News for hackers. Stuff that matters.
Re:Oxford University breakthrough on global COVID-19 vaccine by throwawayiionqz on Monday November 23, 2020 @03:15AM (#25184608)
Another huge differentiator is price. At $3 to $4, many countries will jump on board ASAP and stay away from the expensive vaccines from Pfizer and Moderna.
Re:Oxford University breakthrough on global COVID-19 vaccine by guilamu on Monday November 23, 2020 @07:54AM (#25186230)
Would you mind to add a source for those price estimates? Thanks!

Edit: just found a source here confirming what you said: https://www.bbc.com/news/health-55040635

Re:Oxford University breakthrough on global COVID-19 vaccine by ddeck on Monday November 23, 2020 @04:08AM (#25184909)
>At $3 to $4, many countries will jump on board ASAP and stay away from the expensive vaccines from Pfizer and Moderna.

The price difference will likely remain substantial, but in case anyone is unaware, the difference is currently greater due to AstraZeneca pledging to the sell the vaccine at cost "during the pandemic", while Pfizer and Moderna have indicated that they fully intend to profit. [1]

Once AstraZeneca deem the pandemic to be over, the price will likely rise.

It was reported a few months ago that internal AstraZeneca documents showed them projecting the "Pandemic Period" to end on 1 July 2021. [2]

[1] https://www.nytimes.com/2020/07/21/health/covid-19-vaccine-c...

[2] https://thehill.com/policy/healthcare/520202-astrazenecas-no...

[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by ddeck on Monday November 23, 2020 @05:48AM (#25185438)
To be fair, Johnson & Johnson (a US company) also made a similar pledge to AstraZeneca.

These two companies have collectively received more than $1.5 billion from the US government [1]. As I understand it, Pfizer have not taken any federal funding. They do have government purchase agreements, but they are dependent on Pfizer delivering a viable vaccine. Their partner BioNTech received German government funding:

Berlin gave the German company $445 million in an agreement in September to help accelerate the vaccine by building out manufacturing and development capacity in its home market. [2]

[1] https://www.nytimes.com/2020/05/21/health/coronavirus-vaccin...

[2] https://www.bloomberg.com/news/articles/2020-11-09/pfizer-va...

[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @09:52AM (#25187275)
>Expensive, inaccessible except to the rich

I don’t think the data bears this out exactly. US healthcare tends to optimize for access and quality to the detriment to cost. As the saying goes: access, quality, or cost... you only get to choose two.

The US tends to measure better than any comparable country of its size on those two metrics (and quite poorly on cost...but some of that is because the US funds about 50% of worldwide medical R&D)

https://www.sciencedirect.com/science/article/pii/S014067361...

Edit: U.S. percentage of worldwide R&D has been waning and, while still the largest contributor, is now a little over 40%

https://data.oecd.org/rd/gross-domestic-spending-on-r-d.htm

Re:Oxford University breakthrough on global COVID-19 vaccine by coliveira on Monday November 23, 2020 @11:18AM (#25188330)
The US healthcare is good only when considering those who can pay to access it. But since large swathes of the US population cannot afford to have access (expensive insurance costs, even with Obamacare support), this becomes a mute point. If that is the metric, then even Brazil (and many other 3rd word countries) also has good medical care, because it works for the small percent of the population with money to access it.

And in fact this is one of the big differentiators between 1st world and 3rd world countries: if the population has access to quality services, in health care or other important areas like education and sanitation. The US seems to be designing its systems to become a big 3rd world country.

Re:Oxford University breakthrough on global COVID-19 vaccine by disabled on Monday November 23, 2020 @01:58PM (#25190261)
> The US healthcare is good only when considering those who can pay to access it.

False: The third leading cause of death in the US is believed to be preventable medical errors. You can go to the best institutions in the US to get care, along with seeing the very best doctors, but you cannot evade a statistic like that, even if you are in the 1%. See: https://www.npr.org/sections/health-shots/2016/05/03/4766361...

Also, this article: U.S. life expectancy will soon be on par with Mexico’s and the Czech Republic’s: https://www.washingtonpost.com/news/to-your-health/wp/2017/0...

Also this: 42% of new cancer patients lose all of their life savings in two years because of treatment. The average amount a cancer patient lost was $92,098.: https://www.insider.com/half-cancer-patients-lose-their-enti...

The truth is that you can be in the top 1%, sitting on a mountain of cash, and still lose an unfathomable amount of money, even while insured, if you have cancer or a rare disease. Both of which are actually common.

It is not the doctors who are the problem here with respect to the medical errors: it’s the healthcare system. A good read on what’s wrong with the system is the short book Our Malady by Timothy Snyder.

If you want to stay alive long term, you may want to consult HealthData.org which analyzes each country’s healthcare systems in depth along with outcomes. The group is world renowned. Ironically, it is also the IMHE group that does the coronavirus statistics that everyone consults.

Personally, I am an American culturally, but I became an EU citizen (Croatia) over the US healthcare system. I never plan on working in the US. I do select the country I am working in now due to healthcare.

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @11:29AM (#25188452)
Your points are baked into the data that I linked. The metric within is "HAQ Index" which stands for "Healthcare Access and Quality". I.e., access is part of the measure. In the US everybody has access, which is part of the problem that drives costs higher.

E.g., if you don't have insurance you can walk into an emergency room and get treated even if it's not an emergent situation. If you don't have insurance, there is a higher risk you won't pay. That cost then gets spread to others who do.

Re:Oxford University breakthrough on global COVID-19 vaccine by coliveira on Monday November 23, 2020 @11:40AM (#25188568)
You probably don't know how the US system works. The only access that is guaranteed by law is to emergency services. If you don't have a paid insurance (through your employer or yourself), then you cannot access preventive care or otherwise normal medical consultation. Millions of people in the US don't have access.

For example, if someone needs to treat cancer, it doesn't make any good to go to an emergency unit: they will discharge the patient as it is not an emergency situation.

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @11:52AM (#25188714)
>if someone needs to treat cancer, it doesn't make any good to go to an emergency unit

That's because the ER is meant to stabilize a patient, not cure chronic disease. Which is to my point: people will forgo preventative medicine until their condition deteriorates and they need to be stabilized in an ER. People get their non-emergent conditions treated all the time in American emergency rooms.

E.g., if I have diabetes, an ER will not put me on a long-term treatment plan. But if I ignore my disease until I start having hypoglycemic symptoms an ER will treat me until I am stabilized enough to be released. Is this the best system? Absolutely not, but it's much different than saying "only the rich have access to healthcare".

FWIW, I used to work in healthcare, including redesigning ER processes

Re:Oxford University breakthrough on global COVID-19 vaccine by coliveira on Monday November 23, 2020 @01:21PM (#25189810)
And how would anyone know if he has diabetes (for example) if the person doesn't have regular visits to medical facilities? In such a case they will go to emergency only when an emergency happens, probably when it is already too late. By saying that such a person has access to health care, you're just redefining health care to "emergency health care".

If this was not enough, hospitals are catching up to the "loopholes" in the law and abandoning poor neighborhoods, to make it even harder for people to use emergency rooms.

https://www.governing.com/news/headlines/health-care-facilit...

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @02:19PM (#25190535)
In the example of diabetes, many people are diagnosed when they show later term symptoms that require an ER visit. Since it's chronic, they won't be "cured" of the disease, meaning an ER can be their main mode of healthcare and the main mode of being diagnosed.

You may not understand the nuances of the article you referenced. Take Detroit, one of the cities used to support the claim in the article. The baseline decade used is the 1960s. Detroit has only about a third of the population it had in the 1960s so it's not rational to think they would maintain their previous healthcare infrastructure. Further, much of that population left for the suburbs of metro Detroit, meaning the healthcare facilities being built are just following the population demographics. Add onto that the point that healthcare has changed dramatically over the last 60 years with much more emphasis on outpatient care, and there are rational, non malevolent reasons to decrease the number of urban hospitals

Re:Oxford University breakthrough on global COVID-19 vaccine by throwaway201103 on Monday November 23, 2020 @12:35PM (#25189269)
Curious, in your healthcare experience, what would you estimate is the percentage of people who do have good insurance, but don't get preventative care by choice?

E.g. for myself, I have good insurance, but I don't have a "primary care doctor." I don't go to the doctor unless I'm injured or sick. And I don't mean a sniffle or cough, I mean sick as in I have felt awful for several days.

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @12:45PM (#25189385)
I don't think I have a good representative sample because facilities I worked for were a specific sub-population that would probably have a very high percentage that fall into the category of "no need for healthcare until something is broken or bleeding profusely"

With that said, it seems to be quite a bit and skewing higher for males than females.

Re:Oxford University breakthrough on global COVID-19 vaccine by coliveira on Monday November 23, 2020 @01:33PM (#25189941)
If you have insurance and are not going for a routine exam once a year, you're doing a disservice to yourself because you miss the opportunity to catch issues that can be easily fixed when caught early but catastrophic if not. In fact many corporate policies require people to have regular exams exactly for this reason.
Re:Oxford University breakthrough on global COVID-19 vaccine by disabled on Monday November 23, 2020 @02:53PM (#25190957)
A lot of countries do not do “yearly physicals” like the American healthcare system recommends. This is because in countries with universal healthcare, patients within the country go to their GP/Primary Care Doctor far many more times on average than the typical American. So, in many countries, this practice is non-existent, basically because people just go to the doctor whenever they feel it is necessary—and far more often than the typical American does.

