News for hackers. Stuff that matters.
Re:Hacking the genome of fungi for smart foods of the future by elevaet on Tuesday March 26, 2024 @03:11PM (#39831662)
This seems like a much more promising avenue than lab-grown meat. Fungi are already rich in protein, are a bit closer on the tree of life to animals than plants are, are sedentary by default, and are absolute chemical powerhouses.

If we can engineer a fungus to produce just the right amino profile, or whatever nutrition you're looking for, then you have a self perpetuating stock that should be much lower tech and simpler to manage than trying to grow muscle tissue in a "petri dish".

Heck, we could just be eating more mushrooms, they already are a pretty good source of protein.

Re:Hacking the genome of fungi for smart foods of the future by baxtr on Tuesday March 26, 2024 @03:39PM (#39831965)
afaik mushrooms contain about 2-3g protein per 100g. Meat has about 20-25g.
Re:Hacking the genome of fungi for smart foods of the future by 0cf8612b2e1e on Tuesday March 26, 2024 @04:14PM (#39832328)
Presumably it is still early days for modern agricultural fungus selection. I heard a story that thousands of years ago, corn had six kernels per cobb(might have been seven). Few generations of selective breeding and you produce monstrous varieties.

Presumably we could do the same thing with fungus if we saw the economic/moral/sustainability incentives.

Edit: an article about ancient corn (https://blogs.ifas.ufl.edu/news/2023/01/24/uf-researchers-di...)

  Teosinte is a small, grass-like plant that forms ears of six to eight kernels. Each kernel is encased in an acorn-like shell. These encased kernels grow on a thin stem, not the thick cob that characterizes modern corn. The whole ear is about two inches long, the kernels no larger than peppercorns.

  About 10,000 years ago, the Indigenous peoples of what is now southern Mexico began selectively breeding teosinte. Over time, those acorn-like coverings retracted and formed a cob. Now exposed, the kernels were easier to harvest and could be bred for increased number and size, Koch said.
Re:Hacking the genome of fungi for smart foods of the future by elevaet on Tuesday March 26, 2024 @03:53PM (#39832118)
That's true, but because mushrooms are so wet (~90% water), if you look at the numbers for dehydrated mushrooms vs meat, mushrooms start looking a lot better.

I think dry mushrooms are about 30% protein by weight, which is in the ballpark of dry meat.

Re:Hacking the genome of fungi for smart foods of the future by IanCal on Tuesday March 26, 2024 @06:44PM (#39833685)
Semi related, I recommend roasting then dehydrating and blending mushrooms if you can. Mushroom powder like this is an incredible addition to many things, though my kids will eat it on its own regardless. A massive pile of mushrooms will become a tiny jar of powder.

And less related, lacto ferment them. They're then outrageously good fried.

Re:Hacking the genome of fungi for smart foods of the future by InSteady on Tuesday March 26, 2024 @04:38PM (#39832556)
However, if you compare the energy and resource inputs to produce that 2-3g the picture starts looking a LOT more competitive. Not to mention a very attractive nutrient profile and potential medicinal benefits (eg a lot of bioactive tryptophan metabolites).
Re:Hacking the genome of fungi for smart foods of the future by fragmede on Tuesday March 26, 2024 @05:04PM (#39832850)
That's the "before" picture. Let's see what these scientists can get to with the "after" picture. If they can get it up to 50g/100g, I know what I'm eating.
Re:Hacking the genome of fungi for smart foods of the future by IanCal on Tuesday March 26, 2024 @06:46PM (#39833700)
There's way more water in mushrooms too. 90+% may simply be water.
Re:Hacking the genome of fungi for smart foods of the future by newzisforsukas on Tuesday March 26, 2024 @07:07PM (#39833856)
Re:Hacking the genome of fungi for smart foods of the future by ShitHNDorksSay on Tuesday March 26, 2024 @04:08PM (#39832256)
Of it is. Who wants to eat lab-grown 'meat', besides Bay Areans and Lefties?
Re:Hacking the genome of fungi for smart foods of the future by Emma_Goldman on Tuesday March 26, 2024 @04:40PM (#39832581)
How far is that from pre-existing products, like Quorn[1], which here in the UK is probably the main producer of vegan/vegetarian meat simulacra? The problem is that people don't like eating straight fungus, and so it is serially transformed through elaborate processing, to create meat-like products. Which it turns out are extremely unhealthy.

I think you are on more promising ground in your final remark. There are plenty of whole food plant-based sources of protein that are tested, economical and low-carbon, while possessing none of the health drawbacks of 'high tech' alternatives.

[1] https://en.m.wikipedia.org/wiki/Quorn

Re:Hacking the genome of fungi for smart foods of the future by Aromasin on Tuesday March 26, 2024 @06:18PM (#39833488)
It should be pointed out that most Quorn products aren't vegan. They use eggs as a binding agent.
Re:Hacking the genome of fungi for smart foods of the future by elevaet on Tuesday March 26, 2024 @06:05PM (#39833392)
> people don't like eating straight fungus

What do you mean? People love eating all kinds of mushrooms!

Re:Hacking the genome of fungi for smart foods of the future by samatman on Tuesday March 26, 2024 @05:29PM (#39833082)
100g at 2.3g carbs, 1.7g fat, and 13g protein? What's extremely unhealthy about that?
Re:Hacking the genome of fungi for smart foods of the future by Emma_Goldman on Tuesday March 26, 2024 @05:46PM (#39833229)
Food, and therefore nutrition, is significantly more complicated than a ledger of macronutrients. In this particular case, I was getting at this:

https://www.bmj.com/content/384/bmj-2023-077310

Re:Hacking the genome of fungi for smart foods of the future by samatman on Tuesday March 26, 2024 @06:50PM (#39833725)
> Ultra-processed foods, as defined using the Nova food classification system, encompass a broad range of ready to eat products, including packaged snacks, carbonated soft drinks, instant noodles, and ready-made meals.

