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Re:'Tooth repair drug' may replace fillings by slimsag on Monday January 09, 2017 @08:16PM (#13361670)
This is insanely cool, and I imagine there is no need for me to explain how useful this would be in comparison to the current dental approaches today.

But is this technology ever going to be available to consumers? I remember reading about similar advancements almost three years ago and haven't heard anything related until now. Maybe I'm pessimistic, but I think we won't see this in practice for a Very Long Time™.

Re:'Tooth repair drug' may replace fillings by brandon272 on Monday January 09, 2017 @08:42PM (#13361804)
I actually find these articles depressing because it seems like nothing like this ever ultimately comes to fruition.

I'm guessing these "breakthroughs" have always been just around the corner. I recall having a conversation with my dentist almost 20 years ago about things that were up and coming that were about to make our lives a lot easier in terms of saving and strengthening and building tooth enamel but none of what he described ever came.

Re:'Tooth repair drug' may replace fillings by advertising on Monday January 09, 2017 @09:17PM (#13361985)
I remember reading an article about these scientists experimenting with blue light and the larger capacity to store data. ~15 years later blu-ray came out. All hope is not lost.
Re:'Tooth repair drug' may replace fillings by astrodust on Monday January 09, 2017 @10:13PM (#13362249)
It takes a lot of time to turn a laboratory discovery into a reliably working prototype, then longer still for the industry to agree on standards and branding, and even longer to ramp up mass-manufacturing and get the distribution chain working.

We could discover teleportation tomorrow morning and it would be twenty years before teleporters were common-place. Everything takes time to be fully realized.

If you want to know what the near future holds look at what was discovered thirty years ago.

Re:'Tooth repair drug' may replace fillings by eganist on Monday January 09, 2017 @11:48PM (#13362667)
> We could discover teleportation tomorrow morning and it would be twenty years before teleporters were common-place. Everything takes time to be fully realized.

I can appreciate this example, though in the specific context of teleportation, there'll probably be a few decades tacked on to resolve the ethical dilemmas arising from the question of whether or not the person arriving out of the other end is in fact the same person.

(I'm of the position that it doesn't matter, but still... anyway, this entire thought was just a tangent off an example)

Re:'Tooth repair drug' may replace fillings by RhodesianHunter on Tuesday January 10, 2017 @12:34AM (#13362864)
You say that now, but when you step up to the machine with the knowledge that you are about to cease to exist, while somewhere else a perfect copy of you gets to go about living your life, I bet you change your mind.
Re:'Tooth repair drug' may replace fillings by timje1 on Tuesday January 10, 2017 @04:53AM (#13363782)
It gets more fun when you start to think about it as different consciousness being created and destroyed, each with the same memories.

At what point do we start being afraid to fall asleep?

Re:'Tooth repair drug' may replace fillings by Filligree on Tuesday January 10, 2017 @11:07AM (#13365845)
When you go to sleep your brain doesn't stop working. Comas, now...
Re:'Tooth repair drug' may replace fillings by neverminder on Tuesday January 10, 2017 @02:07AM (#13363238)
Exactly. What if there's a bug and when your "copy" is created at destination original is not destroyed? Would you agree to be killed, should your copy agree instead? Even worse, what if there's an anomaly in transporting data, original is destroyed and copy emerges disfigured, dead or something in between? Teleportation scares the shit out of me.
Re:'Tooth repair drug' may replace fillings by avip on Tuesday January 10, 2017 @04:29AM (#13363701)
Re:'Tooth repair drug' may replace fillings by astrodust on Tuesday January 10, 2017 @05:45PM (#13369929)
Original NFB source: https://www.nfb.ca/film/to_be/
Re:'Tooth repair drug' may replace fillings by CM30 on Thursday January 12, 2017 @01:03PM (#13384526)
Take full advantage of it?

I mean, cloning things has its advantages too. Could be a good idea for some people to deliberate screw up the process and drastically cut down on their daily workload. Or perhaps as a way for the less ethical to not kill or work alongside their accidental copies, but ship 'em off to join the army or something.

Teleportation going wrong can be just as exciting as prospect as it working out fine. Cloning has a lot of useful applications as well.

Re:'Tooth repair drug' may replace fillings by bigtunacan on Tuesday January 10, 2017 @12:02PM (#13366384)
Did you by chance read the short story "Think Like a Dinosaur" or see the episode of The Outer Limits based off it?

It presents this exact same dilemma. Up until that point I never really considered the potential ethical ramifications of teleportation.

Re:'Tooth repair drug' may replace fillings by gm-conspiracy on Tuesday January 10, 2017 @10:17AM (#13365365)
[dead]
Re:'Tooth repair drug' may replace fillings by zo1 on Tuesday January 10, 2017 @09:17AM (#13364859)
In case anyone isn't aware, you've just read a spoiler.
Re:'Tooth repair drug' may replace fillings by Cerium on Tuesday January 10, 2017 @01:25AM (#13363080)
I think it depends on implementation. I wake up every morning and I'm pretty sure I'm still me. I go in elevators and each time the doors open I'm still me. So, what sort of transportation experience would change that?

Admittedly, the closes to teleportation I've ever felt was my first trip on a cruise ship. I went to sleep in one city, and when I opened my eyes I was suddenly in a city hundred miles away. It was magic. I also still felt like myself.

Re:'Tooth repair drug' may replace fillings by simonh on Tuesday January 10, 2017 @08:18AM (#13364549)
“I thought you said you could just read his brain electronically,” protested Ford.

