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Re:The neuroinvasive potential of SARS-CoV2 by aazaa on Wednesday March 04, 2020 @12:46PM (#22485895)
From the paper:

> If the neuroinvasion of SARS-CoV-2 does take a part in the development of respiratory failure in COVID-19 patients, the precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasally. The possible neuroinvasion of SARS-CoV-2 may also partially explain why some patients developed respiratory failure, while others not. It is very possible that most of the persons in Wuhan, who were the first exposed to this previously unknown virus, did not have any protective measure, so that the critical patients is much more in Wuhan than in other cities in China.

This is a good example of why writing off COVID-19 as no more dangerous than the flu is itself so dangerous.

I should also point out that most people in the US face similar conditions to those in Wuhan. The extent of infection is not known, and therefore protective measures are not in place. We have been actively discouraged from "buying masks" and told that they are ineffective.

Re:The neuroinvasive potential of SARS-CoV2 by morpheuskafka on Wednesday March 04, 2020 @12:52PM (#22485952)
Yes, only a N95 or better mask would protect you from incoming, as opposed to outgoing, viruses, and these masks are both impractical for everyday wear and need to be conserved for public health users.
Re:The neuroinvasive potential of SARS-CoV2 by Symmetry on Wednesday March 04, 2020 @01:57PM (#22486680)
I think that different sources are using different definitions of "effective" here. If a simple surgical mask cuts down transmission rates by 50% that isn't anywhere near good enough for health workers working with sick patients every day. But it might still make a significant improvement in your chances of getting infected and, combined with social distancing, might drop the R0 below 1. Hence why Chinese and Korean authorities are encouraging everyone to wear surgical masks but the CDC saying they're ineffective.
Re:The neuroinvasive potential of SARS-CoV2 by sagebird on Wednesday March 04, 2020 @02:58PM (#22487393)
I completely agree. Even having a mask that only results in a 20% reduction of transmission could be the difference between a growth factor that is less than 1, vs a growth factor of greater than one. It could be the difference between taking off or halting.

I suspect that even a spare cotton t-shirt material affixed over the face would stop a significant amount of droplets from transmitting.

It would be worth researching the effectiveness improvised masks, at the very least.

Re:The neuroinvasive potential of SARS-CoV2 by TeMPOraL on Wednesday March 04, 2020 @02:54PM (#22487354)
The problem is that a mask that isn't regularly replaced and handled very carefully actually increases your chances of catching the virus, via a mask->hand->face transmission.
Re:The neuroinvasive potential of SARS-CoV2 by cameldrv on Wednesday March 04, 2020 @04:07PM (#22488128)
Is there data or a study that says that risks increase from using masks poorly? I’ve looked into the literature and everything I’ve seen says they are significantly protective in real-world use.
Re:The neuroinvasive potential of SARS-CoV2 by whatshisface on Wednesday March 04, 2020 @03:17PM (#22487585)
Wait, how? If it's on the mask wouldn't it be on the face if the mask wasn't there? What process puts viruses on masks but not faces?
Re:The neuroinvasive potential of SARS-CoV2 by vanniv on Wednesday March 04, 2020 @11:40PM (#22491024)
The masks encourage a warm moist environment surrounding your nose and mouth.

If the mask becomes contaminated, it becomes an ideal vector for encouraging infection -- so if you touch the inside of the mask with your contaminated hands (say you move the mask to touch your face or adjust it or whatever), for example, the mask becomes the opposite of protective.

Masks are somewhat effective at reducing spread if the already-infected person is wearing the mask.

Re:The neuroinvasive potential of SARS-CoV2 by penagwin on Wednesday March 04, 2020 @03:33PM (#22487738)
IMO the biggest problem is people "feel safe" with a mask on, they may not take other precautions.

Also my understanding is that a N95 mask that isn't properly worn (doesn't have a good seal) then it's nearly equivalent to no mask at all.

So you combine those two together and you have people who aren't effectively protected by the mask and are making riskier decisions.

Re:The neuroinvasive potential of SARS-CoV2 by cameldrv on Wednesday March 04, 2020 @04:08PM (#22488142)
Is this based on data or just a feeling you have?
Re:The neuroinvasive potential of SARS-CoV2 by fishmaster on Thursday March 05, 2020 @04:10AM (#22492082)
I have read these comments often now and it's just something people make up to justify not being able to buy masks.
Re:The neuroinvasive potential of SARS-CoV2 by TeMPOraL on Thursday March 05, 2020 @05:42AM (#22492469)
Which part of this is being made up? That improperly fitted mask isn't protective? That unless you very carefully handle a mask when taking it off, you'll transfer the contaminants from it onto your hands and/or face? That people compensate for risk[0]? That those masks are disposable and lose their protective power over short time (hours)?

--

[0] - https://en.wikipedia.org/wiki/Risk_compensation

Re:The neuroinvasive potential of SARS-CoV2 by cameldrv on Thursday March 05, 2020 @09:36PM (#22500562)
Yes. Do you have a study that shows that a mask that has not been fit tested either provides no protection or actually increases the overall risk to the wearer?

I have looked at a fair bit of research on masks lately, and everything I've seen is that they are significantly protective, and, for example, reduce your risk of catching SARS by about 70%.

Yes, if a mask doesn't fit properly, some air will come through the sides. Even in that case though, the mask is still filtering some air, and it's protecting you from touching your mouth or nose, and it's protecting you from droplets hitting your mouth or nose from being coughed or sneezed on.

Re:The neuroinvasive potential of SARS-CoV2 by __s on Wednesday March 04, 2020 @03:41PM (#22487823)
The best practice is to not touch your face with your hands. Wearing a mask may increase the frequency you touch your face due to discomfort
Re:The neuroinvasive potential of SARS-CoV2 by TeMPOraL on Wednesday March 04, 2020 @03:24PM (#22487640)
Greater surface area, more hand-face contact, and risk compensation.
Re:The neuroinvasive potential of SARS-CoV2 by crusty on Wednesday March 04, 2020 @02:55PM (#22487364)
TL:DR: The most effective use of disposable masks for blocking germ transmission is by the people with the germs who might pass them to this without but at risk.

Surgical masks are meant to protect surgery patients from the medical staff and the droplet-encased germs they emanate. N95 masks are meant to protect the wearer from particulate matter (harmful dust) in the air, specifically those particles over 30 microns. SARS-CoV02 is roughly half the size, so as an aerosolized virion, as opposed to droplet-suspended virions, they may have limited effect. N95 masks also often come with exhalation valve releases to improve inhalation fit - so exhalation pressure does not break the seal around the sides. A sick person wearing a mask with a valve that releases right in front of their mouth may be better than no mask, but it is a potential bypass for droplet suspended virions.

The US just doesn't have the culture where everyone puts on masks during flu season, like some places (HK for one), and that level of herd usage is really what might be likely to slow transmission to a breakable rate.

Re:The neuroinvasive potential of SARS-CoV2 by Symmetry on Wednesday March 04, 2020 @03:28PM (#22487687)
What I've read about Coronaviruses is that most transmission is either through hand to face contact or droplet-suspended virions so a mask that doesn't protect against aerosolized droplets would still be fairly effective. I understand that surgical masks aren't intended to prevent inhalation of droplets but the substantial symmetry between air passing through one way or the other would suggest at least broadly similar effects either way. Given the empirical results from elsewhere in the thread it seems like that may be the case.
Re:The neuroinvasive potential of SARS-CoV2 by therealdrag0 on Wednesday March 04, 2020 @08:30PM (#22490094)
Are surgical masks sealed around the edges? I've only worn N95 before and if you don't have a proper seal you're not even filtering the air. That's what I've always assumed was the problem with surgical masks. It's not that they're not a good enough filter, it's that they aren't even filtering the air when you breath in. But I might be wrong.
Re:The neuroinvasive potential of SARS-CoV2 by nucleardog on Wednesday March 04, 2020 @03:45PM (#22487882)
> N95 masks are meant to protect the wearer from particulate matter (harmful dust) in the air, specifically those particles over 30 microns. SARS-CoV02 is roughly half the size, so as an aerosolized virion, as opposed to droplet-suspended virions, they may have limited effect.

