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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by neom on Saturday October 12, 2024 @10:18AM (#41819250)
Psilocybin saved my life. I'm no longer suicidal, I'm no longer a practicing alcoholic, and outside of a few things here and there, I'm generally at peace with my life. I cannot express how grateful I am for psilocybin.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by M4v3R on Saturday October 12, 2024 @10:44AM (#41819452)
Thanks for sharing this, you’re not the only one. I have a close friend who tried LSD as a last resort to get the best of his severe depression and suicidal thoughts (after being on SSRIs for his entire life) and just one session completely removed his suicidal thoughts for months. After this experience he repeats this whenever he feels the dark thoughts are coming back and it always curbs them down almost completely. It’s mind-blowing how well it worked for him.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Saturday October 12, 2024 @06:47PM (#41823395)
just consider, if it's so powerful in adjusting his brain, it's probably equally powerful in adjusting anybody's brain, and what if your brain doesn't need adjustment? there's no reason to think it's "idempotent" so to speak.

https://en.wikipedia.org/wiki/Idempotence is the property of certain operations in mathematics and computer science whereby they can be applied multiple times without changing the result beyond the initial application

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by throwup238 on Saturday October 12, 2024 @07:22PM (#41823629)
I suspect there’s a lot of self selection at work already. The vast majority of people don’t jump straight into psilocybin and LSD, they progress to them by taking softer drugs like alcohol and cannabis. I think a lot of people who don’t need “adjustment” figure out drugs don’t do much for them and stop before they take the intense psychedelics, or they figure it out at lower doses and stop before they take the intense dose.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by asveikau on Saturday October 12, 2024 @08:27PM (#41824066)
Are you saying the claim that psychedelics are effective treatment for depression, PTSD, addiction etc. are simply because those who try it suffer those conditions? What about the part where they say it works effectively? Because I don't think alcohol or cannabis are claimed to be an effective treatment for these conditions in the same way that psychedelics are. The idea that it works seems irrelevant to your conclusion.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by throwup238 on Saturday October 12, 2024 @09:22PM (#41824365)
No that’s not what I’m saying.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by asveikau on Saturday October 12, 2024 @09:36PM (#41824436)
Ok. Then I misread.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Sunday October 13, 2024 @02:46PM (#41830475)
sounds like a reasonable hypothesis, that people who are unhappy with their emotional/mental state might be more attracted to altering it, or might experience results they consider more positive.

how do our brains decide to do anything, like eat ice cream? "hey, I loved that last time". We know that drugs are not experienced as universally positive because many people who try them in college do not go on use them throughout their adult lives.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by asveikau on Sunday October 13, 2024 @10:02PM (#41833521)
But the part you miss is that it works. This is anecdotal for now but people are looking at evaluating that more objectively.

It's not even a stretch if you squint at this. The currently accepted treatment is SSRIs, the second S standing for serotonin. Psychedelics work on serotonin receptors. Why would it be surprising that if you tweak your serotonin receptors, you get treatment for depression? Again, this is not true of alcohol or cannabis.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by tripzilch on Thursday October 17, 2024 @05:57AM (#41868021)
Maybe this is anecdotal, but I feel this is dependent on age. What you describe would have been true when I was younger. But nowadays I know quite some people who never used cannabis / hardly drink any alcohol, and still tell me they'd like to try LSD or shrooms some day.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by yieldcrv on Saturday October 12, 2024 @07:13PM (#41823564)
everyone considers that, but because they’ll be dead by the time the studies narrow down anything they chose the substance that moves them towards results - or doesn’t

everyone can perceive that psychedelic is doing many highly variable things at once and probably shouldn't be recommended, so they just say their experience

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Saturday October 12, 2024 @07:47PM (#41823801)
the vast majority of people who try psychedelics are not trying to escape untreatable clinical depression, they are doing it recreationally, for a roller coaster ride which they believe connects them with the Almighty or the Unknowable or the Dao or the All-loving Everpresent or the "insert word that sounds profound" <-- oh, the Profundity!