“Oh yes,” said Frankie, “but we’d have to get it out first. It’s got to be prepared.” “Treated,” said Benjy. “Diced.”

“It could always be replaced,” said Benjy reasonably, “if you think it’s important.”

“Yes, an electronic brain,” said Frankie, “a simple one would suffice.”

“A simple one!” wailed Arthur.

“Yeah,” said Zaphod with a sudden evil grin, “you’d just have to program it to say What? and I don’t understand and Where’s the tea? Who’d know the difference?”

“I’d notice the difference,” said Arthur.

“No, you wouldn’t,” said Frankie mouse, “you’d be programmed not to.”

- Hitch Hiker's Guide to the Galaxy. Not actually about teleportation, but still apropos IMHO.

Re:'Tooth repair drug' may replace fillings by raquo on Tuesday January 10, 2017 @02:36AM (#13363329)
Well, sleep and cruise ships don't destroy and copy your body. Teleportation would be equivalent to being killed the way I see it, until we get a better understanding of conscience at least.
Re:'Tooth repair drug' may replace fillings by adrianN on Tuesday January 10, 2017 @03:46AM (#13363549)
Your body slowly replaces itself. I'm reasonably sure that when you die you have replaced almost all of its atoms at least once.
Re:'Tooth repair drug' may replace fillings by simonh on Tuesday January 10, 2017 @08:22AM (#13364571)
I've been using the same broom for 20 years! Never needed a new one and I'd never think of getting a new one. Of course I've replaced the handle twice and the brush four or five times.
Re:'Tooth repair drug' may replace fillings by contra64 on Wednesday January 11, 2017 @01:18AM (#13372132)
Eventually, the constituent atoms themselves perform a complete cycle (at the slowest rates) every ~7 years. Some substances (e.g. water) cycle much faster, obviously.

http://www.npr.org/templates/story/story.php?storyId=1189358...

Which tells us that sentient consciousness and identity is mostly about the continuity of a signal across only some cells (nerves), and mostly rides on top of standing waves supported by those special cellular processes, at frequencies of oscillation faster than the underlying polarized/ionic chemical processes.

Re:'Tooth repair drug' may replace fillings by soylentcola on Tuesday January 10, 2017 @09:30AM (#13364968)
Theseus' Meatbag?
Re:'Tooth repair drug' may replace fillings by Cerium on Tuesday January 10, 2017 @09:54AM (#13365186)
How do I know? I don't know what happened while on was sleeping. I fell asleep, and perpetually a few minutes later woke up, but my clock told me it was 8 hours. What happened??
Re:'Tooth repair drug' may replace fillings by raquo on Tuesday January 10, 2017 @11:57AM (#13366319)
You know what happens when other people sleep. It's not an issue.
Re:'Tooth repair drug' may replace fillings by greggman on Tuesday January 10, 2017 @03:14AM (#13363473)
Here's a great old animation on this topic

https://m.youtube.com/watch?v=pdxucpPq6Lc

Re:'Tooth repair drug' may replace fillings by ZeroGravitas on Tuesday January 10, 2017 @05:53AM (#13363992)
Better quality (but with Flash requirement):

https://www.nfb.ca/film/to_be/

Re:'Tooth repair drug' may replace fillings by MrQuincle on Tuesday January 10, 2017 @03:34AM (#13363519)
I can think of an experience. The kind of teleportation in which you (or your copy) is teleported too close in time and space and the original is not destroyed.

Then your copy claiming your job, your house, your wife and your children. Just as you would do.

Also if the transport process takes 20 lightyears, when do you send the ACQ? Will your original walk around for 20 years and then have an automated kill switch?

Re:'Tooth repair drug' may replace fillings by Arizhel on Tuesday January 10, 2017 @12:14PM (#13366548)
>Then your copy claiming your job, your house, your wife and your children. Just as you would do.

This sounds like a great scenario to me. I'm sure I would get along just fine with a duplicate of myself, and we could live together and get a lot more done. It sure would help a lot with avoiding burnout at work: we could take turns going to work, me one month and him the next month for instance. But two of us sharing one wife might be a bit much for her, so it'd be a lot better if we brought a second woman into the mix and lived as a polyamorous foursome (though this might be easier if we could create a teleportation clone of the wife too). It'd also be great having a double to help me on house projects, hobby projects, working on a side business, etc. And you mentioned kids: having an extra adult around the house to deal with them can only be a help, and since it's actually another me and not some other person, we're guaranteed to get along, have the same views on parenting, etc.

Honestly, I don't see any downside to this situation at all.

Re:'Tooth repair drug' may replace fillings by logfromblammo on Tuesday January 10, 2017 @01:23PM (#13367372)
I would get a lot less [productive work] done if I had an exact duplicate of myself. My spouse would be jealous and disgusted at the same time.

But I am 90% certain that if my spouse had a duplicate, they would be yelling at each other all the time.

It would be interesting to correlate answers to the question "If you had an exact duplicate, with the same body as you, the same thoughts as you, and the same memories as you up until yesterday, how would you get along?" with various aspects of psychology.

Re:'Tooth repair drug' may replace fillings by Arizhel on Tuesday January 10, 2017 @01:36PM (#13367536)
The only problem I see here with your question is that no one really knows the answer, they can only speculate. I, for instance, think that I'd get along just great with my duplicate, and that we'd work together on getting more stuff done and enjoying more free time as a result. But I don't really know that; it's not like I've tried it before.

Why would your spouse be jealous of your clone? She'd now have two of you, so she's more likely to get attention when she wants it.

