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Re:Autopsy-based characterization of myocarditis after anti-... by vannevar on Thursday December 15, 2022 @02:43PM (#34004600)
The problem here isn't the study---of course we should study possible vaccine side effects. The problem is the massive leaps of logic being made by people who have (quite wrongly, based on available evidence) become convinced that the vaccines are a greater threat to healthy people than the virus is. As unlikely as it is that an otherwise healthy young person will die from covid, it is even less likely that they'll die from a vaccine side effect. That's just a statistical fact at this point, we have millions of both covid cases and vaccinations to back that up.

This study looked at 25 cases of unexpected death in people aged 46-75 and found 5 cases of myocarditis. Without any control group to compare to, there is literally nothing that can be drawn from this study about the risk presented by the vaccine, and the authors admit as much:

"The nature of our autopsy study necessitates that the data are descriptive in quality and does not allow any epidemiological conclusions in terms of incidence or risk estimation."

Re:Autopsy-based characterization of myocarditis after anti-... by bb88 on Thursday December 15, 2022 @02:50PM (#34004694)
Since the Musk takeover, conspiracy theorists on $8Chan have talked about Grant Wahl dying suddenly because of the "clot shot".

Then we find out he died of a ruptured aortic aneurysm.

Then people still refuse to believe it because it doesn't fit their narrative they're pushing. And anyone who dies suddenly must have died because of the vaccine.

https://twitter.com/DiedSuddenly_/status/1603103342481342465

This killed John Ritter, George C. Scott, Lucille Ball and Albert Einstein. But somehow the vaccine is to blame for anyone who dies of it now...

Re:Autopsy-based characterization of myocarditis after anti-... by kennend3 on Thursday December 15, 2022 @03:37PM (#34005361)
There is also the "Canadian doctors" story the anti-vax group continue to flog yet it has being proven wrong over and over again.

https://www.thestar.com/news/canada/2022/11/07/why-wont-a-de...

One of the doctors drowned in a river attempting to save his kids, yet the anti-vax group elect to leverage his tragedy for their narrative.

Re:Autopsy-based characterization of myocarditis after anti-... by vfclists on Thursday December 15, 2022 @03:58PM (#34005659)
> One of the doctors drowned in a river attempting to save his kids, yet the anti-vax group elect to leverage his tragedy for their narrative.

One out of how many?

Re:Autopsy-based characterization of myocarditis after anti-... by kennend3 on Thursday December 15, 2022 @04:28PM (#34006020)
The number of doctors who "died" after getting their fourth dose is a moving target, but the article i posted did a bit of a breakdown:

" The cluster of deaths back in the summer helped kindle what is now a fire — a conspiracy theory that today peddles a list of dozens of doctors online, including the three who died in July, as well as — according to its own descriptions — several who drowned, one who was in the middle of biking 105 kilometres and a doctor who died coming down K2, a mountain deadlier than Everest. "

It started out as "three" doctors, now it is "dozens".

Re:Autopsy-based characterization of myocarditis after anti-... by LarryMullins on Thursday December 15, 2022 @11:35PM (#34010278)
Conflating "died from the vaccine" with "died with the vaccine". Quite ironic!
Re:Autopsy-based characterization of myocarditis after anti-... by westmeal on Thursday December 15, 2022 @03:28PM (#34005246)
People will believe whatever they want to believe, just let them stew.
Re:Autopsy-based characterization of myocarditis after anti-... by bb88 on Thursday December 15, 2022 @03:48PM (#34005523)
This works until it leads to politicians asking for grand juries to investigate anyone associated with the vaccine.

https://www.theguardian.com/us-news/2022/dec/13/ron-desantis...

Re:Autopsy-based characterization of myocarditis after anti-... by phtrivier on Thursday December 15, 2022 @04:49PM (#34006272)
Unfortunately, some of them don't stew in silence - and consider anyone who got vaccinated with exactly the same contempt as you do.

Which is all fun and games until you have to, you know, _live_ with them in the real world because they're your family and / or loved ones ?

Re:Autopsy-based characterization of myocarditis after anti-... by OrvalWintermute on Thursday December 15, 2022 @05:05PM (#34006475)
Are you saying that aneuryms are not a potential adverse event associated with MRNA Covid vaccination [1]?

Furthermore, we know hypertension is also associated with dissections, and there are several documented cases of acute and non-acute hypertension after MRNA covid vaccination [2]

I'm saying that to say there are some possibilities there, but I am also going to say the opposite too.

I don't know that we know enough about the adverse events associated with these vaccinations, and whether or not a vaccine is implicated, or if there was a previous medical condition.

Retrospectively speaking, I don't know that an autopsy would give us any novel answers either, because of the gaps we have around passive medical surveillance vs active medical surveillance.

I am sorry that Mr. Wahl died at such a relatively young age

[1] https://pubmed.ncbi.nlm.nih.gov/35646499/

[2] https://www.ahajournals.org/doi/epub/10.1161/HYPERTENSIONAHA...

Re:Autopsy-based characterization of myocarditis after anti-... by bb88 on Friday December 16, 2022 @12:20AM (#34010723)
These are at least 4 known causes of aortic aneurysms.

1) Smoking (behavioral)

2) High blood pressure (dietary or genetic)

3) High cholesterol (dietary of genetic)

4) Marfan's syndrome (genetic)

Last I checked, doctors (who know these things) were seriously considering it was #4.

Re:Autopsy-based characterization of myocarditis after anti-... by OrvalWintermute on Friday December 16, 2022 @09:56AM (#34015181)
Actually, this list is insufficient according to the NIH [1] an article in Circulation [2] and my wife, a boarded surgeon. Where she provided data I have italicized it, all others are from NIH and the other source. Interestingly, Diabetes can also have a protective effective against aneuryms [3]. There is also evidence that viral infection can likewise play a contributing role to local inflammation in aorta, similar to the better-known effects of bacterial infections ...CMV infection can stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms. [4]

Genetic/History

    Ehlers–Danlos syndrome

    Loeys–Dietz syndrome

    Marfan syndrome

    Turner syndrome

    Familial thoracic aortic aneurysms

    Bicuspid aortic valve (BAV), which is an abnormal aortic valve
Birth Defect

Diabetes, particularly uncontrolled diabetes

Lifestyle Habits

    Aneurysms of blood vessels in other parts of your body

    Chronic obstructive pulmonary disease (COPD)

    Cardiovascular conditions, such as atherosclerosis, coronary heart disease, and peripheral artery disease

    Unhealthy blood cholesterol level

    High blood pressure, which is the leading risk factor for thoracic aortic aneurysms but also a risk factor for abdominal aortic aneurysm

    Bacterial infections, which are a risk factor for thoracic aortic aneurysms.

    Kidney conditions, such as renal failure, chronic kidney disease, and polycystic kidney disease

    Obesity

    Pheochromocytoma external link , a rare tumors of the adrenal gland that can lead to high blood pressure

    Vasculitis
[1] https://www.nhlbi.nih.gov/health/aortic-aneurysm/causes

[2] https://www.ahajournals.org/doi/10.1161/circulationaha.110.0...

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198737/

[4] https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26901

Re:Autopsy-based characterization of myocarditis after anti-... by tempsy on Thursday December 15, 2022 @02:49PM (#34004680)
Ok, so if you believe your chance of dying of covid is improbably small due to age and overall health, why is it necessary to be vaccinated even if there's only a small chance of side effects? Rare is not zero.

I don't even take OTC pain killers like advil unless I absolutely feel like I have to.

Re:Autopsy-based characterization of myocarditis after anti-... by lamontcg on Thursday December 15, 2022 @03:42PM (#34005442)
Because the risk of e.g. dying of myocarditis from the virus still exceeds the risk of dying of myocarditis from the vaccine.

Particularly with the mRNA vaccines there isn't much in the vaccine that isn't in the virus already.

There has to be a name for this fallacy. It is like we're living in the dark ages where contracting covid is just "God's will" and it doesn't count in risk assessments, while no matter how small the risk is over the vaccine that is all that matters.

Re:Autopsy-based characterization of myocarditis after anti-... by woodruffw on Thursday December 15, 2022 @03:51PM (#34005561)
It's definitely not a standard name, but I call kind of reasoning error "active/passive bias": we're generally much more afraid of risks that manifest from action (mauled by a shark while swimming, getting in a car crash) than inaction (dying of obesity, getting hit by a car on the sidewalk).

In the case of COVID-19: you have to actively get the vaccine, meaning that people overweight its risks relative to the risks latent in not getting it.

Re:Autopsy-based characterization of myocarditis after anti-... by cnelsenmilt on Thursday December 15, 2022 @04:13PM (#34005861)
I think you're right, and an additional factor is that the vaccine is tangible and certain where the virus is invisible and may or may not be present in any given situation (and in unknown quantity).
Re:Autopsy-based characterization of myocarditis after anti-... by lamontcg on Thursday December 15, 2022 @05:55PM (#34006975)
At its core it may be more that people can't think past binary logic. Either something works or it doesn't work. Either something is perfectly safe or it is too risky. But that doesn't address why they don't apply the same logic to the virus itself (although there are some people on the flip side who still do).
Re:Autopsy-based characterization of myocarditis after anti-... by mhb on Thursday December 15, 2022 @03:46PM (#34005502)
Because the risk of e.g. dying of myocarditis from the virus still exceeds the risk of dying of myocarditis from the vaccine.

It's good to point that out, but the first term needs to be multiplied by the chance of getting the virus.

Re:Autopsy-based characterization of myocarditis after anti-... by bryanlarsen on Thursday December 15, 2022 @03:57PM (#34005651)
That's likely a number greater than 1 since there is a really good chance of contracting the disease multiple times.
Re:Autopsy-based characterization of myocarditis after anti-... by pexabit on Thursday December 15, 2022 @04:11PM (#34005832)
That isn't relevant because there is no evidence that the vaccine reduces your risk of suffering from myocarditis after infection. (It isn't even necessarily true, but that is a separate matter).
Re:Autopsy-based characterization of myocarditis after anti-... by lamontcg on Thursday December 15, 2022 @04:53PM (#34006347)
> The risk of COVID-19 infection-related myocarditis risk was cut in half among people infected after vaccination (received at least one dose of a COVID-19 vaccine).

https://newsroom.heart.org/news/myocarditis-risk-significant...

Re:Autopsy-based characterization of myocarditis after anti-... by 2devnull on Thursday December 15, 2022 @05:22PM (#34006658)
Based on the original strain. Not that I would want to argue. There are several nations that do not recommend vaccination for younger people. They could be wrong of course, but to be so certain about science of a rapidly changing virus and wave away methodological difficulties, like measuring myocarditis without an autopsy, strikes me as scientifically naive, perhaps bordering on religiosity.
Re:Autopsy-based characterization of myocarditis after anti-... by amluto on Thursday December 15, 2022 @05:13PM (#34006549)
> Particularly with the mRNA vaccines there isn't much in the vaccine that isn't in the virus already.

I don’t find this compelling at all. At the very least, the mRNA vaccines have the lipid nanoparticles themselves, and LNPs are quite clearly biologically active.

And the mRNA gets delivered to cells that would not be infected by the actual virus. One might imagine that such cells would be targeted to at some some extent by CD8+ T cells that learn to recognize spike protein. As far as I can tell, there is nothing published examining what actually happens, but you certainly don’t end up with massive death of muscle cells when vaccinated. See, for example, the comments here:

https://www.science.org/content/blog-post/mrna-vaccines-what...

Re:Autopsy-based characterization of myocarditis after anti-... by lamontcg on Thursday December 15, 2022 @05:45PM (#34006864)
The lipid nanoparticle itself is basically a cell wall and it fuses with your cell wall and deploys its payload. There isn't a lot there. It isn't like the adenovirus capsid that binds to PF-4 and causes the clotting disorders in J&J and ChAdOx1. It would have to be something related to ALC-0315 and/or ALC-0159 and be active in the very tiny quantities which are administered. Those are lipids and it is most likely that they're eventually just disassembled.

> One might imagine that such cells would be targeted to at some some extent by CD8+ T cells that learn to recognize spike protein.

This is exactly what we want to see happen, and you're going to get CD8+ T-cells from the virus as well (and if you don't, then you're going to get very extremely ill).

The tissue distribution is a reasonably good point, but that should be considered in light of the evidence that the virus itself likes to hide out in places like the gut and that liver and gut activation after vaccination may be protective. And if that argument is wrong, that would be an argument to try to produce nasal mRNA vaccines.

