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Re:Oxford University breakthrough on global COVID-19 vaccine by MagnumOpus on Monday November 23, 2020 @06:58AM (#25185793)
> The AstraZeneca vaccine also has 90 percent efficacy when used twice

No it doesn't. Both dosings use two shots, and the "90%" number from the smaller dosing is from an unreliably small sample set of 33 infections -- it could easily be 70-80% by next month when more data comes in.

Re:Oxford University breakthrough on global COVID-19 vaccine by Jedd on Monday November 23, 2020 @08:10AM (#25186370)
> Both dosings use two shots, and the "90%" number from the smaller dosing is from an unreliably small sample set of 33 infections."

Can you count infections as a metric of efficacy for a vaccine that's designed to stop infection?

Consider [1]:

"However, protection was 90% in an analysis of around 3,000 people on the trial who were given a half-sized first dose and a full-sized second dose."

AFAIK it's not known how many of those 3,000 in that trial were exposed to potential infection.

[1] https://www.bbc.com/news/health-55040635

Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @09:55AM (#25187297)
Couldn’t the same be said in reverse? I.e., due to sampling error the reports could be amended to a 95% efficacy when more data comes in?
Re:Oxford University breakthrough on global COVID-19 vaccine by twoslide on Monday November 23, 2020 @10:55AM (#25188052)
I don't think we know based on public information. Some media report "up to 90%" which suggests the upper bound of the confidence interval, rather than the centre. Could also be a very wide CI, that overlaps with the standard dosage.
Re:Oxford University breakthrough on global COVID-19 vaccine by bumby on Monday November 23, 2020 @11:31AM (#25188471)
That's a fairer statement than the original which seemed biased towards only reporting the lower end of the interval without acknowledging the upper bound.
Re:Oxford University breakthrough on global COVID-19 vaccine by acqq on Monday November 23, 2020 @07:53AM (#25186221)
At the moment possibly wider error bars don’t come from just “33 infections” but more from possibly smaller number of those who received the observed treatment.

The bars are to be calculated using conditional probabilities.