Re:'Tooth repair drug' may replace fillings by rebuilder on Tuesday January 10, 2017 @06:09AM (#13364046)
Why is it better if the original is destroyed? That's the whole issue here, the process in your example, when working as intended, just kills a person and makes an identical copy.
Re:'Tooth repair drug' may replace fillings by mathgeek on Tuesday January 10, 2017 @01:07AM (#13362995)
Ah yes, the dilemma of whether the person on the other end having your memories means that the current you didn't cease to exist at the departing end.
Re:'Tooth repair drug' may replace fillings by filoeleven on Tuesday January 10, 2017 @01:45PM (#13367625)
This is why I have no problem walking through wormholes, but will never set foot in a teleporter.
Re:'Tooth repair drug' may replace fillings by kbutler on Tuesday January 10, 2017 @01:29AM (#13363101)
Think about that as you're taking also tonight. Is the person that wakes up the same person?
Re:'Tooth repair drug' may replace fillings by Arizhel on Tuesday January 10, 2017 @12:16PM (#13366582)
Yes. You're not unconscious when you're asleep, you're just in an altered state of consciousness. Being actually unconscious is a very different experience; if you'd ever been through surgery with general anaesthesia you'd know about this.
Re:'Tooth repair drug' may replace fillings by rebuilder on Tuesday January 10, 2017 @06:14AM (#13364065)
Why draw the line at sleep? Your consciousness, such as it is, is pretty fleeting and vague anyway. What reason do you have to think any self survives from one moment to another?
Re:'Tooth repair drug' may replace fillings by animal531 on Tuesday January 10, 2017 @07:24AM (#13364317)
At least while awake, you may be fleeting but you exist in a near constant stream of "you", which make it feel constant. When you go to sleep your brain enters an altered state, which is only a subsection of yourself.

Who knows what will wake up from that?

Re:'Tooth repair drug' may replace fillings by Angostura on Tuesday January 10, 2017 @04:08AM (#13363615)
Damnit Jim!
Re:'Tooth repair drug' may replace fillings by babuskov on Tuesday January 10, 2017 @06:41AM (#13364157)
> it doesn't matter

There's a pun in there.

Re:'Tooth repair drug' may replace fillings by amelius on Tuesday January 10, 2017 @04:05AM (#13363608)
Teleportation will not happen soon, if only because we've invested too much in autonomous cars already.
Re:'Tooth repair drug' may replace fillings by sethrin on Wednesday January 11, 2017 @07:40AM (#13373509)
Teleportation would violate Relativity, so the good news is that the dilemma in question is actually impossible.
Re:'Tooth repair drug' may replace fillings by Jugurtha on Tuesday January 10, 2017 @07:27AM (#13364332)
You are right, it takes time to invent and discover, and then time to roll down to consumers... But I think the second interval has been shrinking. It used to take much, much, longer between the time something is actually invented, and its use by the public (I think 80 years or something for some technologies). It doesn't take that long anymore for its use, not only in its home country, but globally. I live in Africa and touched an iPhone for the first time in 2007, the same year it came out. Why? Because I have a friend who used to watch Jobs keynotes (like wait for them)..and suddenly, the whole world knew about a product. Trade circuits have improved. Doing business with people you never met. All these shrink the time between the time Jobs wrapping up the show, and the moment it is available everywhere.

The first interval seems frozen, but I think this is Parkinson's law at work. Today's scientists and engineers have the best technology in History, and they're pursuing the boldest endeavors by that very fact.

Re:'Tooth repair drug' may replace fillings by ptaipale on Tuesday January 10, 2017 @06:56AM (#13364207)
And when we're discussing medical care, the mandatory regulatory approvals are a significant cause of delay and cost. E.g. FDA approvals in the U.S.

They are a barrier to entry, and they are a measure to ensure safety of new cures. It's a tough balance.

Re:'Tooth repair drug' may replace fillings by chiph on Tuesday January 10, 2017 @11:59AM (#13366342)
Based on the history of drugs like Thalidomide, I'll pick safety.

https://en.wikipedia.org/wiki/Thalidomide#History

Re:'Tooth repair drug' may replace fillings by tommorris on Wednesday January 11, 2017 @06:36AM (#13373220)
The flipside of that is the response to the AIDS crisis. If it hadn't been for activists from groups like ACT-UP and Queer Nation screaming, shouting and making a big stink about the need for a response from the FDA, the federal government more generally, and the pharmaceutical industry, there'd be a whole lot of people who wouldn't be alive today.

http://healthland.time.com/2012/09/27/how-to-survive-a-plagu...

https://www.opendemocracy.net/transformation/ray-filar/silen...

Re:'Tooth repair drug' may replace fillings by ptaipale on Tuesday January 10, 2017 @01:37PM (#13367548)
Safety is good, but it's not a dichotomy of "absolutely no safety" or "safety trumps all other things".

It seems to me that the safety aspect is currently very strong, on the expense of long time-to-market and high barrier of entry to market.

Re:'Tooth repair drug' may replace fillings by splawn on Tuesday January 10, 2017 @02:56PM (#13368350)
.....but we are talking about healthcare. Safety should trump all other things.

https://en.wikipedia.org/wiki/Primum_non_nocere

Re:'Tooth repair drug' may replace fillings by ptaipale on Wednesday January 11, 2017 @01:35AM (#13372190)
If safety absolutely trumps all other things, then there can be no trials of anything (because by definition, a trial is there to experiment and find out about possible safety issues) and there would be no development of new medicines at all.

That would not mean staying where we are, it would mean starting to slowly go backwards in the tools available for health care (because e.g. some antibiotics are slowly becoming inefficient and new ones should be developed - and currently the world is not doing enough of that.)

