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Re:Found: A protein that drives ageing without unleashing in... by dimavolo on Saturday November 14, 2026 @03:57AM (#50495319)
I was having the same old boring debate with someone the other day: "why would you want to live forever when after age 80 ~ 90+ there's no point in living anymore?"

Most people, even technical people, can't imagine being 90 years old and being indistinguishable visually and in terms of mental capacity from a 20-year-old. They imagine decades of suffering with bone aches, diseases and dementia... even technical people who should know better that when you optimize a system that's full of technical debt, it's almost all upside.

I'll have plenty to do and plenty to think about when I'm 100 years old, assuming I have a body and brain capable of it.

"Yes, but what about all the people you'll have lost by then?"

First of all, if I get to live a long and healthy life they probably do too.

Second of all, we adapt. It's not all sunshine and rainbows, but getting to live for as long as you want, as healthy as you want, is worth the grief.

Re:Found: A protein that drives ageing without unleashing in... by duskdozer on Saturday November 14, 2026 @04:34AM (#50495510)
I can only imagine it being a defense mechanism because ultimately, you'd still have the option of dipping out whenever you wanted.
Re:Found: A protein that drives ageing without unleashing in... by alexey-salmin on Saturday November 14, 2026 @05:31AM (#50495841)
Well you personally can dip out but your kids will have to live in a fucked up society run by the old and wise. I would rather them dipping out too.
Re:Found: A protein that drives ageing without unleashing in... by duskdozer on Saturday November 14, 2026 @08:11AM (#50496749)
That's true, but also feels like a separate concern.
Re:Found: A protein that drives ageing without unleashing in... by alexey-salmin on Saturday November 14, 2026 @09:43AM (#50497407)
It's like saying that famine is a separate concern from drought.

Continuous renewal of humans plays an extremely important role in our society, it's a huge blessing. Get rid of it and it's all fucked.

Re:Found: A protein that drives ageing without unleashing in... by duskdozer on Saturday November 14, 2026 @10:43AM (#50497917)
What I mean is that when I hear oppositions like in the oc, it doesn't seem like it's about some consideration of what the world would be like, just strictly about the idea itself. Like they aren't saying that it will result in the worst people in the world becoming even more powerful and not even their mortality can save us and we'll live in a dystopian hellscape.
Re:Found: A protein that drives ageing without unleashing in... by godelski on Saturday November 14, 2026 @03:12PM (#50500352)

  > It's like saying that famine is a separate concern from drought.
Well... they are. They have different solutions. They have different roots. Famine can by created by many things besides drought. You can have a drought and no famine. This still holds true when talking about old people.
Re:Found: A protein that drives ageing without unleashing in... by throwaway27448 on Saturday November 14, 2026 @05:15AM (#50495737)
> but getting to live for as long as you want, as healthy as you want, is worth the grief.

If wishes were fishes there'd be no room for water.

Re:Found: A protein that drives ageing without unleashing in... by alexey-salmin on Saturday November 14, 2026 @05:23AM (#50495791)
No, it's not that. Even if at 90 I had a body of a 20 year old, I would still have the mind of 90 year old. With all the experience, all the mistakes and presuppositions and biases.

Luckily there is in fact a procedure that allows to reset BOTH the body and the mind into a clean healthy state. It's called "having kids".

Re:Found: A protein that drives ageing without unleashing in... by Gupie on Saturday November 14, 2026 @07:42AM (#50496582)
Age does bring wisdom, at least for most. They look back at the stupid things they did in their twenties, and see twenty year olds doing the same as they did. Youth is wasted on the young.
Re:Found: A protein that drives ageing without unleashing in... by alexey-salmin on Saturday November 14, 2026 @10:45AM (#50497928)
Saying that youth are stupid and old are wise is nearsighted. Both play important roles. I would never ever voluntarily confine myself to a society where everyone is wise and no one does stupid things. Nor would I want that for my kids.
Re:Found: A protein that drives ageing without unleashing in... by Gupie on Saturday November 14, 2026 @12:35PM (#50498942)
Yes both have important roles. The older you are the more experienced you are, while I expect societies would stagnate without the young. However I would myself like to be in a society where everyone was wise and didn’t do stupid, meaning harmful, things.
Re:Found: A protein that drives ageing without unleashing in... by latentsea on Sunday November 15, 2026 @11:25AM (#50508154)
I'd give anything to be 14 again.
Re:Found: A protein that drives ageing without unleashing in... by bossyTeacher on Saturday November 14, 2026 @12:51PM (#50499113)
> there is in fact a procedure that allows to reset BOTH the body and the mind into a clean healthy state. It's called "having kids".