The N95 filters are tested with particles at 30 microns, but that doesn't say anything about their effectiveness against other particles.

3M, naturally, has released some information on this exact topic [1] which goes into a fair bit of detail on the various methods by which masks effect filtration. The tl;dr version is that there are several ways by which filtration is achieved that generally overlap and work towards providing effective protection well above and below 30um. There is generally a small dip in the transition between two primary methods which creates a specific size range where filtration is less effective.

Whether that's an issue depends on your definition of "limited effect". For the masks they tested, that dip generally occurred around 0.04-0.1um. Even in the worst case scenario, however, the worst masks tested were still filtering ~94% of the particles (in a mask that only claims 95% effectiveness to begin with). The linked document has coronaviruses listed as being about 0.125um in size, which has them falling toward the end of the dip where the mask is trending back towards 100% efficacy.

(For what it's worth, they also have the distribution of droplet sizes in a sneeze and they are all smaller than 30um as well. However they're still in a range where the mask will be about 100% effective.)

Which is all to say I certainly wouldn't describe an N95 mask as being of "limited effect".

[1] https://multimedia.3m.com/mws/media/409903O/respiratory-prot...

Re:The neuroinvasive potential of SARS-CoV2 by crusty on Wednesday March 04, 2020 @03:00PM (#22487419)
And as to that not our culture comment, I mean it's the American of course who got told to isolate himself on suspicion of infection but decided to go to a group political event across state lines regardless, only to infect at least one other person and lead to further isolation calls for everyone else he came into contact with.
Re:The neuroinvasive potential of SARS-CoV2 by kaylynb on Wednesday March 04, 2020 @01:16PM (#22486207)
I'm not sure I would call them impractical for everyday wear. I wear N95 masks when commuting during active wildfires. The news always says not to wear them because you won't put them on properly, but it's really not that hard to ensure the fitment is correct. It's not like the construction workers that wear them occupationally are rocket scientists.

My partner is more vulnerable to respiratory problems and has always worn N95 masks when in public during flu season. What's changed now is she gets all kinds of shit from people because they think she somehow hoarded masks away from healthcare workers. We've had boxes N95 masks for years, but now we're assholes for hoarding...

Re:The neuroinvasive potential of SARS-CoV2 by drcode on Wednesday March 04, 2020 @01:28PM (#22486328)
Telling people they should wear masks because they don't put them on properly is like telling people they shouldn't drive cars because some people drive them into trees.
Re:The neuroinvasive potential of SARS-CoV2 by _spoonman on Wednesday March 04, 2020 @02:36PM (#22487157)
I think what OP means is N95 masks must be properly fitted to the individual. When my wife started working at a hospital she had to undergo such a fitting. So unless you get the proper size, you could still be exposed. I think that’s what he meant.
Re:The neuroinvasive potential of SARS-CoV2 by Seenso on Wednesday March 04, 2020 @03:21PM (#22487616)
> N95 masks must be properly fitted to the individual.... So unless you get the proper size, you could still be exposed.

I'd really like to know how often those fit tests actually result in someone needing to select a different respirator size or style.

I wonder if they're only needed if you're required to be 100% sure all your people can use their respirators with near-100% effectiveness. That's probably necessary if you're working in a contagious disease isolation unit or removing asbestos all day every day, but maybe not for less dangerous environments.

Re:The neuroinvasive potential of SARS-CoV2 by allendoerfer on Wednesday March 04, 2020 @01:36PM (#22486431)
I am bookmarking this comment for the time after self-driving cars have become universally available.
Re:The neuroinvasive potential of SARS-CoV2 by samatman on Wednesday March 04, 2020 @02:00PM (#22486731)
Just remember to hold off on the gloating until after the self-driving cars stop occasionally driving into trees.
Re:The neuroinvasive potential of SARS-CoV2 by geggam on Wednesday March 04, 2020 @01:54PM (#22486652)
given the longevity of webservices online I bet HN is gone before that day happens
Re:The neuroinvasive potential of SARS-CoV2 by samatman on Wednesday March 04, 2020 @02:03PM (#22486765)
HN was founded in 2007, so per the Lindy Effect we should bet on it being around until 2033.

I don't know what your over-under on self-driving cars being prevalent is, so I don't know if this supports your point or not.

Re:The neuroinvasive potential of SARS-CoV2 by geggam on Wednesday March 04, 2020 @03:06PM (#22487480)
Looking at the current infrastructure and the current investment in said infrastructure. I think it’s a safe bet to go out 30 years or more before self driving cars are the norm.

In cities sure. Rural areas not happening. Add the fact people like to drive to Mexico Canada and Alaska I’d call it a non starter.

Example. I have a place where the road on google maps and the place people drive vary because rural Arizona uses washes as roads. Cars driven by humans get stuck.

Re:The neuroinvasive potential of SARS-CoV2 by samatman on Wednesday March 04, 2020 @03:18PM (#22487595)
A lot hinges on whether one considers level 4 or level 5 to be "self-driving".

I wouldn't want to own a car without a steering wheel, sometimes you have to do weird stuff like park on a specific patch of grass at a rural wedding and it's going to be easier to do that myself than try and convince a robot.

But a car that can a) handle 'most' driving for some value of 'most' and can b) safely hand over or come to a stop under basically all circumstances including a sleeping driver? That's actually a much simpler task and it's a very useful vehicle. I would want one of those even if I lived somewhere where road conditions were such that I had to steer it myself on a daily basis.

Like in Arizona, once you got to paved road you could enter an address in Phoenix and kick back in actual safety, without having to worry about taking over at a moment's notice. I think that's achievable in 10-20 years, and it could be less.

Re:The neuroinvasive potential of SARS-CoV2 by TeMPOraL on Wednesday March 04, 2020 @03:00PM (#22487422)
People have to go through 30+ hours of hands-on training, and an exam, before they're allowed to use a car on their own.

It's not just about putting the mask on; it's also about ensuring they swap them out regularly and don't self-infect in the process.

Re:The neuroinvasive potential of SARS-CoV2 by dmos62 on Wednesday March 04, 2020 @02:51PM (#22487325)
> some people drive them into trees

I wouldn't say it's a certain type of people ("some people" vs. "sometimes people"). You could argue for it, though seems like a hard argument to push.

Cars are inherently dangerous, because there isn't a reasonable guarantee that something will not go critically wrong (as opposed to, say, a train). Also, when driving a car, you're not only betting that you won't make a mistake, but also that someone else won't make a mistake (that would affect you).

Re:The neuroinvasive potential of SARS-CoV2 by soperj on Wednesday March 04, 2020 @01:57PM (#22486681)
I agree, but there are definitely people out there that shouldn't be driving that are.
Re:The neuroinvasive potential of SARS-CoV2 by smoyer on Wednesday March 04, 2020 @02:31PM (#22487099)
Are you implying that Tiger Woods wouldn't put his mask on correctly?
Re:The neuroinvasive potential of SARS-CoV2 by nimbius on Wednesday March 04, 2020 @02:53PM (#22487345)
Occupationally I'm a diesel mechanic,so I suppose I could be lumped into the non occupational rocket scientist category. Im learning python.