See e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095020/

Re:'Tooth repair drug' may replace fillings by splawn on Friday January 13, 2017 @05:33PM (#13395390)
that is disingenuous... as you said "a trial is there to experiment and find out about possible safety issues". You have to test drugs before you can feed them to everyone safely.... but you obviously already knew that and just wanted to be contrarian.
Re:'Tooth repair drug' may replace fillings by zzzzz99997 on Thursday January 12, 2017 @08:36AM (#13382041)
..no. Treating sick people and improving the health of our species should trump all other things.
Re:'Tooth repair drug' may replace fillings by splawn on Friday January 13, 2017 @05:34PM (#13395398)
I will just cross my fingers that you eat a bunch of untested drugs then... for your health! :D
Re:'Tooth repair drug' may replace fillings by dghughes on Monday January 09, 2017 @10:40PM (#13362368)
I recall watching a man being interviewed in a swamp talking about finding some organisms there that had emit blue light. (?) years later we have OLED monitors.
Re:'Tooth repair drug' may replace fillings by brazzledazzle on Monday January 09, 2017 @09:48PM (#13362124)
I remember when SSDs were always around the corner.
Re:'Tooth repair drug' may replace fillings by hackits on Monday January 09, 2017 @09:09PM (#13361943)
I would of liked to been told `Nothing is going to come on the market` instead of `All this wonderful technology is going to solve any problems you're going to have`. The latter results in careless behavior, the former results more careful behavior.

Personally as someone as a kid was going up out-back Australia who's parents and care giver didn't put fluoride tablets into the water because it caused the water to `taste bad`. As a result I have screwed up teeth. Discussed this with this with my parents years later. Their reasoning for my teeth problem was poor diet and eating sugary food (Completely ignoring the fact they tossed the tablets into the bin).

Fast forward into the future with a family and two children I don't have soft drink, fruit juice in the house. Who would of known, all the kids teeth are great since our last dentist visit.

Re:'Tooth repair drug' may replace fillings by kalleboo on Monday January 09, 2017 @10:40PM (#13362370)
Most of Europe and Japan doesn't fluoridate their water and they don't have notably worse dental outcomes.

It really has to do with toothbrushing and diet. Water fluoridation is just a way to get to the people who refuse to brush their teeth.

Re:'Tooth repair drug' may replace fillings by stplsd on Monday January 09, 2017 @11:28PM (#13362565)
I think genetics have a part too. My grandmother was deported to Siberia (https://en.wikipedia.org/wiki/Soviet_deportations_from_Lithu...) for 20 years where they have 200 grams of bread a day at best and never brushed her teeth in her life and never had a tooth filling or missing tooth before her retirement, and I have half my teeth missing and I am only 30 years old. Fuck my life.
Re:'Tooth repair drug' may replace fillings by torinmr on Monday January 09, 2017 @11:52PM (#13362685)
Could that also be related to diet? I'm guessing your grandmother practically never ate sugar if she was living on 200 grams of bread a day.

I've also heard that early modern humans had fairly good teeth for their age despite the presumed lack of dental care, presumably also due to differences in their diet from us.

Re:'Tooth repair drug' may replace fillings by Cerium on Tuesday January 10, 2017 @01:27AM (#13363091)
Diet is super important. I used to drink orange juice every day. I got a cavity every 6 months. I have stopped drinking orange juice and have not had a cavity since.
Re:'Tooth repair drug' may replace fillings by filoeleven on Tuesday January 10, 2017 @01:48PM (#13367663)
I just heard a radio piece about how basically all humans had Hollywood smiles (where the teeth lined up perfectly) until the Industrial Revolution, when our jaws began to shrink and there was no longer enough room for all the teeth. I didn't get to hear the part where they discussed/hypothesized whether the changes were due to diet or environment or something else.
Re:'Tooth repair drug' may replace fillings by robbiep on Tuesday January 10, 2017 @03:50AM (#13363560)
So ¼ of your genetic material had a diet in which she never had a filling, and you on a different diet at age of 30 are missing many teeth, and you conclude that it's genetics?

Either some leap of logic or information is missing there or you're drawing the wrong conclusion from your data

Re:'Tooth repair drug' may replace fillings by cookiecaper on Tuesday January 10, 2017 @02:27AM (#13363298)
Yeah, there is undoubtedly a genetic side to it. My teeth decay rapidly -- as an under-two toddler, I had to undergo full anesthesia for a dental rehabilitation. Though neither my siblings nor my parents have very bad teeth, I've always been the exception (I guess I got just the right mutation). My pediatric dentist was always expressing astonishment at how quickly my teeth decay.

You know how dentists say "Hey, I can tell you drink a ton of soda, you need to stop"? I would get told this every time I'd go in for a cleaning, despite not drinking any soda and very little fruit juice/other sugary drinks for many years, 90%+ water only.

Fast forward 20-something years, and 2 of my daughters have had to undergo a dental rehab similar to mine at very young ages (though not quite as young as me), despite the stringent dental regimen my wife enforces to prevent this fate. There's no doubt that they got my bad teeth genes.

We're talking young kids here, ages 2-3 at the time of the operation (I was 18 mos. when I went down). They don't eat an inordinate amount of sugar, and as I stated above, my wife is very thorough with their dental hygiene. The water is fluoridated where we live. A lot of kids this age surely have much worse diets and much worse dental hygiene, but their teeth seem to be problem-free for many years.

Personally, I've had tons of fillings, 7-ish root canals, two teeth fully extracted because they were past saving, and several that badly need work and I'm not even 30 yet. Pretty much the only people living with worse teeth are opiate addicts.