The average American sees a doctor 3 times per year. In France it is 6-7 times per year. In Japan, it’s 13 times per year. This statistic is directly linked to the cost of care.

Re:Oxford University breakthrough on global COVID-19 vaccine by fjdjsmsm on Monday November 23, 2020 @12:12PM (#25188974)
In Europe, Canada, Australia, etc everyone has access. Why doesn’t access drive up their cost? Clearly access isn’t what is driving up the costs in the USA.
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @12:24PM (#25189126)
Because it's not as simple a model as "access vs. cost". It's access vs. quality vs. cost.

Canada's HAQ index in 2015 was 87.6 vs. 81.3 for the US. However, Canada spent about $27B US on R&D vs. $495B for the US. On a per capita basis, the US outspends most the world on medical R&D. That drives the US total healthcare costs up while helping to drive down the healthcare quality costs elsewhere. To a certain extent, the US subsidizes the healthcare costs through much of the world, effectively allowing them to optimize for a 2 parameter model while the U.S. must still deal with a 3 parameter model.

Re:Oxford University breakthrough on global COVID-19 vaccine by jason0597 on Monday November 23, 2020 @03:35PM (#25191457)
Yes, the US spends much more per-capita on medical R&D than other countries. But how do we know all this money is going into real R&D? How do we know most of it is not going into e.g. me-too drugs?
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @04:04PM (#25191863)
That's a potential real problem, but the concern should be across the board (i.e., how do we know other countries aren't funding me-too drugs) so it doesn't really help illuminate any disparity between countries (which is the context of this discussion).

I'm not trying to be dismissive, I just don't know how it's germane to the discussion unless we view all the other data through the same lens. The data I linked is per country in absolute and per capita basis that tries to put it in unbiased terms.

Are you claiming the US is disproportionately funding non-useful research? If so, how do we measure "useful" research funding?

Re:Oxford University breakthrough on global COVID-19 vaccine by jason0597 on Monday November 23, 2020 @04:45PM (#25192312)
I do not know how to objectively measure useful research funding. However, this discussion reminded me of a graph I saw on the wtfhappenedin1971.com site [1]. It's not direct measurement of R&D development, but it sure as hell doesn't paint a good picture for all the spending that's going on. I wouldn't be surprised if a similar allocation of funds was happening in medical R&D as well.

[1] https://wtfhappenedin1971home.files.wordpress.com/2020/05/ey...

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @05:04PM (#25192487)
Yes, I'm familiar with that graph. There's a similar one for college tuition in the U.S.; interesting that both are industries where costs have been growing at more than GDP year over year.

However, the point between comparing countries still holds. If you use older data, you'll see that the U.S. had even more disproportionate R&D funding

Re:Oxford University breakthrough on global COVID-19 vaccine by coliveira on Monday November 23, 2020 @04:07PM (#25191900)
The important issue is that R&D spending is not a good measure of outcomes. A lot of R&D spending goes to high administrative salaries, equipment, facilities (real estate), and related costs that do not translate into outcomes.
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @04:18PM (#25192040)
What would you propose as a better metric of innovation?

I don't think there's a single perfect measure but if you put it in broader context of measures like Nobel prizes R&D spending, patents, etc. it does seem to paint the picture that the US disproportionately contributes to medical innovation.

It's very similar to the measure of health. There is no single great metric. Using a single metric like BMI or blood pressure is flawed. However, you can get a clearer picture if you bring together multiple metrics.

Re:Oxford University breakthrough on global COVID-19 vaccine by _jahh on Monday November 23, 2020 @11:53AM (#25188719)
this is completely missing the point, people don't take chronic or slow-developing issues to the ER so they get worse and have catastrophic consequences resulting in both worse health outcomes and more expense because by the time they do come to ER it's a more serious intervention = $$$$
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @11:57AM (#25188784)
I addressed that in a different comment (I think we submitted comments at roughly the same time).

I completely agree that preventative healthcare is lacking, partly due to the system and partly due to culture. If the OP had originally said "preventative healthcare" I wouldn't have much to disagree on, but they used a blanket statement implying only the wealthy have access to healthcare in general.

The US also gives free preventative healthcare to many subsets of the population

Re:Oxford University breakthrough on global COVID-19 vaccine by taejo on Monday November 23, 2020 @08:27AM (#25186508)
BioNTech is not a German/Turkish company. It's a German company, two of whose founders are of Turkish descent.
Re:Oxford University breakthrough on global COVID-19 vaccine by egeozcan on Monday November 23, 2020 @09:15AM (#25186938)
As someone who migrated to Germany from Turkey, people like me (and everything we are involved in) are "German" when we do something they're[0] not proud of, we are "Turkish" if we ever come close to success, and "of Turkish descent" in the normal times. Of course it depends who you are asking :) It's a bit annoying to be honest but not a huge deal.

I suppose all immigrants have similar problems.

[0]: I mean people living in Turkey

Re:Oxford University breakthrough on global COVID-19 vaccine by dboreham on Monday November 23, 2020 @09:45AM (#25187210)
Same thing all over humanity: Scottish when losing the race, British when winning..
Re:Oxford University breakthrough on global COVID-19 vaccine by taejo on Tuesday November 24, 2020 @04:28AM (#25196776)
I didn't mean to make any judgment about the "Turkishness" or "Germanness" of Drs. Şahin and Türeci. I just mean to clarify that BioNTech was founded and is based in Germany, just as Google is an American company (not Russian-American) even though Sergey Brin was born in Moscow.
Re:Oxford University breakthrough on global COVID-19 vaccine by egeozcan on Wednesday November 25, 2020 @05:47AM (#25207856)
Sorry, I understood your intention, and you are completely right, mine was rather a rant that was just relevant.
Re:Oxford University breakthrough on global COVID-19 vaccine by allendoerfer on Monday November 23, 2020 @09:44AM (#25187202)
I have read it‘s a bigger problem and a source for islamism, especially for the 2nd or 3rd generation of descendents of immigrants: When Germans still see you as Turkish, but Turks see you as German, it makes sense to a) be angry and b) search for some other identity.
Re:Oxford University breakthrough on global COVID-19 vaccine by jason0597 on Wednesday November 25, 2020 @10:30AM (#25210228)
As a Greek, I can relate a lot to this!

Maybe we're more similar than we like to pretend

Re:Oxford University breakthrough on global COVID-19 vaccine by IanDrake on Monday November 23, 2020 @08:47AM (#25186686)
Someone has never been to a doctors office or the hospital in the US or has a very loose definition of rich.
Re:Oxford University breakthrough on global COVID-19 vaccine by MagnumOpus on Monday November 23, 2020 @06:58AM (#25185793)
> The AstraZeneca vaccine also has 90 percent efficacy when used twice

No it doesn't. Both dosings use two shots, and the "90%" number from the smaller dosing is from an unreliably small sample set of 33 infections -- it could easily be 70-80% by next month when more data comes in.

Re:Oxford University breakthrough on global COVID-19 vaccine by Jedd on Monday November 23, 2020 @08:10AM (#25186370)
> Both dosings use two shots, and the "90%" number from the smaller dosing is from an unreliably small sample set of 33 infections."

Can you count infections as a metric of efficacy for a vaccine that's designed to stop infection?

Consider [1]:

"However, protection was 90% in an analysis of around 3,000 people on the trial who were given a half-sized first dose and a full-sized second dose."

AFAIK it's not known how many of those 3,000 in that trial were exposed to potential infection.

[1] https://www.bbc.com/news/health-55040635

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @09:55AM (#25187297)
Couldn’t the same be said in reverse? I.e., due to sampling error the reports could be amended to a 95% efficacy when more data comes in?
Re:Oxford University breakthrough on global COVID-19 vaccine by twoslide on Monday November 23, 2020 @10:55AM (#25188052)
I don't think we know based on public information. Some media report "up to 90%" which suggests the upper bound of the confidence interval, rather than the centre. Could also be a very wide CI, that overlaps with the standard dosage.
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @11:31AM (#25188471)
That's a fairer statement than the original which seemed biased towards only reporting the lower end of the interval without acknowledging the upper bound.
Re:Oxford University breakthrough on global COVID-19 vaccine by acqq on Monday November 23, 2020 @07:53AM (#25186221)
At the moment possibly wider error bars don’t come from just “33 infections” but more from possibly smaller number of those who received the observed treatment.

The bars are to be calculated using conditional probabilities.

Re:Oxford University breakthrough on global COVID-19 vaccine by Frost1x on Monday November 23, 2020 @08:52AM (#25186733)
>These two companies have collectively received more than $1.5 billion from the US government [1]. As I understand it, Pfizer have not taken any federal funding. They do have government purchase agreements, but they

So where did Pfizer's capital come from to shoulder these costs? It didn't come out of thin air, they've accumulated capital from somewhere. If not from taxpayers, someone is subsidizing Pfizer's expenses through Pfizer's revenue stream. Taxpayer subsidies really make sense here seeing how this issue effects everyone.