Yes, we wear n95, but we also get OSHA/niosh specific training on fitment, changing, PPE exposure limit, and appropriate environments. You do not. What people are hoping is that an industrial particulate mask is going to somehow prevent the flu or corona, which honestly I have never understood. Wearing a mask while pressure cleaning a paccar12 engine? Yes, you don't want fine grease mist in your lungs. Powder coating something? Better mask up. Wearing it for a fire? Yes, but change it out once or twice a day and check it often. The flu? How?

Re:The neuroinvasive potential of SARS-CoV2 by rustyminnow on Wednesday March 04, 2020 @03:02PM (#22487447)
I used to be a residential painter. AIUI (and I could be wrong here) biological and water-based molecules are larger than other chemical molecules so can be stopped by the particulate mask. This is why you can wear a dust-cup when spraying with acrylic (water-based), but need a respirator for oil or lacquer-based paint. TBH I'd expect the n95 to work better for infection than a surgical mask because you can get a better seal to your face
Re:The neuroinvasive potential of SARS-CoV2 by decebalus1 on Wednesday March 04, 2020 @01:34PM (#22486405)
> I'm not sure I would call them impractical for everyday wear. I wear N95 masks when commuting during active wildfires.

Right on. For the past couple of years, because the Seattle summers have been hazy due to the wildfire smoke, I still have quite a large batch of N95 masks. I too used to wear them during my commute and the only problem I see is that if you're at risk (underlying respiratory/heart problems) you'll not be able to tolerate the mask... With a good fitment, it makes it harder to breathe.

I think it's unfair to label people hoarders for having these masks... After a couple of consecutive years of wildfire smoke, I think this is the new normal and everyone should have them. It's not my problem that the healthcare industry has a supply issue with these masks, they should have a different, hopefully more efficient and preferential supply chain. I hope they don't buy them from Home Depot (where I got them from).

Re:The neuroinvasive potential of SARS-CoV2 by OJFord on Wednesday March 04, 2020 @01:43PM (#22486516)
I was under the impression that there isn't (yet? But not even close to) a supply issue for the healthcare sector, but rather only at retail, due to a combination of increased demand and supply switching over to for-healthcare-only mode.

This will be something that's routine, just following the plan, that exists to serve some combination of regulation, duty, and risk (burning important healthcare customer or government relationship) mitigation.

Re:The neuroinvasive potential of SARS-CoV2 by usrusr on Wednesday March 04, 2020 @03:21PM (#22487614)
Not yet, because outside of active infection hotspots healthcare workers don't yet use significantly more masks than usual.
Re:The neuroinvasive potential of SARS-CoV2 by OJFord on Wednesday March 04, 2020 @03:29PM (#22487689)
use of course, but they're still stocking up. Despite that I don't believe it's an issue. It's just prioritising supply.
Re:The neuroinvasive potential of SARS-CoV2 by droithomme on Wednesday March 04, 2020 @03:37PM (#22487786)
Here's how to put them on and take them off properly, courtesy of Singapore General Hospital:

https://www.youtube.com/watch?v=zoxpvDVo_NI

Re:The neuroinvasive potential of SARS-CoV2 by mirthflat83 on Wednesday March 04, 2020 @01:23PM (#22486275)
Mask fit testing isn’t really about whether you feel like it’s fitting or not but if you have the money I don’t see a reason not to wear the N95
Re:The neuroinvasive potential of SARS-CoV2 by op00to on Wednesday March 04, 2020 @01:58PM (#22486692)
The reason is that we need the N95 to keep our healthcare workers from getting infected and letting the rest of us die.
Re:The neuroinvasive potential of SARS-CoV2 by zapita on Wednesday March 04, 2020 @01:14PM (#22486183)
Regular surgical masks won't protect your from inhaling the virus, but they will protect you from rubbing your face and nose 100 times a day with contaminated hands, without even noticing it. I wouldn't dismiss their efficacy.
Re:The neuroinvasive potential of SARS-CoV2 by lisper on Wednesday March 04, 2020 @01:34PM (#22486409)
If that's your goal (and it is not an unreasonable one) you can achieve that with a bandanna. You don't need a surgical mask.
Re:The neuroinvasive potential of SARS-CoV2 by giancarlostoro on Wednesday March 04, 2020 @01:45PM (#22486541)
I'm enjoying the thought of software engineers everywhere coming into work with bandanas covering their faces.
Re:The neuroinvasive potential of SARS-CoV2 by propogandist on Wednesday March 04, 2020 @02:01PM (#22486742)
don't worry the facial recognition technology has been perfected to track through face masks / bandanas

https://www.thetimes.co.uk/article/coronavirus-china-tech-fi...

Re:The neuroinvasive potential of SARS-CoV2 by koolba on Wednesday March 04, 2020 @02:08PM (#22486819)
Why would they not remote work?
Re:The neuroinvasive potential of SARS-CoV2 by usrusr on Wednesday March 04, 2020 @03:30PM (#22487708)
Who cares for software engineers in bandanas anyways if you can have bank clerks in bandanas!

And even that would hardly look weirder than in surgical masks. Color-coordinated bandanas with a company logo pin?

Re:The neuroinvasive potential of SARS-CoV2 by onychomys on Wednesday March 04, 2020 @03:45PM (#22487878)
Bank customers in bandanas would probably be a good way to get shot by a security guard in a bandana. The days of Butch and Sundance aren't that far behind us!
Re:The neuroinvasive potential of SARS-CoV2 by derivagral on Wednesday March 04, 2020 @02:18PM (#22486938)
Many places small and large put a large value on butts in seats.

For a less cynical take, there's a lot of conversations that do happen more efficiently in-person, particularly at a lot of places that aren't set up for "full remote".

Re:The neuroinvasive potential of SARS-CoV2 by digibo on Wednesday March 04, 2020 @02:52PM (#22487328)
It's sometimes seen as a security issue, especially if you are not provided with a company-issued laptop. Or your work may require specialized equipment like beefy machines for 3D rendering or local access to a server.
Re:The neuroinvasive potential of SARS-CoV2 by jcadam on Wednesday March 04, 2020 @02:22PM (#22486991)
Because boss says no.
Re:The neuroinvasive potential of SARS-CoV2 by SpicyLemonZest on Wednesday March 04, 2020 @12:58PM (#22486014)
I think there's a legitimate question here. Intuitively, if a non-N95 mask only stops 25% or 50% of incoming viruses, that still seems helpful? It's worth noting that in countries where wearing masks is normalized, making sure the general public can get some is a top priority.
Re:The neuroinvasive potential of SARS-CoV2 by erentz on Wednesday March 04, 2020 @01:11PM (#22486142)
On top of providing some limited protection of the wearer, it also works like herd immunity in that if everyone wears them, then those that don’t yet know they’re sick are reducing their spread.

At the moment because of the misinformation people wearing masks are being mocked and chided in public and its really unhelpful. Especially since there are immune compromised individuals and individuals with other conditions that really need to take every precaution they can, including that 10% reduction a surgical mask may give them.

Re:The neuroinvasive potential of SARS-CoV2 by jrandm on Wednesday March 04, 2020 @01:17PM (#22486217)
My layman's understanding is that any barrier will stop some percent of most things. In the case of small, airborne particles, this stopped percentage of already-dry, floating material is very small. That means inhaling through them is relatively ineffective at stopping you from inhaling the particles.

When you exhale it is more wet and the moisture causes the barrier to catch more of the airborne particles. The barrier also catches any more-solid material that would otherwise land elsewhere, providing a mechanism for the particle to spread.