You must have not met many parents because this procedure you speak of isn't guaranteed at all to do this reset you speak of. One could even argue that this outcome is the outlier. Go work as a teacher at a secondary school and tell us the percentage of parents whose mind and body is in a "clean healthy state".

Re:Found: A protein that drives ageing without unleashing in... by naasking on Saturday November 14, 2026 @01:25PM (#50499420)
> Even if at 90 I had a body of a 20 year old, I would still have the mind of 90 year old. With all the experience, all the mistakes and presuppositions and biases.

I think you're underestimating how many of your thoughts, inclinations, moods and attitude are driven by the body (hormones, energy, etc). The mind is not separate from the body, they are one system. If you rejuvenate the body, the mind is also changed. I agree neuroplasticity is something that needs care as well, but it's simply not the case that it's a separate thing.

Re:Found: A protein that drives ageing without unleashing in... by noosphr on Saturday November 14, 2026 @05:57AM (#50495975)
150 years ago a third of all white families in the southern states owned slaves and there were 3 million slaves.

If you think either group would have let the other live forever after the civil war I have a stone that grants you immortality to sell you.

Re:Found: A protein that drives ageing without unleashing in... by XorNot on Saturday November 14, 2026 @06:13AM (#50496050)
I think that's also a conversation that comes from younger people struggling with encountering the first signs of physical aging being a limitation. One thing that sticks out from when it comes up on reddit is people (claiming to be) in their 50s to 70s basically saying you don't really realize it's happened.

And I mean certainly I'm not constantly aware I'm in my 40s. And the healthy 80 and 90 year olds I've known don't seem "over it" - and the unhealthy ones aren't ready to give up either, they're usually just frustrated their body can't keep up.

Re:Found: A protein that drives ageing without unleashing in... by jamesyoungquist on Saturday November 14, 2026 @09:49AM (#50497467)
I had a moment when I was around 25... I was very active, but I was noticing that I was starting to heal and recover more slowly than I did when I was 19. Then it hit me, this is basically just going to get worse and worse over the decades, and then I'm going to die.

It helped, I kept being like "wtf is wrong with me" but actually, no, I was just noticing the first little tiny signs of aging.

Now the trajectory has kept up, and I have to squint to read things that I could once read easily. Both my parents used reading glasses, and in 5 years I'm going to need them myself.

Re:Found: A protein that drives ageing without unleashing in... by agumonkey on Saturday November 14, 2026 @07:09AM (#50496390)
Occasionally you run into a 85 or 90yo that physically is quite limited, but mentally is sharp as f. Some were even learning new things fluidly. It's a bit too rare, but it's something to develop socially.
Re:Found: A protein that drives ageing without unleashing in... by qubex on Saturday November 14, 2026 @07:39AM (#50496565)
Sir Roger Penrose springs to mind.
Re:Found: A protein that drives ageing without unleashing in... by mejutoco on Saturday November 14, 2026 @07:23AM (#50496473)
> Most people, even technical people, can't imagine being 90 years old and being indistinguishable visually and in terms of mental capacity from a 20-year-old

Because it never happened. What person is 90 and looks 20?

> assuming I have a body and brain capable of it.

> as healthy as you want

If we are playing thought experiments it is fine but right now there is no reason to think that is possible. This is what people are telling you. They do not lack imagination, they say it does not seem likely. It is fun to fantasize about as a science-fiction topic though.

Re:Found: A protein that drives ageing without unleashing in... by quantumink on Saturday November 14, 2026 @08:20AM (#50496809)
The 90 to 20 contrast may be too large a spread to be anything but hyperbolic at this time, however:

when seeing someone like Larry Ellison speak and move, it is very clear that dedicated optimization has major benefits and productive results.

Show a recent interview of Ellison to a random person and ask them how old the guy is - the responses I often get from people are estimates in the 40-50's range.

While obviously this is not '20', it is still almost a halving in how old one is perceived (if you didn't know his temporal age, go watch a few minutes of a recent interview, then guess how old he is, then look up his actual age). Though this comment may bias one to guess on the older side, that's why we can blind the experiment by asking someone else you know.

Re:Found: A protein that drives ageing without unleashing in... by delta_p_delta_x on Saturday November 14, 2026 @09:10AM (#50497164)
> dedicated optimization

So, plastic surgery, and hair dye?

