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Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Saturday October 12, 2024 @06:47PM (#41823395)
just consider, if it's so powerful in adjusting his brain, it's probably equally powerful in adjusting anybody's brain, and what if your brain doesn't need adjustment? there's no reason to think it's "idempotent" so to speak.

https://en.wikipedia.org/wiki/Idempotence is the property of certain operations in mathematics and computer science whereby they can be applied multiple times without changing the result beyond the initial application

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by throwup238 on Saturday October 12, 2024 @07:22PM (#41823629)
I suspect there’s a lot of self selection at work already. The vast majority of people don’t jump straight into psilocybin and LSD, they progress to them by taking softer drugs like alcohol and cannabis. I think a lot of people who don’t need “adjustment” figure out drugs don’t do much for them and stop before they take the intense psychedelics, or they figure it out at lower doses and stop before they take the intense dose.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by asveikau on Saturday October 12, 2024 @08:27PM (#41824066)
Are you saying the claim that psychedelics are effective treatment for depression, PTSD, addiction etc. are simply because those who try it suffer those conditions? What about the part where they say it works effectively? Because I don't think alcohol or cannabis are claimed to be an effective treatment for these conditions in the same way that psychedelics are. The idea that it works seems irrelevant to your conclusion.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by throwup238 on Saturday October 12, 2024 @09:22PM (#41824365)
No that’s not what I’m saying.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by asveikau on Saturday October 12, 2024 @09:36PM (#41824436)
Ok. Then I misread.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Sunday October 13, 2024 @02:46PM (#41830475)
sounds like a reasonable hypothesis, that people who are unhappy with their emotional/mental state might be more attracted to altering it, or might experience results they consider more positive.

how do our brains decide to do anything, like eat ice cream? "hey, I loved that last time". We know that drugs are not experienced as universally positive because many people who try them in college do not go on use them throughout their adult lives.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by asveikau on Sunday October 13, 2024 @10:02PM (#41833521)
But the part you miss is that it works. This is anecdotal for now but people are looking at evaluating that more objectively.

It's not even a stretch if you squint at this. The currently accepted treatment is SSRIs, the second S standing for serotonin. Psychedelics work on serotonin receptors. Why would it be surprising that if you tweak your serotonin receptors, you get treatment for depression? Again, this is not true of alcohol or cannabis.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by tripzilch on Thursday October 17, 2024 @05:57AM (#41868021)
Maybe this is anecdotal, but I feel this is dependent on age. What you describe would have been true when I was younger. But nowadays I know quite some people who never used cannabis / hardly drink any alcohol, and still tell me they'd like to try LSD or shrooms some day.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by yieldcrv on Saturday October 12, 2024 @07:13PM (#41823564)
everyone considers that, but because they’ll be dead by the time the studies narrow down anything they chose the substance that moves them towards results - or doesn’t

everyone can perceive that psychedelic is doing many highly variable things at once and probably shouldn't be recommended, so they just say their experience

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Saturday October 12, 2024 @07:47PM (#41823801)
the vast majority of people who try psychedelics are not trying to escape untreatable clinical depression, they are doing it recreationally, for a roller coaster ride which they believe connects them with the Almighty or the Unknowable or the Dao or the All-loving Everpresent or the "insert word that sounds profound" <-- oh, the Profundity!

These people are inspired—perhaps by the Almighty, i'm not judging—to preach The Gospel of psychedelics and praise any confirmation of these miracles. I'm simply pointing out that what appears to be the Omnipotence of the Almighty might very well be Selling Your Soul to the Devil for all you know. I'm an atheist, simply using metaphor to get the point across to you.

When you talk about how powerful medication is in warping the brain to cure intractable mental problems, that is not at all an endorsement of recreational use. Heroin makes you feel like your mother not only loves you, but makes up for her not loving when she abandoned you as a baby. Is heroin therefore a good idea? (and if you say "that's chemical dependency", you completely miss the point)