I'm not seeing the relevance.

Re:Hacking the genome of fungi for smart foods of the future by Emma_Goldman on Tuesday March 26, 2024 @08:09PM (#39834298)
The list of illustrative examples may be misleading you. It is a wide category. Look at the Nova classification, then look at the ingredients list of meat substitutes. There is no debate on this point.

See also:

https://www.theguardian.com/lifeandstyle/2018/feb/12/quorn-r...

Re:Hacking the genome of fungi for smart foods of the future by InSteady on Wednesday March 27, 2024 @07:48AM (#39837829)
Quorn and other meat substitutes most certainly fit the criteria of ultra-processed foods, and as such may be implicated in poor health outcomes if they make up a significant portion of one's diet.
Re:Hacking the genome of fungi for smart foods of the future by hombre_fatal on Wednesday March 27, 2024 @07:58AM (#39837901)
We can do better than "it's processed so it's bad".

The SWAP-MEAT trial concluded that processed alt-meat products improved health markers over animal meat: https://pubmed.ncbi.nlm.nih.gov/32780794/

> Among generally healthy adults, contrasting Plant with Animal intake, while keeping all other dietary components similar, the Plant products improved several cardiovascular disease risk factors, including TMAO; there were no adverse effects on risk factors from the Plant products.

Re:Hacking the genome of fungi for smart foods of the future by westurner on Wednesday March 27, 2024 @02:15AM (#39836127)
Are there other macronutrients in that much mass of food?

30g of Hemp Hearts (shelled hemp seeds) have 10g protein, 12g polyunsaturated fats (Omega 3 and 6), 1g sugar, and a bunch of other vitamins and minerals; but some brands have 2.3g Manganese (which 100% RDI) and Manganese toxicity occurs beyond 11mg (UL) and other brands don't have those nutrients listed on the nutrition facts label for their similar product: https://images.app.goo.gl/a2v9imfaWWyG5hSn8

Flax has a better Omega 6:3 PUFA polyunsaturated fats ratio, but only 2g protein out of 11g.

Manganese and MSG both have something to do with Glutamate, which apparently affects motivation; https://news.ycombinator.com/item?id=35885204 :

>> High glutamine-to-glutamate ratio predicts the ability to sustain motivation: The researchers found that individuals with a higher glutamine-to-glutamate ratio had a higher success rate and a lower perception of effort.

Re:Hacking the genome of fungi for smart foods of the future by InSteady on Wednesday March 27, 2024 @08:18AM (#39838054)
That is interesting about the manganese and glutamate-to-glutamine angle, although it's worth noting that manganese in foods has very poor bioavailability:

Humans absorb only about 1% to 5% of dietary manganese. Infants and children tend to absorb greater amounts of manganese than adults. In addition, manganese absorption efficiency increases with low manganese intakes and decreases with higher intakes

https://ods.od.nih.gov/factsheets/Manganese-HealthProfession...

Another interesting tidbit from the links you provide, 90% of glutamine synthesis happens in muscle cells (from glutamate and ammonia). So in theory, building more muscle mass (while getting adequate dietary glutamine and glutamate) be beneficial for regulating glutamine-to-glutamate ratios. Although it doesn't look like this has been studied specifically as of yet.

On the other hand, over-training and extreme endurance training without proper protein intake leads to depletion of circulating glutamine levels. It is suggested that depleted glutamine may be the cause of increased risks of infection and chronic fatigue during periods of over-training (even in elite athletes).

https://pubmed.ncbi.nlm.nih.gov/9562160/

Re:Hacking the genome of fungi for smart foods of the future by westurner on Wednesday March 27, 2024 @08:39PM (#39846441)
TIL there are vegan sources of MSG, and that peas, tomatoes, and processed meats have high amounts of glutamate: https://www.webmd.com/diet/high-glutamate-foods

Muscles burn Lactic Acid before they burn glucose.

FWIU LAB Lactic Acid Bacteria use Glutamate to control pH by GABA production.

And GABA, well https://en.m.wikipedia.org/wiki/%CE%93-Aminobutyric_acid :

> [GABA] is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system.

So, IIUC, when you feed LAB glutamate, you get GABA?

Re:Hacking the genome of fungi for smart foods of the future by samatman on Wednesday March 27, 2024 @05:43PM (#39844959)
> Are there other macronutrients in that much mass of food?

By convention, those three are the macronutrients. Dietary fibre is sometimes included, 100g of quorn mince has 7.5 g.

The Wiki article has a detailed breakdown of the protein fraction by amino acid, but only breaks fats out into 'saturated' and 'not', which is reasonably common.

Re:Hacking the genome of fungi for smart foods of the future by westurner on Wednesday March 27, 2024 @08:18PM (#39846298)
https://news.ycombinator.com/item?id=34674644 :

> Omega-3s and Omega-6s would be listed under "Polyunsaturated Fats" if it were allowed to list them on the standard Nutrition Facts label instead of elsewhere on the packaging.

Maybe someone else should ask FDA to allow food labelers to optionally include a breakdown of PUFAs Polyunsaturated Fats into at least Omega 6 and Omega 3 next time there is a public comment register on Nutrition Facts labels. There may be more justifying research on Omegas' relevancy to health now?

Re:Hacking the genome of fungi for smart foods of the future by lukan on Tuesday March 26, 2024 @04:42PM (#39832602)
"Heck, we could just be eating more mushrooms, they already are a pretty good source of protein. "

Definitely, but mushrooms and meat also go very well together..

And I am open towards engineered mushrooms, but I doubt they will result in meat. But maybe in something that can convince enough people to reduce their meat consumption by eating that instead.