And at this point we do have a really massive amount of data on the safety and efficacy of the mRNA vaccines and we're having to sift the data very closely to find effects lower than one in million. Other vaccines perform worse. I think it probably is because we're getting closer and closer to minimalism.

Re:Autopsy-based characterization of myocarditis after anti-... by amluto on Thursday December 15, 2022 @06:56PM (#34007590)
> The lipid nanoparticle itself is basically a cell wall and it fuses with your cell wall and deploys its payload.

The LNPs are most certainly active in the quantities used:

https://www.news-medical.net/news/20221109/Empty-lipid-nanop...

(Also, you don’t have cell walls.)

> This is exactly what we want to see happen, and you're going to get CD8+ T-cells from the virus as well (and if you don't, then you're going to get very extremely ill).

No. What you want to see is protection from the virus, hopefully prevention of infection entirely, hopefully long lasting, hopefully in a form that the virus can’t easily evolve its way out of. And you want this with as little in the way of side effects as practical.

You might think this would happen with an appropriate antibody response or an appropriate CD8+ response or some combination or something else. That’s a hypothesis that may or may not be correct.

But saying that you want your T cells attacking your muscle cells after a vaccine seems absurd. Maybe you can tolerate that (as people apparently can), but I can’t imagine it’s desirable. As far as I can tell, the actual desired means to get CD8+ T cells is for antigen-presenting cells to present pieces of the protein in question attached to MHC1 on their surface, along with the appropriate signals to nearby T cells to encourage them to develop into the right kind of T cell. Your muscle cells are not those antigen presenting cells!

> And at this point we do have a really massive amount of data on the safety and efficacy of the mRNA vaccines … Other vaccines perform worse.

I’m a fan of Covid vaccines too, but this feels like drinking the Kool-Aid. The chickenpox vaccine is effective. The measles vaccine is effective. The tetanus vaccine is pretty effective.

The current crop of monovalent Covid mRNA were highly effective from a week or so after the second dose out to quite a few months against variants closely enough related to the original. [0] Otherwise they are, frankly, far from highly effective. The bivalent vaccines, as far as I can tell, look decent in terms of immunogenicity, but haven’t really been studied well for efficacy against actual infection.

So maybe these mRNA vaccines achieve a form of minimalism, and maybe they’re better than other Covid vaccines, but on the scale of vaccines overall, they’re not great.

[0] Compare to the chickenpox vaccine. In actual randomized trials, they were nearly completely effective even in patients exposed to chickenpox a few days before vaccination. The two-dose series appears to protect recipients for life, or at least decades, strongly enough that epidemic chickenpox is gone in the US. And that continues to work despite chickenpox surely being reintroduced by visitors from abroad on a regular basis and from older infectious shingles patients. That is an effective vaccine.

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @07:18PM (#34007756)
> Because the risk of e.g. dying of myocarditis from the virus still exceeds the risk of dying of myocarditis from the vaccine.

There's several studies that have shown myocarditis from the virus is indistinguishable from previously-measured myocarditis in the population in general - that the virus isn't actually causing any. At least one of them included vaccine-caused myocarditis and showed it's several times higher.

Re:Autopsy-based characterization of myocarditis after anti-... by lamontcg on Thursday December 15, 2022 @09:21PM (#34008829)
> People who were infected with COVID-19 before receiving any doses of the COVID-19 vaccines were 11 times more at risk for developing myocarditis during days 1-28 after a COVID-19 positive test.

https://newsroom.heart.org/news/myocarditis-risk-significant...

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @10:18PM (#34009511)
If we're just going to quote stuff at each other...

> Post COVID-19 infection was not associated with either myocarditis (aHR 1.08; 95% CI 0.45 to 2.56) or pericarditis (aHR 0.53; 95% CI 0.25 to 1.13). We did not observe an increased incidence of neither pericarditis nor myocarditis in adult patients recovering from COVID-19 infection.

https://pubmed.ncbi.nlm.nih.gov/35456309/

But also your source is kind of bad. It doesn't have an unvaccinated control group, so from that research there's no way to know if what they found was virus or vaccine related. But they did find an age and sex based correlation which lines up with other sources saying the vaccines are bad for young men:

> The risk of COVID-19 vaccine-associated myocarditis was higher in men younger than age 40 after a first dose of an mRNA vaccine or after a second dose of any of the 3 vaccines.

Re:Autopsy-based characterization of myocarditis after anti-... by shagie on Thursday December 15, 2022 @03:11PM (#34004988)
That first part is a mistaken belief.

There's also a useful metric for the "chance of dying" - it's known as a micromort. Each micromort is a one in a million chance of dying https://en.wikipedia.org/wiki/Micromort

A fair bit of statistical work has been done on COVID-19 and it is summarized in the wikipedia article.

    AstraZeneca vaccination against COVID-19 – 2.9 micromorts[31]
    COVID-19 infection at age 10 – 20 micromorts
    COVID-19 infection at age 25 – 100 micromorts
    COVID-19 infection at age 55 – 4,000 micromorts
    COVID-19 infection at age 65 – 14,000 micromorts
    COVID-19 infection at age 75 – 46,000 micromorts
    COVID-19 infection at age 85 – 150,000 micromorts [32]
Yes, many people survived - but those are not numbers I want to be betting against on a daily basis.

NYT - Putting the Risk of Covid-19 in Perspective Is the risk of dying from Covid-19 comparable to driving to work every day, skydiving or being a soldier in a war?

https://www.nytimes.com/2020/05/22/well/live/putting-the-ris...

> Converting this to micromort language, an individual living in New York City has experienced roughly 50 additional micromorts of risk per day because of Covid-19. That means you were roughly twice as likely to die as you would have been if you were serving in the U.S. armed forces in Afghanistan throughout 2010, a particularly deadly year.

Rare is not zero - but if you are risk adverse, then avoiding things that are fairly high up on the risk counter would be reasonable. Likewise, if there are two options (driving in a car vs driving in a motor cycle), taking the one that adds the least amount of additional risk is reasonable.

Re:Autopsy-based characterization of myocarditis after anti-... by vikingerik on Thursday December 15, 2022 @03:33PM (#34005312)
These numbers are useless going forward if they are based on the original Covid-19 strains and not the Omicron strains, which now account for virtually every case and are tens of times less lethal.
Re:Autopsy-based characterization of myocarditis after anti-... by gdavisson on Thursday December 15, 2022 @04:17PM (#34005893)
That's not true. Death rates are now much lower, but that seems to be mostly due to people having (partial) immunity due to vaccination and/or previous infection, and better treatment. Omicron variants are less intrinsically severe than delta, but delta was more intrinsically severe than the earlier variants, so it's not clear omicron's actually any lower than the original strain, alpha, etc.

For example, according to "Challenges in Inferring Intrinsic Severity of the SARS-CoV-2 Omicron Variant" (https://www.nejm.org/doi/full/10.1056/NEJMp2119682?query=fea...): "This meaningful but fairly small difference [vs Delta] implies that omicron, alpha, and wild-type SARS-CoV-2 have similar intrinsic severity."

Re:Autopsy-based characterization of myocarditis after anti-... by incrudible on Thursday December 15, 2022 @08:11PM (#34008198)
The argument does not hold water. As Omikron replaced Delta, case mortality reduced immediately, despite skyrocketing cases. Population immunity does not explain this. The figure of 75% is only arrived at by correcting for underascertainment, which is an arbitrary estimate.
Re:Autopsy-based characterization of myocarditis after anti-... by nradov on Thursday December 15, 2022 @03:15PM (#34005048)
How do those numbers change when you adjust for presence or absence of pre-existing conditions such as obesity and type-2 diabetes?
Re:Autopsy-based characterization of myocarditis after anti-... by shagie on Thursday December 15, 2022 @03:31PM (#34005276)
On the scale that micromorts work, that isn't something that it measures well. Micromorts work best for the acute risk "do X and this is your chance of dying." Adding in things that are chronic risks doesn't factor into micromorts well.

Consider "traveling 230 miles by car is 1 micromort"... but that doesn't account for impaired driving or any of the other factors known to influence likelihood or survival of a car crash.

The numbers would likely change if you further specified them, but they are useful for the broad comparisons and risk analysis.

If you've got someone going skydiving every weekend, what does that do to their life insurance rates? Well, skydiving is 8 micromorts per jump. So that's 400 micromorts per year. And that goes into some insurance premium cost calculations.

From Wikipedia:

> Micromorts for future activities can only be rough assessments, as specific circumstances will always have an impact. However, past historical rates of events can be used to provide a ball park, average figure.

Another part of this is a study about risk acceptance.

> An application of micromorts is measuring the value that humans place on risk. For example, a person can consider the amount of money they would be willing to pay to avoid a one-in-a-million chance of death (or conversely, the amount of money they would receive to accept a one-in-a-million chance of death). When offered this situation, people claim a high number. However, when looking at their day-to-day actions (e.g., how much they are willing to pay for safety features on cars), a typical value for a micromort is around $50 (in 2009). This is not to say the $50 valuation should be taken to mean that a human life (1 million micromorts) is valued at $50,000,000. Rather, people are less inclined to spend money after a certain point to increase their safety. This means that analyzing risk using the micromort is more useful when using small risks, not necessarily large ones.

That last sentence is an important one when looking at this.

Would you be willing to be paid $150 to get vaccinated?

Re:Autopsy-based characterization of myocarditis after anti-... by ajross on Thursday December 15, 2022 @03:28PM (#34005247)
Please don't. What you are doing is called "P-hacking". Yes, if you keep selecting for subsets of a dataset you'll eventually find one that, just due to random chance, looks like a statistically significant result that proves whatever it is you want to see. That's not the way you do science.

As always, xkcd explains it best: https://www.explainxkcd.com/wiki/index.php/882:_Significant

Re:Autopsy-based characterization of myocarditis after anti-... by nradov on Thursday December 15, 2022 @03:36PM (#34005352)
No that's not P-hacking. The majority of US residents have been infected at this point. The sizes of those population groups both with and without serious pre-existing conditions are so huge that there is minimal chance of an incorrect random result.

Your link is not relevant to this issue so I don't know what point you're trying to make.

To be clear I support vaccination. But patients should make their own decisions free of coercion based on informed consent with full knowledge of the risks on both sides. Don't presume to patronize them with spurious, bad faith comments about "P-hacking". Let's see the actual data.

Re:Autopsy-based characterization of myocarditis after anti-... by ajross on Thursday December 15, 2022 @03:38PM (#34005379)
Right, you have a hypothesis. But you don't have data. Trying to tease out evidence for your hypothesis from existing data by slicing the data set up is the very definition of p-hacking. If you refuse to believe existing work on the basis of an unmeasured hypothesis, well, that's a different sort of logical fallacy on top of the bad statistics.

And FWIW, if you want a more complete (but much less amusing) explainer on the subject, wikipedia always comes through: https://en.wikipedia.org/wiki/Data_dredging

Re:Autopsy-based characterization of myocarditis after anti-... by s1artibartfast on Thursday December 15, 2022 @03:52PM (#34005585)
This is not at all correct. By your definition looking at anything in greater detail is P hacking.

For example, peanut allergies don't exist because most people don't have reactions to them. You absolutely can ask the question for if peanuts are good or bad for a subpopulation.

The alternative is just sticking your head in the sand.

Re:Autopsy-based characterization of myocarditis after anti-... by kbenson on Thursday December 15, 2022 @04:18PM (#34005898)
The difference is in the motivations for asking the question and what's done with the answer (so agenda). People are assuming and agenda of others in this thread, and are crafting responses to head of that perceived agenda without actually answering the question, which is rarely productive, IMO. Better to ask than assume, or if the answer is known, provide it with a caveat that it doesn't actually support the specific cases you're worried it might be used for erroneously.
Re:Autopsy-based characterization of myocarditis after anti-... by nradov on Thursday December 15, 2022 @07:03PM (#34007642)
Wrong, I do not have a hypothesis (or any sort of preconceived notion). I am just curious to see what the data shows about risk stratification across age groups with and without common risk factors. Do you have any references to recent peer reviewed studies on that topic?

I'm not sure why you're trying to derail the discussion by bringing up data dredging. That would only potentially be relevant as a possible criticism of the methodology in a particular study. So what's your point?

