News for hackers. Stuff that matters.
Re:Found: A protein that drives ageing without unleashing in... by jamesyoungquist on Saturday November 14, 2026 @09:43AM (#50497406)
I could get on board with being 90 in the body of a 20-30 year old, but I really don't see that being the situation we arrive at to start. Isn't it much more likely that we incrementally extend life by preserving the function of one system or another while the others continue to deteriorate? Or do you think that there's going to be a single switch (or maybe a small handful) that will stop or reverse aging across systems?
Re:Found: A protein that drives ageing without unleashing in... by jareklupinski on Saturday November 14, 2026 @12:07PM (#50498627)
> Or do you think that there's going to be a single switch (or maybe a small handful) that will stop or reverse aging across systems?

there's not even a switch that turns _on_ ageing (https://en.wikipedia.org/wiki/Evolution_of_ageing)

im beginning to think its all in the mind (your cohort forces you to age as you watch them think they should age)

Re:Found: A protein that drives ageing without unleashing in... by jamesyoungquist on Saturday November 14, 2026 @01:24PM (#50499411)
You believe aging is psychosomatic? This seems unlikely, to put it mildly. Any evidence for this?
Re:Found: A protein that drives ageing without unleashing in... by jareklupinski on Saturday November 14, 2026 @02:02PM (#50499777)
easy: i feel younger when i hang out with people who feel that life is to be lived, and i feel older when i hang out with people that act like they are dying before their time. i dont even need to know their biological age

my results at least confirm my hypothesis for a sample of one, try it out and lmk :)

Re:Found: A protein that drives ageing without unleashing in... by andriy_koval on Saturday November 14, 2026 @12:28PM (#50498855)
> but I really don't see that being the situation we arrive at to start

there are people who by following fitness/diet routine have good physique in 60-70 (face is aging, but body looks young). I am waiting to see how that generation will push limits in 80-90.

Re:Found: A protein that drives ageing without unleashing in... by lithocarpus on Saturday November 14, 2026 @01:58PM (#50499742)
I live in a rural area and know / have known a number of people in their mid 90s who were still getting around pretty well, including climbing on their roofs to remove snow, etc. One in particular was really sharp-minded right up to his last year at 95.

There are a lot of factors, but there's a lot we can do to make that more likely for ourselves. Never guaranteed, but most of the diseases of the elderly are not simply caused by old age, there are contributing factors from lifestyle.

I don't want or expect to live forever but I want to have a sharp mind, good memory, and be as mobile as I can be right up to near the end, if I'm lucky, hopefully in my 90s or 100s.

Re:Found: A protein that drives ageing without unleashing in... by andriy_koval on Saturday November 14, 2026 @02:13PM (#50499859)
> One in particular was really sharp-minded right up to his last year at 95.

imo this is not correct example. That guy just survivor who was not hit by many other health risks from leaving in rural area and climbing to roofs.

Good example would be someone who has good life basics (work/life balance, income covering all his basic needs, healthcare and safety), following good balanced fitness protocol (e.g. running + compound movements + rest + good split program) and healthy diet (fiber, protein, healthy-fats, micro-nutritions, reasonable calories).

I believe if we would have some A/B trial, we would see that this cohort would be healthier and more active by like factor 10x compared to avg Joe when reaching 70yo age.