This means the net gain for wearing them to keep from catching the disease is relatively small compared to the gain by wearing them to prevent the spread if you may have been exposed.

Re:The neuroinvasive potential of SARS-CoV2 by pbhjpbhj on Wednesday March 04, 2020 @01:42PM (#22486500)
Would you agree a fair corollary of that is: if everyone wears masks then spreading of the contagion would be reduced considerably.

It may primarily be about preventing spread from those infected, but that's still super helpful.

Re:The neuroinvasive potential of SARS-CoV2 by jrandm on Wednesday March 04, 2020 @02:15PM (#22486915)
I would agree if everyone exposed wore masks the spread of this contagion would be reduced considerably.

Logically, I might extend it to everyone wearing masks would considerably reduce the spread of exhaled contagions. This might first be encouraged in high population density areas, like parts of Asia, and first need to be integrated with fashion[0] to have any chance of broad success. I suspect it will never be a preference everywhere barring some sort of serious consequence (like death) for not wearing the mask.

In this situation, I think the most important thing is to know that normally available or homemade masks are helpful for presenting the spread of the disease. The more expensive masks are better but in this instance, not better in a meaningful way for the average person. The current supplies should be saved for those at-higher-risk populations like medical staff.

[0]: https://www.pinterest.ca/charmed4evr/fashionable-surgical-fa...

Re:The neuroinvasive potential of SARS-CoV2 by baq on Wednesday March 04, 2020 @01:37PM (#22486435)
You must also remember about disposing of the mask properly. E.g. don’t put used masks in your pockets.
Re:The neuroinvasive potential of SARS-CoV2 by drcode on Wednesday March 04, 2020 @01:26PM (#22486310)
I will argue this is wrong: Only N95 or better masks have studies proving their effectiveness. I don't think we have good data on weaker masks or even "home made" masks- It's totally possible they are also effective, with proper technique.

Please somebody show me data that proves otherwise, I'm totally open to it. (Note: I'm not saying I want you to post opinions from people in authority, I'm saying I want to see data)

Re:The neuroinvasive potential of SARS-CoV2 by doublekill on Wednesday March 04, 2020 @01:52PM (#22486627)
No, there is a 2009 study which compares N95 mask efficiency with surgical masks, because they predict that during a pandemic N95 masks will be in shorter supply. (1)

They don't find significantly more efficiency for N95 masks, but other studies do find N95 masks slightly better. (2)

(1) https://jamanetwork.com/journals/jama/fullarticle/184819

(2) https://onlinelibrary.wiley.com/doi/full/10.1111/j.1750-2659...

Do a search on Google Scholar for "N95" in combination with "virus" or "sars" for more studies.

Really a shame that authorities, including the Surgeon General, claim that masks are not protective, despite medical science to the contrary.

Re:The neuroinvasive potential of SARS-CoV2 by greenburger on Wednesday March 04, 2020 @02:54PM (#22487347)
Even a simple homemade mask has some efficacy [1] though it significantly less. The primary author’s summary of wether they would be protective is “no” [2]

[1] https://www.researchgate.net/publication/258525804_Testing_t...

[2] https://twitter.com/chaiclate/status/1232972182667612162?s=2...

Re:The neuroinvasive potential of SARS-CoV2 by drcode on Wednesday March 04, 2020 @02:15PM (#22486911)
Great link!

Yes, it really hurts me, as a science-based person, to have scientists with authority say things that are unscientific.

Re:The neuroinvasive potential of SARS-CoV2 by ceejayoz on Wednesday March 04, 2020 @01:48PM (#22486580)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373043/?fbclid...

> Quality commercial masks are not always accessible, but anecdotal evidence has showed that handmade masks of cotton gauze were protective in military barracks and in healthcare workers during the Manchurian epidemic.

> The prototype mask achieved a fit factor of 67 for 1 author with a Los Alamos National Laboratory (LANL) panel face size of 4, a common size. Although insufficient for the workplace, this mask offered substantial protection from the challenge aerosol and showed good fit with minimal leakage.

Re:The neuroinvasive potential of SARS-CoV2 by drcode on Wednesday March 04, 2020 @02:22PM (#22486994)
Great link!
Re:The neuroinvasive potential of SARS-CoV2 by headsupftw on Wednesday March 04, 2020 @02:02PM (#22486752)
One of my coworkers, who is a staunch supporter for wearing face masks to protect against coronavirus, wears an N95 the entire time he's in the office. Yesterday he claimed he's having chest discomfort (which is what some people will feel when they wear N95 24x7 awake) and went to a hospital to demand a test for coronavirus infection. Needless to say his request got declined and he's doing just fine but I am simply speechless at the irony.
Re:The neuroinvasive potential of SARS-CoV2 by GuB-42 on Wednesday March 04, 2020 @02:18PM (#22486946)
Nocebo effect?

If you are thinking about coronavirus, you are more likely to feel the symptoms of a coronavirus infection, or what you think are the symptoms.

Re:The neuroinvasive potential of SARS-CoV2 by pmiller2 on Wednesday March 04, 2020 @02:37PM (#22487167)
Paranoia is more like it. N95 masks make it harder to breathe, which can lead to mild chest pain.
Re:The neuroinvasive potential of SARS-CoV2 by wbl on Wednesday March 04, 2020 @01:58PM (#22486693)
Meanwhile in South Korea everyone has masks. In WWII we built one bomber an hour at one plant, and now we can't figure out how to build millions or billions of masks.
Re:The neuroinvasive potential of SARS-CoV2 by irrational on Wednesday March 04, 2020 @02:14PM (#22486903)
That's because that bomber was built by the "greatest" generation. By definition, we aren't the greatest generation.
Re:The neuroinvasive potential of SARS-CoV2 by hellofunk on Wednesday March 04, 2020 @02:34PM (#22487140)
Now that made me laugh!
Re:The neuroinvasive potential of SARS-CoV2 by gamblor956 on Wednesday March 04, 2020 @03:01PM (#22487433)
Multiple companies in the US, China, and Europe have announced that they will be producing millions or more masks a month with availability beginning as soon as next week, just 2 months after the virus went global...

It took most of the war for that plant to get to the point of building a bomber an hour.

Re:The neuroinvasive potential of SARS-CoV2 by thu2111 on Wednesday March 04, 2020 @02:27PM (#22487048)
Be fair. Nobody was building one bomber an hour two months after the very first sign of trouble.
Re:The neuroinvasive potential of SARS-CoV2 by adrianN on Thursday March 05, 2020 @06:41AM (#22492730)
You'd think that we have improved our ability to mass manufacture things since 1940.
Re:The neuroinvasive potential of SARS-CoV2 by SkyMarshal on Wednesday March 04, 2020 @01:45PM (#22486535)
Even N95 masks are not fully sufficient. They typically block particles at 0.3 microns or larger, but coronaviruses tend to be smaller, around 0.1 - 0.3 microns.

You need an ASTM Level 2 or higher surgical mask to block coronavirus from completely penetrating the mask.

That said, any mask is better than no mask, first because it prevents you touching your mouth and nose with potentially infected hands, and second because coronavirus travels in water droplets which can be stopped by the mask from going straight into your mouth or nose.

Re:The neuroinvasive potential of SARS-CoV2 by UncleOxidant on Wednesday March 04, 2020 @01:58PM (#22486695)
Yes, the virus itself is small enough to get through, but typically the virus comes in a water droplet (as in being coughed or sneezed out) and those will be mostly stopped by an N95 mask.
Re:The neuroinvasive potential of SARS-CoV2 by jeffmcmahan on Wednesday March 04, 2020 @02:17PM (#22486930)
Hmm. Based on what I read, particles smaller than 0.3 microns have a widely "wandering" path of travel through the mask fibers on account of Brownian motion. My understanding was that 0.3 micron particles are the size that the N95 mask is least effective at blocking. Smaller particles are blocked more effectively, not less, until you get down to a scale so small that you pretty well exclude live biological material.