Re:Autopsy-based characterization of myocarditis after anti-... by asterix_pano on Thursday December 15, 2022 @03:43PM (#34005467)
I would not call "P-Hacking" wishing to know the stats of the group you're in, especially if there are significant differences between groups.
Re:Autopsy-based characterization of myocarditis after anti-... by lurquer on Thursday December 15, 2022 @04:31PM (#34006057)
The global risk of death from childbirth is X.

It isn’t p-hacking for a dude to inquire what the chances are for the male subgroup.

Re:Autopsy-based characterization of myocarditis after anti-... by VancouverMan on Thursday December 15, 2022 @04:25PM (#34005994)
We have to be extremely cautious when considering any of the death-related statistics for this particular situation.

For example, we know that a dubious methodology was used for counting deaths in Toronto (Canada's most populous city, and the fourth most populous city in North America).

This was publicly admitted to by Toronto Public Health itself, as early as June 2020:

"Individuals who have died with COVID-19, but not as a result of COVID-19 are included in the case counts for COVID-19 deaths in Toronto."

https://twitter.com/TOPublicHealth/status/127588839006028596...

I can't see how that significant city's death stats could be considered reliable or usable for analytic purposes, after considering how the counting was done. The provincial and national stats would also be affected to some extent.

This makes me quite doubtful about the stats coming out of other regions, too.

Re:Autopsy-based characterization of myocarditis after anti-... by shagie on Thursday December 15, 2022 @04:56PM (#34006379)
The paper those numbers are based on is Assessing the age specificity of infection fatality rates for COVID-19: systematic review, meta-analysis, and public policy implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721859/

The meta-analysis is looking at that question that you are asking.

It also has all the papers that it cites for analysis and an analysis of its own limitations.

> The systematic review encompassed 113 studies, of which 27 studies (covering 34 geographical locations) satisfied the inclusion criteria and were included in the meta-analysis.

Re:Autopsy-based characterization of myocarditis after anti-... by cthulha on Thursday December 15, 2022 @06:36PM (#34007387)
The question nobody else has been able to answer is "What is a satisfactory analysis for these purposes?"

The closest I've seen to an answer is to remove accidental deaths (eg, hit by a car, firearms fatality, etc) but there's a huge range of arguable cases like stroke which is plausibly covid-affected. Second, you have the problem of comparing stats between locations that used different definitions, so it's harder to do post-hoc correlations.

The decisions seems to have been avoiding false-negative mistakes by increasing false positives in the first wave of analysis: "Let's include everything under a simple rule for covid stats so that we at least have some kind of worst-case baseline modelling with similar datasets, and we can figure out afterwards which are real and which aren't"

Anyway, just wanted to see if you actually have a better answer to the problem than the standard that was used.

Re:Autopsy-based characterization of myocarditis after anti-... by graeme on Thursday December 15, 2022 @08:18PM (#34008257)
You have to look at both sides of the equation. There are excess deaths in every region coinciding with Covid spikes. It takes enormous mental gymnastics to say “some deaths were over counted so deaths as a whole must be over counted” and completely discount the probability of missing deaths too.

The recent Paxlovid study supports this. It reduces deaths days 30-90. Deaths that would not be counted as Covid deaths. But they clearly are if paxlovid reduces them.

Re:Autopsy-based characterization of myocarditis after anti-... by JamisonM on Thursday December 15, 2022 @09:10PM (#34008731)
Yeah, it is just wacky stuff for people to be "COVID-19 NBD" while the hospitals are full and the morgues can't keep up with refrigeration requirements... it is not worth engaging with. The exact count doesn't matter, the spikes demonstrate the truth of the issue.
Re:Autopsy-based characterization of myocarditis after anti-... by stephen_g on Thursday December 15, 2022 @10:57PM (#34009930)
I think that's a pretty specious argument though. Other statistics are available (especially excess deaths) that can pretty clearly help show what was going on along with the COVID death numbers (i.e. a significant increase in the number of people dying through the pandemic who most likely wouldn't have died during that time otherwise, in proportions generally tracking more or less to the reported COVID deaths). It's not like the reported numbers of COVID deaths exist in a vacuum to be able to be so sceptical of them!
Re:Autopsy-based characterization of myocarditis after anti-... by rallison on Friday December 16, 2022 @12:06AM (#34010589)
> This was publicly admitted to by Toronto Public Health itself, as early as June 2020:

> "Individuals who have died with COVID-19, but not as a result of COVID-19 are included in the case counts for COVID-19 deaths in Toronto."

I don't know the particulars of Toronto Public Health, but this wasn't uncommon for immediate reporting vs death record reporting. Since, in many places, comprehensive death records can take a few weeks (or longer!) to go through the pipeline before ending up on finalized reports, it's useful to have more immediate death reporting during a pandemic. Such immediate reporting is necessarily going to be a little rougher around the edges, but it generally gets you pretty close to the real numbers.

But, it's absolutely true that this immediate reporting isn't perfect. Still, it's very useful, and usually close enough for near term needs. Taking the Toronto example, the main tradeoffs are that a) you include some deaths where Covid wasn't actually a contributing factor and b) you miss deaths where the person was never tested for Covid (especially applicable to deaths that occurred at home). Often, these two somewhat balanced themselves out, but only in places with fairly high levels of testing.

Then, in the medium to longer term, you can switch over to relying on more comprehensive death records. This helps to filter out non-causal scenarios (e.g. the "hit by bus, tested positive for covid, died" scenarios). It also helps add in cases that were initially missed (had symptoms of covid, never went to hospital, died at home, etc).

Finally, to validate numbers, we can also look at excess deaths. This helps ensure that we're not wildly off base with reported numbers. Excess deaths isn't a perfect metric to compare to, but it's still a great benchmark.

To wrap up this comment, let me respond to this:

> We have to be extremely cautious when considering any of the death-related statistics for this particular situation.

I fully agree, but.. I would suggest that your comment missed a lot of the accuracy refinement that happens in practice over the medium to longer term. Additionally, it's very much worth pointing out that, with additional analysis (from death records, from excess death analysis, etc), we've found that very few places were likely over-reporting Covid deaths, but that a significant number of places were under-reporting Covid deaths. So, yes, take shorter term Covid death stats with a grain of salt, but know that we've generally ended up reporting too low, not too high.

Re:Autopsy-based characterization of myocarditis after anti-... by Mawr on Thursday December 15, 2022 @04:58PM (#34006405)
> "Converting this to micromort language, an individual living in New York City has experienced roughly 50 additional micromorts of risk per day because of Covid-19. That means you were roughly twice as likely to die as you would have been if you were serving in the U.S. armed forces in Afghanistan throughout 2010, a particularly deadly year."

This is highly misleading. The average individual may be at such risk, just like humans have ~1.9 legs on average, but that doesn't mean that everyone walks around with their 1.9 legs.

So those statistics are based on the risk to the general population and therefore have approximately zero relevance to any single person.

Almost by definition, the disease will claim those most vulnerable first, so questioning whether vaccination is worth it for those less vulnerable is valid.

What're the risks of vaccination vs covid for a healthy 25 year old who works from home?

Re:Autopsy-based characterization of myocarditis after anti-... by s1artibartfast on Thursday December 15, 2022 @05:52PM (#34006946)
This exactly. You would want to see the micromort breakdown for the same populations as covid infection. You might also want to dive deeper and see if there's more specific populations and how they compare.
Re:Autopsy-based characterization of myocarditis after anti-... by shagie on Thursday December 15, 2022 @06:36PM (#34007389)
The 50 micromorts per day is from the excess deaths in NYC during spring of 2020 and comparing that mortality to being a soldier in Afghanistan in 2010.

I don't believe that comparing those two is unreasonable.

However, to your last question that is what micomorts can answer.

The risk of death from a vaccination is 2.9 micromorts. The risk of death from contracting Covid-19 for a 25 year old is 100 micromorts. So 30x greater risk.. and those are directly comparable numbers.

The other point to consider - you're not always going to be 25. I'm much closer to the 55 bracket than the 25 bracket, and that represents a 40x increase in risk... so about 1200x greater risk than vaccination.

Assuming you remain a hermit for some number of years (and Covid-19 remains endemic), is there a point where you would change your mind on the value proposition of a vaccination? And if the answer is yes - why not do it now?

Yea, currently you're comparing 2.9 micromorts vs 100 micromorts. At 25, that comparison doesn't have too much to it. 100 micromorts is not something that I think too much about either (comparable to the risk of death while giving birth for the women out there). I've done road trips that racked up 100 micromorts cumulative (more if you add in the hiking and skiing micromorts on that trip).

I'll also note I'm older now than when I was when I did that roadtrip... and there are things that I would do now to further mitigate the risks that I took back then.

It's not wrong for your age, but it is something that should be said "yes, its a risk and it is a lot riskier."

That said, there's a number even beyond that 100 micromorts to consider.

New data shows long Covid is keeping as many as 4 million people out of work - https://www.brookings.edu/research/new-data-shows-long-covid...

> 1.6 million full-time equivalent workers could be out of work due to long Covid. With 10.6 million unfilled jobs at the time, long Covid potentially accounted for 15% of the labor shortage.

That 4M number is not part that I want to be part of. While I have better than average health insurance, the not-dying also has a significant risk to it too. It is harder to quantify as it isn't an accurate cause of mortality - but it is not something that should be ignored.

Many people here enjoy better than average salaries - consider the risk of going on long term disability for the next 40 to 60 years with the corresponding reduction in compensation. And yes, I know people who are no longer able to work on anything that has a deadline or expectations of attendance in meetings; their lifestyle has changed significantly from three years ago.

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @07:15PM (#34007738)
> The 50 micromorts per day is from the excess deaths in NYC during spring of 2020 and comparing that mortality to being a soldier in Afghanistan in 2010.

So in other words it's pretty inflated.

1) Putting covid-positive patients in nursing homes instead of isolating them

2) Excess use of ventilators set to maximum

3) Omicron

4) I feel like I'm forgetting something...

Re:Autopsy-based characterization of myocarditis after anti-... by shagie on Thursday December 15, 2022 @08:52PM (#34008581)
The NYC numbers are from the spring of 2020. This was before Omicron and before Delta.

https://www.cdc.gov/mmwr/volumes/69/wr/mm6919e5.htm was a initial report on the excess deaths in NYC in the spring of 2020.

The by age micromorts are based on a paper that was published in December of 2020. Delta was first detected in the US in Feb of 2021 and named in May of 2021 - again, those numbers are before Delta and Omicron (and vaccination).

The numbers may not be current, but they are not inflated. They are an accurate representation of the excess deaths at that time.

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @10:13PM (#34009445)
> This was before Omicron and before Delta.

> The numbers may not be current, but they are not inflated. They are an accurate representation of the excess deaths at that time.

That is exactly my point for mentioning Omicron: When you introduced them above you were using them for current risk.

Re:Autopsy-based characterization of myocarditis after anti-... by CrimsonRain on Friday December 16, 2022 @03:12AM (#34012100)
Why does vaccine has one micromort where COVID has it broken down by age group? Are you saying vaccine sets the risk to constant regardless of age?
Re:Autopsy-based characterization of myocarditis after anti-... by jtc331 on Thursday December 15, 2022 @10:33PM (#34009693)
You didn’t stratify vaccination risk by age which immediately calls into question your comparative data. Indeed the myocarditis risk appears to be inversely correlated with age (exactly the opposite of the positive correlation of risk COVID itself has with age).
Re:Autopsy-based characterization of myocarditis after anti-... by vannevar on Thursday December 15, 2022 @02:53PM (#34004741)
Because a) the risk from covid, while small, is still greater than the risk from the vaccines and b) unvaccinated people are more likely to be infected and become a vector for the virus, infecting other people.
Re:Autopsy-based characterization of myocarditis after anti-... by dtauzell on Thursday December 15, 2022 @03:00PM (#34004834)
Is there any evidence for (b)? My understanding is that you are just as likely to get vaccinated and "shed" the virus for just as long, but are less likely to be severely sick.
Re:Autopsy-based characterization of myocarditis after anti-... by mtillman on Thursday December 15, 2022 @03:12PM (#34005001)
I think you mean "get sick" which is untrue. You are less likely to get sick if vaccinated. You are also less likely to experience severe symptoms if vaccinated. https://health.howstuffworks.com/wellness/preventive-care/va...
Re:Autopsy-based characterization of myocarditis after anti-... by bryanlarsen on Thursday December 15, 2022 @03:15PM (#34005049)
Your understanding is wrong. Vaccinated and unvaccinated people with symptomatic COVID shed at comparable rates, but vaccinated people are less likely to get symptomatic COVID. The difference wanes considerably if your last shot was > 6 months ago, but is still present.
Re:Autopsy-based characterization of myocarditis after anti-... by bscphil on Thursday December 15, 2022 @04:23PM (#34005958)
> unvaccinated people are more likely to be infected and become a vector for the virus, infecting other people.