Re:Found: A protein that drives ageing without unleashing in... by cwmoore on Saturday November 14, 2026 @11:39AM (#50498376)
and a couple of islands
Re:Found: A protein that drives ageing without unleashing in... by latentsea on Sunday November 15, 2026 @11:18AM (#50508097)
Islands have been known to be sources of youth.
Re:Found: A protein that drives ageing without unleashing in... by dimavolo on Sunday November 15, 2026 @10:47AM (#50507806)
Nah he’s got the youthful quickness to go with it
Re:Found: A protein that drives ageing without unleashing in... by mso3i on Saturday November 14, 2026 @07:42AM (#50496584)
The better argument I have heard is optimizing/stabilizing one subsystem, while not finding ways to stabilize or prevent natural rate of decay of other subsystems causes gaps in keeping things in sync. The gaps then grow with time. System fails in new ways.
Re:Found: A protein that drives ageing without unleashing in... by jamesyoungquist on Saturday November 14, 2026 @09:43AM (#50497406)
I could get on board with being 90 in the body of a 20-30 year old, but I really don't see that being the situation we arrive at to start. Isn't it much more likely that we incrementally extend life by preserving the function of one system or another while the others continue to deteriorate? Or do you think that there's going to be a single switch (or maybe a small handful) that will stop or reverse aging across systems?
Re:Found: A protein that drives ageing without unleashing in... by jareklupinski on Saturday November 14, 2026 @12:07PM (#50498627)
> Or do you think that there's going to be a single switch (or maybe a small handful) that will stop or reverse aging across systems?

there's not even a switch that turns _on_ ageing (https://en.wikipedia.org/wiki/Evolution_of_ageing)

im beginning to think its all in the mind (your cohort forces you to age as you watch them think they should age)

Re:Found: A protein that drives ageing without unleashing in... by jamesyoungquist on Saturday November 14, 2026 @01:24PM (#50499411)
You believe aging is psychosomatic? This seems unlikely, to put it mildly. Any evidence for this?
Re:Found: A protein that drives ageing without unleashing in... by jareklupinski on Saturday November 14, 2026 @02:02PM (#50499777)
easy: i feel younger when i hang out with people who feel that life is to be lived, and i feel older when i hang out with people that act like they are dying before their time. i dont even need to know their biological age

my results at least confirm my hypothesis for a sample of one, try it out and lmk :)

Re:Found: A protein that drives ageing without unleashing in... by andriy_koval on Saturday November 14, 2026 @12:28PM (#50498855)
> but I really don't see that being the situation we arrive at to start

there are people who by following fitness/diet routine have good physique in 60-70 (face is aging, but body looks young). I am waiting to see how that generation will push limits in 80-90.

Re:Found: A protein that drives ageing without unleashing in... by lithocarpus on Saturday November 14, 2026 @01:58PM (#50499742)
I live in a rural area and know / have known a number of people in their mid 90s who were still getting around pretty well, including climbing on their roofs to remove snow, etc. One in particular was really sharp-minded right up to his last year at 95.

There are a lot of factors, but there's a lot we can do to make that more likely for ourselves. Never guaranteed, but most of the diseases of the elderly are not simply caused by old age, there are contributing factors from lifestyle.

I don't want or expect to live forever but I want to have a sharp mind, good memory, and be as mobile as I can be right up to near the end, if I'm lucky, hopefully in my 90s or 100s.

Re:Found: A protein that drives ageing without unleashing in... by andriy_koval on Saturday November 14, 2026 @02:13PM (#50499859)
> One in particular was really sharp-minded right up to his last year at 95.

imo this is not correct example. That guy just survivor who was not hit by many other health risks from leaving in rural area and climbing to roofs.

Good example would be someone who has good life basics (work/life balance, income covering all his basic needs, healthcare and safety), following good balanced fitness protocol (e.g. running + compound movements + rest + good split program) and healthy diet (fiber, protein, healthy-fats, micro-nutritions, reasonable calories).

I believe if we would have some A/B trial, we would see that this cohort would be healthier and more active by like factor 10x compared to avg Joe when reaching 70yo age.

Re:Found: A protein that drives ageing without unleashing in... by shevy-java on Saturday November 14, 2026 @10:09AM (#50497632)
> Most people, even technical people, can't imagine being 90 years old and being indistinguishable visually

But this assumes that you'd stay with all these problems. Why would this be the case? You seem to connect that one has to be old and frail. I don't see the connection.

> Second of all, we adapt. It's not all sunshine and rainbows, but getting to live for as long as you want, as healthy as you want, is worth the grief.