Not my original source, but discusses the same thing: https://multimedia.3m.com/mws/media/376179O/nanotechnology-a...

This is to say, 95% filtration is the worst the mask will perform, with particles of any size, as it relates to coronavirus.

Re:The neuroinvasive potential of SARS-CoV2 by hurrdurr2 on Wednesday March 04, 2020 @02:54PM (#22487351)
This is correct.

Particles smaller in size than 0.3 microns will have HIGHER capture efficiency.

This is similar for HEPA filtration as well.

Re:The neuroinvasive potential of SARS-CoV2 by agumonkey on Wednesday March 04, 2020 @03:56PM (#22487988)
can't sub .3 microns particles get stuck in the fibers along the way even if they can pass the first (due to turbulent flow)?
Re:The neuroinvasive potential of SARS-CoV2 by StanislavPetrov on Wednesday March 04, 2020 @01:36PM (#22486432)
>need to be conserved for public health users.

I think we should all ask ourselves why we take it for granted that we should simply have to ration masks. Why aren't there enough masks available for everyone for inevitable outbreaks like this? Why don't we have the industrial capacity to manufacture masks in the US, leaving us reliant on foreign imports?

We spend ~$80 billion dollars a month on our endless war, military and spy agencies in the name of "national security", but I'd argue that having ample medical supplies (and the ability to manufacture them) are just as, if not more important, to our "national security" as the vast majority of our military activities. Hopefully this crisis will not become to severe and will serve as a wakeup call for us to rethink our national priorities before the next inevitable crisis.

Re:The neuroinvasive potential of SARS-CoV2 by jklhjklhtoeiru on Wednesday March 04, 2020 @01:55PM (#22486663)
There was an article recently about an US mask manufacturer (small one, not 3M), which for years warned that this will happen: a pandemic will hit and there will be a severe lack of masks anywhere.

He also recounted how after the 2009 flu scare everyone was telling him how after it ends they will now stockpile masks to be ready for the next one, he increased production, but then was stuck with it because people stopped taking his calls the moment the flu faded.

Re:The neuroinvasive potential of SARS-CoV2 by vonmoltke on Wednesday March 04, 2020 @01:58PM (#22486705)
> Why aren't there enough masks available for everyone for inevitable outbreaks like this?

I don't know anyone who has conclusively demonstrated there are not. What we have right now are runs on Home Depot and the like buying out respirators and dust masks faster than the stores can restock them.

> Why don't we have the industrial capacity to manufacture masks in the US, leaving us reliant on foreign imports?

We haven't and aren't. 3M manufactures their masks in the US.

[dead]
Re:The neuroinvasive potential of SARS-CoV2 by StanislavPetrov on Wednesday March 04, 2020 @02:25PM (#22487019)
It comes down a question of priorities - the money is being spent right now. Is the average American better off if we spend $25 billion dollars next week arming Turkish Jihadists and sending missiles to Ukraine, or spending that money to build up our own country and respond properly to this outbreak before it gets out of control?
Re:The neuroinvasive potential of SARS-CoV2 by droithomme on Wednesday March 04, 2020 @02:42PM (#22487226)
> only a N95 or better mask would protect you from incoming

That is not only completely false but is extremely dangerous misinformation.

https://www.sciencedaily.com/releases/2019/09/190903134732.h...

> The study reported 'no significant difference in the effectiveness' of medical masks vs. N95 respirators for prevention of influenza or other viral respiratory illness.

Re:The neuroinvasive potential of SARS-CoV2 by bluGill on Wednesday March 04, 2020 @12:56PM (#22485992)
I have a small box of N95 masks in my shop - bought last summer for dust protection. When is the right time for me to put them on my family. Part of this is how long will they last before I must replace them. Or should I put them on eBay for a million dollars and hope I life to enjoy my new found wealth?
Re:The neuroinvasive potential of SARS-CoV2 by Leary on Wednesday March 04, 2020 @01:13PM (#22486173)
Save them right now and have them as an insurance against if things go really bad and you have to go to a crowded place.
Re:The neuroinvasive potential of SARS-CoV2 by drcode on Wednesday March 04, 2020 @01:29PM (#22486355)
Surely you have elderly friends and relatives, give each one one of your masks (once things are dire enough that people will actually learn to use masks properly and not waste it.)
Re:The neuroinvasive potential of SARS-CoV2 by oh_sigh on Wednesday March 04, 2020 @03:42PM (#22487846)
N95 filters, if cared for(ie no compression/ripping damage), work until you can't effectively breathe through them any more.
Re:The neuroinvasive potential of SARS-CoV2 by mongol on Wednesday March 04, 2020 @12:58PM (#22486010)
For a million dollars - no doubt.
Re:The neuroinvasive potential of SARS-CoV2 by tdstein on Wednesday March 04, 2020 @01:13PM (#22486163)
Or you could donate them to your local hospital since there is a shortage. I’m not sure they would take them, but it’s worth considering.
Re:The neuroinvasive potential of SARS-CoV2 by ceejayoz on Wednesday March 04, 2020 @01:51PM (#22486608)
Local hospitals are not going to be able to take masks from some random person off the street.
Re:The neuroinvasive potential of SARS-CoV2 by OJFord on Wednesday March 04, 2020 @03:44PM (#22487867)
There isn't a shortage if you're a hospital. There's a run on the retail supply, and retail restocking will be very limited, if at all. But your local hospital is fine.

And it would have to be apocalyptic for them to accept a box of medical equipment from some guy wandering in.

Re:The neuroinvasive potential of SARS-CoV2 by katmannthree on Wednesday March 04, 2020 @01:10PM (#22486132)
I've used them a fair bit at work, you get used to them. Proper fit is important though, and many people with facial hair will need to remove it before the mask will be effective.

It's almost a moot point right now though because they're sold out pretty much everywhere.

Re:The neuroinvasive potential of SARS-CoV2 by bitxbit on Wednesday March 04, 2020 @02:03PM (#22486766)
This is NOT true. N95 is needed for health professionals in an active care environment. THIS DOES NOT IMPLY MASKS in general ARE NOT EFFECTIVE for individuals in public spaces who may run into someone who’s infected.
Re:The neuroinvasive potential of SARS-CoV2 by mirekrusin on Wednesday March 04, 2020 @03:17PM (#22487581)
Protection from outgoing is the same as protection from incoming if you don’t look at it only from your own perspective, right?
Re:The neuroinvasive potential of SARS-CoV2 by wintorez on Wednesday March 04, 2020 @01:55PM (#22486666)
Also, you need to wear eye protection as well.
Re:The neuroinvasive potential of SARS-CoV2 by headsupftw on Wednesday March 04, 2020 @02:07PM (#22486812)
Which nobody does if she's not a healthcare worker.
Re:The neuroinvasive potential of SARS-CoV2 by Leary on Wednesday March 04, 2020 @01:16PM (#22486204)
Surgical masks are effective against droplets from coughing and sneezing.
Re:The neuroinvasive potential of SARS-CoV2 by chaostheory on Wednesday March 04, 2020 @02:51PM (#22487320)
Given the size of the viruses, N100 is the minimum
Re:The neuroinvasive potential of SARS-CoV2 by adrianN on Thursday March 05, 2020 @06:43AM (#22492740)
The virus is not airborne, it spreads via droplets. Those are typically MUCH larger than a virus.
Re:The neuroinvasive potential of SARS-CoV2 by jcims on Wednesday March 04, 2020 @01:13PM (#22486176)
I see this a lot but there obviously have to be some kind of effectiveness curve for masks below N95.
Re:The neuroinvasive potential of SARS-CoV2 by tjt on Wednesday March 04, 2020 @01:24PM (#22486293)
This is super scary. Before I read this I was happily thinking hey it's no worse than flu. Now... I'm wishing I didn't live in a huge city riding the subway daily.
Re:The neuroinvasive potential of SARS-CoV2 by Symmetry on Wednesday March 04, 2020 @02:06PM (#22486805)
Learning about the mechanism by which it kills shouldn't change our estimates of the lethality of the disease. We already knew that for most people it was just a bad flue but a noticeable fraction of those infected needed to get to an ICU. Now we just have a better idea of why.
Re:The neuroinvasive potential of SARS-CoV2 by empath75 on Wednesday March 04, 2020 @02:40PM (#22487205)
we actually have no idea what the long term effects are.