I'd add to this the fact that it was especially true earlier in the pandemic, and at that time COVID was significantly more likely to be fatal. Even if someone rejects the idea of getting a fourth dose of the vaccine (rightly or wrongly), it's possible to think that the first two doses were an entirely reasonable one-time intervention into an ongoing pandemic that saved many thousands of lives.

Re:Autopsy-based characterization of myocarditis after anti-... by commandlinefan on Thursday December 15, 2022 @05:45PM (#34006860)
> unvaccinated people are more likely to be infected and become a vector for the virus

I've read conflicting accounts of whether that's true or false, but even if it is - what difference does it make? We're not going to reach heard immunity here. Everybody's going to get it, several times throughout their lives, no matter what we do at this point.

Re:Autopsy-based characterization of myocarditis after anti-... by driggs on Thursday December 15, 2022 @03:18PM (#34005094)
Because vaccination prevents you from spreading covid to others, whose risk of dying may be higher than yours.

Choosing not to take Advil affects nobody but you. Choosing not to get vaccinated against a highly-contagious virus affects society.

Re:Autopsy-based characterization of myocarditis after anti-... by ceejayoz on Thursday December 15, 2022 @03:22PM (#34005166)
> Because vaccination prevents you from spreading covid to others...

I agree with your general point, but to be clear, it likely reduces your chances of doing that, to some extent. It does not prevent you from spreading COVID.

Re:Autopsy-based characterization of myocarditis after anti-... by bryanlarsen on Thursday December 15, 2022 @03:29PM (#34005254)
Those two sentences are equivalent, not contradictory. We commonly say that condoms prevent pregnancy and STD's, but they're not perfect either.

If the vaccine prevents one case of spread while not preventing another, it has still prevented COVID spread.

Re:Autopsy-based characterization of myocarditis after anti-... by ceejayoz on Thursday December 15, 2022 @03:32PM (#34005294)
"Not perfect" and "has a small impact" aren't the same. If condoms had the same failure rate in preventing STDs/pregnancy as the COVID vaccines do for preventing infection, we wouldn't use them. Luckily, preventing infection isn't the only goal of vaccines, so it's still worth getting for the protection from severe illness and death.
Re:Autopsy-based characterization of myocarditis after anti-... by bscphil on Thursday December 15, 2022 @04:19PM (#34005914)
> If condoms had the same failure rate in preventing STDs/pregnancy as the COVID vaccines do for preventing infection, we wouldn't use them.

No? If they were the best form of contraception we had (which is the relevant comparison w.r.t. vaccines), of course people would use them! It would make abstinence marginally more appealing, of course, but there are already people who don't want or can't afford a pregnancy who unwisely choose to forgo contraception. There would certainly be an enormous number of people who would choose to use condoms rather than forgo sex entirely.

Re:Autopsy-based characterization of myocarditis after anti-... by driggs on Thursday December 15, 2022 @05:33PM (#34006762)
If vaccination prevents you from catching covid, then it has prevented you from spreading covid to those you would have otherwise.

If vaccination causes you to experience an early immune response, versus several asymptomatic days while unknowingly contagious, then it has prevented you from spreading covid to some of those you would have otherwise.

If vaccination results in a less severe infection with lower viral load, then it has prevented you from spreading covid to some of those you would have otherwise.

My reply was intentionally simple in order to drive home a point about selfish versus societal viewpoints.

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @07:27PM (#34007818)
> If vaccination prevents you from catching covid, then it has prevented you from spreading covid to those you would have otherwise.

Depends on what you mean by "covid" here. If you're referring to the virus, then no - this is a misconception. The vaccines at best only reduce symptoms, they don't stop infection or transmission.

> versus several asymptomatic days while unknowingly contagious

This was also an early guess that turned out to be wrong. We've known this wasn't a thing for years, at least before these vaccines.

> My reply was intentionally simple in order to drive home a point about selfish versus societal viewpoints.

Right now, getting vaccinated is the selfish action because it's likely to turn you into an asymptomatic spreader. At least when unvaccinated you'll know to stay home.

Re:Autopsy-based characterization of myocarditis after anti-... by ceejayoz on Thursday December 15, 2022 @08:41PM (#34008465)
> Right now, getting vaccinated is the selfish action because it's likely to turn you into an asymptomatic spreader. At least when unvaccinated you'll know to stay home.

This is a) insane and b) directly contradicts the point you tried to make above it.

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @10:21PM (#34009549)
How does it contradict it? These vaccines reduce symptoms without stopping infection/transmission -> you're helping yourself without helping the community -> it's the selfish action.
Re:Autopsy-based characterization of myocarditis after anti-... by ceejayoz on Thursday December 15, 2022 @10:24PM (#34009576)
You can't argue asymptomatic spread isn't a thing, and then claim the vaccines are bad because they cause asymptomatic spread.
Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @11:14PM (#34010086)
> > We've known this wasn't a thing for years, at least before these vaccines.

If I remember the timeline right it was mid/late 2020 we realized that assumption was wrong, then about a year later it was apparent the vaccines weren't stopping the spread. So yeah, my statements are entirely consistent: There wasn't before the vaccines, there was after.

Re:Autopsy-based characterization of myocarditis after anti-... by nradov on Thursday December 15, 2022 @03:49PM (#34005536)
Vaccination has only limited and temporary effects in reducing the risk of transmission. I would encourage everyone eligible to protect themselves by getting vaccinated but this does very little to prevent it from spreading in society.

https://doi.org/10.1056/nejmoa2116597

Re:Autopsy-based characterization of myocarditis after anti-... by woodruffw on Thursday December 15, 2022 @03:53PM (#34005600)
Spread is just one social effect. I think the GP meant that there are plenty of other civic motivations, like not overloading medical institutions and minimizing the extent to which society needs to be halted to prevent particularly harmful spread.
Re:Autopsy-based characterization of myocarditis after anti-... by nradov on Thursday December 15, 2022 @04:03PM (#34005742)
By all means I would encourage everyone eligible to get vaccinated. But there was never any valid reason to halt society in the first place, so your comment is a non sequitur.

Even before the COVID-19 pandemic, it was routine for medical institutions to be overwhelmed by respiratory viruses. We didn't halt society, we just accepted the consequences and moved on.

https://time.com/5107984/hospitals-handling-burden-flu-patie...

https://peterattiamd.com/covid-19-current-state-omicron/

Re:Autopsy-based characterization of myocarditis after anti-... by woodruffw on Thursday December 15, 2022 @04:23PM (#34005964)
There's a significant difference in kind between "a nasty cold or flu season" and the excess mortality rate we've seen during COVID, particularly earlier in the pandemic[1].

There's no non sequitur here: getting vaccinated reduces every demographic's risk of serious illness (even when serious illness is not especially likely!), which in turn reduces the burden on healthcare institutions. That is a good civic reason to get vaccinated that has nothing to do with transmission.

[1]: https://www.cdc.gov/nchs/nvss/vsrr/covid19/excess_deaths.htm

Re:Autopsy-based characterization of myocarditis after anti-... by JamisonM on Thursday December 15, 2022 @10:31PM (#34009668)
"there was never any valid reason to halt society in the first place"

Look whatever you think about anything full hospitals everywhere and people in Spain being left for dead in old folks homes were definitely real things - I am not sure about your definition of "halt society" here but policy choices that reduced social contact in indoor spaces was absolutely required. You just can't rewrite history if that is what you are trying to imply.

Re:Autopsy-based characterization of myocarditis after anti-... by jszymborski on Thursday December 15, 2022 @02:54PM (#34004753)
[deleted, I retract my statement]
Re:Autopsy-based characterization of myocarditis after anti-... by tempsy on Thursday December 15, 2022 @03:06PM (#34004920)
Myocarditis literally has it's own page on the CDC covid vaccine website https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/my...
Re:Autopsy-based characterization of myocarditis after anti-... by ajross on Thursday December 15, 2022 @03:25PM (#34005208)
With all respect, this is terrible logic. You have two probabilities to compare, not one to compare to zero! If and only if the vaccine is more dangerous then your "improbably small chance of dying of covid", you should forego the vaccination.

Is it? No. It is not. Not even for the best protected youngest cohort. Get your shot. You're being misled by politics and tiny, difficult numbers.

Re:Autopsy-based characterization of myocarditis after anti-... by neuralRiot on Thursday December 15, 2022 @05:07PM (#34006498)
> why is it necessary to be vaccinated even if there's only a small chance of side effects? Rare is not zero.

In my case i vaccinated because i knew i was a transmission node in case of being infected and not noticing, potetially endangering multitude of vulnerable people.

Re:Autopsy-based characterization of myocarditis after anti-... by encryptluks2 on Thursday December 15, 2022 @02:54PM (#34004752)
There is a lot of evidence that the system to report vaccine injuries is largely ignored and people that report issues are ostracized for doing so. It also begs to question how often injuries would go unreported or misreported because of the difficulties of being linked to the actual cause, and many doctors may be unwilling to claim a vaccine caused an injury just due to the stigma around vaccine injuries, especially in regards to COVID-19.
Re:Autopsy-based characterization of myocarditis after anti-... by Daishiman on Thursday December 15, 2022 @03:17PM (#34005074)
I really hope you're not talking about VAERS, because that's about the flimsiest mechanism you could conceive.
[dead]
Re:Autopsy-based characterization of myocarditis after anti-... by addingadimensio on Thursday December 15, 2022 @03:09PM (#34004964)
Wow down votes and no fucking refutations of the Central point I can tell I’m surrounded by liberals
Re:Autopsy-based characterization of myocarditis after anti-... by dang on Thursday December 15, 2022 @03:31PM (#34005283)
We've banned this account for using HN primarily for ideological battle. You can't do that here, and yes that rule holds regardless of which ideology you're battling for or against. It's not what this site is for, and destroys what it is for. Please don't create accounts to break HN's rules with.

https://news.ycombinator.com/newsguidelines.html

Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @03:49PM (#34005538)
> The problem is the massive leaps of logic being made by people who have (quite wrongly, based on available evidence) become convinced that the vaccines are a greater threat to healthy people than the virus is.

In some cases, it may well be true that the vaccine is a greater risk than the virus. For example, in Australia, the official recommendation is that people under 30 not receive a fourth dose of COVID-19 vaccine, since Australian health officials believe the risk from vaccine side effects (such as myocarditis) in that age group outweighs the risk of COVID-19 itself. [0] Furthermore, in the 30-49 age group, the official Australian position on fourth doses is "permitted but not recommended", since it is unclear if the risk of COVID-19 is greater than that of the vaccine. This is different from the recommendations made by a number of other countries (US, UK, Canada, Singapore), but it appears Australian health authorities weigh the risk of vaccination side effects versus the risk of COVID-19 differently than they do.

[0] https://www.smh.com.au/national/why-you-won-t-get-another-co...

Re:Autopsy-based characterization of myocarditis after anti-... by wsc981 on Thursday December 15, 2022 @04:10PM (#34005820)
Denmark doesn’t recommend COVID vaccines anymore to anyone under 50 who is not at risk or work in health sector [0].

> People aged under 50 are generally not at particularly higher risk of becoming severely ill from covid-19. In addition, younger people aged under 50 are well protected against becoming severely ill from covid-19, as a very large number of them have already been vaccinated and have previously been infected with covid-19, and there is consequently good immunity among this part of the population.

———

[0]: https://sst.dk/en/English/Corona-eng/Vaccination-against-cov...

Re:Autopsy-based characterization of myocarditis after anti-... by birken on Thursday December 15, 2022 @05:21PM (#34006652)
While I think it is certainly fair to talk about the policies of other countries, I don't think just because another country has a different policy necessarily dictates that policy is better or worse.

Additionally, I think it's very easy to see something like "Denmark doesn't recommend the vaccines to anybody under 50" and conflate that it means that Denmark doesn't think vaccines were ever beneficial to people under the age of 50 (which is the leap in logic you often see on anti-vax sites). But that isn't the case. What was good health policy in 2021 is different from good health policy now, because we have way more information about the virus, better and more effective drug to treat it, new variants, etc.