These people are inspired—perhaps by the Almighty, i'm not judging—to preach The Gospel of psychedelics and praise any confirmation of these miracles. I'm simply pointing out that what appears to be the Omnipotence of the Almighty might very well be Selling Your Soul to the Devil for all you know. I'm an atheist, simply using metaphor to get the point across to you.

When you talk about how powerful medication is in warping the brain to cure intractable mental problems, that is not at all an endorsement of recreational use. Heroin makes you feel like your mother not only loves you, but makes up for her not loving when she abandoned you as a baby. Is heroin therefore a good idea? (and if you say "that's chemical dependency", you completely miss the point)

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by yieldcrv on Saturday October 12, 2024 @07:52PM (#41823831)
what point do you think needed to get across to me? did you think you were replying to someone else? my response was sufficiently broad to factor in non-positive and negative experiences and had nothing to do with the hyperbolic praise of some psychedelic users and that community
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Saturday October 12, 2024 @11:18PM (#41824917)
turns out I don't write my comments just for you. what did you write that you think so clearly showed you understood what I originally said that I wouldn't think other people suffered the same misapprehensions?
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by BigGreenJorts on Sunday October 13, 2024 @05:35AM (#41826504)
Idk how many people trying psychedelics for the first time are that interested in the shamanic gods or whatever as much as they want life altered in a fun weird way. In college when people did LSD or mushrooms, they were usually most interested in the visuals.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by seec on Sunday October 13, 2024 @05:29PM (#41831782)
I have tried and use those things (mushrooms, LSD, MDMA) just for fun and I think they are alright if you understand that it is just that: a fun experience, like alcohol or cannabis can be. But I agree that there is a large amount of people taking those things and coming up with large amount of bullshit to justify taking it, in an attempt at pretending that they are more than just fun. It's always people who are very status conscious, hipster like, with narcissistic tendencies who want to impose their viewpoint in a way that makes them feel superior.

As far as I'm concerned, I think those things should be legal because not only sourcing them is easy anyway but it also escapes all quality control and regulation even though we still agree to sell much worse things as a society (like tobacco) and that's very incoherent.

I don't think any of the new age bullshit theory about healing mental illness (an already loosely defined thing) or whatever else is correct, but what is probably true, is that most of the stuff sold by the pharmaceutical companies is not any better (when it's not much worse) yet it is legal.

This is a classic case of capitalism bullshit: if you are having fun, you can't be a productive individual so that's not right, but in the meantime please buy our very similar drugs that's supposedly have the same results, without the fun.

One reason the advocates are going overboard with all the claims is probably because the industry is allowed to do the same with much less scrutiny, so it is an attempt at equilibrium, I guess. I doubt they will be successful at fighting fire with fire but it is annoying that it is such a political issue, people should be allowed to take those things if they want to...

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by yieldcrv on Sunday October 13, 2024 @10:59PM (#41833827)
although I criticize the same people, I think your viewpoint is too dismissive

without prior knowledge of what psychonauts say, I also experienced increased empathy or ability to relate to more people and animals. body language, cues, things that maybe come with mental development or maturity but seemed more refined and accelerated. on the empathy and EQ, it seems to wear off. so noticing that is a shared experience is fascinating to me, I wish it could be controlled for specifically to refine that aspect of the substance or trigger in our minds instead of jumping into the debate about legalizing that specific substance, and I understand the limitations in testing it, both from a legal and regulatory standpoint and from a control group and study standpoint

this leaves us at square one, where I can appreciate others experiencing it but I cant quite recommend either due to how varied the experience is

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by whoknw on Sunday October 13, 2024 @12:25AM (#41825140)
My experience with psychedelics is the following: they shift your perception of things temporarily. The way the "adjustment" works is that you are able to "see" and "touch" experiences you could not before, because they would have annihilated you. They open a door to re-living things and re-processing. Hard for me to see that you would come out of that "broken", if there's nothing to process your trip will be a pleasant high.