I hope I win the lottery some day so I can get a mouth full of implants and be done with it. I hear the going rate for this is about $75,000.

A lot of people refuse to believe that genetics play any role, but that's absolutely not consistent with my experience, nor the opinion of most of the dentists I've had.

Re:'Tooth repair drug' may replace fillings by 52-6F-62 on Tuesday January 10, 2017 @10:16AM (#13365358)
I feel your pain on this one. I have a very similar problem.

My parents enforced our dental care and we went to the dentist regularly when I was young. Always once a year checkup and twice a year cleaning and still I had regular dental issues.

In the second grade I can recall being brought out of class to a tooth-care specialist the school brings in to teach kids who seem uncared-for to brush their teeth. I brushed twice a day.

When I was fifteen I remember being yelled at by my dentist about how I don't look after my teeth because I had "16" cavities (the dentist, mind you, in my later years I realized was actually a bit of a hack -- all of his work fell out of my mouth and left me in terrible pain).

Around this time the dentist put me on regular fluoride mouth washes -- I went home with a bottle of some god-awful "cherry" flavoured stuff. I _still_ had repeated problems.

Fast forward to the present -- I've had one infected wisdom tooth, one infected molar -- both had to be removed. I have one half-decayed wisdom tooth that will be extracted soon. This fall I've had to have 4 fillings (some of them were put off for a while mind you).

The next year I am pending a root canal and a crown, and my dentist also has informed me that (at age 30) I require jaw surgery or I face the possibility of regular migraines due to molar wear.

I floss, brush, and use mouth wash daily. I don't eat much sugar. My parents actually raised us on a lot of raw vegetables (my mother grew, and I was raised in rural southern Ontario in Canada -- something of a agriculture belt).

The only neglect would be that my parents could not afford braces when I was young.

There has got to be some genetic aspect. Or does Hacker News as a consensus believe in shit luck?

Re:'Tooth repair drug' may replace fillings by awfgylbcxhrey on Tuesday January 10, 2017 @01:19PM (#13367325)
Have you tried oral probiotics? Mind you, I have no reason to believe they'll help you, but at this point why not?

I think I first heard about them on HN. BLIS and K12 are the keywords, if I remember correctly.

Re:'Tooth repair drug' may replace fillings by throwaway00061 on Tuesday January 10, 2017 @04:17AM (#13363637)
You might want to pay Dr. Kim Kutsch a visit, or at least watch some of his webinars on YT. One of the things he recommends that could help you is ordinary bleach (sodium hypochlorite) heavily diluted to about 0.05% as an anti-microbial rinse.
Re:'Tooth repair drug' may replace fillings by grzm on Tuesday January 10, 2017 @04:36AM (#13363725)
Serious question. Why are you posting health-related advice from a throwaway account? If it's something you are recommending to others, posting from an established account would have much more weight.
Re:'Tooth repair drug' may replace fillings by throwaway00061 on Tuesday January 10, 2017 @04:47AM (#13363761)
I always use throwaway accounts and don't see why account karma should confer additional weight on anything I say.

Here's an article that reviews the literature on diluted bleach rinsing: http://www.rdhmag.com/articles/print/volume-35/issue-6/colum...

Re:'Tooth repair drug' may replace fillings by grzm on Tuesday January 10, 2017 @05:22AM (#13363880)
It doesn't have anything to do with karma. From a throwaway account, I have no basis to know who you are based on your other participation. HN is a community. Pseudonymity is fine, but anonymity is counter to the idea of community. I encourage you to establish yourself and be part of it.
Re:'Tooth repair drug' may replace fillings by cookiecaper on Tuesday January 10, 2017 @09:14PM (#13371210)
I know the other guy is giving you a hard time about the throwaway, but I do appreciate this. I'll watch some of his stuff, it looks interesting. Thanks for sharing.
Re:'Tooth repair drug' may replace fillings by shoover on Tuesday January 10, 2017 @08:18AM (#13364550)
I was astounded when Viktor Frankl reported the same thing in Man's Search For Meaning, observed in his time in a Nazi concentration camp. Your grandmother may well have superior dental genes, but there is something unique about that bread diet and camp/deportation life, too. Sorry to hear about your teeth.
Re:'Tooth repair drug' may replace fillings by adrianN on Tuesday January 10, 2017 @03:53AM (#13363571)
I think your oral microbiome is also important. I've heard about experimental treatments which replace the cavity causing bacteria with other strains that don't produce acids.
Re:'Tooth repair drug' may replace fillings by dethswatch on Wednesday January 11, 2017 @04:35PM (#13377687)
I read about that in the 90's- did anything become of it?
Re:'Tooth repair drug' may replace fillings by Johnythree on Tuesday January 10, 2017 @03:19AM (#13363481)
You are completely missing the point. Many areas already have sufficient fluoride.

It depends on the natural amount of fluorine in the water, if there's sufficient, then it's fine.

It's only in the relatively few areas where there is a deficiency that it's a problem.

And of course it also depends on diet.

Offsetting your claim are studies which show that where people exclusively drink rain water, there is a higher incidence of tooth decay.

Re:'Tooth repair drug' may replace fillings by kalleboo on Tuesday January 10, 2017 @06:25AM (#13364099)
The countries that don't fluoridate their water don't have minimum levels of fluoride required. Whereas they have maximum levels of fluoride contamination allowed.