Two things can be true at the same time: The vaccines are (on net) incredibly beneficial to people and the population as a whole, and yet at the present time there are certain specific populations of people whose optimal number of doses might be fewer than others.

Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @05:49PM (#34006907)
> While I think it is certainly fair to talk about the policies of other countries, I don't think just because another country has a different policy necessarily dictates that policy is better or worse.

Sure. But if a person is aware that other countries have different policies, that gives them a legitimate reason to question whether the policy of their own country is correct. If a person looks into the matter, and decides not to follow the recommendations of their own government, because they think some other country's government is more likely to have got it right, such a person isn't necessarily being irrational/irresponsible/etc, nor would it necessarily be irrational/irresponsible/etc for them to share their conclusion with others.

> and conflate that it means that Denmark doesn't think vaccines were ever beneficial to people under the age of 50 (which is the leap in logic you often see on anti-vax sites)

Yes, many people do seem to conflate these two claims:

(1) "for healthy children and young people, the safety risk of additional doses of the vaccine currently outweighs the risk of COVID-19"

(2) "for healthy children and young people, the safety risk of any dose of the vaccine has always outweighed the risk of COVID-19"

While the claim (1) is disputed, some highly respected medical experts agree with it; the same cannot be said for claim (2).

However, I think this conflation goes in both directions – some people who want to defend (2) do so by conflating it with (1); but conversely, some people attack (1) by conflating it with (2).

Some people can't distinguish reasonable scepticism about vaccinations from unreasonable scepticism.

Re:Autopsy-based characterization of myocarditis after anti-... by birken on Thursday December 15, 2022 @06:31PM (#34007349)
Yeah, I agree completely.

It also is difficult position for health agencies to be in, because they want to make clear guidelines to prevent confusion, but there are gray areas. For example, it's completely possible that:

(a) The benefits outweigh the risks of a 4th shot for any age group

or

(b) The risks outweigh the benefits of a 4th shot for some or all age groups [not because the risk are high, but the benefits so low]

AFAIK, there aren't any super high quality studies anywhere in the world that have robust data on the 4th shot in particular for all age groups. So one health agency might guess one way, another health agency might guess another way. Reasonable people can disagree. The CDC got a little bit ahead of the science when they were initially recommending the 3rd shot, but in the long run it was proven to be a good gamble that no doubt saved thousands of lives. But now maybe that same logic is a mistake for the 4th shot.

But regardless of the CDC's recommendations, most people seem to have figured out the cost/benefit for themselves: The vast majority of people in the US have 2 shots, a little under half have the booster, and very few have the 4th shot. Most people probably have made the right choices for themselves given the various risks and benefits for them personally.

Re:Autopsy-based characterization of myocarditis after anti-... by polynox on Thursday December 15, 2022 @07:17PM (#34007749)
I trust that when I drive over a bridge it won't collapse.

But I cannot say I know that the bridge won't collapse.

Knowledge is a true and justified belief. But trust is not a justification - quite the opposite. If you had a justification, you wouldn't need trust.

Trust whomever you want, on whatever basis you want, but that's fundamentally not reason or rationality, it's just an argument from authority [1]. No statement becomes more true just because someone said it, regardless of who they are.

I'm not saying it's easy or even possible to do in practice. Science is insanely complex. But let's not confuse trust for rationality, not least of which because it brings to the fore the very real need for institutions that are worthy of our trust.

[1] https://en.wikipedia.org/wiki/Argument_from_authority

Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @07:41PM (#34007933)
> Trust whomever you want, on whatever basis you want, but that's fundamentally not reason or rationality, it's just an argument from authority [1]. No statement becomes more true just because someone said it, regardless of who they are.

A statement can become more likely to be true just because someone said it, depending on the nature of the statement and the person making it. For example, my brother is an oncologist. If I had some health concern about cancer, I would certainly be asking for his opinion. His opinions on that topic are not guaranteed to be correct, but as an oncologist, they are significantly more likely to be correct than that of the average person.

One problem with the frequent popular invocation of claimed "fallacies", such as "argument from authority", is many of them are only strictly speaking fallacious when used as purely deductive arguments, but real world human reasoning isn't purely deductive, it involves a great deal of induction and abduction as well. There is nothing inherently wrong with an "argument from authority" as an inductive or abductive argument.

> Knowledge is a true and justified belief. But trust is not a justification - quite the opposite. If you had a justification, you wouldn't need trust.

One can estimate the conditional probability P(proposition X is true|agent A says that X is true) based on observations of what kinds of things agent A has said in the past, and how many of them turned out to be true or false, and also for other agents similar to them. You can then use that conditional probability estimate to inform your own decision as to how much credence to give to proposition X. That is both trust and justification.

Re:Autopsy-based characterization of myocarditis after anti-... by polynox on Thursday December 15, 2022 @10:48PM (#34009850)
I was not aware of abduction before today, thank you!

I think we may agree in practice if not in theory. I did have the Hume-an problem of induction explicitly on my mind. It would be quite fair to say my epistemology is quite conservative.

Re:Autopsy-based characterization of myocarditis after anti-... by autoexec on Friday December 16, 2022 @02:13AM (#34011641)
> One problem with the frequent popular invocation of claimed "fallacies", such as "argument from authority", is many of them are only strictly speaking fallacious when used as purely deductive arguments,

There's a fallacy for that: https://en.wikipedia.org/wiki/Argument_from_fallacy

Re:Autopsy-based characterization of myocarditis after anti-... by thatcat on Thursday December 15, 2022 @08:48PM (#34008538)
You could do some theoretical calculations about bridges yourself, inspect for cracks, and prove from first principles that the bridge is in fact safe; it's not some complicated biological process.
Re:Autopsy-based characterization of myocarditis after anti-... by jasonhansel on Thursday December 15, 2022 @09:52PM (#34009176)
Isn't your citing Wikipedia, in itself, an appeal to authority? Why should we accept Wikipedia as an authority on which arguments are fallacious and which are rational?

(Also, that wiki page mentions that many authors don't see it as a fallacy.)

Re:Autopsy-based characterization of myocarditis after anti-... by polynox on Thursday December 15, 2022 @11:00PM (#34009954)
I'm just citing it for the context of the argument both for and against appeal to authority being fallacious and irrational, not that Wikipedia is the final arbiter of what's rational or not. It's more to say that my position is not novel than anything else. Indeed, to be consistent I would need to say that I don't care how many authors do or don't see it as a fallacy :)
Re:Autopsy-based characterization of myocarditis after anti-... by l8rlump on Friday December 16, 2022 @01:01AM (#34011010)
> While I think it is certainly fair to talk about the policies of other countries, I don't think just because another country has a different policy necessarily dictates that policy is better or worse.

Other countries compared to who? Not everyone here is from the same country as you :)

I don't think anyone is making a value judgment based on where the policy is from.

Re:Autopsy-based characterization of myocarditis after anti-... by entropicgravity on Saturday December 17, 2022 @01:20PM (#34030561)
The change in policy by Denmark very likely comes down to the risk of overloading their ICU's with a naive covid population. When covid first arrived everyone was susceptible to covid and the long tail of poor outcomes was enough to plug up the hospitals (and primarily the ICU's).

Now, much of the population has become either naturally or through vaccination much less susceptible to poor outcomes from a covid infection, and this is especially true of younger people.

So the response to covid was never really about the health of the population as much as it was about the health of the hospitals. The risk to the hospitals is now much lower and therefore the reasonable vaccination effort has now changed.

Re:Autopsy-based characterization of myocarditis after anti-... by blub on Thursday December 15, 2022 @04:33PM (#34006072)
I’ve been watching the vaccine discussions on HN these years and one can see that too many people are stuck fighting vaccination windmills from days gone by, while downplaying vaccine risks which by now are established and continue to be investigated as this publication shows.

Meanwhile many EU countries have understood that heart problems are a real risk and have adjusted recommendations accordingly. They’ve also stopped obsessing about vaccinating people.

The vaccination crusade’s dead folks, please stand by for the next pandemic.

Re:Autopsy-based characterization of myocarditis after anti-... by failuser on Thursday December 15, 2022 @04:55PM (#34006365)
So you argue that you should increase the risk of death or disability by COVID by not vaccinating. Got it.
Re:Autopsy-based characterization of myocarditis after anti-... by throw4659261 on Thursday December 15, 2022 @05:14PM (#34006564)
Pfizer really has you in the palm of their hand lmao
Re:Autopsy-based characterization of myocarditis after anti-... by meindnoch on Thursday December 15, 2022 @05:34PM (#34006767)
It’s the paradox of intelligence: smart people are more prone to fight tooth and nail, and do all kinds of mental gymnastics, rather than to admit that they too have been misled. People of average or below average intelligence tend to accept it much more easily.

I don’t know if there’s already a name for this phenomenon…

Re:Autopsy-based characterization of myocarditis after anti-... by marvin on Thursday December 15, 2022 @05:53PM (#34006956)
Would love to see the incidence of this by IQ. My intuition says it spikes in slightly smarter-than-average folks.
Re:Autopsy-based characterization of myocarditis after anti-... by chromatin on Thursday December 15, 2022 @07:36PM (#34007896)
This is the so-called "midwit" meme.

https://knowyourmeme.com/memes/iq-bell-curve-midwit

Re:Autopsy-based characterization of myocarditis after anti-... by api on Thursday December 15, 2022 @06:17PM (#34007190)
In my experience smart people are also far more likely to create elaborate self-reinforcing systems of belief that are detached from reality.

Any moron can understand the idea of a round Earth and stuff orbiting around it. It takes a genius to comprehend the sublime intricacies of ether vortex theory which explains how a flat Earth can still permit satellites to stay airborne over the plane.

I've met an extremely intelligent person who was convinced we never landed on the Moon and that Stanley Kubrick faked the whole thing and left clues to this in his production of The Shining. I've also met one who thinks the Nazis invented anti-gravity and are hiding the technology to this day in underground bases in Antarctica and South America.

Re:Autopsy-based characterization of myocarditis after anti-... by mancerayder on Thursday December 15, 2022 @07:19PM (#34007761)
That sounds a lot more like creativity than capacity to reason logically, or a number of other facets of intelligence. That's probably part of the issue, which properties of 'intelligence' we are talking about.

There are also a lot of crazy and intelligent people. I certainly know so many, it almost becomes a correlation.

Re:Autopsy-based characterization of myocarditis after anti-... by lsllc on Thursday December 15, 2022 @08:17PM (#34008249)
Actually, the Nazi's hid on the moon wit their anti-gravity tech:

https://www.imdb.com/title/tt1034314/?ref_=nv_sr_srsg_0

(which is an entertaining movie if you haven't seen it).

Re:Autopsy-based characterization of myocarditis after anti-... by rnd0 on Thursday December 15, 2022 @08:43PM (#34008490)
Were they convinced, or are you convinced that they were convinced? The Kubrick thing is an old joke (which usually ends by saying he insisted on filming "on location" for the sake of authenticity)
Re:Autopsy-based characterization of myocarditis after anti-... by api on Friday December 16, 2022 @08:04AM (#34014084)
They were convinced.
Re:Autopsy-based characterization of myocarditis after anti-... by rnd0 on Thursday December 15, 2022 @08:41PM (#34008471)
I don't either. Personally speaking, after watching the effects of disinformation campaigns over the last 7 or so years -particularly regarding Covid and vaccinations I am pretty much 1,000% unwilling to listen to any "skepticism" simply because I don't trust the source that anyone is getting their information from.

The only reasonable course I can see is to not take any chances and vaccinate early and vaccinate often.

Re:Autopsy-based characterization of myocarditis after anti-... by smeej on Thursday December 15, 2022 @09:09PM (#34008721)
Why would you trust the source on the side that's telling you something new, but not the side that's skeptical of it?
Re:Autopsy-based characterization of myocarditis after anti-... by majormajor on Thursday December 15, 2022 @11:28PM (#34010215)
"Misled" is a stupid word for "we constantly learn more and should be adapting our positions."

There is zero evidence for a "haha i told you you were being misled" position. You are performing either foolish or disingenuous logical gymnastics to equate something like "adjusted recommendations accordingly" with "it was intentionally misleading the whole time."

