News for hackers. Stuff that matters.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by sytelus on Monday October 02, 2023 @06:10AM (#37736177)
In the times when so many people are up in arms against covid vaccines, we keep forgetting how things were and how these vaccines allowed to open up en-mass. Yes, there were problems but number of lives saved is just awe inspiring.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by logicchains on Monday October 02, 2023 @06:36AM (#37736389)
Some places never locked down, like Sweden and South Dakota, and their death rate wasn't significantly higher. Overall there's no evidence that lockdowns actually reduced mortality: https://onlinelibrary.wiley.com/doi/full/10.1002/hec.4737 .

>Using an event study approach and data from 43 countries and all U.S. states, we measure changes in excess deaths following the implementation of COVID-19 shelter-in-place (SIP) policies. We do not find that countries or U.S. states that implemented SIP policies earlier had lower excess deaths. We do not observe differences in excess deaths before and after the implementation of SIP policies, even when accounting for pre-SIP COVID-19 death rates.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by TheBigSalad on Monday October 02, 2023 @06:41AM (#37736438)
What we call "lock down" was hardly anything. And usually in reaction to surging cases. So the data probably couldn't show it working, even if it did. And it probably didn't.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by Garvi on Tuesday October 03, 2023 @08:33AM (#37751001)
You believe quarantines have no effect on the spread of contagions? With data on zero-covid countries (Australia, New Zealand, China, S Korea, Vietnam,...) so readily available for comparison... I would actually fire you if you worked for me as an engineer. And for the fact that you were obviously not following quarantine procedures, for which you're now overcompensating by spreading medical disinformation. It's not hard spotting the people that caused all the deaths during covid. It's pretty easy actually.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by ethbr1 on Monday October 02, 2023 @06:46AM (#37736481)
South Dakota, the state that ranks 46 (out of 50) in terms of population density?
Re:Nobel Price in Medicine goes to development of mRNA vaccines by sampo on Monday October 02, 2023 @07:13AM (#37736685)
> Some places never locked down, like Sweden and South Dakota, and their death rate wasn't significantly higher.

In 2020 it clearly was higher. Denmark, Finland and Norway avoided the spring 2020 death wave, whereas in Sweden mortality was 20% to 50% (well, 48%) higher during the weeks of April and May 2020.

https://ourworldindata.org/grapher/excess-mortality-raw-deat...

https://ourworldindata.org/grapher/excess-mortality-raw-deat...

https://ourworldindata.org/grapher/excess-mortality-raw-deat...

https://ourworldindata.org/grapher/excess-mortality-raw-deat...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by stringsandchars on Monday October 02, 2023 @07:40AM (#37736902)
> Some places never locked down, like Sweden

After the first two devastating waves during the Spring and Autumn of 2020, Sweden in fact 'locked-down' in some ways more restrictively than our nordic neighbors - all of which made timely interventions that meant their restrictions on meeting en-masse in public were for shorter periods and less intrusive on people's everyday lives.

The narrative that it was a 'free-for-all' in Sweden has been fostered retrospectively by neo-liberal groups that placed economics above human lives. In their eagerness to be 'proved right' after the fact, most Swedes now embrace this historical revisionism.

The statistics that show that Swedish "excess deaths" were low or even lower than other countries were cooked-up by a journalist from a right-wing newspaper in Sweden (SvD), who noticed that if one discounts the downward trend in excess death for the last 25 years in Sweden, together with dispensing with demographic weighting, and then averaging the 3 years from 2019 onwards (which includes the period after vaccination), then miraculously you can squeeze the numbers you want from the raw figures.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by brutusborn on Monday October 02, 2023 @09:28AM (#37737802)
How was Sweden more restrictive than it’s neighbours?
Re:Nobel Price in Medicine goes to development of mRNA vaccines by heyoni on Monday October 02, 2023 @10:01AM (#37738251)
Yea I’m dying to hear this too because that’s what I’ve seen: it was a free for all.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by stringsandchars on Monday October 02, 2023 @10:30AM (#37738615)
> Yea I’m dying to hear this too because that’s what I’ve seen: it was a free for all.

If you go to:

https://ourworldindata.org/covid-stringency-index

take away the default countries, and instead add Denmark, Finland, Norway and Sweden.

Then make sure you also click "Align axis scales" you will see that Sweden only had fewer restrictions than its neighbors during a very short period at the beginning of the pandemic (during the first wave).