Re:Oxford University breakthrough on global COVID-19 vaccine by jefftk on Monday November 23, 2020 @08:55AM (#25186770)
> someone is subsidizing Pfizer's expenses through Pfizer's revenue stream

Companies taking a portion of what they earn from their existing products and investing this money to create new products is beneficial, and we should have more of it.

Additionally, while this is probably not the case for Pfizer, another possibility is that a company can take outside investment to fund development of a new product.

Re:Oxford University breakthrough on global COVID-19 vaccine by paganel on Monday November 23, 2020 @09:03AM (#25186842)
Not the OP, but what she/he is probably hinting at is that the majority of Western Governments (i.e. both the US and the EU) have poured trillions of dollars/euros into the market as the pandemic started, money that has helped the capital markets stay afloat (and even more than that).

Without those trillions of dollars/euros most probably the capital markets would have been down by at least 50% (my guesstimate, or at least that's where we were headed mid-March), which means that the money available to companies like Pfizer would have been a lot less.

As such, Pfizer saying that they didn't receive federal money is technically correct, but without federal money most probably their market value would have been a lot less right now.

Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @10:35AM (#25187802)
Just because Pfizer's stock drops doesn't mean they can't fund their R&D. Pfizer has $10B in cash.[1]

[1]https://finance.yahoo.com/quote/PFE/balance-sheet/

Re:Oxford University breakthrough on global COVID-19 vaccine by paganel on Monday November 23, 2020 @11:43AM (#25188618)
A 40-50% reduction in share price would have most probably eliminated the dividends completely, especially in a very adverse deflationary market, which most definitely would have seen the most of that $10 billion sum allocated to other things than R&D.
Re:Oxford University breakthrough on global COVID-19 vaccine by mlyle on Monday November 23, 2020 @02:35PM (#25190711)
I don't understand why you think this.

Pfizer's cash situation or ability to spend/pay a dividend has nothing to do with stock price. Pfizer does not have their cash balance invested in other stocks. Ability/willingness to pay a dividend has to do with excess cash.

To the extent there's any relation, it's a high stock price that discourages paying a dividend. If the dividend yield will be basically nothing, why bother spending down precious cash that could be reinvested (because obviously the market values future cash flows a lot more than current ones).

Deflation might encourage a little bit of holding of corporate cash rather than spending it on R&D, sure. But even then I think you're overstating the case.

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @09:48AM (#25187237)
Can you help me understand your point a little better?

I think the OP was reflecting on cash flow being used for R&D but your post seems to be more about market capitalization.

Re:Oxford University breakthrough on global COVID-19 vaccine by Frost1x on Monday November 23, 2020 @10:49AM (#25187985)
The question was simply to stimulate a more holistic view of the example at hand: that Pfizer did this on their own and essentially didn't need/get any financial help. Sure, Pfizer didn't receive direct subsidy in the short term related to COVID R&D and is taking on risk.

But let's look at this more holistically. Pfizer and pharma benefit a reasonable amount from public research. Pfizer has received their fair share of governmental funding in the form of products, services, and research: https://www.usaspending.gov/search/85a918fa6adf5152dbac723d2...

They've also been subsidized by people with illness over the years that isn't related to COVID (directly or through their insurance provider pools). It's in other cases the previously sick that have padded Pfizer's profit margins enough to enable them to accumulate enough capital they could take on this sort of risky R&D. Theres also the costs of enabling laws and defending their IP rights from external pressures the US pushes.

It may not be direct subsidy but there are plenty of indirect subsidies that enabled Pfizer to do this. Let's stop pretending these businesses pull themselves up by their bootstraps to success and take on all the risk: they don't. They very often take low risk returns and transfer to high risk and use subsidized activity (e.g. federally funded research) to their advantage. Anything high risk like pharma is prone to failure and needs assistance.

Should we continue assistance? Absolutely, I think so, it's good for everyone. As one parent mentioned, it is good to see these businesses reinvest in further R&D that lead to new discoveries in therapy and treatment as opposed to simply hoarding capital.

Apparently the thought of the narratives that Pfizer didn't pull themselves up by their bootstraps financially makes some people cranky. Everyone needs assistance (especially in high risk arenas), let's not pretend that assistance doesn't exist simply because its indirect, time delayed, and being shifted around.

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @11:02AM (#25188158)
I agree with your overall point that it needs to be looked at holistically, but I don't think I agree with your stance on some of the subsidy arguments.

A subsidy is, by definition, a governmental funding mechanism. "People with illness" who used Pfizer products in the past aren't subsidizing the COVID vaccine anymore than I subsidize an automobile manufacturer making pickups when I buy my tiny hatchback. It's built into the business model and not really a "subsidy".

I agree with you in terms that we shouldn't view these companies as operating in a vacuum, I just don't think the idea of the markets being propped up is the most congruent way of framing the discussion. Pfizer benefited along with most other publicly traded companies, irrespective of their COVID vaccine.

Re:Oxford University breakthrough on global COVID-19 vaccine by thehappypm on Monday November 23, 2020 @10:37AM (#25187830)
Where did Pfizer's capital come from? I don't know, maybe just that they're one of the bigger and more successful companies in human history?
Re:Oxford University breakthrough on global COVID-19 vaccine by mhb on Monday November 23, 2020 @09:53AM (#25187284)
Venturing A Perspective On The Drug Pricing Debate

https://lifescivc.com/2019/12/venturing-a-perspective-on-the...

Re:Oxford University breakthrough on global COVID-19 vaccine by GhostVII on Monday November 23, 2020 @09:03AM (#25186841)
Pfizer is partnered with a German company
[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by erikstarck on Monday November 23, 2020 @04:24AM (#25185001)
Will you then also pay those who put huge effort and expense in to research that was perhaps necessary but didn't lead anywhere?
Re:Oxford University breakthrough on global COVID-19 vaccine by aquadrop on Monday November 23, 2020 @04:40AM (#25185077)
Is there somewhere any numbers on how much exactly does it cost? What portion is really "research" and what portion is marketing budget? How much trial phase 1/2/3 cost etc?
Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @05:13AM (#25185234)
When I studied pharmaceutical sciences ten years ago, the rule-of-thumb was that it cost around 1 billion dollars from idea to the product being launched. That's only r&d costs and regulations have become stricter over the years, so I imagine the cost has risen since then
Re:Oxford University breakthrough on global COVID-19 vaccine by beagle3 on Monday November 23, 2020 @05:36AM (#25185370)
I’ve seen this number with some justification being the amortized cost of a successful product, which covers r&d and marketing but also the failed attempts that lead nowhere in between.

There are plenty of 50-100M pharma startups; they wouldn’t exist if your number was right.

Re:Oxford University breakthrough on global COVID-19 vaccine by yomly on Monday November 23, 2020 @06:42AM (#25185707)
>There are plenty of 50-100M pharma startups; they wouldn’t exist if your number was right.

Isn't there a selection bias in that the startups that got to 50-100M survived because they were lucky with a candidate treatment. The ones that failed were the ones that never found a candidate in time? The difference being that large pharmaceutical companies have to swallow ALL the failures, whereas startups can "just" die.

Not to say that pharma companies don't have some fat that can be trimmed...

Re:Oxford University breakthrough on global COVID-19 vaccine by yodelshady on Monday November 23, 2020 @08:24AM (#25186479)
>which covers r&d and marketing but also the failed attempts that lead nowhere in between.

How do you account for the failed attempts?

As yomly alludes to, pharma startups exist because they don't own the risk - their investors bought it when they were funded. Big pharma does own the risk.

Re:Oxford University breakthrough on global COVID-19 vaccine by beagle3 on Monday November 23, 2020 @10:52AM (#25188022)
You sum the expenditure and divide by number of successes, with some accounting for the delay. It is actually much easier than trying to figure out the cost of a specific drug, because research is sometimes shared.
Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @07:19AM (#25185939)
"Pharma start-up" is a broad definition which might not only be drug development and there might already be work done on their product before they look for funding

A company that is spun out from a PhD project in a research group, that has done a lot of the groundwork on grants will need less funding

Same goes for a start-up that for instance make non-invasive assays for diagnosis, since the documentation requirements are lower for such products

Producing something that has to be injected into humans is an entirely different league, since the amount of documentation required for such products is staggering

The cost for marketing will vary significantly depending on your definition of the word, and I suspect that it might be misconstrued as only being "commercials and paid holidays for doctors"

Re:Oxford University breakthrough on global COVID-19 vaccine by mensetmanusman on Monday November 23, 2020 @08:39AM (#25186601)
90% of start ups fail, so the numbers in that case would be about correct.
Re:Oxford University breakthrough on global COVID-19 vaccine by beagle3 on Monday November 23, 2020 @10:43AM (#25187909)
No.

GP said idea to product costs 1B just for r&d. That and 1B amortized over failures (and including marketing) cannot be true at the same time unless there are no failed attempts and unless marketing cost is zero.

Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @02:03PM (#25190329)
I've seen you mention marketing several times. What expenditures would you include as a marketing expense?