Show me a place where people haven't adjusted their behavior as the virus has evolved, more time has passed creating more data, vaccination rounds have been administered, death rates have evolved, and exposure/infection has happened. It ain't here in liberal California, so is there any such strawman place you're arguing against in the US? Go out on the street and look around and observe that people are being rational and adapting over time instead of keeping up your silly little "haha i'm smarter than you you fell for a hoax" keyboard battle.

Re:Autopsy-based characterization of myocarditis after anti-... by simplotek on Thursday December 15, 2022 @08:54PM (#34008594)
> For example, in Australia, the official recommendation is that healthy people under 30 not receive a fourth dose of COVID-19 vaccine (...)

It should be stressed that this guidance explicitly refers to a fourth dose of a vaccine. I feel it's disingenuous to use this example to try to refute the OP when the problem lies in people taking massive leaps of logic such as going from "it's ok to take 3 doses of a vaccine but the benefits of a fourth might not justify it" to "don't get vaccinated ever because you will die".

Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @09:16PM (#34008779)
> "it's ok to take 3 doses of a vaccine but the benefits of a fourth might not justify it"

That's not what the Australian health authorities are saying. They aren't just saying that "the benefits of a fourth might not justify it", they are saying "(for healthy young people) the health risks of the fourth dose likely outweigh the health benefits"–your rephrasing ignores that safety risk aspect.

In my mind, there are three different positions here:

(1) "Vaccines are perfectly safe, and anyone who even mentions death or serious injury caused by vaccination is just being an alarmist"

(2) "Everyone who took the deadly COVID vax is about to drop dead! Just watch!"

(3) "Vaccines have real safety risks, some people have died from vaccination, and it is certain that more people will die from them in the future. However, sometimes, the risk of death or disability from the disease the vaccine is intended to prevent, is going to be significantly higher than the risk of death or disability from the vaccine. Whether or not that is true in any particular case is going to vary depending on the particular disease, its current prevalence, availability of treatments for it, etc; whether the disease or the vaccine poses the greater health risk will vary across time, place, disease and vaccine; our estimates of those respective risks are always going to be imperfect, evolving, and open to informed disagreement; generally we should trust the public health authorities to make that judgement for us, but they are not infallible, and it can be legitimate to doubt or question their judgement in any particular case"

I see myself as defending (3), whereas what some other people in this conversation are saying seems to me to be closer to (1), and also encouraging the fallacious conflation of (3) with (2).

Re:Autopsy-based characterization of myocarditis after anti-... by OrvalWintermute on Thursday December 15, 2022 @10:39PM (#34009750)
There is actually a (4) also, which we can see evidence for in a paper such as [1] in the paper Efficacy and effectiveness of covid-19 vaccine - absolute vs. relative risk reduction

Summarized: The Covid vaccines have real safety risks for which there is a body of evidence, that taken in totality, leads one to believe that the temporal and Absolute Risk Reduction of =< 0.85% is not worth the adverse events. Given the suppression of data around the true adverse events, and the time limited protections from the vaccines, it should be used sparingly after the patient is fully informed of the risks, and minimal protections provided. Given the uniqueness of each patient's medical situation though, patients are in the best position to decide if their comorbidities are sufficient to merit the risks of these vaccines. Similarly to the Nordic countries, any younger person without severe comorbidities < 50 should not take the vaccine, but they should be able to make their own decision fully informed of the risks and limited protection, and without any type of coercion.

I don't believe that all Covid vaccines share the same risks since the microgram dosing of the MRNA vaccines vary greatly, and the Novavax vaccine [2] [3] is coming onto the scene, unfortunately with a few of the same adverse events as the MRNA vaccines though

[1] https://www.tandfonline.com/doi/full/10.1080/14760584.2022.2...

[2] https://www.yalemedicine.org/news/novavax-covid-vaccine

[3] https://us.novavaxcovidvaccine.com/hcp

Re:Autopsy-based characterization of myocarditis after anti-... by simplotek on Friday December 16, 2022 @06:44AM (#34013507)
> That's not what the Australian health authorities are saying. They aren't just saying that "the benefits of a fourth might not justify it", they are saying "(for healthy young people) the health risks of the fourth dose likely outweigh the health benefits"–your rephrasing ignores that safety risk aspect.

This is a red herring.

It's irrelevant if anyone feels that the 3rd or 4th or 5th dose of Pfiser's increases health risks. The problem is the misrepresentation of these findings. You cannot in good faith jump from "a residual number of people experience health issues when taking the 4th or 5th dose of Pfiser's vaccine" to "do not take any vaccine at all ever or you'll die" specially when they deny that COVID poses a threat and already killed over 6million people.

You're talking about health concerns of taking a vaccine when not taking the vaccine poses a far greater threat, and somehow that's left out of the equation. That's the problem: the disingenuous misrepresentation of the problem.

Re:Autopsy-based characterization of myocarditis after anti-... by kyleblarson on Thursday December 15, 2022 @03:52PM (#34005577)
I think a lot of the resentment comes out of "the experts" changing their narratives a dozen times about the efficacy of the vaccines over the last 3 years while browbeating anyone who voiced any amount of skepticism.
Re:Autopsy-based characterization of myocarditis after anti-... by ajross on Thursday December 15, 2022 @03:58PM (#34005661)
I see this point so often that it's sort of become a shibboleth for identifying political affiliation. And I still don't really understand it. Have the experts ever been saying anything significantly different than "get your shot"? Have they ever been wrong about that? No on both counts, right?

I'm genuinely curious what you mean here about "changing their narratives a dozen times about the efficacy of the vaccines"?

Re:Autopsy-based characterization of myocarditis after anti-... by mrguyorama on Thursday December 15, 2022 @04:23PM (#34005969)
These people also seem to ignore that CIRCUMSTANCES HAVE CHANGED QUITE A BIT over the entire pandemic. Of COURSE recommendations made when the vaccine first came out might need to be modified or updated as more gets learned about possible side effects and how it interacts with different variants.

These people never seem to have a problem with the changes in the polio vaccine over the years, or chickenpox

Re:Autopsy-based characterization of myocarditis after anti-... by mcronce on Thursday December 15, 2022 @05:04PM (#34006466)
They also like to yell and scream about how "science can't make up its mind"

Yes, because that's how science works. When new information is acquired, new hypotheses are created and tested.

Re:Autopsy-based characterization of myocarditis after anti-... by gjsman-1000 on Thursday December 15, 2022 @05:11PM (#34006531)
People were literally fired from their jobs, removed from 30+ year military careers, over the science, only for the science to keep changing.

If science can't make up its mind and this is "how science works," anyone who thinks anything should be mandated based on science should be shot. You can't tell people something, have it directly and deeply affect their personal lives, then tell them something substantially different 2 years later, without people grabbing pitchforks. Your theoretical definition of science is irrelevant and makes popular perception of "science" a whimsical joke.

Re:Autopsy-based characterization of myocarditis after anti-... by dekhn on Thursday December 15, 2022 @06:12PM (#34007147)
The military isn't a good example because they already have mandatory vaccines and those were completely supported, it wasn't until the fairly recent anti-vaccine drama (autism/mercury) mixed with the distrust of the establishment promoted by Trump, that military people (or right-wing media) began to turn this into an issue that people cared about.
Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @06:38PM (#34007411)
> that military people (or right-wing media) began to turn this into an issue that people cared about

Historically, the majority of opposition to vaccines has been "left-wing" rather than "right-wing". It was only really with COVID that it suddenly picked up on the right as well. I've had some rather frustrating conversations online with people (mostly Americans it seems) who are utterly convinced that it is fundamentally a "right-wing" phenomenon, and seem to just want to ignore the evidence of its long history among self-identified "progressives":

https://www.smh.com.au/lifestyle/health-and-wellness/how-one...

Re:Autopsy-based characterization of myocarditis after anti-... by dekhn on Thursday December 15, 2022 @06:47PM (#34007494)
I am not aware of what was the case historically (roughly before I was vaccinated as a kid), but I will point out the switch happened before covid- around 2015- and was fairly partisan. Note that extreme idealogies sort of "wrap around" the political spectrum- another area with extremely low vax rates for some time was Marin, which is highly educated and liberal.
Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @07:05PM (#34007661)
I wonder to what extent any "partisan switch" is primarily a US thing? Here in Australia, while some right-leaning people (especially the "hard" right) have in recent years become "anti-vaccine", I haven't seen any comparable evidence of traditional left-leaning "anti-vaccine" adherents abandoning it

I can think of two people my wife and I know personally who are vocally "anti-vax" – one is a rather conservative Christian, the other is a woman with a long-standing interest in the New Age / Tarot / occult / crystals / psychics / alternative medicine / etc. The first, when I was younger (15–20 years ago), I used to run in his circles a lot, and I never heard anybody say anything remotely against vaccines at any of the churches / youth groups / bible studies / etc I used to go to with him. He only started becoming "anti-vax" around when COVID started, and it obviously had a lot to do with US politics (he was a big Trump fan, and so was his church–I'm not sure if they still feel the same way about him now), despite living on the other side of the planet. Even then, he was always primarily "anti-COVID vax" rather than "anti-vax" in general.

Our "New Age" friend, her being "anti-vax" was entirely expected, because "anti-vax" opinions have always been very common among people like her. She became very political about it around COVID, organising protests, etc. It became even more intense when she lost her government job (as an adult vocational education teacher) due to her refusal to be vaccinated against COVID. But, the anti-vax protest movement she became involved in was rather left-leaning, it was all composed of New Age types, hippies, etc, who live in a "hippy area" (the Northern Rivers district of New South Wales). I think if someone like our other friend – a conservative Christian spouting pro-Trump rhetoric – had turned up at one of her protests, she would have run them off.

> Note that extreme idealogies sort of "wrap around" the political spectrum

I don't know if that's really true though. While opposition to COVID vaccination may be one of the very few things these two friends of ours could agree on, I think their reasons for their respective positions are very different. I'm not sure the whole "wrap around" or "horseshoe" thesis is really that useful in understanding why two people from opposite ends of the political spectrum may occasionally end up agreeing on something, even something outside the mainstream.

Re:Autopsy-based characterization of myocarditis after anti-... by gs17 on Thursday December 15, 2022 @09:30PM (#34008916)
Yeah, I remember an episode of The Simpsons circa 2016 (so they probably wrote it in 2015) where they call it out as a "liberal" thing.
Re:Autopsy-based characterization of myocarditis after anti-... by gjsman-1000 on Thursday December 15, 2022 @06:48PM (#34007508)
It's not an unreasonable position, or lacking in common sense, to insist that any new drug, particularly one using new technology that has not been used before, have more than one year of testing before it is made mandatory, regardless of the assurances of scientists.

Furthermore, entering the military requires accepting a predefined list of vaccines and that is understood when entering - but adding new vaccines requires following the USC Code, which if you read, I can fully understand why some would feel very uncomfortable with it, and may feel that their protections against being "guinea pigs" have been ran around, as the USC Code would imply that this should not have happened so easily.

https://www.govinfo.gov/content/pkg/USCODE-2020-title10/html...

Re:Autopsy-based characterization of myocarditis after anti-... by skissane on Thursday December 15, 2022 @06:23PM (#34007260)
It wasn't "science" which was changing its mind though – "science" doesn't have a mind – it was the public health authorities. The same authorities would change their recommendations over time, and authorities in different countries were making different recommendations at the same time. In part, this was due to differences in circumstances (across both time and space) around the severity of the pandemic, availability of vaccines, hospital resources, etc. But, another factor was that, despite (at any given point in time) all having largely the same scientific evidence, they sometimes interpreted it in different ways, drew different conclusions from it, differed in the weight they decided to give to individual pieces of evidence, etc. It is legitimate for people to question whether they were interpreting the available evidence correctly – and this is not just a matter of hindsight, even at the time, there were qualified professionals who disagreed with their judgements.

I think this frequent conflation of "science" with "public health authority interpretations of science" is rather misguided – and it isn't just "anti-vax" people who commit that conflation, many "pro-vax" people do the exact same thing. I've always been supportive of vaccination – indeed, I have all my recommended doses of COVID-19 vaccine – but I think the excessive rhetoric which some people use against those who express doubts has been very harmful – it has actually been a major unnecessary setback in the cause of encouraging vaccination.