After that, Sweden had both more stringent restrictions than all its neighbors, and had those restrictions in place for a longer period of time.

The narrative - the historical revisionism, the myth that a very large number of people want to promote, and which has even become some sort of amnesiac 'reality' for many Swedes - should not be mistaken for what really happened.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by heyoni on Monday October 02, 2023 @10:40AM (#37738756)
Thanks for the source! And I'm not saying I'm 100% right but I do remember reading articles from the economist and other solid publications about them not having any restrictions. I won't be able to find the article but I will look...and also look at this one.

/edit I actually found this in my bookmarks fyi: https://www.nature.com/articles/d41586-020-01098-x

Re:Nobel Price in Medicine goes to development of mRNA vaccines by stringsandchars on Monday October 02, 2023 @11:11AM (#37739175)
> edit I actually found this in my bookmarks fyi: https://archive.ph/7y7gF

But Tegnell is the architect and main proponent of the historical revisionism that I'm talking about. He is the man at the center of the controversial policies.

Even while they were being enacted, Sweden was fed a narrative of exceptionalism by Tegnell and the mainstream media, who never mentioned the comparative liberality of the other Nordic states' policies, and maintained the fiction that we were still following the most liberal strategy (even to this day).

Tegnell is massively popular in Sweden. In fact, as deaths accumulated and it looked more and more like he was following a disastrous path, his popularity increased exponentially.

Criticism or even mildly questioning Tegnell was (and for a large part, still is) totally off-limits: there is absolutely no way I'd mention my doubts about him or his policies to my fellow Swedish colleagues or friends.

edit: Incidentally, for those who can read Swedish (or use Google Translate), this series of contemporary articles is a really great overview of the events in Sweden seen from a skeptical perspective:

https://floderochtekoppar.blogspot.com/2021/09/sveriges-hant...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by cycomanic on Monday October 02, 2023 @12:34PM (#37740578)
As a foreigner living in Sweden during covid was just bizarre. I certainly appreciated that school were kept open and that the country never went into complete lock down. However the making fun of masks at the highest level, because there hadn't been any definite studies that showed they work (and after the turnaround later they wondered why so few people put them on), or the policies for medical personal who were not allowed protective gear (because it scares patients) even for ones working directly in the covid wards.

And yes there is definitely a weird "Swedish exceptionalism", which interestingly Swedes from all sort of political persuasion exhibit.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by bjourne on Monday October 02, 2023 @04:17PM (#37743834)
Well, even now, many years later there is still no evidence that mask mandates reduced covid infections. https://www.nytimes.com/2023/02/21/opinion/do-mask-mandates-...
Re:Nobel Price in Medicine goes to development of mRNA vaccines by belorn on Monday October 02, 2023 @08:23PM (#37746338)
From the analysis I saw in Sweden, the conclusions was that the wast majority of deaths were caused by failures in the elderly care. The pandemic spread like wildfire by the overworked personal who did not get protective gear or time to keep health standards. Some did not even have time to wash their hands between patients. The wast majority of housing for elderly is also located near the capital, similar to Copenhagen in Denmark, resulting in major hot spots for the virus. The government body responsible for supervision and control over healthcare also came to the conclusion that care for the elderly had critical flaws during the pandemic, with only half of patients meeting a doctor in person and as high as 1/5 of patients never even got to talk to a doctor.

None of the international discussions about restrictions has been about restrictions around elderly care. Sweden did actually issue some, which some described as prison-like for those impacted, but that was about a year into the pandemic. It was also seen as too late, with vaccine and proper staff/gear/protocols being more effective tools.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by nvm0n2 on Monday October 02, 2023 @11:24AM (#37739347)
The Oxford Stringency Index doesn't correlate in any way with COVID deaths so it's unclear what point you're getting at here. None of the NPIs had any effect on COVID.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by RandomLensman on Monday October 02, 2023 @11:00AM (#37739003)
At the very least not practically, a lot of companies went WFH, for example. There might have been less official forcing but behavior for sure changed.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by nvm0n2 on Monday October 02, 2023 @11:28AM (#37739383)
> the first two devastating waves during the Spring and Autumn of 2020

Sweden had negative excess mortality from Jan 2020 to Spring 2021, so fewer people died than expected in this period. These COVID waves just weren't devastating in any way, and yielded virtually no deaths "of" and not "with" COVID. It's strange that you are so convinced that Sweden's data doesn't disprove the effectiveness of lockdowns...