I'm also not sure what you would define as a failure. Drug development often starts with several candidates for a target. Over the cause of development the list is trimmed, as candidates show lack of affinity for the target or have side-effects that make them unviable. Would you consider each of the excluded candidates a failure?

Re:Oxford University breakthrough on global COVID-19 vaccine by beagle3 on Monday November 23, 2020 @02:35PM (#25190713)
> I've seen you mention marketing several times. What expenditures would you include as a marketing expense?

I don't get to define that, companies do, but basically it includes everything that does not involve a lab, technician, doctor, nurse, statistician/programmer, etc. The US and the rest of the world are quite different here - if you've ever watched US broadcast in the evening, you'd see TONS of ads for prescription only medicine ("suffering from foo? Ask your doctor about bar"); that's marketing. Taking three hundred cardiologists on an all-expenses-paid 7-day cruise with one 30-minute "purely informative lecture about our new drug" and 7 days of fun? That's marketing too. Lobbying to congress? That's also marketing.

Outside of the US, the marketing budgets are smaller and less overt - but the cruise-style legal bribe-like events are prevalent everywhere.

> Would you consider each of the excluded candidates a failure?

Possibly. You've described one style, but it's not the only one. Many times, it's a weird result from some other research (how Viagra was discovered, how DCA tests were started).

But many things are essentially complete and utter failures - you have a line of research where no viable compound was found at all. BiondVax just failed a 15-year mission trying to develop a universal flu vaccine. Remdesivir is essentially failed even though it is FDA approved (It failed for Ebola; if you look at the data critically, it failed for SARS-COV-2 -- which the WHO's recent studies show even more clearly).

There is some benefit from this research - new techniques, often new devices - but the drug itself is a failure in the sense that it will not generate any income to the company.

Edit: just saw your earlier comment about marketing. It is those things (which you and I mentioned) and a lot more, but it is basically for the company to define in their books and a rule of the thumb would be “an expense a university department developing this to completion without expectation of profit would not have to spend”

Re:Oxford University breakthrough on global COVID-19 vaccine by wbl on Monday November 23, 2020 @10:09AM (#25187480)
The usual course for a biotech is multiple raises as the drug progresses through trials and an early IPO. At each step investors see it as a surer shot.
Re:Oxford University breakthrough on global COVID-19 vaccine by Ericson2314 on Monday November 23, 2020 @11:40AM (#25188564)
> regulations have become stricter over the years

Not this year!

Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @01:52PM (#25190172)
Touche! :P
Re:Oxford University breakthrough on global COVID-19 vaccine by jsmith99 on Monday November 23, 2020 @07:11AM (#25185872)
It's not so much the cost, it's also the delay. At a 5% cost of capital, and a 10 year lag between R&D and final approval, your real cash flows are 40% lower due to the delay. At a 10% cost of capital, they are 60% lower. Sales also take several additional years to ramp up.

This doesn't apply so much to Covid vaccines, as the time frame is accelerated and demand is already high.

Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @08:01AM (#25186303)
The 1bn is only the out-of-pocket cost for development and doesn't factor in for instance opportunity cost. If we include everything required to develop a vaccine, I'd imagine we're looking at something north of 2.5bn

There's so many ways to calculate the cost, that I think it's more important to be aware of the assumptions made for the estimate, than the number itself (which I also failed to do in my original answer)

I think people underestimate the cost of drug development, because the numbers are so big, that it doesn't seem realistic for companies to survive

Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @05:19AM (#25185264)
I talked to a bunch of CROs about the cost of Phase 3 trials. It varies, but is roughly $10,000 to $15,000 per patient year.

Pfizer’s trial will run for 2 years, so ~$900M for the trial alone. That’s excluding all the work to scale up the production, regulatory filing, distribution, etc.

Edit: my math sucks. $900M, not $90M

Re:Oxford University breakthrough on global COVID-19 vaccine by aquadrop on Monday November 23, 2020 @05:53AM (#25185468)
Is it really $10-15k each additional patient year requires or it's more of "total cost was this much, we divide it by number of patients". Where do this money go to? Fx, with these covid trials, 40000 people in pfizer trial, half a year cost would be $200-300 mln. People presumably weren't paid for this. Of course there's some work by doctors that needs to be paid for, but that can't be this large amount. Also, does this all assume USA standards of pricing? Because in rest of the world healthcare is much cheaper.

I just think big pharma are fundamentally ok with huge cost for trials and are not motivated to decrease it/make it more efficient, since they're ok with their pie being larger. They will just shift costs to healthcare system and will be happy with larger profit.

Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @06:55AM (#25185784)
Ha! You think big pharma likes spending that kind of money on trials? I’ve been a part of those negotiations with the FDA. It costs that much because the company says “we believe a 6 month trial is sufficient to prove both safety and efficacy” and the FDA says “if you want it approved, you need to collect 2 years of data”.

Now, $10-15k per patient-year is for a typical therapeutic. And that is an average across global trial sites, not just the US. It’s not much money. You go a 15 min doctors appointment and your insurance is billed $150. Now imagine going 1 per week and having multiple tests run each time. Or having to stay in the hospital for a day when the drug is administered. You can burn through $1,000 per month pretty damn quickly.

Re:Oxford University breakthrough on global COVID-19 vaccine by aquadrop on Monday November 23, 2020 @03:22PM (#25191283)
I don't see a reason they would be really against it. FDA says it to everyone, so all companies in same condition. And they can shift cost to healthcare system and have larger revenue. They probably don't mind their pie as a whole being larger, because having revenue of 50 billions and profit of 10 billions is better than revenue of 5 and profit of 1, even though proportionally it's the same. All big pharma companies are massively profitable, fx Novartis net income in 2017 $17.8bln on $50.4bln revenue. Pfizer's $14bln operating income on $53.6bln revenue in 2018. And it's year after year. They really don't seem to suffer from those high costs trials. Also, Pfizer reports only $8bln on R&D in same 2018. I'm sure there' a lot of inefficiencies in those trials, same as it turned out vaccine could be created in year instead of a decade. (btw, previous large scale epidemic of swine flu was largely profitable for pharma companies). They just don't have incentive to reduce the inefficiencies. You're telling it's not just US but then you cite high healthcare costs (retail vs large scale trial, definitely can be cheaper at scale), which is much cheaper outside of US. I would be very interested in reading numbers of detailed case study of creation of some real world vaccine/drug.
Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @07:11PM (#25193587)
They probably don't mind their pie as a whole being larger, because having revenue of 50 billions and profit of 10 billions is better than revenue of 5 and profit of 1, even though proportionally it's the same

It doesn't work this way. Pricing of pharmaceuticals is independent of the cost of development. Nobody will pay $200 per Covid vaccine dose just because the cost to develop it went up 10x. Every extra dollar spent on development, is one less dollar of profit.

That's why some drugs never make it to market - the cost to bring them to market and the low price means they'll never be profitable.

Re:Oxford University breakthrough on global COVID-19 vaccine by aquadrop on Monday November 30, 2020 @01:12PM (#25256911)
Even if it doesn't happen for each and every drug, that can easily be the trend on average. And it probably already happened with covid vaccines. Moderna comes out and says it will cost ~$30 per shot. Why not 3? And for others drugs, when price goes into thousands and don't have much competition that easily can be the case.
Re:Oxford University breakthrough on global COVID-19 vaccine by msabalau on Monday November 23, 2020 @12:20PM (#25189067)
I'm a volunteer for this vaccine, in the first month I have three in-patients visits, involving two inoculations, 6 blood draws, 2 Covid tests, and three nasal absorption tests. My first visit lasted a little over three hours including a very comprehensive medical history and physical exam, and time taken to ensure that I was giving truely informed consent. I interacted with three medical professionals on the first visit, sometimes in the exam room, and sometimes via phone from the exam room to protect each other from long in person indoor exposure. Like any medical visit this year, a considerable amount of PPE was used. I was given an app use daily to record my health, and a digital thermometer so that all subjects are using the same calibrated equipment. Having reported a headache two days in a row in the app, there was a remote phone call follow up by a research clinician, in addition to the planned check in phone calls that I haven't mentioned. They do pay me a very modest ammount, so I've bought myself a couple of ebooks after paying for big city parking near the research clinic. They need to pay for that office space. Before I entered the study I needed to interact with recruiters, to qualify that it was safe enough for me to participate and to ensure that they were getting people from a variety of backgrounds. They needed to be ready to respond if I had a severe adverse reaction to the the trial vaccine. There is an entirely separate independent review board that I can go to with questions. In the event that I had Covid symptoms, there is an entirely separate set of assessments, visits and samples taken.

Given the amount of work being done by this and other research labs hired Astrazeneca, and comparing this to quotes I've received for a very modest UX usability studies, it's hard to see see this an sort of money grab.

Re:Oxford University breakthrough on global COVID-19 vaccine by Laakeri on Monday November 23, 2020 @04:34AM (#25185043)
Most research is government funded
Re:Oxford University breakthrough on global COVID-19 vaccine by mensetmanusman on Monday November 23, 2020 @08:40AM (#25186607)
Research broadly fits into two categories, basic research and research with near to midterm industrial viability.

Most basic research is government funded.

Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @10:37AM (#25187829)
No, it's not. Private R&D spending is at least doouble that of the gov't. Look up the budget of the NIH and compare it with the R&D budget of big pharma.
Re:Oxford University breakthrough on global COVID-19 vaccine by vixen99 on Monday November 23, 2020 @07:19AM (#25185941)
I.e., tax payer funded either directly or via debt servicing.
Re:Oxford University breakthrough on global COVID-19 vaccine by tcptomato on Monday November 23, 2020 @05:13AM (#25185230)
the expenses paid by governments you mean?
Re:Oxford University breakthrough on global COVID-19 vaccine by mioelnir on Monday November 23, 2020 @05:48AM (#25185439)
BioNTech developed the vaccine now mass-produced by Pfizer. For that, they received $445m from the German government. So, as a tax-paying German citizen I can say, not only will I do that, but even better, I already did.

It also feels deeply wrong to pull the "but all the research efforts that did not lead anywhere" argument, when Pfizer did not do the research in the first place. They should get compensation for organizing the huge trial, of course; that expertise was why they were on-boarded in the first place. And nobody expects them to manufacture that stuff at loss or cost. But we should not accept public money buying them goose laying golden eggs either.

Re:Oxford University breakthrough on global COVID-19 vaccine by Tinyyy on Monday November 23, 2020 @07:43AM (#25186151)
Nobody’s getting a goose laying golden eggs from a covid vaccine. It’s a one time, relatively low-cost vaccine that is going to go out of demand once the population is immunized.

Oh, and now there are multiple competitors in the market.

Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @08:05AM (#25186328)
Only if the vaccine gives permanent immunity, which I haven't found any research suggesting that it will. In all likelihood, it will be necessary to give yearly booster shots, so the companies developing the vaccines will be able to sell vaccines every year

The quantity of vaccines needed will make even a $0.50 markup worth billions of dollars every year

Re:Oxford University breakthrough on global COVID-19 vaccine by Exmoor on Monday November 23, 2020 @11:16AM (#25188306)
You can't measure long-term immunity on a virus that's only been in the wild for ~11 months. That said, all the recent studies I've seen show no signs that immunity is going to drop significantly after a year.

I hate to link to a Youtube video, but this doctor walking through the research in the first part of the video is honestly better than any news article I've seen: https://www.youtube.com/watch?v=gFeJ2BqCFY0

Re:Oxford University breakthrough on global COVID-19 vaccine by Scandiravian on Monday November 23, 2020 @01:50PM (#25190150)
Thank you for the link. The study definitely suggest a best-case scenario is viable. I do however think that the sample population of 183 subjects is too small to support the conclusion in the paper. The study only got a single sample from the majority of the participants andI couldn't find any indication of how many subjects from each location participated (or which locations were included outside of California), which makes me think it might not be a representative population used

I also noted that 40 of the participants were excluded because they had no PCR test done to confirm covid and no antibodies were found in the assay. This is in my opinion a major flaw, as the subjects could have been infected, but had no antibodies left, when the blood sample was taken

Finally seven of the 18 authors declare competing interests, which might have affected the research

Getting back to your post itself, I agree that you can't measure immunity for a longer period than the virus has been around, but that also means you can't say that there will only be a need for one round of vaccines, which was what I was disagreeing with

It might very well turn out, that you gain permanent immunity for a specific strain off the virus, but unfortunately that immunity also introduces selective pressure. Whether the virus is able to mutate in a way that bypass existing antibodies in a subject is obviously still an unknown, but we have seen that it's able to jump to other species like mink, which caused the emergence of the Cluster-5 variant

Since the virus is able to use other species as a reservoir and selective pressure is being introduced, I think it's reasonable to prepare for a scenario, where a vaccine won't be a permanent fix

Re:Oxford University breakthrough on global COVID-19 vaccine by ghaff on Monday November 23, 2020 @10:56AM (#25188070)
Vaccines are not a great business in general. (Which is not the same as saying they're unprofitable.) But one reason vaccine makers are generally indemnified against lawsuits in the US, it that at least some companies would probably pull out of making vaccines if they weren't.
Re:Oxford University breakthrough on global COVID-19 vaccine by eternalban on Monday November 23, 2020 @10:40AM (#25187872)
These nickle and dime arguments are for "old normal".

The society at large is making huge sacrifices and making painful changes to address this collective problem. Are these companies part of "Human society" or not? If they are party of Humanity, then they can make 'adjustments' as much as we are asked to make adjustments.

Re:Oxford University breakthrough on global COVID-19 vaccine by hkt on Monday November 23, 2020 @05:20AM (#25185275)
That seems fair.

Still won't be a fraction of the profit that stands to be made from these vaccines.

Re:Oxford University breakthrough on global COVID-19 vaccine by oblio on Monday November 23, 2020 @05:09AM (#25185208)
Have these companies provide a detailed list of expenses for researching and developing this vaccine, review that, pay it as a one time cost and THEN vacate the patent.

They then get to recover their R&D expenses and make a smaller but probably decent profit from its production.

Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @05:20AM (#25185272)
Of course. And if they spent $100M on R&D and it failed? What then? Would the gov’t pay those costs? And maybe a small profit?

It’s easy to complain about Pharma profits when you ignore all the money spent that goes “poof”.

Re:Oxford University breakthrough on global COVID-19 vaccine by oblio on Monday November 23, 2020 @05:46AM (#25185427)
When was the last time one of there big pharma companies went bankrupt, barring massive fraud?

I'd be glad to be shown some examples, otherwise it's "privatize profits, socialize losses".

Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @06:45AM (#25185716)
Bankrupt? Not many. Bought for pennies on the dollar? Plenty. Where is Upjohn? Parke-Davis? Schering-Plough? All companies with multi-billion dollar sales figures and all swallowed up when the money stopped coming in.

And if you fold in the start-ups who have one shot and if it doesn’t work out? Plenty of those. They go bankrupt.

Busting the patents on Covid vaccines would be “socializing the gains and privatizing the losses”.

Re:Oxford University breakthrough on global COVID-19 vaccine by factsaresacred on Monday November 23, 2020 @06:05AM (#25185544)
Survivorship bias. The bankrupt businesses never get the chance to become big and so you don't hear about them.

However I'm certain that the category "bankrupt pharma company" is littered with examples.

Re:Oxford University breakthrough on global COVID-19 vaccine by oblio on Monday November 23, 2020 @06:27AM (#25185635)
How many of these small companies are

a) researching Covid-19 vaccines?

b) will they actually get to produce millions and millions of doses?

Almost every case I know of, it's a huge company or even a state owned one.

Who are we actually arguing for/against? The hypothetical "small pharma"?

Keep in mind that just like for banking, due to the amount of (necessary) regulation, there aren't many small pharma companies out there.

Re:Oxford University breakthrough on global COVID-19 vaccine by andi999 on Monday November 23, 2020 @07:14AM (#25185898)
Well Biontech wasnt big until beginning of this year.
Re:Oxford University breakthrough on global COVID-19 vaccine by postingawayonhn on Monday November 23, 2020 @04:23AM (#25184991)
I don't see why they shouldn't be able to make a fair profit.
Re:Oxford University breakthrough on global COVID-19 vaccine by alephu5 on Monday November 23, 2020 @04:58AM (#25185157)
When things go the other way, society doesn't let them make a fair loss.
Re:Oxford University breakthrough on global COVID-19 vaccine by evandijk70 on Monday November 23, 2020 @05:12AM (#25185227)
There are currently 54 vaccines being tested on humans. Getting the necessary data to obtain approval for human testing requires a lot of funding. Testing on humans requires a lot of funding. In the end, maybe 4 vaccines will be used. Do you think the companies that produced and tested the ~50 vaccines that will not be used will get their investment back?
Re:Oxford University breakthrough on global COVID-19 vaccine by PunchTornado on Monday November 23, 2020 @05:33AM (#25185354)
yes, all of these vaccine research are funded by the taxpayer.
Re:Oxford University breakthrough on global COVID-19 vaccine by bobcostas55 on Monday November 23, 2020 @06:00AM (#25185516)
[citation needed]
Re:Oxford University breakthrough on global COVID-19 vaccine by tcptomato on Monday November 23, 2020 @05:13AM (#25185237)
what's you definition of fair? What the market would bear?
[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by HPsquared on Monday November 23, 2020 @05:28AM (#25185321)
Except for how, you know, weapons and medicines have slightly different effects when used.
[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by dri_ft on Monday November 23, 2020 @06:54AM (#25185775)
With weapons, it costs money to kill someone; with medicine, it costs money to save them.
[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by dash2 on Monday November 23, 2020 @09:27AM (#25187042)
This isn't responding to the OP's point, which was that war profiteering (making money by providing weapons to kill people) is morally different from selling vaccines (making money by providing medicines to save people's lives).
Re:Oxford University breakthrough on global COVID-19 vaccine by guipsp on Monday November 23, 2020 @12:55PM (#25189494)
I'm not sure I follow? Profiteering off of healthcare has a cost, in terms of people not cared for due to various market reasons.
Re:Oxford University breakthrough on global COVID-19 vaccine by tomhoward on Tuesday November 24, 2020 @02:22AM (#25196133)
I'm very familiar with the perverse outcomes that emanate from profit-driven medical research, having been personally affected by illnesses that the mainstream medical science community sees no incentive to invest in.