I'm not one of those "fluoridation is a government plot to make everyone pliable" crazies. Just saying that it's far, far more important to BRUSH YOUR TEETH than to have a fluoridated water supply. Just seems to me like water fluoridation is just one of those crazy things Americans and places America has influenced do (such as using the customary measure system and circumcising their male children - sure if you dig deep enough you can justify it, but plenty of people get along just fine without it)

Re:'Tooth repair drug' may replace fillings by logfromblammo on Tuesday January 10, 2017 @02:10PM (#13367894)
The active component of tooth-brushing is removal of mutans-type bacterial colonies from the teeth.

Cavities do not form without cariogenic bacteria, provided with a food supply of simple sugars. If you have such bacteria, there are several ways to inhibit cavity-formation, such as by chemically hardening bioapatite with fluoride ions, or by re-mineralizing tooth enamel.

Communities would be better served by mutans eradication efforts, even though they could cost far more than the $1/person-year that fluoridation costs.

If I had the cash and political backing, I would put mutans-specific bacteriophages and tricalcium phosphate in a municipal water supply. I'd then subsidize dental office visits for persons in the affected area, such that anyone desiring fluoride treatments can get them at no additional charge, and offer gratis chlorhexidine/xylitol mouth rinse after every visit.

Kill the S. mutans; end cavities.

Re:'Tooth repair drug' may replace fillings by nkozyra on Tuesday January 10, 2017 @09:10AM (#13364788)
> The countries that don't fluoridate their water don't have minimum levels of fluoride required.

I think the point is that fluoridation is often unnecessary because of the natural amount of fluoride in the water.

Re:'Tooth repair drug' may replace fillings by dkersten on Tuesday January 10, 2017 @04:48AM (#13363765)
Water fluoridation is just a way to get to the people who refuse to brush their teeth.

That's not really true in and of itself -- fluoridation won't fix damage done by bad hygiene or diet. As someone else mentioned, genetics and other factors all play a part too.

Re:'Tooth repair drug' may replace fillings by robbiep on Tuesday January 10, 2017 @03:53AM (#13363572)
I grew up in rural Australia, my parents fed us fluoride tablets when we were young. 1-2 fillings between 3 siblings, although I'm fairly sure our bore had a bit of fluoride in it.

I'm sorry you missed out on that, teeth problems are shitty

Re:'Tooth repair drug' may replace fillings by Ftuuky on Tuesday January 10, 2017 @04:26AM (#13363685)
Same here but in Switzerland. 4 fillings between 3 brothers (2 are mine).
Re:'Tooth repair drug' may replace fillings by user837387 on Monday January 09, 2017 @10:04PM (#13362205)
Didn't you use toothpaste with fluoride? Or is that not enough?
Re:'Tooth repair drug' may replace fillings by hackits on Monday January 09, 2017 @10:32PM (#13362330)
Used toothpaste with fluoride. Though the fridge was constantly stoked with sugar, fruit juice, bread and bread toppings. Kid of ironic that my Mum is a dietitian who is mobility obese.
Re:'Tooth repair drug' may replace fillings by test1235 on Tuesday January 10, 2017 @04:21AM (#13363660)
>mobility obese

morbidly?

Re:'Tooth repair drug' may replace fillings by hackits on Tuesday January 10, 2017 @07:43PM (#13370759)
Stupid auto correct, yes.
Re:'Tooth repair drug' may replace fillings by throwaway91111 on Monday January 09, 2017 @10:42PM (#13362378)
Reasearch indicates that fluorided water is better at covering the surface area of your teeth--brushing with toothpaste mostly removes the layer of plaque and allows the active ingredient to work better.

It's actually phenomenal how little dental research has ever reached consumer behavior or dental care.

Re:'Tooth repair drug' may replace fillings by Arizhel on Tuesday January 10, 2017 @12:23PM (#13366671)
Instead of fluoridated water, you can always just use fluoride mouthwash/rinse which many dentists now recommend to be used daily.

Personally I only drink RO water as tap water tastes bad to me, but I use a fluoride mouthwash (Crest) every night after brushing and flossing.

Re:'Tooth repair drug' may replace fillings by poikniok on Monday January 09, 2017 @09:37PM (#13362073)
Fluoride decreases IQ significantly, be thankful that at least you are intelligent, albeit with bad teeth.
Re:'Tooth repair drug' may replace fillings by mrob on Monday January 09, 2017 @10:10PM (#13362233)
Regardless of whether fluoride is a serious risk or not, it seems ridiculous to take a topical drug systemically. Fluoride works by inorganic reactions with the teeth themselves. There's no benefit to flooding the whole body with it. It's reasonable to be suspicious of water fluoridation when the same benefit can be achieved with fluoridated toothpastes, which deliver the fluoride only where it's needed.
Re:'Tooth repair drug' may replace fillings by olejorgenb on Monday January 09, 2017 @10:52PM (#13362418)
That is a good point, but according to http://www.ada.org/~/media/ADA/Member%20Center/FIles/fluorid... (p.10)

"Systemic fluorides can also give topical protection because ingested fluoride is present in saliva, which continually bathes the teeth providing a reservoir of fluoride that can be incorporated into the tooth surface to prevent decay."

It also says fluoride ingested during teeth-formation is incorporated into the teeth.

