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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by agumonkey on Saturday October 12, 2024 @10:22AM (#41819273)
Is it something that you still take here and there or was it a time limited therapy ?

Congrats on finding a cure for your ailments

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by neom on Saturday October 12, 2024 @10:45AM (#41819461)
I did 3 sessions of 8 grams in silent darkness for 3 weekends in a row and that basically "beat the devil out of me" as they say - it was very very difficult, and a lot of work, but well worth it.I've only felt the "brain haze" (I call it) once since then, I took a gram and went for a long walk in the forest, back to no haze. It's been about 7/8 months and I can feel the "haze" building in my mind again, so I plan to do another 1g in the forest sometime in the coming weeks.

However, my personal experience has been that Psilocybin != Psilocybin - the mushroom itself is super important to the process, much like Indica and Sativa have different ways of connecting you to the mind and the aether, Psilocybin (at least for me) VERY much is the same thing, and it's much starker than cannabis is. Getting into woo-woo land here so apologize: I have some concern that just "Psilocybin" isn't a good prescription, that the "spirit" that works on you is unique to the mushroom family, and that both not knowing the mushroom to prescribe and also being clinical about it (Psilocybin vs Mushroom) may not be a good direction to go in to help people with their issues. I also think that about LSD, it might work a bit for a while, but imo it's not the best tool.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by samatman on Saturday October 12, 2024 @12:28PM (#41820294)
Anecdotal case study involving a community of about a hundred enthusiasts: many in this community held the opinion you do, which is that something about the mushrooms themselves is unique to the psilocin experience (psilocybin is not always present, and in any case, metabolizes to psilocin).

Then 4-actyl DMT, sometimes call psilacetin, became broadly available. This is a synthetic pro-drug for psilocin, just as psilocybin is a naturally-occurring pro-drug for psilocin.

After that, the opinion that the mushroom per se had anything to do with the experience became very rare. It turns out that psilocin is meaningfully different from, in particular, LSD, 2C-B, and MD(M)A.

There's definitely something special about it. But that something is also present when it comes in vitro, not just in vivo.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by tristanMatthias on Saturday October 12, 2024 @01:00PM (#41820576)
Totally agree. The variance between species can be dramatic! 2.5 grams of Golden teacher was a standard trip, vs 0.5 grams of PES Amazonian was enough to send my friend into a full blown “awakening” (physical responses and everything).

It’s fascinating how they can hit different.

Also important to keep in mind the same dose can hit someone different each time depending on surrounding life conditions. I’m a big believer that the mushrooms “show you what you need to see” at any given moment, and that can sometimes range considerably.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Saturday October 12, 2024 @05:48PM (#41822978)
It's really hard to say because your mental state of being, how tired/hungry/etc you are, and thr environment you take it in are huge factors.

Taking it alone vs with friends is going to be a dramatic difference on its own, just because of what neural pathways are active when you take them.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by slibhb on Saturday October 12, 2024 @08:19PM (#41824012)
> The variance between species can be dramatic! 2.5 grams of Golden teacher was a standard trip, vs 0.5 grams of PES Amazonian was enough to send my friend into a full blown “awakening” (physical responses and everything).

Hallucinogenic experiences are rarely the same. So you can use the same amount of the same batch 3 different times and have 3 totally different experiences.

Some people claim that you can control experiences by contolling "set and setting." I don't buy even that; all we can really say is that the experiences are not consistent between trips and we don't know why.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by namaria on Saturday October 12, 2024 @01:37PM (#41820895)
I'm of the opinion that psychedelics can fulfill a similar role to religious catharsis for the maintenance of mental health.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Saturday October 12, 2024 @05:39PM (#41822907)
8 grams in one sitting? Im not even so worried about the psychological response but even a gram can give me extreme stomach pain and nausea that ruins the whole thing.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by neom on Saturday October 12, 2024 @07:58PM (#41823880)
8g dried, overnight in lemon juice in the fridge then in the blender, chug a small glass of some type of smoothie from the store, chug the mix, chug a bit more smoothie, get into bed totally naked, wait. I did a looot of research and talked to a lot of people who have been down this trip and decided just to remove the variance of middle dose land and just put myself in "not aware" set. It worked well for me, ymmv.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by xkcd-sucks on Saturday October 12, 2024 @06:17PM (#41823205)
making a tea with slightly acidic not-too-hot water helps quite a lot

also chewing fresh ginger or ginger tea

starting on an empty stomach, of course

but surprisingly, sometimes a little bit of miso soup midway can help with the "gastroparesis" type nausea that can emerge late stage

and also a little bit of diphenhydramine if it's still bad (like less than an antihistamine dose)

even if it is all kind of lipstick on a pig :)

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by matrix87 on Sunday October 13, 2024 @01:15AM (#41825348)
the taste is really horrible and the lemon doesn't go well with it
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by galaxyLogic on Sunday October 13, 2024 @03:02AM (#41825824)
My friend once described to me how mushrooms differ from alcolhol: With mushroom you get the hangover first and then the high. With alcohol it is the opposite.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by seec on Sunday October 13, 2024 @05:45PM (#41831922)
LSD has somewhat the same effect but in a cleaner way. It's not really about the mushroom itself or the way you ingest it.

That being said, mushrooms are not very good regardless so you can process them in a way that makes it palatable (teas, blended smoothies, etc). But that won't make that weird nausea feeling disappear, you just get used to it and it slowly becomes unnoticeable as you progress on the "experiment".

The nausea is a response of your body, telling you that you ingested something bad, because that basically what those things are: a poison, just a non-lethal one, and we know the positive fun effects so it makes it worth it, otherwise you would just want to throw up !

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by andoando on Sunday October 13, 2024 @07:56PM (#41832817)
I havent had the same effect from LSD, I also didnt have it the first few times I took it weirdly enough. I think how anxious you are seems to determine how much attention you give to the stomach pain.

Last time I was sitting there miserable for an hour and I started thinking this is life in general. I can either continue to cry about the bad or try and fill my time with something positive. I started to take a walk and think more positively and it seemed to do the trick, for a bit anyway

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by gtvwill on Saturday October 12, 2024 @07:18PM (#41823606)
^^^ much like the terpenes in weed different mushrooms have different chemical compositions that alter the way your body interprets the psilocybin. Cubensis make me laugh/most folks I know get the giggles on them. Blue meanies make you see things (super visual). Or atleast this has been mine and others experience over eh, probably around 20 to 30 trips over the years.

Lsd is good but definitely not as good or as easy on the brain as mushrooms. Dmt is wild, dmt with a maoi I'm too scared to try.

I've tripped a lot. It's my preferred way to party, but these days I party rarely. Mdma,ket,coke,heroin,speed all leave me feeling gross and the risk factors for addiction are far too high for my liking.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by infamouscow on Saturday October 12, 2024 @10:44AM (#41819445)
Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by dymk on Saturday October 12, 2024 @11:01AM (#41819596)
Tolerance also wanes quickly. In 3 days of abstaining, you’re nearly entirely back to baseline tolerance. In 2 weeks you’re entirely back to baseline.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by vlabakje90 on Saturday October 12, 2024 @11:01AM (#41819590)
100mg psilocybin is several times a heroic dose, but 100ug is far below a microdose. Do you mean 100mg of dried mushrooms?
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by dymk on Saturday October 12, 2024 @11:04AM (#41819606)
I think he means 100mg of mushroom body, which might be 1-2mg of psilocybin.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by hilux on Saturday October 12, 2024 @05:27PM (#41822798)
Is there evidence of this?