakes and high-intensity workouts, with light movement, and their appetite quickly starts growing as they start consuming healthy fats.
The same engine which starts this appetite can also have a "thermal runway" kind of mechanism where your appetite just becomes very large and it becomes harder to dial down.
How many people you see with 3 eyes and 4 on regular basis to claim people are different? I'd argue most people aren't that different.
Calorie balance works for majority of people.
>I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".
Here's a thing, most of the underweight people tell me they are genetically predisposed to not gaining weight. When I calculate calories in their regular diet, what I notice is a very low-calorie diet.
After that, I put them on calorie-dense shakes and high-intensity workouts, with light movement, and their appetite quickly starts growing as they start consuming healthy fats.
The same engine which starts this appetite can also have a "thermal runway" kind of mechanism where your appetite just becomes very large and it becomes harder to dial down.
The question is why reach that point?