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A comment on Hacking the genome of fungi for smart foods of the future. Parent comment

Re:Hacking the genome of fungi for smart foods of the future by ch4s3 on Tuesday March 26, 2024 @10:54PM (#39835240)
Sure it’ll work but ketone bodies are acids c and the ver time you’ll end up with metabolic acidosis[1].

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341377/#:~:tex....

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Re:Hacking the genome of fungi for smart foods of the future by loopdoend on Wednesday March 27, 2024 @12:14AM (#39835654)
*in rats
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Re:Hacking the genome of fungi for smart foods of the future by ch4s3 on Wednesday March 27, 2024 @10:22AM (#39839535)
Diabetic Ketoacidosis is well documented in diabetic people[1], alcoholics, and in conditions of starvation[2] and the mechanism is the same. Ketone tests were developed for this purpose. Note starvation there, where the body starts using its own fats for energy. Here's a case report of it happening to someone on a ketogenic diet[3].

[1] https://www.cdc.gov/diabetes/basics/diabetic-ketoacidosis.ht...

[2] https://www.ncbi.nlm.nih.gov/books/NBK534848/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220017/

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Re:Hacking the genome of fungi for smart foods of the future by kelipso on Wednesday March 27, 2024 @05:24PM (#39844771)
The body is designed to use its own fats for energy. All logic says you are talking about extreme conditions.
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Re:Hacking the genome of fungi for smart foods of the future by ch4s3 on Thursday March 28, 2024 @10:11AM (#39851710)
The body does that under circumstances of low calorie intake. The case study I posted shows a person developing keto acidosis just from following a ketogenic diet, it’s a well documented risk of ultra low carbohydrate diets if you bother to look. It happens frequently in people using these diets to treat diabetes, it just happens to be less dangerous than Type II diabetes.
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