> neo-liberal groups that placed economics above human lives

Ah, I see.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by sampo on Monday October 02, 2023 @12:48PM (#37740816)
> Sweden had negative excess mortality from Jan 2020 to Spring 2021

According to this, Sweden had quite bad excess mortality in 2020 in April and May, and some in June. And then again from mid-November 2020 to mid-January 2021.

https://ourworldindata.org/grapher/excess-mortality-raw-deat...

There are many different ways different sources have tried to estimate cumulative excess mortality. Depending on the calculation methods, different sources have ended up with quite different results.

What is your source, and what method did they use?

Re:Nobel Price in Medicine goes to development of mRNA vaccines by nvm0n2 on Monday October 02, 2023 @02:04PM (#37742051)
2015-2019 average baseline.

It can be debated what model should be used and governments don't always have consistent methods of baselining. With different models you can compute some excess mortality in Sweden but those have their own flaws.

But it's worth calling out here that the reason you have to dive into the details of what precise baseline model you use is because the number of deaths was so very tiny on the scale of a country. A simple graph showing the absolute numbers puts it in perspective:

https://www.statista.com/statistics/525353/sweden-number-of-...

Alternatively, a graph of deaths per 100k people shows how surprisingly normal 2020 was in Sweden:

https://i0.wp.com/swprs.org/wp-content/uploads/2023/04/swede...

It looks initially dramatic but that's only due to the massive drop in 2019. In reality 2020 had the same number of deaths per pop as in 2015! Nothing special happened in 2015.

Given that 2019 was an abnormally low year, 2020 would have been a bit higher than normal anyway even with no pandemic. But we're still looking at numbers pretty much within the realm of normal variance. If somehow you'd never heard of COVID, then someone had shown you that graph and asked "did something catastrophic happen in this decade" you'd probably have said no. Although 2020 is a bit higher, it's on the order of a few thousands of people, not something you could have noticed in a country of millions short of saturation-level media coverage.

That's why it's hard to say but important to hear: these levels of death simply do not matter. How do we know? Because some countries have had high and persistent levels of excess death since the end of the pandemic, but as COVID isn't the explanation hardly anyone cares. There's just no link between levels of death and severity of reaction, in our society.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by sampo on Monday October 02, 2023 @03:17PM (#37743034)
> 2015-2019 average baseline.

Many European countries have an ageing population, and thus the number of yearly deaths increase year to year. For example Finland in 2010–2019 had about 0.8% increase in yearly deaths every year. If the deaths followed this model and thus there was absolutely no excess mortality (and no random variation), the simple method you cite would compare 2020, 2021 and 2022 to the average of 2015–2019, and would estimate 2.4%, 3.2% and 4.0% excess mortality for years 2020, 2021, 2022 for Finland.

Whereas Sweden doesn't have an ageing population structure, due to lots of immigration in the past 20 years. And Sweden didn't have an increasing trend in yearly deaths in 2010–2019.

This simple method overestimates the excess mortality for many countries, if they have an ageing population structure. Then you end up comparing overestimated values to Sweden's value that it not overestimated.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by nvm0n2 on Monday October 02, 2023 @03:48PM (#37743502)
You can project a baseline like that and get a higher number for 2020, but 2019 is still abnormally low and those people who survived 2019 had to die at some point.

I'm happy to grant a different baseline though. It goes from being a really small number to a really small number. Remember that everything that happened was justified by claiming a 3.something% IFR and 100% infection rate in a single giant wave. That never came close to happening and the places that used very light touch approaches had no different outcomes to places that went full totalitarian. That's the important thing here.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by chimprich on Monday October 02, 2023 @07:41AM (#37736904)
> Some places never locked down, like Sweden and South Dakota, and their death rate wasn't significantly higher

Many factors: different demographics, population density, culture, what does "locked down" mean in different countries / areas, what does "significantly higher" mean...

One important point though is this probably confuses correlation and causation. Areas that were hit harder tended to lock down harder.