Re:Autopsy-based characterization of myocarditis after anti-... by zuminator on Thursday December 15, 2022 @08:16PM (#34008245)
Furthermore, not only did we learn more, but the virus itself mutated substantially over time. There were different efficacy rates given in large part because there were literally different vaccine efficacy rates for different strains of the virus.
Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Thursday December 15, 2022 @08:24PM (#34008311)
The irony of people on this site not getting that.
Re:Autopsy-based characterization of myocarditis after anti-... by kyleblarson on Thursday December 15, 2022 @05:03PM (#34006456)
"two weeks to flatten the curve", "if you get the vaccine you won't get covid", "the vaccine is 95% effective", "the vaccine is 80% effective", "the vaccine is 50% effective", "well you'll still get covid but you won't spread it to others", "well actually you can spread it to others"
Re:Autopsy-based characterization of myocarditis after anti-... by TacticalCoder on Thursday December 15, 2022 @06:39PM (#34007431)
and more... "masks serve no purpose" followed by months if not years coercing everybody into going out with a mask.

But the best one, to me, is when we go back at the very root... "You're a conspiracy theorist like those who believe the moon landing was faked if you don't accept that it's a pure coincidence that the outbreak started in a market next to a lab known to do gain-of-function research on modified bat viruses".

That tune changed too and, at least, discussing the lab leak possibility became acceptable.

It's all seriously WTF. I got two Pfizer shots but I always fought for and respected those who didn't want to get the shot.

And with all the evidence out now and all the countries saying: "We don't recommend a fourth shot if you're below this or that age", I certainly don't plan to ever get a third shot.

Re:Autopsy-based characterization of myocarditis after anti-... by yosame on Thursday December 15, 2022 @09:02PM (#34008651)
Covid was mutating, that's why the advice kept changing. Vaccines were 80% effective, than immune escape happened and the vaccines got less effective. At the same time, covid was getting better at spreading, which is why 2 weeks to flatten the curve wasn't enough.

It's not a bad thing for experts to change their opinion as new evidence comes out.

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @07:31PM (#34007846)
> efficacy of the vaccines over the last 3 years

It's only been 2 years, they were announced at the end of 2020.

Re:Autopsy-based characterization of myocarditis after anti-... by Bud on Thursday December 15, 2022 @07:35PM (#34007881)
No part of this happened. Also, experts are actually experts, so let's lose the quotation marks.

Please cite instances of "browbeating" from Fauci or other prominent public health figures. Please support this wild story in, well, any way at all.

Re:Autopsy-based characterization of myocarditis after anti-... by kyleblarson on Saturday December 17, 2022 @12:31PM (#34029989)
Like the experts who closed beaches in CA and filled in skate parks with sand so children couldn't get exercise and sunlight? Those experts?
Re:Autopsy-based characterization of myocarditis after anti-... by sudden_dystopia on Thursday December 15, 2022 @04:28PM (#34006023)
They are making these leaps of logic because people have refused to look into it…
Re:Autopsy-based characterization of myocarditis after anti-... by claytongulick on Thursday December 15, 2022 @04:42PM (#34006186)
Many other people have replied with great information, but I'm going to respectfully disagree with:

> The problem is the massive leaps of logic being made by people who have (quite wrongly, based on available evidence) become convinced that the vaccines are a greater threat to healthy people than the virus is.

I believe the problem is that we were so convinced that our solution to covid was infallible that we removed a basic human right: the ability to make informed choice about your medical care.

I'm not a conspiracy theorist, I believe that most people involved did this out of a genuine desire to save lives and help people.

The issue is the hubris.

The idea that "I know better than you do what's good for you and for society, so I'm going to force you to do a thing".

This is where we went wrong. The forcing.

If we'd presented vaccination as informed choice, had recommendations but not coercion, I think there would have been a lot less resistance.

We decided that public health was a trump card that allowed us to ignore almost every civil liberty the U.S. was founded on.

We actively limited speech and debate, going to far as to silence and destroy the lives and careers of qualified physicians who dissented.

We restricted freedom of assembly.

We seized property through forced business closing without compensation.

We restricted free movement.

We coerced vaccination in the strongest possible ways shy of physical force.

The list goes on.

We did this out of a hubris that "we know better than you".

It doesn't really matter whether this is true or not, it's fundamentally anti-liberal.

It's made worse by the unfortunate fact that in most cases we were wrong.

Asymptomatic spread wasn't a thing. The initial studies that said it was were based on flawed methodology. Even China isn't counting asymptomatic cases anymore.

Pretty much every model that we based policy off of, predicting extreme fatality rates and recommending extraordinary interventions, were dead wrong.

As others have pointed out, mortality counts were wildly off due to many factors, including how death certificates were filled out (died with covid v/s died from covid).

The vulnerable populations were identified fairly early on, but we chose to implement draconian restrictions for everyone, regardless of their individual risk.

This was the problem.

Hubris.

Re:Autopsy-based characterization of myocarditis after anti-... by TrispusAttucks on Thursday December 15, 2022 @05:00PM (#34006420)
Yep.

Fuck authoritarians!

Never forget.

Re:Autopsy-based characterization of myocarditis after anti-... by zhrvoj on Thursday December 15, 2022 @06:12PM (#34007146)
<IMHO>Pharma could go on with huge gains, just selling immunity boosters, like C, D vits, exposing to solar flares... But boosted with 'media', they were forced to take an "social" experiment. Instead, they even forbid going out, and in my town police chased couples sitting on the park bench!! MAdnESs!! My lungs and 55+ sorts me under vulnerables. Even my doctor argued, freightening me, explaining weak immunity, in spite of mentioned immunity boosters my mamma told me to take :) ! At the end my covid experience is funny - weak flu - good to stay at home - want one again! Divide and Conquer policy, don't you see?</IMHO>
Re:Autopsy-based characterization of myocarditis after anti-... by TacticalCoder on Thursday December 15, 2022 @06:11PM (#34007135)
> We coerced vaccination in the strongest possible ways shy of physical force.

Totally.

Re:Autopsy-based characterization of myocarditis after anti-... by RocketOne on Thursday December 15, 2022 @07:15PM (#34007735)
I couldnt have written that any better. And THIS is why thousands of people showed up in downtown Ottawa and stayed for three weeks. Because we were disgusted and DEEPLY offended by the hubris.

And what was the gov's response? An even greater swing toward authoritarianism - the Canadian government literally locked people out of their own bank accounts, seized property and arrested and charged hundreds.

Incredible. Absolutely incredible. The anger is still palpable. And its going to simmer til our current gov is replaced.

Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Thursday December 15, 2022 @08:22PM (#34008287)
> As others have pointed out, mortality counts were wildly off due to many factors, including how death certificates were filled out (died with covid v/s died from covid).

This has never really been shown to be that accurate considering the excess deaths from the averages every year. You’re ignoring an inconvenient fact.

Re:Autopsy-based characterization of myocarditis after anti-... by claytongulick on Thursday December 15, 2022 @10:45PM (#34009816)
Which inconvenient fact am I ignoring?

I took screen shots almost daily of all-cause mortality stats through the lockdown.

The entire time it tracked pretty close to the expected linear increase that we see year over year with an aging population, with the exception of a bump in April that was almost exclusively New York City. Given the reported quality of care issues that drove a lot of that, there are still a lot of unanswered questions.

I also saw a sudden jump in these numbers right at the end of the year. Could have been completely legitimate due to delays in reporting, but for some reason the CDC refuses to release anonymized data sets that would allow independent analysis.

Which is highly abnormal.

Additionally, all-cause mortality measures don't do a good job of indicating covid deaths, necessarily. Many deaths were due to delays of care for critical conditions. I experienced this myself, and was fortunate to not have become a statistic. We had deaths of despair, and we have several conflicting studies about those. We also have a significant (maybe majority) number of the deaths attributed to covid being a six to twelve month acceleration of death for those who were at end of life, especially the elderly with comorbidities.

While sad, it's not quite the terrifying tragedy that the numbers without nuance present. It will be interesting to see if 2022 and 2023 see a concomitant dip in expected mortality.

I also spent countless hours hunting down source data (as much as was available) understanding how Covid ID was generated for cross region case tracking, data collection methodology and evaluting transmission studies and models.

I saw massive revisions of numbers post-investigation in several counties, such as Collin county in TX.

If there's one thing we know for sure, it's that the data is a collosal mess. If you spend any time digging into the data collection methods and how reporting was happening you'd see this for yourself.

FWIW, my background is in healthcare logistics, data analysis and technology.

So if you are aware of some facts that I'm ignoring, I'd love to understand them.

Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Thursday December 15, 2022 @11:01PM (#34009964)
The data is easy to find.

https://ourworldindata.org/grapher/cumulative-excess-deaths-...

I wonder what happened in 2020 and beyond that so many more died? It must just be the weather

Re:Autopsy-based characterization of myocarditis after anti-... by claytongulick on Thursday December 15, 2022 @11:56PM (#34010484)
When you've spent the time that I have looking into the source and methodology behind that data, rather than just spending 30 seconds googling, please let me know.

But here, I'll save you some time. Those pretty graphs you're linking to use the HMD database as the primary source through Feb 2021.

Take a look at how the HMD database derives it's numbers [1].

Now we can discuss the issue in rational, educated terms.

[1]https://www.mortality.org/File/GetDocument/Public/Docs/Metho...

Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Friday December 16, 2022 @12:11AM (#34010637)
Ah an attempt to appeal to authority with no proof of any credentials. That’s when you know you lost.
Re:Autopsy-based characterization of myocarditis after anti-... by claytongulick on Friday December 16, 2022 @12:48AM (#34010929)
All cause mortality for US source NVSS:

2018 - 2,839,205

2019 - 2,854,838

2020 - 3,383,729

Expected deaths for a given year are based on a combination of factors such as the population age, and function fitting previous trends. It would have been around 2.9 million for 2020.

So the raw excess death count for 2020 is somewhere south of 500k.

Many of these deaths were due to covid directly. The vast majority of which were people already at end of life, very elderly and with significant comorbidities.

We're still doing research on how many of these excess deaths were due to downstream effects of covid interventions, such as lack of access to care, deaths of despair, etc...

Also, when researching all cause mortality in 2020 and 2021 make sure to take into account fentanyl, which has exploded during those years and account for over 100,000 deaths in 2021 alone.

Re:Autopsy-based characterization of myocarditis after anti-... by jasonhansel on Thursday December 15, 2022 @10:10PM (#34009414)
> If we'd presented vaccination as informed choice, had recommendations but not coercion, I think there would have been a lot less resistance.

Honestly, I seriously doubt it. I think the resistance would have been about the same; even the most gentle "recommendation" would have been cast as coercive by those who oppose the vaccine now. All a more "gentle" approach would have done is to dissuade those on the fence.

Re:Autopsy-based characterization of myocarditis after anti-... by commandlinefan on Thursday December 15, 2022 @05:34PM (#34006773)
> even less likely that they'll die from a vaccine side effect

My understanding is that there've always been risks associated with vaccines, and they were always relatively small risks. What I can't find any unbiased information about is how the risks of the Covid vaccine compare with the risks of, say, the mumps or rubella vaccines.

Re:Autopsy-based characterization of myocarditis after anti-... by zmgsabst on Thursday December 15, 2022 @06:18PM (#34007201)
Okay, please explain my leap in logic:

- I was curious

- I went to OECD to get datasets for COVID, excess, and all mortality [1]

- I subtracted COVID deaths from excess deaths to get “likely non-COVID excess deaths”

- then I made a chart [2], showing the ratio of COVID to non-COVID; log-2 scale with a black line at zero (equal COVID and non-COVID)

- I expected mostly COVID excess, like during the delta wave near the 2020/2021 boundary

- chart doesn’t look like that

- I would like the FDA to explain more, including serious studies

What is wrong about that process?

[1] - https://stats.oecd.org/index.aspx?queryid=104676

[2] - https://zmichaelgehlke.com/images/relative-mortality.png

Re:Autopsy-based characterization of myocarditis after anti-... by Izkata on Thursday December 15, 2022 @07:30PM (#34007836)
What are the overlapping curves here? Different age groups, different countries, something else?
Re:Autopsy-based characterization of myocarditis after anti-... by zmgsabst on Thursday December 15, 2022 @10:21PM (#34009543)
Each curve is one of the countries from the OECD dataset with partial opacity; the darker regions are overlaps.
Re:Autopsy-based characterization of myocarditis after anti-... by marcosdumay on Thursday December 15, 2022 @11:11PM (#34010061)
Ok, let's see.