Re:Hacking the genome of fungi for smart foods of the future by makeitdouble on Tuesday March 26, 2024 @08:00PM (#39834227)
TBH many of us are not looking for a replacement for meat. I personally want something that potentially tastes better, and don't really care for the "fake meat" marketing (don't need it to be red or meat like)
Re:Hacking the genome of fungi for smart foods of the future by hiddencost on Tuesday March 26, 2024 @07:48PM (#39834146)
You're really missing out on the incredible variety of mushrooms.

Hen of the woods, fried with batter, is next level.

Re:Hacking the genome of fungi for smart foods of the future by lukan on Wednesday March 27, 2024 @03:38AM (#39836475)
It's not bad, I know. But add some wild boar meat, and it gets even better ..

But I can also enjoy it without, yes.

Re:Hacking the genome of fungi for smart foods of the future by wintermutestwin on Tuesday March 26, 2024 @04:56PM (#39832746)
>a pretty good source of protein.

Unlike many things that are referred to as a "good source of protein," mushrooms have a really great macronutrient profile:

100g of common button mushrooms = 3g protein, 3.3g carb, .3g fat

Compared to Lentils (which are the best of the standard foods labeled as "good source of protein") 100g = 9g protein, 20g carb,.4g fat.

The problem with lentils is that you have to eat a lot of carbs to get protein. The ratios are terrible for most other legumes, soybeans and nuts.

Re:Hacking the genome of fungi for smart foods of the future by barbazoo on Tuesday March 26, 2024 @07:31PM (#39834046)
How about insects like crickets (1). Claims to have 13g of protein per 20g powder.

(1) https://ca.entomofarms.com/products/organic-cricket-powder

Re:Hacking the genome of fungi for smart foods of the future by wintermutestwin on Tuesday March 26, 2024 @08:18PM (#39834372)
Yes, like other meats, insects have good protein:carb and protein:fat. Specifically with that powder, 13:4 protein:fat and 13:2 protein:carb
Re:Hacking the genome of fungi for smart foods of the future by loopdoend on Wednesday March 27, 2024 @12:13AM (#39835648)
I will not eat the bugs
Re:Hacking the genome of fungi for smart foods of the future by histories on Wednesday March 27, 2024 @03:08AM (#39836342)
No one's forcing you
Re:Hacking the genome of fungi for smart foods of the future by z3ncyberpunk on Thursday March 28, 2024 @12:10AM (#39847704)
There is a literal global organization trying to do just this.
Re:Hacking the genome of fungi for smart foods of the future by fnordian_slip on Thursday March 28, 2024 @09:04AM (#39850790)
There is a literal global organization trying to force us to eat bugs?

Could we please not discuss ridiculous conspiracy theories on hn? Reddit is already infected with qanon an the like, we don't need that rubbish here. Thank you.

Re:Hacking the genome of fungi for smart foods of the future by londons_explore on Wednesday March 27, 2024 @03:28AM (#39836436)
Ya know, red food due for most of the 20th century was ground up bugs...

The only reason we don't do it now was that it's kinda expensive compared to lab made dyes.

Re:Hacking the genome of fungi for smart foods of the future by konfusinomicon on Wednesday March 27, 2024 @08:42AM (#39838292)
RIP Ocean Spray Mauna Lai juice drink. the ingredients list on that opened my eyes to the red bug food coloring conspiracy
Re:Hacking the genome of fungi for smart foods of the future by mythrwy on Wednesday March 27, 2024 @04:44PM (#39844376)
Also some people are quiet allergic to cochineal, like life threatening anaphylactic shock allergic.
Re:Hacking the genome of fungi for smart foods of the future by pigpang on Wednesday March 27, 2024 @04:02AM (#39836600)
You already eat crabs, crayfish, shrimp, and honey. Asian peoples also consume many other insects as food, which reduces the demand and price for Western food.
Re:Hacking the genome of fungi for smart foods of the future by iamacyborg on Wednesday March 27, 2024 @05:42AM (#39837090)
There’s a world of difference between eating an insect and eating honey though.
Re:Hacking the genome of fungi for smart foods of the future by vinhcognito on Wednesday March 27, 2024 @06:16AM (#39837289)
Not much between a cockroach and a lobster though
Re:Hacking the genome of fungi for smart foods of the future by konfusinomicon on Wednesday March 27, 2024 @08:40AM (#39838280)
drown it in butter and whos gonna know the difference?
Re:Hacking the genome of fungi for smart foods of the future by belorn on Wednesday March 27, 2024 @10:40AM (#39839814)
Has the shell, legs, head, intestine and organs been removed from the cockroach so that only the meat is left? I would like to see the machinery needed to replicate the edible part of a lobster abdomen (or tail as it is called) in a cockroach.

The part that people generally eat on a lobster is the muscles of the claws and the muscles of the abdomen. The rest is generally discarded. It similar to how most people don't tend to eat the hair of cows, but rather the meat from cow muscles.

I would claim that it is actually a large difference between eating a cockroach and a lobster.

Re:Hacking the genome of fungi for smart foods of the future by __MatrixMan__ on Wednesday March 27, 2024 @12:47AM (#39835786)
Even though insect exoskeleton and fungi are both made of chitin, I find bouncy fungi tissue kind of fun to chew, while bug parts are crunchy in a sort of uncomfortable get-stuck-in-your-teeth sort of way, like the downsides of popcorn, but with less upside.

I also tried some "chirps" which were chips made with cricket powder, and then the texture just wasn't right. Hopefully the right chef is out there to change my mind, but for now I'm team fungus all the way.