> Overall there's no evidence that lockdowns actually reduced mortality

People post this occasionally, and I'm going to keep calling bullshit. What happens is someone posts a fringe paper that supports their view whilst conveniently ignoring the large body of established scientific orthodoxy that supports the obvious conclusion: that restricting human interaction slows down transmission of a respiratory disease that transmits through human interaction.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by brutusborn on Monday October 02, 2023 @09:34AM (#37737869)
I agree that the mechanism for lockdowns helping is sound (less interaction -> less infection) but I still believe lockdowns were harmful overall (eg including aspects like additional deaths of despair - suicide and overdose, less healthy activities - exercise and socializing etc).

I must admit this belief mostly comes from the claim Sweden did better, and the fact that where I live had almost no lockdowns and did better than the rest of my country.

Do you know of any good evidence that lockdowns were effective, or are you calling bullshit based on intuition?

Re:Nobel Price in Medicine goes to development of mRNA vaccines by chimprich on Monday October 02, 2023 @10:07AM (#37738342)
> I still believe lockdowns were harmful overall (eg including aspects like additional deaths of despair - suicide and overdose, less healthy activities - exercise and socializing etc).

Lockdowns were absolutely harmful - I don't think anyone is claiming otherwise. They were effective in stopping health systems collapsing, which is why pretty much everywhere implemented them when it looked like their health systems were about to be overwhelmed. (cf Italy in early 2020). That would have been catastrophic compared to the harms of lockdown.

In terms of suicides specifically, the evidence is not clear. I've seen studies that indicate suicide rates did not increase or actually fell during the pandemic, e.g. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5... . There were also fewer deaths from road traffic accidents etc. However, there were lots of other harmful effects such as secondary effects from the economic impact.

> Do you know of any good evidence that lockdowns were effective, or are you calling bullshit based on intuition?

There have been a number of studies concluding that lockdowns were effective. I doubt digging them up will convince any of the sceptics in this thread.

But since you ask... how about this Royal Society report? https://royalsociety.org/topics-policy/projects/impact-non-p...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by brutusborn on Monday October 02, 2023 @11:00AM (#37739006)
I’m skeptical but open to changing my mind. The suicide paper was interesting, I think it makes sense that early in the pandemic suicides would decrease. I would be interested to see a similar analysis for 2022 and 2023 since I would expect there to be many second-order suicides (not a suicide during the lockdown but a later suicide as a result of lost social interactions, additional addictions and economic impacts).

Are there any particular papers in the report that you think are evidence that lockdowns prevented health system collapse and were beneficial overall?

I had a preliminary skim of it and decided to check the first relevant citation for lockdown effectiveness. It has the same problems as most of the studies I have seen: it does not include any of the second order effects. Of course virus transmission is reduced by limiting interactions but this is only one part of the story. This may be answered in some of the other references but I need to put it aside for now.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by xorcist on Monday October 02, 2023 @11:13AM (#37739196)
We do not need to look further than excess mortality during the period.

It's three years later now and the numbers are in. There is plenty of high quality data from all Western countries.

However data driven policy decisions should be much more fine grained than that. We should instead identify specific situations where different type of lockdowns would make sense.

But the data is clear. Prolonged periods looks bad, at closing schools were clearly the wrong decision on every time scale.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by lawn on Monday October 02, 2023 @09:35AM (#37737891)
In Sweden it was notably higher initially.

What made a difference in Sweden was that vaccination rates were really high and they were administrated quickly.

Had the anti-vaccine ideas spread more Sweden would be much, much worse off.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by andyjohnson0 on Monday October 02, 2023 @09:51AM (#37738104)
Parent comment was referring to vaccines not lockdowns.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by dudinax on Tuesday October 03, 2023 @12:14AM (#37747901)
Compared to it's neighbors, sweden had a huge excess death rate in 2020.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by Garvi on Tuesday October 03, 2023 @06:59AM (#37750191)
I know you're spreading misinformation to cover the fact you were breaking all kinds of quarantine procedures because a coward called you a coward one time. Now you're faced with an overwhelming mountain of evidence that your behaviour lead to many deaths and the cowardice resurfaced. You're now a conspiracy theorist and limit yourself to circles that share your mistake. You must be spending a lot of time on Facebook and Reddit.

I could cite the most objective sources and statistics, but if you haven't figured it out by now, you don't want to. You're on the level of flat-earthers. The only difference being there's way more of you than of those idiots. And if you think the number of people believing in something somehow gives it credibility, then you should start preparing yourself to meet Allah in the afterlife.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by dalore on Monday October 02, 2023 @06:17AM (#37736217)
I'm not convinced.