But the reasons and ethics of the system being the way it is are separate from the reality of what it is for the purposes of getting things done in the here and now.

For better or worse, as things stand right now, pharmaceutical companies, like other companies, need to make profits - or at the very least avoid crippling losses - in order to survive and continue doing their work.

That includes covering the formidable costs of the many research studies that go nowhere and yield no revenues.

I'm sure you wouldn't find a single person in a pharmaceutical company who would feel good about withholding treatment from any person with a life threatening illness. But what they also have to care about is remaining in business so they can treat and cure many more people with serious illnesses.

Re:Oxford University breakthrough on global COVID-19 vaccine by pizza234 on Monday November 23, 2020 @05:13AM (#25185232)
Pharmaceutical corporations are not exactly well known to seek "fair" profits.

Practically speaking, I suppose a hypothetical scenario could be that the:

- the companies are granted patents

- the vaccine lasts for a limited amount of time

- before each patent expiry they companies make minor modifications (say, storage temperature requirement decreased by half a degree)

- the company make "unfair" profits by extending the oligopoly for a very long amount of time

I'm not stating that this will happen, but on the other hand, I find this plausible.

Re:Oxford University breakthrough on global COVID-19 vaccine by drran on Monday November 23, 2020 @05:19AM (#25185270)
It looks like a huge opportunity! Start your own pharmaceutical company and disrupt these bastards! You found the problem, now bring the solution.
Re:Oxford University breakthrough on global COVID-19 vaccine by guipsp on Monday November 23, 2020 @05:57AM (#25185493)
Unfortunately, this area has a very high start up cost, which limits disruption. This is the big problem when people say "just disrupt".

In addition, the aforementioned patents prevent disruption. Even long after the original patent expires.

Re:Oxford University breakthrough on global COVID-19 vaccine by BurningFrog on Monday November 23, 2020 @10:52AM (#25188026)
I think it should always be insanely profitable to save the world!

That is something we want to encourage!

Re:Oxford University breakthrough on global COVID-19 vaccine by Ericson2314 on Monday November 23, 2020 @11:43AM (#25188616)
We should have drug bounties for that, rather than trying to make up R&D costs with per-dose price gouging.

This ensures equitable access, ...you know, that the whole world is actually saved.

Re:Oxford University breakthrough on global COVID-19 vaccine by BurningFrog on Monday November 23, 2020 @02:25PM (#25190612)
Yeah, I'm sure there are better possible systems, but in the imperfect 2020 real world, things work the way they work.

In reality, these costs are microscopical compared to the cost of the Covid recession, and all the "stimulus packages" across the planet.

I assume most governments will pay the cost of vaccines, or even pay people to take the shots. The US says it will.

Re:Oxford University breakthrough on global COVID-19 vaccine by WalterBright on Monday November 23, 2020 @05:50AM (#25185449)
> Pay them their costs and not one cent more.

I prefer a system where it's very worthwhile for people to risk a lot and work hard to save my life.

If it was all about altruism, I doubt a vaccine would be developed for many more years.

Re:Oxford University breakthrough on global COVID-19 vaccine by CaptainZapp on Monday November 23, 2020 @09:32AM (#25187089)
Regarding vaccines and altruism I suggest you read up on Jonas Salk, who developed one of the first successful polio vaccines[1]

Money quote from linked article:

"News of the vaccine's success was first made public on April 12, 1955.[7] Salk was immediately hailed as a "miracle worker", and chose to not patent the vaccine or seek any profit from it in order to maximize its global distribution."

[1] https://en.wikipedia.org/wiki/Jonas_Salk

Re:Oxford University breakthrough on global COVID-19 vaccine by WalterBright on Monday November 23, 2020 @04:55PM (#25192405)
I do not dispute that altruistic people exist, and often do great things.

But I also know that my grandmother suffered terribly from rheumatoid arthritis, and it destroyed her life. Long after she died, enbrel was developed for profit which was the first really successful treatment for it.

    No profits => no treatment => misery.
You can sit around waiting for and hoping for someone to step up and sacrifice their time and money for your benefit, but I prefer the much more reliable method of paying them.
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @10:39AM (#25187852)
Not to take anything away from his contribution, but it's a bit more complicated with Salk.

The organizations who funded the research looked into the viability of a patent and concluded it wouldn't have succeeded.

"the idea of patenting the vaccine had been directly analyzed and the decision was made not to apply for a patent mainly because it would not result in one."[1]

The distinction should also be made that a patent doesn't necessarily affect global distribution. It just gives the rights to license the technology. They could have patented it and then licensed it for free.

[1]https://www.bio.org/blogs/real-reason-why-salk-refused-paten...

Re:Oxford University breakthrough on global COVID-19 vaccine by CaptainZapp on Monday November 23, 2020 @02:11PM (#25190439)
Interesting read. Thank you.

It doesn't really scratch at his integrity though, since it was the institution he worked for that raised the issue.

If he was just a brilliant salesman (apart from a brilliant scientist) we never know.

What is beyond dispute is that his discovery saved (arguably) millions of people from a life in misery.

Re:Oxford University breakthrough on global COVID-19 vaccine by anoncake on Monday November 23, 2020 @06:31AM (#25185652)
You don't even need altruism. Vaccine researchers want the pandemic to end like everyone else plus they're interested in vaccine research anyway.
Re:Oxford University breakthrough on global COVID-19 vaccine by usrusr on Monday November 23, 2020 @07:36AM (#25186095)
Here comes my old publicly traded corporation rant: a company with a well defined owner, even with a well defined group of owners, would, given the opportunity, profit handsomely. But not overdo it. They'd rather be seen as a global saviour, not as a global ransomer.

Enter public trading: the opportunity alone for global ransoming will inevitably become the projection that defines the street price for shares and once valuation is up there ransom-level profits would suddenly appear not excessive but appropriate, given the level of paper investments of the latest, valuation-defining round of buyers.

Re:Oxford University breakthrough on global COVID-19 vaccine by ericmay on Monday November 23, 2020 @08:03AM (#25186317)
I don’t think this is a very good rant. Private companies have investors too, and board leadership varies from company to company.
Re:Oxford University breakthrough on global COVID-19 vaccine by usrusr on Monday November 23, 2020 @02:17PM (#25190514)
Private (as in: not publicly traded) is indeed pretty much equivalent to publicly traded if it's a private ownership structure consisting of VC funds. But that's a startup bubble peculiarity, elsewhere private ownership either means being a subsidiary where the parent ownership structure transitively applies (strictly speaking, the VC funded startup falls into this category as well) or a much more conventional setup where the role of outside investors is taken by old-fashioned banks whose possible returns are strictly limited to what the credit contract says.
Re:Oxford University breakthrough on global COVID-19 vaccine by bigmanwalter on Monday November 23, 2020 @09:55AM (#25187298)
So true! Anonymous masses vs private fiefdoms. Almost everything commercially successful is run by tyrants.

I wish regulating anti-social behaviour out of industry was more popular.

Re:Oxford University breakthrough on global COVID-19 vaccine by WalterBright on Monday November 23, 2020 @05:01PM (#25192465)
> Almost everything commercially successful is run by tyrants.

Sounds like you're simply defining a tyrant as someone who runs a profitable company.

Re:Oxford University breakthrough on global COVID-19 vaccine by ericmay on Monday November 23, 2020 @11:00AM (#25188113)
The main issue is identifying what anti-social behavior is. It's easy to say "coal is anti-social! don't you care about the environment!", but it's just as anti-social to just shut down an industry and say "best of luck, I heard you can move to California and build websites in JavaScript". Often times there just aren't easy answers.

I also want to push back on "everything commercially successful is run by tyrants" kind of narrative. I get the frustration, but these blanket, ideological statements do not help anyone, anywhere. Do you make money? I guess you're a tyrant!

Let's not forget, the countries that we put up on a pedestal as the shining examples of how a country should be run (Norway or whatever) are very much capitalistic countries with free markets, IPOs, and commercial companies. I hardly see businesses there characterized as tyrannical.

I do really get the frustration, but it needs to be directed at the failures of our elected representatives. Not, commercial entities.

Re:Oxford University breakthrough on global COVID-19 vaccine by bigmanwalter on Monday November 23, 2020 @09:07PM (#25194484)
The tyrannical boss is a classic trope due to the necessities of competition.

Companies are unlikely to stay profitable if they’re overly generous. They need to profit handsomely to survive.

Re:Oxford University breakthrough on global COVID-19 vaccine by ericmay on Monday November 23, 2020 @09:54PM (#25194782)
> The tyrannical boss is a classic trope due to the necessities of competition.

Eh, I think that’s kind of old-school thinking.

> Companies are unlikely to stay profitable if they’re overly generous. They need to profit handsomely to survive.

Yep. That’s fine. (Also ignores low-margin industries that rely on volume, but whatever).

If you want a modern society, people have to be able to take risks with their money in order to make more money. Otherwise we can go back to subsistence farming. Do you work? You’re charging a profit. How evil of you! Being a few steps removed from the transaction doesn’t make you any less guilty of profiteering. You’re just as bad as these tyrannical CEOs, the difference is you’re a sucker for building their product while they make money hand over fist.

