Psilocybin Bests SSRI for Major Depression in First Long-Term Comparison

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by infamouscow on Saturday October 12, 2024 @10:44AM (#41819445)

Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.

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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by dymk on Saturday October 12, 2024 @11:01AM (#41819596)

Tolerance also wanes quickly. In 3 days of abstaining, you’re nearly entirely back to baseline tolerance. In 2 weeks you’re entirely back to baseline.

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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by vlabakje90 on Saturday October 12, 2024 @11:01AM (#41819590)

100mg psilocybin is several times a heroic dose, but 100ug is far below a microdose. Do you mean 100mg of dried mushrooms?

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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by dymk on Saturday October 12, 2024 @11:04AM (#41819606)

I think he means 100mg of mushroom body, which might be 1-2mg of psilocybin.

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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by hilux on Saturday October 12, 2024 @05:27PM (#41822798)

Is there evidence of this?

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