Your graph does clearly have a peak at the 2020/2021 boundary, that falls down after the vaccines got widespread, by the middle of 2021 (with most countries going into negative excess deaths). There is another, smaller peak at the end of 2021, that's when omicron got widespread.

What exactly were you expecting to see?

Re:Autopsy-based characterization of myocarditis after anti-... by zmgsabst on Friday December 16, 2022 @01:08PM (#34017946)
This chart isn’t absolute death: it’s the ratio of two causes of death.

You’re not seeing countries go into negative excess in 2021 and 2022 — you’re seeing non-COVID excess surge.

I was expecting during the omicron wave that we had more than two COVID deaths compared to non-COVID excess deaths — and that more broadly, we’d see more COVID than other excess death

What we see instead is that during the height of omicron, 33% of the excess death was non-COVID — and that for most of 2021 and 2022, 66% of the excess death was non-COVID.

What has been killing as many people as a global pandemic? — and if there’s so many non-COVID excess deaths, did our policies help?

Re:Autopsy-based characterization of myocarditis after anti-... by marcosdumay on Friday December 16, 2022 @01:45PM (#34018406)
When that ratio turns negative, it literally means that there has been negative excess deaths when compared to the average. You can claim that the average is abnormally high, but that's quite a wild claim.

Negative excess deaths through the pandemics were pretty common and very well explained.

Anyway, such concepts like "non-COVID excess" doesn't even start to make sense. Either you are determining the death causes, or you are doing statistical analysis over unknown causes.

Re:Autopsy-based characterization of myocarditis after anti-... by zmgsabst on Saturday December 17, 2022 @04:47AM (#34026385)
No — it doesn’t.

When that chart turns negative, it means that the ratio of COVID deaths to non-COVID excess is less than one, ie there is more non-COVID excess death than COVID deaths. When there is no non-COVID excess, but still COVID deaths, the chart shoots up; when there’s none of either, it clamps to the black line. This is a log-scale chart of their ratio; that solid black line represents a ratio of 1, ie, equal amounts.

The chart going below the black line represents positive excess death in a ratio that favors non-COVID excess deaths.

Edit: I’ve added a log chart of excess deaths, with the black line at zero, ie, the expected amount.

https://zmichaelgehlke.com/images/shaded-excess-mortality.pn...

> concepts like "non-COVID excess" doesn't even start to make sense

Sure they do: excess deaths which exceed the number of registered COVID deaths in the same period. We can detect that by looking at all cause mortality and subtracting identified COVID mortality.

Re:Autopsy-based characterization of myocarditis after anti-... by __blockcipher__ on Thursday December 15, 2022 @06:28PM (#34007312)
> The problem is the massive leaps of logic being made by people who have (quite wrongly, based on available evidence) become convinced that the vaccines are a greater threat to healthy people than the virus is.

That may be true overall (and it may not btw, only time will tell), but it's certainly not true on a by-indvidual basis. Someone who's, say, 18 with no major health disorders is going to experience a lot more risk of adverse outcome from any of the vaccines than from SARS-CoV-2. That's partially a function of the incredible SARS-CoV-2 outcomes in the "not old" age range but also because vaccination is also a fundamentally different intervention than exposure to the entire SARS-CoV-2 virus. If we're talking about the mRNA vaccines (Pfizer/moderna/etc), those are basically spike protein mRNA suspended in lipid nanoparticles. It makes your cells express the spike protein, not the whole SARS-CoV-2 virus. So metaphorically speaking you're getting pure spike protein antigen, and different peoples' genetic predispositions/etc are going to play out differently in that scenario as opposed to contact with the normal virus.

...Like those of the people in the case report we're looking at.

Re:Autopsy-based characterization of myocarditis after anti-... by yosame on Thursday December 15, 2022 @08:50PM (#34008552)
You literally just made the wild leap of logic the parent comment was talking about.

The mRNA vaccines have a modified spike protein, that is non functional compared to natural infection. On top of that, cells naturally infected with covid also express the spike protein [1], and would do so in far greater amounts than what would be caused by the vaccine.

People's different genetic dispositions will change their immune response, and that might maybe change how they respond to the vaccine as opposed to the virus. But there's no way of knowing which way you will fall, and our current evidence suggests that getting the vaccine is probably always the safer alternative.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941975/

Re:Autopsy-based characterization of myocarditis after anti-... by chiefalchemist on Thursday December 15, 2022 @07:21PM (#34007777)
> we have millions of both covid cases and vaccinations to back that up.

This study looked at 25 cases of unexpected death in

Fair enough, but where is that data? Why a study of only 25 if there are millions?

It's not a conspiracy theory to say such things simply don't add up. The largest drug test in history and no encompassing and definitive follow up? Why?

Not trolling. Serious question (i.e., why).

Re:Autopsy-based characterization of myocarditis after anti-... by svnt on Thursday December 15, 2022 @09:53PM (#34009191)
Without spending much time you could determine why by reading the paper. Most likely it is because they could only find 25 out of millions.
Re:Autopsy-based characterization of myocarditis after anti-... by isityouyesitsme on Thursday December 15, 2022 @07:45PM (#34007969)
As someone who is also fully vaccinated, I am not sure how you can say it is overall good simply because most people will not react poorly. That is like saying Russian Roulette is a perfectly fine game to play because only one person is going to die, and that's OK.

Shouldn't people decide that for themselves?

Note, I am not saying you are saying it is not that they should decide for themselves, it is more that yours is the same logic used to defend vaccine mandates.

Re:Autopsy-based characterization of myocarditis after anti-... by throwawaylinux on Thursday December 15, 2022 @08:06PM (#34008147)
My entire issue actually has nothing to do with health, and everything to do with authoritarianism.

Before the vaccine mandates and coercion I had a seething hatred of corrupt and incompetent little tyrants in positions of power, afterward was nothing new, it just confirmed what I already knew about them. I don't care if I would have a statistically better outcome with the vaccine, I took great pleasure in standing up and defying their bullying and coercion. The wailing and the gnashing of teeth and name calling and crocodile tears from these pathetic clowns about people not getting vaccinated really warmed my heart gave me great pleasure and has mentally helped me tremendously in the past few years. I'm actually starting to feel a bit sad they're slithering back into their holes now, I was hoping for a showdown, but these people are nothing if not cowards like all bullies so this is to be expected.

What surprised me more was how many and how quickly people folded, or never even had any concerns in the first place. Obviously a good portion of the population are a meek and subservient type who just want to be ruled. After that a good number are flighty and will panic and run with the heard if something spooks them, sadly a trait that's easily exploited. I really should not have been surprised though, I've seen the same dynamic play out time and time again to start wars, invade privacy, take rights, and take money so irrational optimism that it would be different next time is my failing.

Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Thursday December 15, 2022 @08:18PM (#34008252)
“I drove my car off a cliff to really stick it to society”

What’s warmed my heart is most Covid deaths being from the unvaccinated. Clearing out the weak and stupid even sooner than natural causes.

Re:Autopsy-based characterization of myocarditis after anti-... by throwawaylinux on Thursday December 15, 2022 @09:35PM (#34008963)
> “I drove my car off a cliff to really stick it to society”

Strawman.

> What’s warmed my heart is most Covid deaths being from the unvaccinated. Clearing out the weak and stupid even sooner than natural causes.

And the wailing and gnashing of teeth continues. You sound like a nasty, sick person xcrunner529. They don't make a jab for that.

Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Thursday December 15, 2022 @11:03PM (#34009977)
The vaccine has stayed just as effective for serious disease as it always was said. I am undeniably safer with the vaccine than without as I have actual family members who like you bought into the “vaccine bad” propaganda and died an early death from…COVID.

There really should be real life DARWIN awards.

The great thing, it’s mostly right wing voters dying. :)

Re:Autopsy-based characterization of myocarditis after anti-... by throwawaylinux on Thursday December 15, 2022 @11:51PM (#34010435)
> The vaccine has stayed just as effective for serious disease as it always was said.

It wasn't, this is just how you're coping with your cognitive dissonance.

> There really should be real life DARWIN awards.

There are. They are called the Darwin Awards. They have a website and everything.

> The great thing, it’s mostly right wing voters dying. :)

No I know you don't really mean it, you're just angry and lashing out because you've been wrong and humiliated so many times. You're a good person deep down I think.

And surprise surprise, you're wrong about this too. Vaccination rates correlate highly with age, and so do right wing political beliefs.

Because the vaccine is more beneficial for older people. And people can in fact make reasonable decisions about their health. Incredible isn't it?

Re:Autopsy-based characterization of myocarditis after anti-... by xcrunner529 on Friday December 16, 2022 @12:13AM (#34010662)
The people dying are almost all unvaccinated. In any age group. Period. It’s a fact you can’t change.
Re:Autopsy-based characterization of myocarditis after anti-... by throwawaylinux on Friday December 16, 2022 @12:33AM (#34010825)
You put on a brave front, but I think deep down your beliefs don't really comfort you from knowing that you've been fooled and wrong many times, and continue to be. I think and hope you are strong enough to one day come to terms with it though.
Re:Autopsy-based characterization of myocarditis after anti-... by momo_O on Friday December 16, 2022 @06:54PM (#34022342)
Source?
Re:Autopsy-based characterization of myocarditis after anti-... by jasonhansel on Thursday December 15, 2022 @10:06PM (#34009368)
When you admit to making your decision based purely on "seething hatred," can you really blame people for seeing that decision as irrational?
Re:Autopsy-based characterization of myocarditis after anti-... by throwawaylinux on Thursday December 15, 2022 @10:17PM (#34009489)
> When you admit to making your decision based purely on "seething hatred,"

I didn't "admit" any such thing. My post is there for everybody to read.

> can you really blame people for seeing that decision as irrational?

I don't care what people think of my choices, but I never blamed people or complained about what they think of me. On the contrary I was quite explicit that a large segment of the population sees subservience to authority and following the herd as positive things and can simply never comprehend an objection to authoritarianism or see anything wrong with medical coercion "for the greater good, according to our betters". Clearly they will think my decision is irrational.

Re:Autopsy-based characterization of myocarditis after anti-... by jancsika on Thursday December 15, 2022 @11:28PM (#34010219)
> I don't care if I would have a statistically better outcome with the vaccine, I took great pleasure in standing up and defying their bullying and coercion.

I don't understand this line of reasoning.

If one is being bullied and coerced into what you and I both consider to be the correct decision, one ought to a) make the correct decision, and then b) deal with the bullies?

Re:Autopsy-based characterization of myocarditis after anti-... by throwawaylinux on Friday December 16, 2022 @12:24AM (#34010757)
I don't think I said I considered it to be correct or incorrect, but yes either way I will never take it now. If I had not been bullied by pissant little tyrants I'd have considered getting the vaccine depending on the situation. I don't get yearly flu vaccines either, but I took them in situations that required it (visiting medically sensitive people/places). Not to compare the diseases, just to compare the situation -- I'm also told a yearly flu vaccine is the "correct decision".

But that's really aside, as I said it's not about the clinical benefit of the treatment. I have principles and I have pride, and it would hurt me mentally to do what they tell me. I believe on balance this choice is better for my health. I know several people who didn't want to get the vaccine but were forced to for their jobs, and are deeply upset by that.

I perfectly realize that there are people who get fearful and panicked and are comforted by subservience to authoritarian leaders, who will never understand my line of reasoning. Just like I will never understand theirs. But I can empathize with them -- it must have been terrifying for them, and I don't blame them for being riled up and angry at people who disagreed with them and with their authorities.

What made me sad was how little empathy there has been from people towards what they don't understand. I guess it goes with the fear mindset, fear of the unknown, the other.

This is how they prey on us, I guess.

Re:Autopsy-based characterization of myocarditis after anti-... by CrimsonRain on Friday December 16, 2022 @03:02AM (#34012028)
why is that logic jump is happening? Mostly because of censorship. If your logic needs censorship to prevent logic jumps, perhaps your logic isn't solid to begin with (or mixed with lies like the vaccine).

For healthy persons in certain age group, COVID risk is almost missing. If they don't want vaccine, regardless of taking 3 doses, I have no right to tell them to take not-thoroughly tested vaccine to help reduce the spread at the potential cost of their own.

The solution is more open studies and acknowledge statistical (in)significance of vax side effects instead of trying to shove it under conspiracy and censorship. Oh, and dont lie about vaccine effectiveness.