(I don’t actually believe the last part, but w/e).

Re:Oxford University breakthrough on global COVID-19 vaccine by bluGill on Monday November 23, 2020 @08:55AM (#25186766)
Today. Just 1 year ago the next pandemic was vaporware. In hindsight we know that covid happened, but there was no more reason to think it would have than any other unlikely event.
Re:Oxford University breakthrough on global COVID-19 vaccine by dash2 on Monday November 23, 2020 @09:30AM (#25187075)
I doubt if vaccine research can be done just by a group of interested people. It's not a paper-and-pencil affair like pure maths. You need a lot of computers, drug manufacturing machinery; then you have to run big, well-organized RCTs. If you've got an example of volunteer-driven health research at scale, I'd like to hear about it.
Re:Oxford University breakthrough on global COVID-19 vaccine by anoncake on Monday November 23, 2020 @11:40AM (#25188567)
Volunteer-driven health research has solved all zero major pandemics of the last century.
Re:Oxford University breakthrough on global COVID-19 vaccine by andi999 on Monday November 23, 2020 @07:18AM (#25185926)
Biontech didnt do vaccine. They pivoted because they saw a big opportunity using their approach might lead to a vaccine for Covid. So to justifies this pivot (and get the investments into the company) there need to be a possibility of big profit at the horizon.
Re:Oxford University breakthrough on global COVID-19 vaccine by trentnix on Monday November 23, 2020 @11:54AM (#25188744)
A profit opportunity requiring significant investment has led to fast and fantastic results that will benefit us all. But you want to punish the opportunists who've absorbed significant risk to bring us those results because you've decided their motivation isn't sufficiently pure.

I pray anyone of like mind is never in a position to enact such progress-killing madness and fear terribly that government is already full of them.

And besides, it is mind-numbingly complicated to calculate "at-cost" because as others have pointed out, that includes all of the dead-end R&D, ongoing legal exposure, interest on the loans used to cashflow operations at pharmaceutical giants, appropriate licensing of existing intellectual property that these vaccines are built on, and the million other ways money is spent to develop pharmaceuticals.

Re:Oxford University breakthrough on global COVID-19 vaccine by tssva on Monday November 23, 2020 @07:56AM (#25186257)
And when the next pandemic hits no drug company will develop, manufacture and distribute a vaccine because they know there is no profit to be had.
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @10:44AM (#25187925)
While I think the current system helps, let's not pretend that profit is the sole reason people decide to work in medicine or research.

We all have things (and people) in our lives who are probably a net negative in terms of financial outcome, but we enjoy them anyways because our value systems are more complex than just "maximize profit"

Re:Oxford University breakthrough on global COVID-19 vaccine by em500 on Monday November 23, 2020 @05:53AM (#25185463)
And in the next pandemic, be shocked - shocked, that a new vaccine takes 10 years instead of 1 to appear...
Re:Oxford University breakthrough on global COVID-19 vaccine by mytailorisrich on Monday November 23, 2020 @04:47AM (#25185101)
I agree that in cases of overwhelming national interests patents and licensing should be ignored if they stand in the way.

But: this is not a medicine made of a molecule that can be synthesised by the chemical industry. Such a vaccine requires input from the creator and then specialist equipment to manufacture. Poor countries don't have the infrastructure to manufacture and the creator labs are not going to tell you how to produce the vaccine just because you ask them.

In any case, governments should pressure labs to enforce an low prove.

Re:Oxford University breakthrough on global COVID-19 vaccine by usrusr on Monday November 23, 2020 @07:58AM (#25186275)
In the context of the vaccination rush I often wonder how military aircraft procurement was doing it when extreme r&d progress and extreme mass production were coinciding during ww2. New types were developed by companies (even the Soviets maintained a healthy competition between design bureaus) but once a type was established and in volume demand it apparently was manufactured wherever a production line could be adapted. Was that just free market subcontracting in the US or did DoD design bids come with something like a premeditated licensing option baked in from the beginning?
Re:Oxford University breakthrough on global COVID-19 vaccine by mytailorisrich on Monday November 23, 2020 @08:40AM (#25186616)
I think that the "free market" stopped to operate during that time. The whole economy was redirected to the war effort and everyone with it.

These programs were federally-funded with the goal to produce as much as possible. For production I'm sure that factories were financially compensated for the work.

Re:Oxford University breakthrough on global COVID-19 vaccine by steerablesafe on Monday November 23, 2020 @05:17AM (#25185255)
That would be a great way to disincentivize vaccine research for the next major pandemic.
Re:Oxford University breakthrough on global COVID-19 vaccine by refurb on Monday November 23, 2020 @05:17AM (#25185253)
I’m sure you’d be willing to play that game? Let’s say your job becomes “essential”. The company pays your costs (rent, food) and nothing more. I mean, to “profit” is unacceptable.
Re:Oxford University breakthrough on global COVID-19 vaccine by guipsp on Monday November 23, 2020 @05:56AM (#25185486)
I'm sure you realize that the rights of corporations are not the rights of the individual.

I'm also sure that you realize the difference between taking a small profit, and the huge margins big pharma companies have.

In addition, the pharma companies have already been compensated with massive grants.

Re:Oxford University breakthrough on global COVID-19 vaccine by andi999 on Monday November 23, 2020 @07:19AM (#25185936)
The biontech vaccine is not from big pharma.
Re:Oxford University breakthrough on global COVID-19 vaccine by SanderNL on Monday November 23, 2020 @06:18AM (#25185601)
While off-putting, these same capitalist forces are what made companies like Pfizer possible in the first place. Where are the socialist factories? I do not see any communist, religious and/or otherwise motivated groups of people producing anything of value right now. Lots of noise, very little substance.
Re:Oxford University breakthrough on global COVID-19 vaccine by howlgarnish on Monday November 23, 2020 @07:54AM (#25186238)
No, the main driver for the price difference is that this is a "traditional" vaccine produced using existing technology, while Pfizer/Moderna are newfangled mRNA ones.

Also, all 3 have made various noises about not making a profit etc, it's quite hard to sort out the marketing from what will actually happen at this point. Oxford/Astra have committed to supplying at least 100M doses to low-income countries for under $3 though.

Re:Oxford University breakthrough on global COVID-19 vaccine by bawolff on Monday November 23, 2020 @03:19AM (#25184637)
Maybe for less developed countries, but i think for major economies, the price difference is insignificant relative to the benefits of any vaccine.
Re:Oxford University breakthrough on global COVID-19 vaccine by markvdb on Monday November 23, 2020 @03:59AM (#25184851)
As I understand it, whatever gets us to herd immunity more quickly is the best solution. That probably means a mix of both heavily tilted to the Oxford one.

This vaccine is cheap, 90% efficient and easy to get people vaccinated. The other ones are expensive, 95% efficient and difficult to get people vaccinated.

Re:Oxford University breakthrough on global COVID-19 vaccine by bluGill on Monday November 23, 2020 @08:20AM (#25186437)
No, it means deploy everything we have as fast as we can. If we have a choice prefer the mRNA vaccines as they seem to be more effective. If you are in a city with cold storage abilities (most have this already, though how much...) the Pfizer is better, but only to reserve the Moderna vaccine for those who don't live so close to cold storage.

The Oxford is best only if you either live in a very remote place, or are a very poor place. If you rely on the oxford vaccine it will be a little longer to get herd immunity, but overall your costs will be cheaper.

But I must reemphasize, the above is only about logistics. Because most people live in cities, all vaccines will be distributed in big cities just to get the numbers they need. What ever vaccine you are offered first is the one to take. You personally are unlikely to be offered a choice other than take it or leave it.

Re:Oxford University breakthrough on global COVID-19 vaccine by dvfjsdhgfv on Monday November 23, 2020 @03:29AM (#25184688)
If they actually get to 90% or more, why would anyone bother with the more expensive and cumbersome vaccines? Except that the EU already signed a deal to buy the vaccines from AstraZeneca, Sanofi and Johnson & Johnson.
Re:Oxford University breakthrough on global COVID-19 vaccine by andylynch on Monday November 23, 2020 @05:15AM (#25185243)
Especially in the next few months, supply of all of these will be limited by production capacity and supply chains. Having multiple available means more doses can be delivered sooner.
Re:Oxford University breakthrough on global COVID-19 vaccine by bawolff on Monday November 23, 2020 @03:37AM (#25184733)
Because there is only so much to go around in the initial stages, so they will buy whichever one is available to them. The 10x increase in price is peanuts compared to the ecconomic benefits of getting more people vaccinated sooner.

Additionally, lots of countries have already preordered all the major candidates, so in those cases its already spent money.

