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Re:GLP-1 drugs led to weight loss and reversed depression-li... by solumunus on Sunday June 28, 2026 @01:19AM (#48704611)
Specifically for me it makes junk food unpleasant. My diet is now impeccable. I hardly ever have a takeaway and if I do it needs to be something that is not greasy and is good clean food.

I also find drinking alcohol much less pleasant. I still drink sometimes but after a few beers or glasses of wine it starts to become very unappealing and I stop.

I do bodybuilding and I’m still getting my 150g of protein in.

I’m barely overweight and I’m losing weight very slowly but I’ve decided I’m likely to stay on GLP’s long term, if not forever, just because the lifestyle changes have been so incredibly good.

Perhaps this helps dispel the myth that GLP drugs inherently = relentless starvation.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @04:32AM (#48705484)
All of what you've mentioned happens for me without any GLPs
Re:GLP-1 drugs led to weight loss and reversed depression-li... by theshrike79 on Sunday June 28, 2026 @06:51AM (#48706212)
People are different. Weird, right?

I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

I'm not like that. Leaving half a burger that I paid for on the plate is something I've never done or even considered a possibility that any sane person would do.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @09:17AM (#48707020)
Same. College nutritionist: "I'm going to give you the opposite advice of everyone else. If you can add butter to something, do it."

Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

I guess the easiest way to describe my subjective experience is that the "You're hungry, eat" audio channel is turned waaay down in my brain, to the extent that anything moderately attention-capturing overrides it (a project, reading, hiking, tv, etc).

I'll feel the physical and psychological symptoms of hunger (body feels cold, irritable, low energy) before I'll feel the signal to eat.

I'd be fascinated to get my gut biome sequenced + see my natural GLP-1 levels, as I've always been like this.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:22AM (#48708137)
>Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

You probably move much less than you used to. Metabolism slowing down with age is already known.

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @12:11PM (#48708653)
I'm not running cross country anymore, so that's about 10 miles less a week on my knees. ;)
Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:21AM (#48708126)
>People are different. Weird, right?

How many people you see with 3 eyes and 4 on regular basis to claim people are different? I'd argue most people aren't that different.

Calorie balance works for majority of people.

>I have a friend who was literally ordered, by a doctor, to eat as much fat as they could because they were too skinny. They're the type of person for whom food is 100% fuel and they can just stop mid-burger and not eat the second half because "they don't feel like it".

Here's a thing, most of the underweight people tell me they are genetically predisposed to not gaining weight. When I calculate calories in their regular diet, what I notice is a very low-calorie diet.

After that, I put them on calorie-dense shakes and high-intensity workouts, with light movement, and their appetite quickly starts growing as they start consuming healthy fats.

The same engine which starts this appetite can also have a "thermal runway" kind of mechanism where your appetite just becomes very large and it becomes harder to dial down.

The question is why reach that point?

Re:GLP-1 drugs led to weight loss and reversed depression-li... by chiply314 on Sunday June 28, 2026 @05:26AM (#48705774)
WOW good for you! Man if everyone would just be like you. That would mean no one would need something like GLPs eh?
Re:GLP-1 drugs led to weight loss and reversed depression-li... by StefanBatory on Sunday June 28, 2026 @10:42AM (#48707741)
"People say they need glasses to see. Why? I can see perfectly without them, have they even tried to actually be looking harder?"