GLP-1 drugs led to weight loss and reversed depression-like behavior in mice

Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @09:17AM (#48707020)

Same. College nutritionist: "I'm going to give you the opposite advice of everyone else. If you can add butter to something, do it."

Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

I guess the easiest way to describe my subjective experience is that the "You're hungry, eat" audio channel is turned waaay down in my brain, to the extent that anything moderately attention-capturing overrides it (a project, reading, hiking, tv, etc).

I'll feel the physical and psychological symptoms of hunger (body feels cold, irritable, low energy) before I'll feel the signal to eat.

I'd be fascinated to get my gut biome sequenced + see my natural GLP-1 levels, as I've always been like this.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by faangguyindia on Sunday June 28, 2026 @11:22AM (#48708137)

>Then add in a fast metabolism. Until middle age, I literally couldn't eat enough food that I remotely enjoyed to hit target weight for my height.

You probably move much less than you used to. Metabolism slowing down with age is already known.

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Re:GLP-1 drugs led to weight loss and reversed depression-li... by ethbr1 on Sunday June 28, 2026 @12:11PM (#48708653)

I'm not running cross country anymore, so that's about 10 miles less a week on my knees. ;)

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