You think this is a good trade-off? To me it does not appear to be a good trade-off at all. I fail to see why health-related issues related to aging components would be anything good.

Also, not everyone makes it to a long life anyway; some people may die early due to a heart attack.

Re:Found: A protein that drives ageing without unleashing in... by lokimedes on Saturday November 14, 2026 @10:16AM (#50497691)
[delayed]
Re:Found: A protein that drives ageing without unleashing in... by dominotw on Saturday November 14, 2026 @10:33AM (#50497827)
> I’ll argue that even a short life in a mental hellscape of unreflected living is worse than physical death

Sounds like mental hellscape of too much reflection( and early death).

Happiest ppl i know just go with flow and dont worry too much. My own parents are on two extreme ends. My dad worried all his life about all sorts of stuff, was healthnut did yoga for 50 plus years every single day, ran 5k 4 times a week, did hard gardening all that stuff. My mom on other hand just let life happen to her and enjoy whats happening along the way. Guess which one died an early death from cancer and who is alive playing with grandchildren.

Re:Found: A protein that drives ageing without unleashing in... by paulryanrogers on Saturday November 14, 2026 @08:42PM (#50503145)
The common theory is men die younger because they have more stressful lives. I imagine some stress is optional, though for too many people most stressors is outside their control.
Re:Found: A protein that drives ageing without unleashing in... by throaway1985asd on Saturday November 14, 2026 @10:54PM (#50503846)
men die younger because they have worse lifestyle choices on average.
Re:Found: A protein that drives ageing without unleashing in... by charlieyu1 on Saturday November 14, 2026 @10:55AM (#50498023)
I'm 42. I struggled financially my 20s and 30s, now I'm finally doing OK. Now I want to live longer to compensate for the lost years.
Re:Found: A protein that drives ageing without unleashing in... by rpastuszak on Saturday November 14, 2026 @12:44PM (#50499032)
:) what do you do now?
Re:Found: A protein that drives ageing without unleashing in... by jareklupinski on Saturday November 14, 2026 @12:04PM (#50498602)
> when after age 80 ~ 90+ there's no point in living anymore?"

ive met people who didnt see the point of life at 20; ive also met 80+ year olds begging for just one more day

its not the years, its what you do with what you got

Re:Found: A protein that drives ageing without unleashing in... by 4gotunameagain on Saturday November 14, 2026 @02:20PM (#50499918)
Physically 25 might be peak, but mentally there's still a long way to go.

Which might even be due to anatomy, who knows.

But hey, being mentally 25 would also be quite more fun and careless I guess

Re:Found: A protein that drives ageing without unleashing in... by owebmaster on Sunday November 15, 2026 @04:54AM (#50505552)
I'm 38 and my body is still getting better. The hack is to have a bad start and not be so healthy at young age, it seems.
Re:Found: A protein that drives ageing without unleashing in... by 1shooner on Saturday November 14, 2026 @12:43PM (#50499024)
We don't do very well at giving people good lives with the years they have now. Let's work on that instead.
Re:Found: A protein that drives ageing without unleashing in... by toddmorey on Saturday November 14, 2026 @12:44PM (#50499034)
I think what helps. The conversation is really admit. It will also bring challenges and not just upside.

Even if you’re able to preserve a healthy body, the increased lifespan will strain society resources, require people to have longer and longer careers, more income, less opportunity for next generations, etc.

Human lifespan has increased markedly since say the middle ages, but has done so on a slower timeline. I am actually pretty nervous about a rapid transition to life spans dramatically increasing. I don’t think that will be a fun point in history.

Re:Found: A protein that drives ageing without unleashing in... by ridgeguy on Saturday November 14, 2026 @12:45PM (#50499049)
Concur.

A comment from age 77: the single thing I am most grateful to have retained at the same intensity it was in my youth is my curiosity.

Re:Found: A protein that drives ageing without unleashing in... by snapplebobapple on Saturday November 14, 2026 @01:33PM (#50499501)
You assume the intelligence that you perceive as you is the main show rather than an accident that improved reproduction chances for the main show, your body. I think this is a common error and so the consequences of near immortality will be a surprise to you when you get there, rather than a modelled acceptable cost.
Re:Found: A protein that drives ageing without unleashing in... by latentsea on Sunday November 15, 2026 @10:52AM (#50507843)
Honestly it gets kind of boring and mentally painful. You either die a hero or living long enough to see yourself become the villain. If you live forever, you're guaranteed to become the villain.