Re:'Tooth repair drug' may replace fillings by popinman322 on Monday January 09, 2017 @10:43PM (#13362380)
As someone who grew up on well water with no fluoride in it I can confirm that my teeth are looking fine after all these years of regular dental checkups and twice daily tooth-brushing.
Re:'Tooth repair drug' may replace fillings by olejorgenb on Monday January 09, 2017 @11:34PM (#13362589)
Fluoride occurs naturally (in varying concentrations) in water. Water with high natural concentrations is how we found out fluoride prevents tooth decay in the first place.
Re:'Tooth repair drug' may replace fillings by sathackr on Monday January 09, 2017 @09:59PM (#13362179)
Source?
Re:'Tooth repair drug' may replace fillings by throwaway91111 on Monday January 09, 2017 @10:45PM (#13362390)
While I can't source the IQ claim, the evidence "showing" that fluoridation is safe to drink (as opposed to measuring by tooth health) is fairly scarce.

OTOH I've heard teeth are especially poor around Portland Oregon where they don't fluoride the water. I'd simply say the jury is still out.

I tend to think of iq claims specifically with a particularly large grain of salt: it's an index of society that people follow closely and is related to many, many factors.

Re:'Tooth repair drug' may replace fillings by MagnumOpus on Tuesday January 10, 2017 @03:21AM (#13363486)
Re:'Tooth repair drug' may replace fillings by vanattab on Monday January 09, 2017 @10:38PM (#13362360)
The practice of fluoride in drinking water does seem to be getting some push back of late. I did a quick google scholar search for "fluoride drinking water" and found some articles on both sides.
Re:'Tooth repair drug' may replace fillings by delecti on Monday January 09, 2017 @10:54PM (#13362428)
So does the practice of vaccinations, and without strong evidence that it's not safe, I'm inclined to take the lack of such evidence as significant, in light of the abundance of evidence that it seems to be helpful.
Re:'Tooth repair drug' may replace fillings by wishinghand on Monday January 09, 2017 @10:01PM (#13362190)
Aw shucks, I'm merely intelligent, rather than a genius?
Re:'Tooth repair drug' may replace fillings by pasquinelli on Tuesday January 10, 2017 @12:11PM (#13366514)
i'd rather be stupid than have bad teeth.
Re:'Tooth repair drug' may replace fillings by nobodyman on Tuesday January 10, 2017 @03:09AM (#13363454)
It's funny. I often have the same reaction as you. Yet last summer I went to the dentist to have an old filling replaced with a crown. They took a 3D scan of my teeth and used that scan to mill a crown on site in about an hour. It fit perfectly and I could scarcely distinguish it from the rest of my real teeth.

20 years ago, all of this would sound like science fiction to me.

Re:'Tooth repair drug' may replace fillings by sah2ed on Tuesday January 10, 2017 @04:21AM (#13363661)
But I bet the cost of the procedure left a sizeable hole in your pocket ;).
Re:'Tooth repair drug' may replace fillings by dv_dt on Tuesday January 10, 2017 @04:01PM (#13368940)
I think it's only really depressing if an advancement is stuck idly behind something non-technical like lack of capital, or legal wrangling, or being acquired and shelved. Other than that, if there were real technical bumps that sidelined the advancement, well that's just part of the process.

What one really wonders at, is technology where there were technical failures, but were really a small distance away from success for lack of combination the right bit of information to push it over the edge - but are now locked away in storage in some proprietary corner somewhere.

Re:'Tooth repair drug' may replace fillings by MichailP on Monday January 09, 2017 @10:44PM (#13362383)
I had a similar talk with my dentist, where I was optimistic about future and he put me back into reality. He took a piece of paper and started drawing tooth in its complexity - nerves, blood supply, several completely different and 'living' layers (somehow I pictured teeth as something rather simple, like a piece of hard stone inserted into gums), and then he said, do you think a simple chemical can rebuild all this interplaying complexity?
Re:'Tooth repair drug' may replace fillings by prostoalex on Monday January 09, 2017 @11:03PM (#13362466)
To be fair, fillings don't rebuild the complexity either.
Re:'Tooth repair drug' may replace fillings by systems on Monday January 09, 2017 @11:02PM (#13362457)
do you think bits and bytes can run the global economy .. plus maybe its a complex chemical ..
Re:'Tooth repair drug' may replace fillings by mikekchar on Tuesday January 10, 2017 @03:37AM (#13363528)
On the plus side, drug patents are 20 years, so there is considerable incentive to get something out the door somewhere in that time frame. Hmm... maybe I'm not so anti-patent as I thought ;-)
Re:'Tooth repair drug' may replace fillings by johnchristopher on Tuesday January 10, 2017 @01:04AM (#13362983)
Re:'Tooth repair drug' may replace fillings by epimetheus on Monday January 09, 2017 @11:20PM (#13362539)
Do you have a site for this 20 years ago claim? The first I've seen is one about 10 years ago, in the UK.
Re:'Tooth repair drug' may replace fillings by saurik on Monday January 09, 2017 @08:27PM (#13361719)
I really enjoyed this thread from a recent (two weeks ago) post about another advance in the treatment of cavities (a year before) that touched on this feeling.

https://news.ycombinator.com/item?id=13274183

Re:'Tooth repair drug' may replace fillings by ricardobeat on Monday January 09, 2017 @10:02PM (#13362196)
That discussion got me on a search spree. Apparently others have picked up on the root-analogue implant idea and it is now available in the Netherlands, maybe soon in the USA: http://www.replicatetooth.com/for-patients

This one is still made of titanium though, the Zirconia ones by BioImplant seem to make more sense.

Anyway, not a cure but at least you don't need someone drilling into your head when cavities win a match.

Re:'Tooth repair drug' may replace fillings by fractallyte on Tuesday January 10, 2017 @05:51AM (#13363985)
There are some major issues with the Replicate system: a paucity of actual cases (I also can't see any long term follow-ups); and the fact that the actual implant is a dark grey - this unpleasant discoloration will show through gums.