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by yieldcrv on Saturday October 12, 2024 @07:52PM (#41823831)
what point do you think needed to get across to me? did you think you were replying to someone else? my response was sufficiently broad to factor in non-positive and negative experiences and had nothing to do with the hyperbolic praise of some psychedelic users and that community
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by fsckboy on Saturday October 12, 2024 @11:18PM (#41824917)
turns out I don't write my comments just for you. what did you write that you think so clearly showed you understood what I originally said that I wouldn't think other people suffered the same misapprehensions?
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by BigGreenJorts on Sunday October 13, 2024 @05:35AM (#41826504)
Idk how many people trying psychedelics for the first time are that interested in the shamanic gods or whatever as much as they want life altered in a fun weird way. In college when people did LSD or mushrooms, they were usually most interested in the visuals.
Re:Psilocybin Bests SSRI for Major Depression in First Long-... by seec on Sunday October 13, 2024 @05:29PM (#41831782)
I have tried and use those things (mushrooms, LSD, MDMA) just for fun and I think they are alright if you understand that it is just that: a fun experience, like alcohol or cannabis can be. But I agree that there is a large amount of people taking those things and coming up with large amount of bullshit to justify taking it, in an attempt at pretending that they are more than just fun. It's always people who are very status conscious, hipster like, with narcissistic tendencies who want to impose their viewpoint in a way that makes them feel superior.

As far as I'm concerned, I think those things should be legal because not only sourcing them is easy anyway but it also escapes all quality control and regulation even though we still agree to sell much worse things as a society (like tobacco) and that's very incoherent.

I don't think any of the new age bullshit theory about healing mental illness (an already loosely defined thing) or whatever else is correct, but what is probably true, is that most of the stuff sold by the pharmaceutical companies is not any better (when it's not much worse) yet it is legal.

This is a classic case of capitalism bullshit: if you are having fun, you can't be a productive individual so that's not right, but in the meantime please buy our very similar drugs that's supposedly have the same results, without the fun.

One reason the advocates are going overboard with all the claims is probably because the industry is allowed to do the same with much less scrutiny, so it is an attempt at equilibrium, I guess. I doubt they will be successful at fighting fire with fire but it is annoying that it is such a political issue, people should be allowed to take those things if they want to...

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by yieldcrv on Sunday October 13, 2024 @10:59PM (#41833827)
although I criticize the same people, I think your viewpoint is too dismissive

without prior knowledge of what psychonauts say, I also experienced increased empathy or ability to relate to more people and animals. body language, cues, things that maybe come with mental development or maturity but seemed more refined and accelerated. on the empathy and EQ, it seems to wear off. so noticing that is a shared experience is fascinating to me, I wish it could be controlled for specifically to refine that aspect of the substance or trigger in our minds instead of jumping into the debate about legalizing that specific substance, and I understand the limitations in testing it, both from a legal and regulatory standpoint and from a control group and study standpoint

this leaves us at square one, where I can appreciate others experiencing it but I cant quite recommend either due to how varied the experience is

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by whoknw on Sunday October 13, 2024 @12:25AM (#41825140)
My experience with psychedelics is the following: they shift your perception of things temporarily. The way the "adjustment" works is that you are able to "see" and "touch" experiences you could not before, because they would have annihilated you. They open a door to re-living things and re-processing. Hard for me to see that you would come out of that "broken", if there's nothing to process your trip will be a pleasant high.

Which is not to say that psychedelics (LSD, 2C-B, Mescaline, Psilocybin) are not powerful stuff and that they allow for mental states that would be unlivable otherwise (clinically that would be schizophrenia or something like it). I do believe that their therapeutical and recreational benefits do outweigh the drawbacks though. There must be a better way to handle this than Schedule-1'ing the whole bunch.

Re:Psilocybin Bests SSRI for Major Depression in First Long-... by jajko on Sunday October 13, 2024 @04:30AM (#41826196)
Powerful they are indeed. Depends on general personality, current mental situation, dosage taken, environment and/or people setting up the vibe. That's why I think they should be 100% available but 100% only under professional supervision, who has chemistry and skills to stop the trip gracefully if needed.

I've only ever done them (mushrooms) alone, mixed with fresh lemon juice that somehow makes them more intense and shorter-acting (say 2.5h very intense trip I prefer much more than 6h of less intensity). A profound, maybe a bit life-changing experience. Laying down, eyes closed, listening to some mellow shamanic music, I went far and beyond anything I can explain with my words, dissolving senses, myself, and putting it back again afterwards piece by piece.

It was pure goodness and positivity, but I can imagine if it was so strong but negative it could have been soul-crushing. Pair it with already fragile personality and the need for professional oversight is always a good idea IMHO. Educate on top. Ignore on your own risk.