If they didn't reduce transmission, but we were told they did, then we suffered the problem of moral hazard. We thought we were protected so we went out and caused more risk to us and others. Possibly increasing the number of deaths.

So I don't think they saved lives at all, they might have increased people's risk thinking they were protected and they weren't, also spreading it more.

They didn't allow us to open en-mass.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by dd36 on Monday October 02, 2023 @06:21AM (#37736258)
Good thing we have data that proves lives were saved and you don’t have to guess.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by logicchains on Monday October 02, 2023 @06:37AM (#37736401)
What data is that? That data on lockdowns suggests that they didn't reduce overall excess mortality: https://onlinelibrary.wiley.com/doi/full/10.1002/hec.4737

>Using an event study approach and data from 43 countries and all U.S. states, we measure changes in excess deaths following the implementation of COVID-19 shelter-in-place (SIP) policies. We do not find that countries or U.S. states that implemented SIP policies earlier had lower excess deaths. We do not observe differences in excess deaths before and after the implementation of SIP policies, even when accounting for pre-SIP COVID-19 death rates.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by jeffbee on Monday October 02, 2023 @09:35AM (#37737894)
Causality. The only thing this survey demonstrates is that government orders have weak effects on actual population behavior.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by dalore on Monday October 02, 2023 @06:43AM (#37736464)
Good thing you're 100% convinced, I'm still looking for the proof
Re:Nobel Price in Medicine goes to development of mRNA vaccines by amelius on Monday October 02, 2023 @08:02AM (#37737063)
Still you are the one making the exceptional claim, so the burden of proof is on you.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by urduntupu on Monday October 02, 2023 @07:23AM (#37736774)
"COVID-19 vaccine-associated mortality in the Southern Hemisphere", a well researched study [0] shows:

This experimental gene therapy has killed 17 million people and had no discernible benefit, according to a very sound study

[0] https://correlation-canada.org/wp-content/uploads/2023/09/20...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by chimprich on Monday October 02, 2023 @07:44AM (#37736919)
Please don't post this nonsense on HN. This is a joke, right? It's a crank website, not a serious medical journal.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by blumomo on Monday October 02, 2023 @01:27PM (#37741490)
Can you say something constructive about the study instead of insulting the messenger who published it?
Re:Nobel Price in Medicine goes to development of mRNA vaccines by notacoward on Monday October 02, 2023 @06:25AM (#37736291)
Related: https://www.natesilver.net/p/fine-ill-run-a-regression-analy...

There was a discussion here too, but it was hot garbage so I'm not linking to it.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by SamBam on Monday October 02, 2023 @08:48AM (#37737402)
The conclusion of that paper:

The higher the vaccination rate in a state, the lower the deaths after the vaccine was introduced. This is unaffected by the age of the state.

The fact that this shift only emerges after the introduction of the vaccine means we can pretty much rule out any demographics-based causes. The "low vax" and "high vax" states were pretty much even before the vaccine. The only reasonable conclusion is that high vax rates directly caused lower death rates.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by raverbashing on Monday October 02, 2023 @06:32AM (#37736348)
Reducing transmission is a bonus, and very hard to measure

Nobody will worry about transmission when it provably reduces mortality

> So I don't think they saved lives at all

Thank deity we have data proving otherwise

And even bigger thanks to Darwin who rarely disappoints

Re:Nobel Price in Medicine goes to development of mRNA vaccines by aredox on Monday October 02, 2023 @06:20AM (#37736247)
They did reduce transmission. We have actual data from US prisons.

If you want to look at dodgy science, anything around "moral hazards" is on very shaky grounds...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by sod on Monday October 02, 2023 @06:27AM (#37736317)
If you have an interest in making your point, I suggest to reference trusted sources one can read through so people on the fence can educate themself.

Blaming and labelling has the opposite effect though.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @06:37AM (#37736396)
https://www.cidrap.umn.edu/covid-19/covid-shots-previous-inf...

> Unvaccinated, infected inmates had an estimated 36% risk of spreading the virus, compared with 28% among infected vaccinees. After adjustment, any vaccination, previous infection alone, and both vaccination and previous infection cut the risk of SARS-CoV-2 transmission by 22%, 23%, and 40%, respectively.