BioImplant has a long history, with comprehensive case histories and follow-ups readily viewable on the website. This is very important for medical credibility. (I worked with the creator of BioImplant.)

On the other hand, Replicate Tooth has a very nice website!

Re:'Tooth repair drug' may replace fillings by Coincoin on Monday January 09, 2017 @08:44PM (#13361816)
You are not pessimistic. It's another one of those thing that have been only a few years away from commercialization for 20 years now.

This is happening so often, there must be a name or a law for that.

Re:'Tooth repair drug' may replace fillings by 13of40 on Monday January 09, 2017 @09:33PM (#13362058)
Reminds me of a successful experiment where they caused mice to develop an immunity to plaque bacteria. I read about that in a dental training manual I found in a thrift shop about 20 years ago. Had photos of healthy rat teeth and everything.
Re:'Tooth repair drug' may replace fillings by sobani on Tuesday January 10, 2017 @08:00AM (#13364478)
According to a researcher on a recent Radiolab episode[1], 99.6% of results on mice don't replicate to humans. I assume for rats a similar figure applies.

[1] http://www.radiolab.org/story/bringing-gamma-back (about treating Alzheimer’s disease with light)

Re:'Tooth repair drug' may replace fillings by simonsarris on Monday January 09, 2017 @08:48PM (#13361837)
Pessimistically, that name is "Stagnation Hypothesis"

(edit, oops the term Peter Thiel/Tyler Cowen like is "Great Stagnation." See: https://www.youtube.com/watch?v=i_yJTCDU4uE)

Re:'Tooth repair drug' may replace fillings by sytelus on Monday January 09, 2017 @10:33PM (#13362335)
One way I filter my science news is to ignore all headlines that contains the word "may", "could be", etc. I don't recall in recent times seeing an actual product release corresponding to one of these headlines. Most of the time its just some research group doing some experiment in very narrow scope, working slowly towards 10 year horizon and doing some PR to renew the funding.
Re:'Tooth repair drug' may replace fillings by Sophistifunk on Monday January 09, 2017 @11:36PM (#13362598)
I distinctly remember seeing a story maybe 20 years ago about a university breeding a bacteria that out-competes the stuff in your mouth, but doesn't excrete the acid that wrecks your teeth. It was supposedly going into products that same year, but I never heard of it again.
Re:'Tooth repair drug' may replace fillings by funkymike on Tuesday January 10, 2017 @12:40PM (#13366864)
This is what humanity really needs. The best part is that once it is out in the wild it should spread naturally, if slowly. Thus it will eventually penetrate to every human society and wipe out the current strains of the bacteria.
Re:'Tooth repair drug' may replace fillings by ChuckMcM on Monday January 09, 2017 @11:04PM (#13362473)
I think this is cool research and I hope they can bring it to market but in the "its cool stage" it just makes it harder to convince your kids to brush :-)

Parent: "Brush your teeth or you will end up with all this dental work like I have."

Kid: "Nah, we'll have regrowable teeth by then."

FWIW, I got an implant a couple of years ago and talked to my dentist about these sorts of things. On the plus side an implant is known to work, will likely last beyond my death, makes my remains easier to identify is an obliteration scenario and is available today. The down side is that you can never regrow that tooth once you've sealed a tungsten post into your jawbone.

Re:'Tooth repair drug' may replace fillings by stplsd on Monday January 09, 2017 @11:17PM (#13362529)
I am only 30 years old and have shitty job, and half of my teeth are missing. Implants are my only hope so far. But compared to natural tooth, implants are so crude replacement. Fuck my life.
Re:'Tooth repair drug' may replace fillings by rincebrain on Tuesday January 10, 2017 @01:37AM (#13363130)
Why not? What makes it more traumatic/infeasible than removing a tooth in the first place?
Re:'Tooth repair drug' may replace fillings by sqldba on Monday January 09, 2017 @11:47PM (#13362664)
I thought implants only have a ten year lifespan?
Re:'Tooth repair drug' may replace fillings by jessaustin on Tuesday January 10, 2017 @12:33AM (#13362857)
At least in USA, there is a vast range in implant placement technique among practicing dentists. Improperly placed, they'll fail in six months. Properly placed, and with no later issues such as abscesses, they should get stronger and stronger over time.
Re:'Tooth repair drug' may replace fillings by sandworm101 on Monday January 09, 2017 @09:19PM (#13361995)
There are limits to its usefullness. Teeth wear down pver time. This may repair a cavity but cannot rebuild a tooth mechanically worn away with age or with fractures, often a result of cavities. Fillings may be less needed but crowns (i have three) arent going away.

Teeth are not perfect. If i was going to mars id have them all either crowned or replaced with implants. Teeth are strong, but not stronger than metal.

Re:'Tooth repair drug' may replace fillings by amelius on Tuesday January 10, 2017 @02:53AM (#13363390)
> Prof Sharpe said a new treatment could be available soon: "I don't think it's massively long term, it's quite low-hanging fruit in regenerative medicine and hopeful in a three-to-five year period this would be commercially available."
Re:'Tooth repair drug' may replace fillings by monkey88 on Tuesday January 10, 2017 @09:58AM (#13365215)
Paul Sharpe has been in the news for these kinds of announcements before.

His company, Odontis, failed to bring any new thing to market, and that was 10 years ago. Perhaps now there is a more mature product.

Re:'Tooth repair drug' may replace fillings by divanvisagie on Tuesday January 10, 2017 @12:14AM (#13362789)
Pretty sure they covered time to market in the article