Which is not to say that psychedelics (LSD, 2C-B, Mescaline, Psilocybin) are not powerful stuff and that they allow for mental states that would be unlivable otherwise (clinically that would be schizophrenia or something like it). I do believe that their therapeutical and recreational benefits do outweigh the drawbacks though. There must be a better way to handle this than Schedule-1'ing the whole bunch.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by jajko on Sunday October 13, 2024 @04:30AM (#41826196)
Powerful they are indeed. Depends on general personality, current mental situation, dosage taken, environment and/or people setting up the vibe. That's why I think they should be 100% available but 100% only under professional supervision, who has chemistry and skills to stop the trip gracefully if needed.

I've only ever done them (mushrooms) alone, mixed with fresh lemon juice that somehow makes them more intense and shorter-acting (say 2.5h very intense trip I prefer much more than 6h of less intensity). A profound, maybe a bit life-changing experience. Laying down, eyes closed, listening to some mellow shamanic music, I went far and beyond anything I can explain with my words, dissolving senses, myself, and putting it back again afterwards piece by piece.

It was pure goodness and positivity, but I can imagine if it was so strong but negative it could have been soul-crushing. Pair it with already fragile personality and the need for professional oversight is always a good idea IMHO. Educate on top. Ignore on your own risk.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by agumonkey on Saturday October 12, 2024 @10:22AM (#41819273)
Is it something that you still take here and there or was it a time limited therapy ?

Congrats on finding a cure for your ailments

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by neom on Saturday October 12, 2024 @10:45AM (#41819461)
I did 3 sessions of 8 grams in silent darkness for 3 weekends in a row and that basically "beat the devil out of me" as they say - it was very very difficult, and a lot of work, but well worth it.I've only felt the "brain haze" (I call it) once since then, I took a gram and went for a long walk in the forest, back to no haze. It's been about 7/8 months and I can feel the "haze" building in my mind again, so I plan to do another 1g in the forest sometime in the coming weeks.

However, my personal experience has been that Psilocybin != Psilocybin - the mushroom itself is super important to the process, much like Indica and Sativa have different ways of connecting you to the mind and the aether, Psilocybin (at least for me) VERY much is the same thing, and it's much starker than cannabis is. Getting into woo-woo land here so apologize: I have some concern that just "Psilocybin" isn't a good prescription, that the "spirit" that works on you is unique to the mushroom family, and that both not knowing the mushroom to prescribe and also being clinical about it (Psilocybin vs Mushroom) may not be a good direction to go in to help people with their issues. I also think that about LSD, it might work a bit for a while, but imo it's not the best tool.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by samatman on Saturday October 12, 2024 @12:28PM (#41820294)
Anecdotal case study involving a community of about a hundred enthusiasts: many in this community held the opinion you do, which is that something about the mushrooms themselves is unique to the psilocin experience (psilocybin is not always present, and in any case, metabolizes to psilocin).

Then 4-actyl DMT, sometimes call psilacetin, became broadly available. This is a synthetic pro-drug for psilocin, just as psilocybin is a naturally-occurring pro-drug for psilocin.

After that, the opinion that the mushroom per se had anything to do with the experience became very rare. It turns out that psilocin is meaningfully different from, in particular, LSD, 2C-B, and MD(M)A.

There's definitely something special about it. But that something is also present when it comes in vitro, not just in vivo.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by tristanMatthias on Saturday October 12, 2024 @01:00PM (#41820576)
Totally agree. The variance between species can be dramatic! 2.5 grams of Golden teacher was a standard trip, vs 0.5 grams of PES Amazonian was enough to send my friend into a full blown “awakening” (physical responses and everything).

It’s fascinating how they can hit different.