Re:Hacking the genome of fungi for smart foods of the future by redweer on Wednesday March 27, 2024 @02:46AM (#39836269)
I ate some food made with mealworm powder this weekend - it blew my mind. Some real good chefs cooked it up, they did blueberry donuts made with 20% mealworm powder. They also did tacos, where the tortillas were 20% mealworm powder, and the rest was just really good veggies/beans/sauce. They had fried ones with crickets you could sprinkle on top.
Re:Hacking the genome of fungi for smart foods of the future by __MatrixMan__ on Wednesday March 27, 2024 @10:23AM (#39839550)
Maybe I've just been hanging out with the wrong crickets.
Re:Hacking the genome of fungi for smart foods of the future by barbazoo on Wednesday March 27, 2024 @01:08PM (#39841780)
I got the cricket powder I linked and I put it in sometimes when I cook or bake something. You can't taste it or smell it so it doesn't feel like eating insects, although there is nothing wrong with that either. I recommend giving it a try. Beware that crickets and shellfish seem to be similar in terms of allergens though.
Re:Hacking the genome of fungi for smart foods of the future by matheusmoreira on Wednesday March 27, 2024 @03:07AM (#39836338)
... Are you seriously advocating that people eat insects? I thought that was just a dystopian meme.
Re:Hacking the genome of fungi for smart foods of the future by soco on Wednesday March 27, 2024 @04:26AM (#39836697)
I think you should be aware that the world is much bigger than the US and in many other countries insects are part of their traditional cuisine: "Over 2 billion people are estimated to eat insects on a daily basis." https://en.wikipedia.org/wiki/Insects_as_food
Re:Hacking the genome of fungi for smart foods of the future by matheusmoreira on Wednesday March 27, 2024 @06:14PM (#39845245)
I'm not american, I'm brazilian. I'm very aware of the fact you mentioned and I think it's disgusting. I work hard because I want to live well in general and that includes not being reduced to eating literal insects.

I seriously didn't think I'd have to justify this. Why does everyone single out americans anyway? Do you think the rest of the world is okay with eating insects? No way. We want to eat well too. We want to live well.

Re:Hacking the genome of fungi for smart foods of the future by soco on Thursday March 28, 2024 @04:43AM (#39848924)
Reducing the entire world to your standards - including what means "eating well" - is common around here to come from that country. But I was wrong in that assumption. And to your other question: yes I am fine eating insects, as a matter of fact I do and don't feel at all dystopian.
Re:Hacking the genome of fungi for smart foods of the future by fnordian_slip on Wednesday March 27, 2024 @07:54AM (#39837865)
How come so many Americans are afraid of eating insects? I have often seen this meme, and never understood it. I know that the average American is a bit more squeamish about a lot of things, from nudity to eating raw meat. The former can be explained by the puritan influence, the latter by the food standards which would possibly make things like Mett[0] a bit unsafe.

This, however - together with the opposition to walkable cities - I can't wrap my head around. How can eating an insect burger be worse than eating chicken nuggets?

[0]: https://en.m.wikipedia.org/wiki/Mett

Re:Hacking the genome of fungi for smart foods of the future by Turing_Machine on Wednesday March 27, 2024 @10:30AM (#39839649)
Excuse me, are you implying that it's only "Americans" who don't eat mealworms and cockroaches on a regular basis?

I can assure you that they aren't standard restaurant fare in Europe, either.

Oh, I see: you saw a chance to bash "Americans", and took it.

> How can eating an insect burger be worse than eating chicken nuggets?

How many restaurants in your city serve "insect burgers"?

Yeah, that's what I thought.

Carry on.

Re:Hacking the genome of fungi for smart foods of the future by matheusmoreira on Wednesday March 27, 2024 @07:00PM (#39845635)
Not just europe! It's quite unheard of here in the developing third world too.

In fact, south american countries seem to be somewhat famous for their meat. Brazil is one of the biggest producers and exporters of meat in the world and if it were up to me I'd burn down the whole amazon jungle to make room for more production.

Re:Hacking the genome of fungi for smart foods of the future by fnordian_slip on Thursday March 28, 2024 @08:43AM (#39850536)
You read a lot more into my comment than is actually there, which is probably the reason for your rather flippant and response.

In Europe, insect meat is still extremely rare, and where it is to be found, it is experimental and expensive. The latter will of course change through economies of scale once they reach a certain stage.

However, the public perception of insects as food is very different. I have never or heard seen a sulky "I will not eat ze bugs" comment in my language, the whole"globalists want you to eat bugs" conspiracy is mostly unknown, and would be seen as foolish.

I have not said that eating insects is the norm, but many here see it as part of the diet of the future, without that squeamishness that seems to be so prevalent in the US.

If I were to respond in the same tone as you, I would imply that you already knew that, but didn't want to let a chance pass to make yourself the victim, as Americans often like to pretend that all Europeans look down on you. However, I actually believe this is just a misunderstanding.

I know I probably won't get any information from you, since you now see me as a debate opponent instead of a discussion partner, but I was genuinely interested in the reason for the extreme opposition to insect food in the US. Maybe since English is my second language, which I learned in part by reading a lot of rather old books, my grammar and word choices are hindering me in making myself clear.

Re:Hacking the genome of fungi for smart foods of the future by Turing_Machine on Thursday March 28, 2024 @03:03PM (#39855993)
Nah, you just wanted to bash "Americans", and the rest of this comment is just an attempt at deflection.

> as Americans often like to pretend that all Europeans look down on you.

No, most Americans don't even care about the opinions of Europeans. If we did, we'd have stayed in Europe.

> many here see it as part of the diet of the future,

What is "many"? Do you have a link to a credible survey saying that the majority (or even a large minority) of Europeans are willing to eat insects?

Re:Hacking the genome of fungi for smart foods of the future by fnordian_slip on Friday March 29, 2024 @10:05AM (#39864265)
>Nah, you just wanted to bash "Americans", and the rest of this comment is just an attempt at deflection.