Some people seem to be bothered by it for months after.

Re:The neuroinvasive potential of SARS-CoV2 by airstrike on Wednesday March 04, 2020 @01:27PM (#22486317)
I keep trying to not look up Coronavirus news online, but I can't help it... and after reading this I'm genuinely terrified. The word "potential" on the title is entirely invisible to me.
Re:The neuroinvasive potential of SARS-CoV2 by drcode on Wednesday March 04, 2020 @01:31PM (#22486372)
Oddly enough, I was on the "pandemic" bandwagon early enough that my period of anxiety and insomnia has now passed already. People get used to new states of affair pretty quickly.
Re:The neuroinvasive potential of SARS-CoV2 by airstrike on Wednesday March 04, 2020 @01:34PM (#22486401)
I hardly ever have to deal with anxiety, but now I have a headcold and my coworker sitting 6-feet to my right has a mask on...
Re:The neuroinvasive potential of SARS-CoV2 by davidw on Wednesday March 04, 2020 @02:46PM (#22487257)
If you have a cold or anything else infectious, please work from home if at all possible.
Re:The neuroinvasive potential of SARS-CoV2 by lagilogi on Wednesday March 04, 2020 @02:00PM (#22486735)
You should be the one wearing the mall though no?
Re:The neuroinvasive potential of SARS-CoV2 by airstrike on Wednesday March 04, 2020 @02:10PM (#22486840)
Still waiting for mine to be delivered... They're hard to come by!

But I'm sure my coworker is wearing a mask for their own set of reasons...

Re:The neuroinvasive potential of SARS-CoV2 by samatman on Wednesday March 04, 2020 @02:46PM (#22487263)
When I lived in Chicago I used to practice riding the L without touching anything with my hands. In the Bay I kept up the habit.

This is never not a good idea, so no time like the present to get into it.

Re:The neuroinvasive potential of SARS-CoV2 by aldanor on Wednesday March 04, 2020 @03:01PM (#22487437)
Or you could just wear cycling gloves.
Re:The neuroinvasive potential of SARS-CoV2 by maxerickson on Wednesday March 04, 2020 @06:32PM (#22489318)
Then you have to handle the gloves.
Re:The neuroinvasive potential of SARS-CoV2 by t420mom on Wednesday March 04, 2020 @01:56PM (#22486672)
Are you able to ride a bike to work?
Re:The neuroinvasive potential of SARS-CoV2 by jklhjklhtoeiru on Wednesday March 04, 2020 @01:57PM (#22486689)
In many cities/countries that's more dangerous than just getting the corona.
Re:The neuroinvasive potential of SARS-CoV2 by tjt on Wednesday March 04, 2020 @02:32PM (#22487108)
I'm pretty lucky that I can ride a bike or work remote. My partner doesn't have either option.
Re:The neuroinvasive potential of SARS-CoV2 by refurb on Wednesday March 04, 2020 @02:05PM (#22486793)
I don't understand the worry.

As of yesterday, China, a country of 1.4B, had 80,000 cases and 3,000 dead.

Last year, the US had 36M infected with the flu and 34,000 died.[1]

Are you panicking about the flu?

[1]https://www.cdc.gov/flu/about/burden/2018-2019.html

Re:The neuroinvasive potential of SARS-CoV2 by Gene_Parmesan on Wednesday March 04, 2020 @03:07PM (#22487493)
Mortality rate of covid19 for people with cancer is estimated at over 6%. My mom has cancer. Every person who gets covid19 but thinks "oh it wasn't that bad" makes it just a little more likely that people like my mom will contract it.

The reason to not panic but be prepared is that humanity has zero immunity to this virus, whereas there's lots of group immunity to influenza. I'm not sure why it's so hard for people to see the issue here.

It's significantly more deadly than the flu. But also, people should probably take influenza more seriously anyways.

Re:The neuroinvasive potential of SARS-CoV2 by refurb on Wednesday March 04, 2020 @03:26PM (#22487659)
That’s no different than the flu. Older people and people with compromised health make up most of the fatalities each year.
Re:The neuroinvasive potential of SARS-CoV2 by adrianN on Thursday March 05, 2020 @06:46AM (#22492758)
Mortality for covid19 is much higher than for the flu.
Re:The neuroinvasive potential of SARS-CoV2 by asveikau on Wednesday March 04, 2020 @04:43PM (#22488472)
3,000 / 80,000 = 0.0375

34,000 / 36,000,000 = ~0.00094

36,000,000 * 0.0375 = 1,350,000

That's the concern.

China also had some pretty extreme measures to get their low number of cases, measures I don't think will play out too well in the US. And probably won't have a full count yet.

We can hope for the best, we can wash hands etc., but it's not unrealistic to say this can get bad.

Re:The neuroinvasive potential of SARS-CoV2 by chinathrow on Wednesday March 04, 2020 @02:09PM (#22486835)
The rates in China are dropping because they have some form of travel restrictions for 780m people. If those restrictions would be removed, the rates would go up immediately as seen before and now in other countries.

Edit: source added

https://inews.co.uk/news/world/china-coronavirus-covid-19-de...

Re:The neuroinvasive potential of SARS-CoV2 by refurb on Wednesday March 04, 2020 @02:34PM (#22487139)
Is there any reason to believe other countries won’t institute travel restrictions if they get a ton of cases?

My point is that based on how many die from the flu each year, you’d have to see 130,000 deaths in China for the impact to be the same as the flu.

Re:The neuroinvasive potential of SARS-CoV2 by gamblor956 on Wednesday March 04, 2020 @03:08PM (#22487505)
You can't compare absolute deaths between the flu and WCV.

The flu infects nearly 20% of the world's population each year. Estimates by the NIH are 10-20% annually in the US, and those numbers are probably similar in other countries. China has a billion people, so that means the flu infects probably 200 million people each year but only 130,000 die. The death rate is below 0.2%.

In contrast, only about 90,000 people have been infected with WCV so far. Thousands have died. The death rate is at 3.8%, or roughly 19-20x higher than the flu.

Re:The neuroinvasive potential of SARS-CoV2 by nopinsight on Wednesday March 04, 2020 @02:53PM (#22487342)
Have you considered the fatality rate and what would happen if it reaches the same percentage of population as seasonal flu?

Check out Spanish Flu for worst case scenario.

China restrictions have been much more stringent than what you imply. People in Wuhan were prevented from leaving their apartments at all and needed to wait for food from the government.

The jury is still out whether softer forms of restrictions can work once the disease is widespread. We will see about that by watching South Korea and Italy. (We know it works if there are not too many cases around, like in Singapore.)