Also important to keep in mind the same dose can hit someone different each time depending on surrounding life conditions. I’m a big believer that the mushrooms “show you what you need to see” at any given moment, and that can sometimes range considerably.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Saturday October 12, 2024 @05:48PM (#41822978)
It's really hard to say because your mental state of being, how tired/hungry/etc you are, and thr environment you take it in are huge factors.

Taking it alone vs with friends is going to be a dramatic difference on its own, just because of what neural pathways are active when you take them.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by slibhb on Saturday October 12, 2024 @08:19PM (#41824012)
> The variance between species can be dramatic! 2.5 grams of Golden teacher was a standard trip, vs 0.5 grams of PES Amazonian was enough to send my friend into a full blown “awakening” (physical responses and everything).

Hallucinogenic experiences are rarely the same. So you can use the same amount of the same batch 3 different times and have 3 totally different experiences.

Some people claim that you can control experiences by contolling "set and setting." I don't buy even that; all we can really say is that the experiences are not consistent between trips and we don't know why.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by namaria on Saturday October 12, 2024 @01:37PM (#41820895)
I'm of the opinion that psychedelics can fulfill a similar role to religious catharsis for the maintenance of mental health.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Saturday October 12, 2024 @05:39PM (#41822907)
8 grams in one sitting? Im not even so worried about the psychological response but even a gram can give me extreme stomach pain and nausea that ruins the whole thing.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by neom on Saturday October 12, 2024 @07:58PM (#41823880)
8g dried, overnight in lemon juice in the fridge then in the blender, chug a small glass of some type of smoothie from the store, chug the mix, chug a bit more smoothie, get into bed totally naked, wait. I did a looot of research and talked to a lot of people who have been down this trip and decided just to remove the variance of middle dose land and just put myself in "not aware" set. It worked well for me, ymmv.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by xkcd-sucks on Saturday October 12, 2024 @06:17PM (#41823205)
making a tea with slightly acidic not-too-hot water helps quite a lot

also chewing fresh ginger or ginger tea

starting on an empty stomach, of course

but surprisingly, sometimes a little bit of miso soup midway can help with the "gastroparesis" type nausea that can emerge late stage

and also a little bit of diphenhydramine if it's still bad (like less than an antihistamine dose)

even if it is all kind of lipstick on a pig :)

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by matrix87 on Sunday October 13, 2024 @01:15AM (#41825348)
the taste is really horrible and the lemon doesn't go well with it
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by galaxyLogic on Sunday October 13, 2024 @03:02AM (#41825824)
My friend once described to me how mushrooms differ from alcolhol: With mushroom you get the hangover first and then the high. With alcohol it is the opposite.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by seec on Sunday October 13, 2024 @05:45PM (#41831922)
LSD has somewhat the same effect but in a cleaner way. It's not really about the mushroom itself or the way you ingest it.

That being said, mushrooms are not very good regardless so you can process them in a way that makes it palatable (teas, blended smoothies, etc). But that won't make that weird nausea feeling disappear, you just get used to it and it slowly becomes unnoticeable as you progress on the "experiment".

The nausea is a response of your body, telling you that you ingested something bad, because that basically what those things are: a poison, just a non-lethal one, and we know the positive fun effects so it makes it worth it, otherwise you would just want to throw up !

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Sunday October 13, 2024 @07:56PM (#41832817)
I havent had the same effect from LSD, I also didnt have it the first few times I took it weirdly enough. I think how anxious you are seems to determine how much attention you give to the stomach pain.

Last time I was sitting there miserable for an hour and I started thinking this is life in general. I can either continue to cry about the bad or try and fill my time with something positive. I started to take a walk and think more positively and it seemed to do the trick, for a bit anyway

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by gtvwill on Saturday October 12, 2024 @07:18PM (#41823606)
^^^ much like the terpenes in weed different mushrooms have different chemical compositions that alter the way your body interprets the psilocybin. Cubensis make me laugh/most folks I know get the giggles on them. Blue meanies make you see things (super visual). Or atleast this has been mine and others experience over eh, probably around 20 to 30 trips over the years.