Ah, I was wrong then. It was not a misunderstanding, you are simply replying in bad faith.

Well, I hope your life gets better, to the point where you are at least partially at peace with your American identity, and no longer feel the need to write such embarrassing comments.

Re:Hacking the genome of fungi for smart foods of the future by Turing_Machine on Saturday March 30, 2024 @03:56PM (#39878062)
That's nice.

I hope you enjoy your cockroach burgers.

Assuming anyone in your country ever gets around to selling them.

Re:Hacking the genome of fungi for smart foods of the future by matheusmoreira on Wednesday March 27, 2024 @05:49PM (#39845018)
Except I'm not american. I'm brazilian. Puritan influence? Can't get any further than that. Do you actually think it's just americans who'd refuse to eat bugs?

I'm not gonna eat insects dude. I'm just not gonna do it. They could be the literal embodiment of protein and I still wouldn't eat them. There's just no way you can convince me to do that.

I don't care how much space, energy, water, whatever else is required for meat production either. That's what I want to eat. That's what I'm gonna eat.

I don't eat chicken nuggets either. I eat meat and assorted vegetables. Properly cooked.

Re:Hacking the genome of fungi for smart foods of the future by fnordian_slip on Thursday March 28, 2024 @08:53AM (#39850654)
OK, so my hypothesis was incorrect when it comes to your comment. But while you have convinced me that you feel quite strongly about it, I don't feel like you answered the "why", or maybe I just don't get it. You repeatedly told me that you would never consider it, and in the other comment you said that "if it were up to me I'd burn down the whole amazon jungle to make room for more production“.

The fact that this would accelerate global warming which will hit third world countries the most aside, why do you feel so strongly about this? I'm also not a vegetarian and I love a good steak, especially when it's served rare, but this does not form a part of my identity, so it's hard for me to understand.

Re:Hacking the genome of fungi for smart foods of the future by matheusmoreira on Thursday March 28, 2024 @02:48PM (#39855820)
The "why" is history. When I studied the past, I saw that in most societies the upper classes would gorge themselves on feasts containing the finest, fattiest meats while the lower classes would feed on left overs from the harvests. I say "history" like it's ancient but that was the reality of my previous generation: I literally grew up with my father telling me of his hardships, a major symbol of which was the fact there were times when he could not afford meat.

That's why it's an indignity to be reduced to eating insects. You can bet your house the billionaires of this world won't be eating them.

Feel strongly about it? A couple years ago in my country a president was elected partly by promising citizens they would be able to eat fine meat regularly again. He's a communist so of course he didn't deliver, and it looks like people are starting to feel the misery of it.

Also, global warming is not really a concern to me. Other countries have been destroying the planet for literal centuries and getting rich off it but when it's our turn to exploit our land we can't? I reject that notion.

People love to talk about the "externalities" of meat production. As far as I'm concerned, the biggest externality of all is the cost of my country not being rich and prosperous and developed. You know, like the former british empire with their famous steaks, now mostly represented by the US. They might want to factor that externality in before they talk to us about climate nonsense.

Re:Hacking the genome of fungi for smart foods of the future by barbazoo on Wednesday March 27, 2024 @01:05PM (#39841728)
I just look at the nutritional profile and the conditions under which they are produced and see a good alternative to industrial meat (cow, pig, ...) production.
Re:Hacking the genome of fungi for smart foods of the future by BobaFloutist on Tuesday March 26, 2024 @06:44PM (#39833683)
100g of Lentils is a lot more food than 100g of mushrooms though.

Also, you do need some fat and carbs in your diet to, you know, live.

Re:Hacking the genome of fungi for smart foods of the future by coldtea on Tuesday March 26, 2024 @07:21PM (#39833978)
Carbs you don't really need to eat to live!

What of them you need, you can make it, gluconeogenesis and such. Proteins on the other hand...

Re:Hacking the genome of fungi for smart foods of the future by ch4s3 on Tuesday March 26, 2024 @10:54PM (#39835240)
Sure it’ll work but ketone bodies are acids c and the ver time you’ll end up with metabolic acidosis[1].

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341377/#:~:tex....

Re:Hacking the genome of fungi for smart foods of the future by loopdoend on Wednesday March 27, 2024 @12:14AM (#39835654)
*in rats
Re:Hacking the genome of fungi for smart foods of the future by ch4s3 on Wednesday March 27, 2024 @10:22AM (#39839535)
Diabetic Ketoacidosis is well documented in diabetic people[1], alcoholics, and in conditions of starvation[2] and the mechanism is the same. Ketone tests were developed for this purpose. Note starvation there, where the body starts using its own fats for energy. Here's a case report of it happening to someone on a ketogenic diet[3].

[1] https://www.cdc.gov/diabetes/basics/diabetic-ketoacidosis.ht...

[2] https://www.ncbi.nlm.nih.gov/books/NBK534848/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220017/

Re:Hacking the genome of fungi for smart foods of the future by kelipso on Wednesday March 27, 2024 @05:24PM (#39844771)
The body is designed to use its own fats for energy. All logic says you are talking about extreme conditions.
Re:Hacking the genome of fungi for smart foods of the future by ch4s3 on Thursday March 28, 2024 @10:11AM (#39851710)
The body does that under circumstances of low calorie intake. The case study I posted shows a person developing keto acidosis just from following a ketogenic diet, it’s a well documented risk of ultra low carbohydrate diets if you bother to look. It happens frequently in people using these diets to treat diabetes, it just happens to be less dangerous than Type II diabetes.
Re:Hacking the genome of fungi for smart foods of the future by hiddencost on Tuesday March 26, 2024 @07:47PM (#39834142)
It's about the ratios.
Re:Hacking the genome of fungi for smart foods of the future by wintermutestwin on Tuesday March 26, 2024 @08:21PM (#39834392)
>Also, you do need some fat and carbs in your diet to, you know, live.