Re:Oxford University breakthrough on global COVID-19 vaccine by ulfw on Monday November 23, 2020 @04:44AM (#25185090)
Because 95% efficacy is twice as good as 90%. And some people are willing to pay the $30 it costs to be 5% likelihood to have a non-functioning vaccine vs. a 10% likelihood the vaccine you just got won't work on you.
Re:Oxford University breakthrough on global COVID-19 vaccine by StavrosK on Monday November 23, 2020 @05:26AM (#25185313)
Aren't people worried about the fact that mRNA vaccines haven't been deployed before? I don't see much apprehension about that generally, but a few months of testing of a brand new delivery technique don't sound that extensive to me.
Re:Oxford University breakthrough on global COVID-19 vaccine by nemo44x on Monday November 23, 2020 @07:21AM (#25185963)
The delivery technique relies on LNP (lipid nano particles) which is fairly refined and existing therapeutics use today. There are potential patent violations though (both Phizer and Moderna possibly violating Arbutus patent) but it’s unclear to me how this affects distribution.
Re:Oxford University breakthrough on global COVID-19 vaccine by wbl on Monday November 23, 2020 @10:12AM (#25187521)
No judge in their right mind will grant an injunction when doing so will cost the lives of third parties. All the harms can be solved with a big check.
Re:Oxford University breakthrough on global COVID-19 vaccine by nemo44x on Monday November 23, 2020 @12:02PM (#25188840)
Yeah I'm not 100% familiar with the potential case here but I'd imagine it's in everyone's best interest to ensure that the medicine is not hindered in its ability to be manufactured and delivered and that the company that holds patents on the delivery vehicle (LNP) would be compensated justly.

It isn't a new thing for what it's worth. Going back to earlier this year it has been looked at, but we don't really have a clear picture on what will shake out.

Re:Oxford University breakthrough on global COVID-19 vaccine by StavrosK on Monday November 23, 2020 @07:41AM (#25186125)
Oh that's encouraging, thanks! It's great if it works well, as I understand it it's a potential gamechanger (cancer vaccines etc).
Re:Oxford University breakthrough on global COVID-19 vaccine by headmelted on Monday November 23, 2020 @05:40AM (#25185398)
If we’re relying on solely getting immunity ourselves then we’re in really bad shape, although its not been well communicated.

We need the vaccine to remove the virus from circulation, not just keep us safe from it as individuals.

Re:Oxford University breakthrough on global COVID-19 vaccine by bluGill on Monday November 23, 2020 @07:19AM (#25185934)
We don't have evidence that is possible. There have been vaccines in the past that protected without stopping spread. We think that the reasons that happened don't apply, but we don't know that.
Re:Oxford University breakthrough on global COVID-19 vaccine by xiphias2 on Monday November 23, 2020 @05:07AM (#25185196)
Also so far the mRNA vaccines look to have less side effects. AstraZeneca is not doing charity, it's cheaper because they have the inferior vaccine.
[dead]
Re:Oxford University breakthrough on global COVID-19 vaccine by xiphias2 on Monday November 23, 2020 @10:08AM (#25187471)
Sure, maybe I just don't understand this whole charity thing. When governments can print trillions of dollars to ,,help the people in the pandemic'', why a few tens of billions of dollars matter when real companies with real experts are doing real work all day and night without sleeping. Instead of buying back bonds, governments should pay companies that help in this situation.
Re:Oxford University breakthrough on global COVID-19 vaccine by dash2 on Monday November 23, 2020 @09:32AM (#25187094)
This would be fine, but delete "fool".
Re:Oxford University breakthrough on global COVID-19 vaccine by triangleman on Monday November 23, 2020 @09:49AM (#25187244)
It's all right, he'll live
Re:Oxford University breakthrough on global COVID-19 vaccine by cdash on Monday November 23, 2020 @05:03AM (#25185176)
Because even with all 3 vaccines we still don't have the supply needed to vaccinate everyone immediately.
Re:Oxford University breakthrough on global COVID-19 vaccine by dvfjsdhgfv on Tuesday November 24, 2020 @11:00AM (#25199590)
Honestly, why would any 1st world country "vaccinate everyone immediately"? Wouldn't it be more prudent for a rich country to wait until 3rd world countries vaccinate first in order to see what the side effects actually are? Not to mention the fact that we know nothing about potential long-term side-effects.
Re:Oxford University breakthrough on global COVID-19 vaccine by thehappypm on Monday November 23, 2020 @10:45AM (#25187927)
The mRNA vaccines are better and protect more people. AZ leaves 10% unprotected, mRNA leaves 5%. That's a big difference if trying to get to herd immunity.
Re:Oxford University breakthrough on global COVID-19 vaccine by elmo2you on Monday November 23, 2020 @04:19AM (#25184974)
While for now just speculation and without a doubt Machiavellian, it could be that this price difference ends up a significant factor for major economies in their choice for an expensive vaccine. I guess we will know, if/when/once examples of individual discrimination based on what vaccine people received start emerging (hopefully, never).

Regretfully, it would be not the first example of major economies using the current reality as an excuse/cover to conveniently push political policies/agendas that would otherwise have been impossible to implement (at least not without violating laws/treaties and maybe even basic human rights). I have no intention to fear monger, but I believe way too many are too naive about some of the things that are currently happening. That is, mostly people within those major economies, for people in less fortunate countries already learned the hard way how double-faced those major economies turned out.

How all this will eventually turn out ... anyone's guess is as good as mine. I guess we will all learn, when the immediate emergency of the current situation is over. I would prefer to be/remain optimistic, but thus far there appear to be more reasons for caution and skepticism (at best).

Re:Oxford University breakthrough on global COVID-19 vaccine by bawolff on Monday November 23, 2020 @04:38AM (#25185065)
What?

I've read this 3 times and can't figure out what you're trying to say.

Are you saying that rich countries are going to intentionally choose more expensive vaccines, with the intention of suppressing the lower classes?

That's so rediculous. In rich countries (other than the usa) the gov pays for these things not the citizens. Even then, the expensive vaccine is only $40, that's within the means of most poor people.

Not to mention that would screw over the rich people who want to benefit from (vaccine induced) heard immunity.

Re:Oxford University breakthrough on global COVID-19 vaccine by elmo2you on Monday November 23, 2020 @06:54AM (#25185778)
Fascinating ...

> .. the gov pays for these things not the citizens .. You do know that the only money governments have, is the money they got from its citizens, right? That is, aside from what they may have earned (though plundered or extorted might be more fitting) from other nations.

> .. the expensive vaccine is only $40, that's within the means of most poor people .. You may want to reevaluate your knowledge about the rest of the world. That is, outside the USA and some the more affluent parts of Europe. Also, that vaccine probably won't cost "just" $40 equally for everyone.

However, believe whatever you want. Time will no doubt teach us all a lessen. Personally, I hope it will teach me that I was wrong with my skepticism.

Re:Oxford University breakthrough on global COVID-19 vaccine by bawolff on Monday November 23, 2020 @01:34PM (#25189943)
I'm not sure why i'm replying here. Guess i'm bored.

> Time will no doubt teach us all a lessen.

I doubt it. You need to actually have a position that can be shown to be true or false with the passage of time before you can learn something from the passage of time. You have a bizare, logically disconnected, rant that does not make any predictions. I don't think any course of events would prove you right (or wrong).

> You may want to reevaluate your knowledge about the rest of the world

In context, we were discussing afluent countries, canada europe, etc.

> Also, that vaccine probably won't cost "just" $40 equally for everyone.

They will cost $0 directly. As you say there will be indirect costs based on taxes. However that will be true regardless of if you get the vaccine and be scaled based on your income, so im not sure how you think that applies to your argument sbout class divide.

Re:Oxford University breakthrough on global COVID-19 vaccine by vixen99 on Monday November 23, 2020 @07:32AM (#25186069)
Needs to be repeated again & again: "Governments have no money of their own, it's citizens' (past, present and future - mostly the latter these days) who provide the cash via taxes".
Re:Oxford University breakthrough on global COVID-19 vaccine by rimliu on Monday November 23, 2020 @10:15AM (#25187568)
This changes nothing. If anything it is wise for goverments to pay for vaccine because that means that economy will no longer be stifled by lockdowns and that means more money in taxes. In any cases many governments already said they will provide vaccine for free.
Re:Oxford University breakthrough on global COVID-19 vaccine by onetimemanytime on Monday November 23, 2020 @09:16AM (#25186941)
Price is not an issue for rich countries. 500 Million vaccines for USA leaving kids and some other out...cost, what $25 Billion? Peanuts, compared to the damage it did /can do. Same for USA, EU, Japan, CA, Australia etc.
Re:Oxford University breakthrough on global COVID-19 vaccine by est31 on Monday November 23, 2020 @09:18AM (#25186963)
Poor countries are hit by covid-19 as well. Those folks deserve a vaccine too. Even if you don't care about the Humanitarian side of this, the west benefits from that directly by not having giant reservoirs for the virus.
Re:Oxford University breakthrough on global COVID-19 vaccine by onetimemanytime on Monday November 23, 2020 @09:29AM (#25187062)
Plus, they travel to the rich countries.New vaccines are coming in. China will probably use their own, India will copy one and costs next to nothing. Donations will make sure everyone has one.
Re:Oxford University breakthrough on global COVID-19 vaccine by wobbly_bush on Monday November 23, 2020 @12:08PM (#25188912)
> India will copy one and costs next to nothing

India's Serum Institute has already partnered to mass produce this vaccine. https://www.ndtv.com/world-news/oxford-says-covid-19-vaccine...