Lsd is good but definitely not as good or as easy on the brain as mushrooms. Dmt is wild, dmt with a maoi I'm too scared to try.

I've tripped a lot. It's my preferred way to party, but these days I party rarely. Mdma,ket,coke,heroin,speed all leave me feeling gross and the risk factors for addiction are far too high for my liking.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by infamouscow on Saturday October 12, 2024 @10:44AM (#41819445)
Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by dymk on Saturday October 12, 2024 @11:01AM (#41819596)
Tolerance also wanes quickly. In 3 days of abstaining, you’re nearly entirely back to baseline tolerance. In 2 weeks you’re entirely back to baseline.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by vlabakje90 on Saturday October 12, 2024 @11:01AM (#41819590)
100mg psilocybin is several times a heroic dose, but 100ug is far below a microdose. Do you mean 100mg of dried mushrooms?
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by dymk on Saturday October 12, 2024 @11:04AM (#41819606)
I think he means 100mg of mushroom body, which might be 1-2mg of psilocybin.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by hilux on Saturday October 12, 2024 @05:27PM (#41822798)
Is there evidence of this?
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by foobiekr on Saturday October 12, 2024 @02:33PM (#41821302)
Same. I came to them as an older person (late 40s) who basically had only tried pot a few times prior, and nothing at all before late thirties. I don't drink.

My few experiences, the first few times, over the course of a year, spread apart by 3-4 months, went from extremely dark to .. just positive, except the last one, where I had no visuals, no bliss at all, and just came to terms with something else in our lives that was going wrong.

The dark ones were rage and anger, and now it seems just gone, like there's nothing there. Like a weight lifted, and seemingly long term.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by ghnws on Saturday October 12, 2024 @03:59PM (#41822005)
SSRIs did the same for me.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by whalesalad on Saturday October 12, 2024 @05:10PM (#41822626)
Same. Grew them myself. Microdose regularly. Take big trips once in a while. It completely changed my life.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by hilux on Saturday October 12, 2024 @05:26PM (#41822788)
That is so wonderful to hear!
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Saturday October 12, 2024 @05:38PM (#41822901)
Can you share some info on how much you took, and in what setting you took them, what you did on the trip, etc? I have a bunch of shrooms sitting in my cabinet but I havent had got any life altering effect out of them.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by Traubenfuchs on Sunday October 13, 2024 @04:22PM (#41831247)
Same: I saw crazy stuff, but when the effects wore off, nothing had changed.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Sunday October 13, 2024 @07:58PM (#41832830)
This would actually be my preferred trip. I just want to have fun, its been so long since I had genuine good fun. Im tired of all the mental reflection.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by seec on Sunday October 13, 2024 @05:38PM (#41831864)
Yes, that's pretty normal, that's actually expected behavior. I think people saying it changed stuff are the ones having a problem in the first place (reality perception, lack of sensitivity or whatever).

Just like alcohol, those things are basically a poison, that you do not die from, provided you don't overdose (you probably have more chance dying of alcohol than mushrooms but still...).

People should take them to have a bit of fun, just like getting inebriated with alcohol and moving on with their life.

Beware of people who tries to pretend more, that are most likely full of shit and you can probably ignore most things they say if they lie about that...

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by puffybuf on Saturday October 12, 2024 @08:25PM (#41824052)
I'm want to try them. I figure growing them myself is the safest way to go. Got 10 bags of Uncle Ben's brown rice growing mycelium right now.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by aorloff on Saturday October 12, 2024 @08:34PM (#41824099)
If you are in the sf bay area, you can just go get what seems to be a variety of high quality, and some tested and stamped (Netherlands) mushroom products at Church of the Zide Door
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by arunix on Sunday October 13, 2024 @09:08AM (#41827717)
That sounds great. How can I try it?
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by rainclouds on Monday October 14, 2024 @12:11PM (#41838901)
Psilocybin has always made me not want to drink for extended periods of time after use. Always saw that as a great benefit.