Absolutely agreed that fat and carbs are part of a balanced diet, but many foods and cuisines have poor macro nutrient ratios and, as hiddencost states, it is all about the ratios.

FWIW, I have been massively successful in eliminating "dadbod" and getting to a super healthy weight by using this diet for several years: https://www.youtube.com/watch?v=_nR1juKxIRM

The TLDR is ~.8grams of protein per pound of body weight, small portions of carbs and fat and half your plate should be low calorie vegetables.

Re:Hacking the genome of fungi for smart foods of the future by slily on Tuesday March 26, 2024 @05:32PM (#39833122)
Poor amino-acid composition is a major problem with non-animal protein sources. Every time we think we can "cheat" nutrition by reducing nutritional value to a small set of cherry-picked nutrients, we find that it leads to deficiencies elsewhere. It's like fad diets for technocrats.
Re:Hacking the genome of fungi for smart foods of the future by rdedev on Tuesday March 26, 2024 @07:57PM (#39834207)
We have enough data on how to supplement enough of those macro and micro nutrients. And there's plenty of studies showing no risk of going on a full plant based diet. Like here's a video discussing plant based protein for body building. The key take away is that you need some diversity in the stuff but it's fairly easy to get there

https://youtu.be/MB7rIAArV2Q

Re:Hacking the genome of fungi for smart foods of the future by Klonoar on Tuesday March 26, 2024 @10:57PM (#39835256)
This has been debunked repeatedly - that's not a big issue if you're actually eating a balanced diet, which you should be doing.

(Plus tofu is fine here)

Re:Hacking the genome of fungi for smart foods of the future by hombre_fatal on Tuesday March 26, 2024 @11:22PM (#39835383)
Yeah, you can debunk this trivially with cronometer.com which kinda reveals how many people repeat things without looking.

It’s like when people regurgitate that “add rice to beans for a complete protein” meme without realizing that rice is less dense in every amino acid, and beans have every amino acid in similar qualities, and you can simply eat more protein dense plant sources if you need more protein.

I eat 550g extra firm cooked tofu and 230g tempeh daily. Plug that into cronometer and show me the plant based amino acid hole.

Re:Hacking the genome of fungi for smart foods of the future by hombre_fatal on Tuesday March 26, 2024 @11:25PM (#39835403)
You shouldn’t be looking at whole mushrooms. You should be looking at mycoprotein which is a dense protein source found in fungi based meat alts like Quorn products.

https://en.wikipedia.org/wiki/Mycoprotein

Re:Hacking the genome of fungi for smart foods of the future by adrian_b on Wednesday March 27, 2024 @07:55AM (#39837876)
While the protein extracts from fungi or from plants solve the problem of the non-animal sources of protein having an undesirable ratio between protein content and energy content, they are much more expensive than meat or eggs and they have an unknown environmental impact, due to high consumption of energy and of chemicals.

The fact that these protein extracts are more expensive than meat, per protein content, should be a strong clue that their real environmental impact is also worse, even if their producers avoid to document it.

I am aware of only a single method of protein extraction that can provide separated protein that is cheaper than chicken meat and which requires no chemicals that could leave residues in the protein and which uses little energy (but it requires an additional non-negligible water consumption). This is the extraction of gluten from wheat flour, by making a dough and washing it.

For the (relatively few) people who have gluten intolerance, this unique method is not applicable, but in many parts of the world (i.e. where soy is expensive) it is the only way that I know of that can be used for achieving a vegan diet that is less expensive than eating meat. Without gluten, a lower protein cost than for meat could be achieved only by combining vegetable protein sources like lentils with chicken eggs.

Re:Hacking the genome of fungi for smart foods of the future by hombre_fatal on Wednesday March 27, 2024 @08:22AM (#39838092)
It's worse than animal agriculture based on what evidence?

Once you look at production at scale, these products dominate animal ag environmentally:

> a study published in Nature 2022 found that replacing 20 percent of per-capita ruminant meat, such as beef, with fermentation derived microbial protein, such as mycoprotein, could cut global deforestation and carbon dioxide emissions by 50% in addition to lowering methane emissions.

Also,

> it is the only way that I know of that can be used for achieving a vegan diet that is less expensive than eating meat.

I don't understand this. Even ChatGPT can come up with a solution to your question if you care to figure out how to eat a sufficient vegan diet without soy/gluten.

e.g. Legumes are cheaper than meat. For the sake of looking at real numbers, 1000 calories of cooked lentils has 80g protein (all of the EAAs) and 67% of the day's nutrients. Also, you'd have to substantiate why optimizing for protein is the only thing you seem to care about given that (1) you can reach the high end 1.6g/kg protein with this food and (2) there are dozens of other nutrients that matter.

But searching for these hypothetical cases where someone can't eat neither soy nor gluten just so you can finally launder in a chicken egg and go "A-ha!" seems to be a red herring that doesn't track anything in this conversation. Okay, now let's pretend they are allergic to chicken eggs, too. Ho hum.

Re:Hacking the genome of fungi for smart foods of the future by adrian_b on Wednesday March 27, 2024 @10:38AM (#39839787)
1000 kcal of lentils do not provide all the EAAs.

A typical value would be to eat at least 1700 kcal of lentils to provide enough methionine (you need 543 g/day of lentils to provide enough methionine for an 170 lb human).

Even eating only 1000 kcal of lentils would not be considered pleasurable by most people, for whom such a quantity would be too much.

When you choose a diet, ensuring that you will enjoy that food is as important as not exceeding the kcal threshold and as exceeding the nutrient threshold.

Legumes are cheaper than meat (but not by much, chicken meat is only about 50% more expensive than legumes, per protein content), but you cannot eat only legumes and they cannot be the only important source of protein, you need at least a second source.