Re:The neuroinvasive potential of SARS-CoV2 by refurb on Wednesday March 04, 2020 @10:04PM (#22490577)
Have you considered the fatality rate and what would happen if it reaches the same percentage of population as seasonal flu?

Yeah, that would be bad, but there is no data to suggest it would get that bad.

Re:The neuroinvasive potential of SARS-CoV2 by empath75 on Thursday March 05, 2020 @08:37AM (#22493378)
This makes zero sense. We know the fatality rate. We know the R0. We know how many people have it currently and how fast it’s spreading. It’s simple math.
Re:The neuroinvasive potential of SARS-CoV2 by stelfer on Wednesday March 04, 2020 @01:43PM (#22486522)
It's not clear that it spreads via aerosols, in fact it's more likely that it spreads via droplet and contact. Thus the virtue of the mask is that it keeps the individual's fingers away from their faces. From the perspective of the theory in the article, masks keep people's fingers out of their noses. Of course, there are other ways to do that.
Re:The neuroinvasive potential of SARS-CoV2 by grogenaut on Wednesday March 04, 2020 @01:46PM (#22486557)
Such as?
Re:The neuroinvasive potential of SARS-CoV2 by spking on Wednesday March 04, 2020 @02:00PM (#22486724)
Not picking your nose.
Re:The neuroinvasive potential of SARS-CoV2 by grogenaut on Wednesday March 04, 2020 @04:33PM (#22488387)
not picking your nose isn't that bad. but try not touching your face.
Re:The neuroinvasive potential of SARS-CoV2 by spyckie2 on Wednesday March 04, 2020 @02:18PM (#22486940)
Wuhan was infected at the worst possible time (CNY) where the entire population underwent a systematic distribution of the virus (visiting relatives) and also likely bodily fluid exchange (via sharing food - Chinese people don't use communal utensils with family).
Re:The neuroinvasive potential of SARS-CoV2 by jessriedel on Wednesday March 04, 2020 @01:37PM (#22486438)
Why is it easier to get to the brain from the nose compares to the mouth or eyes?
Re:The neuroinvasive potential of SARS-CoV2 by hazeii on Wednesday March 04, 2020 @01:49PM (#22486595)
Very possibly because the olfactory bulb is basically a bit of the brain exposed to the atmosphere. See the illustration on the wikipedia page [0].

[0] https://en.wikipedia.org/wiki/Olfactory_bulb

Re:The neuroinvasive potential of SARS-CoV2 by jessriedel on Wednesday March 04, 2020 @02:09PM (#22486836)
The retina is basically an extension of the brain as well, no? If not, what is the key difference? Do you have a link talking about the atmosphere?
Re:The neuroinvasive potential of SARS-CoV2 by angst_ridden on Wednesday March 04, 2020 @02:25PM (#22487022)
But the retina is not exposed to the outside world. It's got the rest of the eye between it and the air.
Re:The neuroinvasive potential of SARS-CoV2 by jessriedel on Wednesday March 04, 2020 @04:02PM (#22488057)
Ok, but is brain tissue uniquely infectable compared to eye tissue or something? The ultimate worry isn't that your olfactory bulb gets hurt, it's that the infection reaches deeper into the brain, and I don't get why it's easier to do that from the olfactory bulb rather than from the eye.
Re:The neuroinvasive potential of SARS-CoV2 by rolph on Wednesday March 04, 2020 @06:23PM (#22489245)
the conjunctiva of the eye is different tissue than optic nerve. there is fat, connective tissue, and muscle surrounding the eye.
Re:The neuroinvasive potential of SARS-CoV2 by jklhjklhtoeiru on Wednesday March 04, 2020 @02:00PM (#22486718)
When you have an infection around the nose area you'll be immediately put on strong antibiotics, because the danger of the infection spreading to the brain through the nose is so big.
Re:The neuroinvasive potential of SARS-CoV2 by rolph on Wednesday March 04, 2020 @01:45PM (#22486539)
https://en.wikipedia.org/wiki/Olfactory_bulb.

however:

Yan-Chao Li [etal.] ABSTRACT Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after pe- ripheral inoculation, resulting in acute deadly encepha- lomyelitis in natural host piglets as well as in experimental younger rodents. This study has system- atically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that mem- branous-coating-mediated endo-/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the syn- aptic junctions. J. Comp. Neurol. 521:203–212, 2013.

https://doi.org/10.1002/cne.23171

it seems if you are not a swine or a rat you have little to worry about.

Re:The neuroinvasive potential of SARS-CoV2 by jessriedel on Wednesday March 04, 2020 @02:06PM (#22486799)
I don't understand what the Wikipedia link is supposed to show. Your eyes are tightly linked to your brain too.
Re:The neuroinvasive potential of SARS-CoV2 by rolph on Wednesday March 04, 2020 @02:11PM (#22486855)
the neuronal terminals leading to a lobe of the brain innervate the nasal mucosa.

the optic nerve is hidden behind the eye with a substantial barrier of non nervous tissue in front of it.

https://upload.wikimedia.org/wikipedia/commons/thumb/1/1e/Sc...

Re:The neuroinvasive potential of SARS-CoV2 by jessriedel on Wednesday March 04, 2020 @04:04PM (#22488078)
Can the infection move through nervous tissue more easily than non-nervous tissue?
Re:The neuroinvasive potential of SARS-CoV2 by rolph on Wednesday March 04, 2020 @04:46PM (#22488504)
that doesnt seem to be the case. this virus really likes your lungs because of a specific protien. this protien exists in your lungs at a greater concentration than elsewhere in your body. The virus would have to undergo a specific series of mutations to get good at targeting neurons.
Re:The neuroinvasive potential of SARS-CoV2 by epmaybe on Wednesday March 04, 2020 @02:13PM (#22486885)
yes, but there isn't a direct route from the outside to your brain. Your eye socket is relatively well insulated from the outside by skin, connective tissue, conjunctiva.
Re:The neuroinvasive potential of SARS-CoV2 by rolph on Wednesday March 04, 2020 @02:19PM (#22486956)
what you should take home from this is that you are not in immedate danger from a neurotrophic virus at this time.

what you should also take from this espescially if you are involved in policy is that this corona virus we are experiencing has in its distant heritage ancestors with reported neurotrophic properties. It is possible, that at some time in the future, this virus will accumulate signifigant genetic drift and gain or lose certain properties.

Re:The neuroinvasive potential of SARS-CoV2 by airstrike on Wednesday March 04, 2020 @01:49PM (#22486587)
> It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasally.

Where can I buy noseplugs?

Re:The neuroinvasive potential of SARS-CoV2 by velosol on Wednesday March 04, 2020 @02:28PM (#22487056)
Foam earplugs work but look a little funny.
Re:The neuroinvasive potential of SARS-CoV2 by odyssey7 on Wednesday March 04, 2020 @02:24PM (#22487011)
Why not use a cheap noseclip for swimming? Perfectly leak-free. The paper suggests intranasal transmission is what you most want to avoid.

> It may also be expected that the symptoms of the patients infected via facal-oral or conjunctival route will be lighter than those infected intranasally.

Re:The neuroinvasive potential of SARS-CoV2 by nopinsight on Wednesday March 04, 2020 @02:38PM (#22487175)
Self-infection is very plausible. Once someone has it in their body, some minor action can transfer it from one organ to another. No one can stay vigilant of their own body 24-7.
Re:The neuroinvasive potential of SARS-CoV2 by Seenso on Wednesday March 04, 2020 @03:18PM (#22487591)
> I should also point out that most people in the US face similar conditions to those in Wuhan. The extent of infection is not known, and therefore protective measures are not in place. We have been actively discouraged from "buying masks" and told that they are ineffective.

