Autopsy-based characterization of myocarditis after anti-SARS-CoV-2-vaccination

Re:Autopsy-based characterization of myocarditis after anti-... by OrvalWintermute on Thursday December 15, 2022 @05:05PM (#34006475)

Are you saying that aneuryms are not a potential adverse event associated with MRNA Covid vaccination [1]?

Furthermore, we know hypertension is also associated with dissections, and there are several documented cases of acute and non-acute hypertension after MRNA covid vaccination [2]

I'm saying that to say there are some possibilities there, but I am also going to say the opposite too.

I don't know that we know enough about the adverse events associated with these vaccinations, and whether or not a vaccine is implicated, or if there was a previous medical condition.

Retrospectively speaking, I don't know that an autopsy would give us any novel answers either, because of the gaps we have around passive medical surveillance vs active medical surveillance.

I am sorry that Mr. Wahl died at such a relatively young age

[1] https://pubmed.ncbi.nlm.nih.gov/35646499/

[2] https://www.ahajournals.org/doi/epub/10.1161/HYPERTENSIONAHA...

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Re:Autopsy-based characterization of myocarditis after anti-... by bb88 on Friday December 16, 2022 @12:20AM (#34010723)

These are at least 4 known causes of aortic aneurysms.

1) Smoking (behavioral)

2) High blood pressure (dietary or genetic)

3) High cholesterol (dietary of genetic)

4) Marfan's syndrome (genetic)

Last I checked, doctors (who know these things) were seriously considering it was #4.

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Re:Autopsy-based characterization of myocarditis after anti-... by OrvalWintermute on Friday December 16, 2022 @09:56AM (#34015181)

Actually, this list is insufficient according to the NIH [1] an article in Circulation [2] and my wife, a boarded surgeon. Where she provided data I have italicized it, all others are from NIH and the other source. Interestingly, Diabetes can also have a protective effective against aneuryms [3]. There is also evidence that viral infection can likewise play a contributing role to local inflammation in aorta, similar to the better-known effects of bacterial infections ...CMV infection can stimulate local inflammation in the aorta but is not a direct cause of most abdominal aortic aneurysms. [4]

Genetic/History

    Ehlers–Danlos syndrome

    Loeys–Dietz syndrome

    Marfan syndrome

    Turner syndrome

    Familial thoracic aortic aneurysms

    Bicuspid aortic valve (BAV), which is an abnormal aortic valve

Birth Defect

Diabetes, particularly uncontrolled diabetes

Lifestyle Habits

    Aneurysms of blood vessels in other parts of your body

    Chronic obstructive pulmonary disease (COPD)

    Cardiovascular conditions, such as atherosclerosis, coronary heart disease, and peripheral artery disease

    Unhealthy blood cholesterol level

    High blood pressure, which is the leading risk factor for thoracic aortic aneurysms but also a risk factor for abdominal aortic aneurysm

    Bacterial infections, which are a risk factor for thoracic aortic aneurysms.

    Kidney conditions, such as renal failure, chronic kidney disease, and polycystic kidney disease

    Obesity

    Pheochromocytoma external link , a rare tumors of the adrenal gland that can lead to high blood pressure

    Vasculitis

[1] https://www.nhlbi.nih.gov/health/aortic-aneurysm/causes

[2] https://www.ahajournals.org/doi/10.1161/circulationaha.110.0...

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198737/

[4] https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26901

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