I care for protein because this is the main difficulty when you do not want to eat meat. Anything else can be easily obtained from vegetable sources or from supplements. I am annoyed when I see people who write vegan propaganda, while at the same time attempting to minimize the protein problem. I have been trying for years to become vegan, but without success, because I could not solve the protein problem, and almost all the vegan advice that I have seen has been completely useless, because it looked like it was written by people who did not care whether they pay $5 or $50 for a meal, or whether they waste 5 minutes for cooking or they waste an hour. Eventually I have solved the problem, but only after personal experiments and I would have liked very much to have wasted much less time with this.

I have no problem with gluten, so for myself gluten is a major source of protein. Nevertheless, if I had gluten intolerance, where I live, in Europe, the only alternative for achieving a 2000 kcal daily energy intake without meat and dairy (and without eating a diet that no free human would accept, like eating only lentils, water and a capsule of vitamins and minerals) would be chicken eggs (as a supplement for legumes).

At least here, protein extracts are typically 5 times more expensive than chicken meat (per protein content), so using them as a staple food would seem stupid.

You have not provided any alternative to what I have said and I bet that ChatGPT would give an answer that is either wrong or irrelevant.

Re:Hacking the genome of fungi for smart foods of the future by adrian_b on Wednesday March 27, 2024 @11:32AM (#39840599)
> It's worse than animal agriculture based on what evidence?

Currently there is no evidence of any kind. The costs of meat production are well known, but the costs in energy and chemicals for the production of various kinds of protein extracts are not known, because they are "proprietary".

I nobody is able to offer for sale low-cost protein extracts for human consumption we can only assume that the production costs are high, i.e. that each pound of protein extract requires a large amount of energy and/or chemicals.

> a study published in Nature 2022 found that

Searching the Internet right now, I have found a non-paywalled copy of that study: "Projected environmental benefits of replacing beef with microbial protein".

Nevertheless, exactly like I have expected, that study is useless. It does not contain what the abstract says.

It contains what seems to be an accurate analysis of what would be gained if the production of meat would be reduced, by using an alternative source of protein.

Nevertheless, to compute the net benefit, we also need a computation of the production costs for the protein provided by the alternative source. Such a computation is missing from the article. There is no information about the energy consumption and about the chemicals consumption that would be required by the alternative sources.

Some forms of microbial fermentation can provide high-quality protein, perhaps even without any harmful substances that must be removed, but the protein has a low concentration in the growth medium. Separating the protein from the water and from the waste products of the fermentation would need much energy.

In the more distant future, growing a bioengineered multicellular organism, like a fungus or a parasitic plant, seems a much more viable path, because such an organism can grow a big edible fruiting body, with whatever nutritional composition and texture is desired. Such an edible fruiting body can be detached and used for cooking with minimal processing, without additional energy consumption.

Re:Hacking the genome of fungi for smart foods of the future by adrian_b on Wednesday March 27, 2024 @07:31AM (#39837736)
The value you give for lentils might be for some kind of boiled lentils, including a lot of added water.

Raw lentils, as you buy them, have about 22% to 25% of protein, i.e. about the same as lean meat. However, while the rest of the meat is mostly water, the rest of the lentils is mostly starch.

Therefore, if you have a sedentary life style, lentils cannot provide a too big fraction of your daily protein intake, i.e. above 40% to 50%, otherwise they would provide too many calories.

Raw mushrooms have a high content of water and chitin, so their nutritional content is very low per mass, like also for most parts of vegetables, except seeds. Among non-animal sources, only the seeds (e.g. of cereals or legumes or nuts) or the oily fruits like olives or avocado, have high nutritional content per mass in their raw, unprocessed state.

For instance eating 167 g per day of lentils would provide a significant part of the daily protein intake and it will cover the daily necessities for all amino-acids except methionine. For a similar nutritional intake you would have to buy and eat more than 1.5 kg of mushrooms, which would be quite a challenge and it would also be much more expensive than eating meat.

Nevertheless, while for now mushrooms could not be a staple food, I agree that the future of food is in capturing solar energy and using it to synthesize some simple organic molecules, like glycine, by capturing carbon dioxide and dinitrogen, and then using those to feed bioengineered fungi or parasitic (i.e. non-photosynthesizing, like mistletoe) plants, which could produce the equivalents of any kind of animal or vegetable food that is eaten today.

Re:Hacking the genome of fungi for smart foods of the future by hombre_fatal on Wednesday March 27, 2024 @08:45AM (#39838312)
> Therefore, if you have a sedentary life style, lentils cannot provide a too big fraction of your daily protein intake, i.e. above 40% to 50%, otherwise they would provide too many calories.

If you're going to respond with six paragraphs to every post, at least indulge us with some numbers when you make claims about food which you seldom seem to do even though you appear in every nutrition thread on the forum.

2000 calories of cooked lentils provides 156g protein which is over even the 1.6g/kg protein high-mark for a 200lb guy who still has more calories to spare. 930 calories of cooked lentils provides 72g protein which is the 0.8g/kg minimum threshold in less than half of the day's calorie budget.

A quick google search says a 200lb sedentary male needs 2150 to 2550 calories per day to maintain.

Re:Hacking the genome of fungi for smart foods of the future by adrian_b on Wednesday March 27, 2024 @10:00AM (#39839206)
Numbers for "cooked lentils" are irrelevant, because they depend on how they are cooked.

All computations are easy and precise in terms of raw ingredients, because you know precisely which ingredients have been used as the starting point for cooking the food.

For lentils I know very well the values because I eat them frequently and if I do not control the amount of ingredients that I use for food I gain weight immediately.

For instance, the lentils that I use have 23% protein and 3120 kcal/kg.