Not exactly. I'm hopeful that differences between the typical American lifestyle and the typical Chinese lifestyle will help make the epidemic less severe in the US.

Americans are more "spread out" than Chinese: we often drive personal cars instead of taking public transit; our homes are freestanding with more private space per person; our public spaces are often less crowded, etc. I think open offices are even more common in China. Hopefully that extra distance will help.

Re:The neuroinvasive potential of SARS-CoV2 by fiter on Wednesday March 04, 2020 @12:57PM (#22486006)
This suggests an advantage to purposeful infection by oral/eye rather than accidental by intranasal. It'll be interesting to see what the case fatality rate is when segmented by infection route.
Re:The neuroinvasive potential of SARS-CoV2 by bryanrasmussen on Wednesday March 04, 2020 @03:01PM (#22487430)
How do you know what infection route it came in by, and how certain is the method for determining the route?
Re:The neuroinvasive potential of SARS-CoV2 by newsbinator on Wednesday March 04, 2020 @01:08PM (#22486112)
It's been suggested to me, in addition to hand washing, to use soap to rinse a bit of my nostrils. Not sure if it makes any difference at all, but I've been doing it on the off-chance.
Re:The neuroinvasive potential of SARS-CoV2 by UncleOxidant on Wednesday March 04, 2020 @02:04PM (#22486784)
I would think this would actually increase the odds of infection via that route since it would tend to dry out the skin in your nostrils and remove some of the natural defenses we have there.
Re:The neuroinvasive potential of SARS-CoV2 by MistahKoala on Wednesday March 04, 2020 @01:29PM (#22486351)
Presumably in anticipation of upper respiratory tract infection. COVID-19 is a lower respiratory tract infection.

I haven't heard of nasal irrigation using soap; hypertonic saline solution is usually recommended.

http://www.elvisstudy.com/

Re:The neuroinvasive potential of SARS-CoV2 by mc32 on Wednesday March 04, 2020 @12:54PM (#22485964)
How often would people have to replace their N95s to be of help?
Re:The neuroinvasive potential of SARS-CoV2 by sndean on Wednesday March 04, 2020 @12:57PM (#22485995)
It looks like CDC recommends to use them for ≤ 8 hours (continuous or intermittent) [0].

[0] https://www.cdc.gov/niosh/topics/hcwcontrols/recommendedguid...

Re:The neuroinvasive potential of SARS-CoV2 by pbhjpbhj on Wednesday March 04, 2020 @01:49PM (#22486597)
Presumably their effectiveness is reduced then, rather than negated. Aren't they just close bound fibres that form a filter?
Re:The neuroinvasive potential of SARS-CoV2 by sndean on Wednesday March 04, 2020 @02:08PM (#22486818)
Yeah probably reduced, but it may be more to do with them becoming contaminated. The link points to a study saying

> One study found that nurses averaged 25 touches per shift to their face, eyes, or N95 respirator during extended use.

How problematic that touching is probably scales with how problematic your environment is. They're pretty sponge-like. Wearing a surgical mask over an N95 would help a lot.

In a controlled biosafety level 3 lab, "single use" things are definitely the most common, where everything exposed to the outside world is destroyed after you're done. What's worn underneath is washed and you're forced to take a shower. So that's what you do if you know you're in a contaminated environment – not sure what I'd do in a public place.

Re:The neuroinvasive potential of SARS-CoV2 by sebazzz on Wednesday March 04, 2020 @02:42PM (#22487227)
> Yeah probably reduced, but it may be more to do with them becoming contaminated.

How effective is the virus after the mask has been unused for a while (so "cold", like a doorknob or a desk)? If it is not, the mask should be good to go then, doesn't it?

Re:The neuroinvasive potential of SARS-CoV2 by samatman on Wednesday March 04, 2020 @02:50PM (#22487313)
I gather that it's too early in understanding COVID to have robust answers to this sort of question.

I use a reusable mask, and honestly, I don't wash it very often. It's there mostly so if I absentmindedly touch my nose I don't actually touch my nose, and so I never remove it until I've thoroughly washed my hands.

Re:The neuroinvasive potential of SARS-CoV2 by mc32 on Wednesday March 04, 2020 @04:07PM (#22488123)
No idea but some people (whose source I don’t know) say the virus can live on some surfaces to nine days. Guess one could use sterilants/disinfectants to accelerate that time dramatically.
Re:The neuroinvasive potential of SARS-CoV2 by ludwigvan on Wednesday March 04, 2020 @04:46PM (#22488501)
Coronavirus can persist up to 9 days on inanimate surfaces. 70% ethanol can disinfect the surface within 1 minute.

Source: https://www.journalofhospitalinfection.com/article/S0195-670...

Re:The neuroinvasive potential of SARS-CoV2 by rolph on Wednesday March 04, 2020 @01:54PM (#22486648)
they may become fomitic , actually carrying aggregations of virions nestled in expectorated particles of mucous
Re:The neuroinvasive potential of SARS-CoV2 by 99_00 on Wednesday March 04, 2020 @02:15PM (#22486907)
>I should also point out that most people in the US face similar conditions to those in Wuhan.

I don't think that's true.

Re:The neuroinvasive potential of SARS-CoV2 by _rrnv on Wednesday March 04, 2020 @02:40PM (#22487203)
This! It really boggles the mind that officials would discourage wearing masks (even surgical masks). You see, the best way to stop COVID-19 is to thwart its infectious potential. And this is done by two things: everybody wears masks (since nobody knows they are contagious until it's too late) and everybody washes hands constantly. But nooo, no need to panic, this is not Asia, this is The West... Freedom!... x_x
Re:The neuroinvasive potential of SARS-CoV2 by hoten on Wednesday March 04, 2020 @02:46PM (#22487258)
The issue is a mask shortage.
Re:The neuroinvasive potential of SARS-CoV2 by SubiculumCode on Wednesday March 04, 2020 @02:48PM (#22487291)
I think that the fear was of a mask shortage. Infected quarantined > Potentially Infected COVID-19 contacts wearing masks > Uninfected wearing masks.
Re:The neuroinvasive potential of SARS-CoV2 by luckylion on Wednesday March 04, 2020 @03:02PM (#22487444)
Can someone shed some light on the difficulties of producing the "simple" surgical masks? I'm not talking about something that filters the incoming air, but the lame kind that just reduces the amount of liquids you disperse when breathing, coughing, sneezing etc.

Are they so high tech you can't just ramp up production? And how many months in advance would you need to ramp it up? We're about 3 months in and nobody got the idea to increase production of masks until about a week ago (similar for hand sanitizer, soaps etc)? What am I missing, why is that a thing?

Re:The neuroinvasive potential of SARS-CoV2 by OJFord on Wednesday March 04, 2020 @03:57PM (#22487999)
Demand is probably relatively (to other products) stable, why would you have been running a factory with unused capacity available to ramp up into for years ?

I read about a hand sanitiser manufacturer ramping up in the UK; by increasing hours, not throughput. And obviously to increase hours you need more staff, training, and maybe to review some policies, local bylaws, and other procedural stuff.

Re:The neuroinvasive potential of SARS-CoV2 by 24gttghh on Wednesday March 04, 2020 @04:21PM (#22488277)
My assumption: They're made in China. Where everything is shut down.
Re:The neuroinvasive potential of SARS-CoV2 by Allower on Wednesday March 04, 2020 @02:07PM (#22486811)
Obviously buying masks is discouraged because there is a shortage and hospitals have a much greater need for them than an uninfected person living in location as of yet untouched by the virus. Its about priorities.