The values that you give for a 200 lb sedentary male seem too big.

I am a male of average height and I weigh 170 lb. There was a time when I had much more than 200 lb (up to 250 lb), but then I was definitely obese and it took a great effort to come back to 170 lb.

Now, at 170 lb, if I eat more than 1900 to 2000 kcal per day I gain weight very quickly, even if I do around a half of hour of intense exercises per day. This is consistent with most studies that I have seen, where 2000 kcal per day was considered as the typical energy intake for a sedentary life.

The lentils have a better protein/kcal ratio than most non-animal alternatives. Nevertheless, you cannot eat only lentils and you cannot even use only lentils as the principal protein source, because they do not have enough methionine. To get enough methionine from lentils you need to eat e.g. 550 g/day, i.e. 1716 kcal, which does not leave enough room for the kcal provided by the rest of the food that you need.

If you replace a part of the lentils with cereals, those have a much lower protein content and after also adding the rest of the food that is required for other nutrients it becomes impossible to get a sum that is not much greater than 2000 kcal.

You can get a sum of 2000 kcal without meat or dairy and without expensive protein extracts by getting some protein from freerange chicken eggs, or, for a 100% vegan diet you can extract at home gluten from wheat flour.

For instance, for myself, an adequate daily protein intake within a vegan diet can be provided by 167 g of lentils + gluten extracted from 500 g of wheat flour (I prefer to not extract pure gluten, because that needs too much time and too much water, so I remove only about 75% of the starch, which needs less than 5 minutes of washing, and with the washed dough I make a bread that is highly enriched in protein in comparison with standard bread).

Also, regarding what you have said in your comment, it is true that I tend to reply to most nutrition threads. The reason is that I have neglected my health and I have been obese for many years. Then, after many failed attempts I have eventually succeeded to reduce my weight from 250 lb to 170 lb and then I have maintained the latter value for more than a decade and I have improved my health tremendously in comparison with my previous state. To achieve this, I had to study much of the existing nutrition literature and it took me years of experiments of cooking various kinds of food in order to find choices for an optimum compromise between how much time I waste for cooking, how much I enjoy the food and how well the food satisfies the nutritional requirements. For many things that I have found after many failed experiments I would have been very happy to find useful advice before wasting time with that.

Re:Hacking the genome of fungi for smart foods of the future by JeremyNT on Wednesday March 27, 2024 @11:38AM (#39840665)
I think the challenges with mushrooms as "whole foods" are similar to that of greens (also "good source of protein").

Challenge one: you need a truly huge volume of the uncooked stuff to get a meaningful amount of protein out. Lentils are way more compact.

Challenge two: when one cooks greens or shrooms, they tend to add a lot of oils and other stuff that destroys that ratio.

The proposal on offer here solves this for shrooms by preparing a packaged patty based on them (like today's extant Quorn product). This is cool and I'd love to see it, but it's not like they're trying to replace soy/lentils (which certainly have "good enough" protein content) as agricultural staples that you can harvest and eat with minimal preparation.

Re:Hacking the genome of fungi for smart foods of the future by ijijijjij on Tuesday March 26, 2024 @06:01PM (#39833359)
arent most mushrooms toxic when uncooked though... which adds some doubts
Re:Hacking the genome of fungi for smart foods of the future by devb on Tuesday March 26, 2024 @08:20PM (#39834389)
There isn't enough data to say what percentage of mushrooms are toxic when uncooked. Anyway, do you eat a lot of raw meat?
Re:Hacking the genome of fungi for smart foods of the future by ijijijjij on Thursday March 28, 2024 @08:25PM (#39859160)
> Anyway, do you eat a lot of raw meat?

At least twice a week... mostly raw fish. I tend to eat some raw beef when I eat steak, but that is pretty rare.

Re:Hacking the genome of fungi for smart foods of the future by exe34 on Tuesday March 26, 2024 @06:32PM (#39833594)
You can eat any mushroom once!
Re:Hacking the genome of fungi for smart foods of the future by darby_eight on Tuesday March 26, 2024 @07:10PM (#39833884)
Remember that you also need to get people to desire the product, and at cost!
Re:Hacking the genome of fungi for smart foods of the future by mc32 on Tuesday March 26, 2024 @07:24PM (#39834005)
Looks like GMOs will get the respect they deserve.
Re:Hacking the genome of fungi for smart foods of the future by dbcooper on Tuesday March 26, 2024 @08:50PM (#39834582)
The critical limit with fungi, and other single cell protein foods, is the high amount of nucleic acid, which are converted into purines and then uric acid. The products have to undergo additional processing to reduce these levels before they can be consumed.
Re:Hacking the genome of fungi for smart foods of the future by xvilka on Tuesday March 26, 2024 @09:38PM (#39834839)
Alternatively, we can modify humans too to be able to metabolize uric acid just like any other mammals.
Re:Hacking the genome of fungi for smart foods of the future by xbmcuser on Wednesday March 27, 2024 @12:56AM (#39835813)
I don't completely agree I think we need to make something that tastes good, is healthy and cheap. As well as something that can also be adopted in as many of the worlds cuisines as possible instead of looking for replacements we should look for something that is liked or loved as that is the only way most people are going to decrease the use of meat. Then we need that ingredient to be adopted by the fast food type restaurant's of the world for it to penetrate into the minds of the world's populations.
Re:Hacking the genome of fungi for smart foods of the future by JoeAltmaier on Wednesday March 27, 2024 @03:40PM (#39843635)
That's oft-repeated - rich in protein. When they have 10% of the protein of meat. How is that 'rich'? Something like 'nearly no protein, just detectable' would be more honest.

Sure, you eat bushels, you get as much protein as say a big mac. Not gonna go there; almost nobody is gonna sacrifice their juicy burger for a quart of spongy fungi. Give up already.