> Booster doses and more recent vaccination further lowered infectiousness among vaccinated inmates, with each dose conferring an 11% risk reduction; the risk of transmission rose 6% for every 5 weeks that had elapsed since the last shot.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by dalore on Monday October 02, 2023 @07:31AM (#37736829)
I don't know about you, 8% sounds a rounding error and probably within the error margins. It certainly wasn't enough to open the country en-mass like the OP believes.

And now we have the opposite situation with those who have had the most boosters and now more likely to catch the new variant that is out.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @08:06AM (#37737084)
> I don't know about you, 8% sounds a rounding error and probably within the error margins.

It is not. The study is available for you to review if you like.

> And now we have the opposite situation with those who have had the most boosters and now more likely to catch the new variant that is out.

I’d like to see that study. Cite, please.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by Workaccount2 on Monday October 02, 2023 @11:02AM (#37739040)
>I’d like to see that study. Cite, please.

Sure:

www.NewEarthTimes.com/publications/VaccinesKill/New-vaccine-makes-more-infections.html

/this is a joke

Re:Nobel Price in Medicine goes to development of mRNA vaccines by nvm0n2 on Monday October 02, 2023 @06:28PM (#37745298)
> 8% sounds a rounding error and probably within the error margins.

It is not.

Erm yes it is ... from the study:

> In adjusted analyses, we estimated that any vaccination ... reduced an index case’s risk of transmitting infection by 22% (6–36%)

CI is much wider than 8pp and the estimated absolute transmission risk CIs actually overlap at 31%. So the study results are consistent with there being no actual difference, also.

If this is the best evidence of a difference in transmission it's not very good.

Also this is Omicron which hardly matters. The justification was the earlier variants.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by empath-nirvana on Monday October 02, 2023 @09:53AM (#37738125)
This is a classic example of the way conspiracy theorists shift goal posts and demand more and more evidence, while waving away any evidence provided. It's _boring_ to engage with people like you. You have no idea what you're talking about, and demand that people who _do_ know what they're talking about give you an education that you don't actually want. You're just _performing_, you aren't having a genuine conversation with people.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by shrubble on Monday October 02, 2023 @10:14AM (#37738424)
Out of 111,000 inmates, 31 were hospitalized and none died. Is there a small city with equivalent population where approximately the same numbers held?
Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @10:17AM (#37738459)
I very much doubt there's a small city with total gender segregation, people living in large buildings they're not permitted to leave, and single-source universal healthcare.

(That's what makes it such a good observational study population; a whole bunch of variables are controlled away by default.)

Re:Nobel Price in Medicine goes to development of mRNA vaccines by aredox on Monday October 02, 2023 @06:39AM (#37736423)
Why should I do it, to "do your own research" types like you?

Do your own research.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by zo1 on Monday October 02, 2023 @06:42AM (#37736446)
I'm one of those people "on the fence". I can tell you now that honestly a good study won't convince me to trust the prevailing narrative.

Hear me out. In my mind, there are so many reasonable and logical ways in which those studies can be manipulated and interpreted in a manner that goes a certain direction (that I'm distrustful of). The reason I'm there is that a lot of trust was lost over a long period of time and multiple instances. So a whole host of related side-issues need to be resolved and "proven" false with studies before I can get back to a high-trust zone with modern medicine when it comes to covid and other such "hot" topics.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ggm on Monday October 02, 2023 @07:03AM (#37736598)
You may want to avoid casting all questions through this lens. Some people seek to leverage this sense of loss of trust to promote other arguments, in politics and the economy.

I appreciate that loss of trust is real, happens fast, and takes longer to recover. Recovery itself demands some acceptance that not all evidence is unequivocal, or comprehensible.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by noarchy on Monday October 02, 2023 @10:41AM (#37738768)
>I'm one of those people "on the fence".

Versus

>I can tell you now that honestly a good study won't convince me to trust the prevailing narrative.

You're not on the fence.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by zo1 on Monday October 02, 2023 @01:26PM (#37741481)
Oh you got me there! I'll pack it up, my argument is void now, you win.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by nicman23 on Monday October 02, 2023 @06:49AM (#37736501)
the fact that antivaxers never source data but instead require normal sane people to do so will never not make me laugh
Re:Nobel Price in Medicine goes to development of mRNA vaccines by Lutger on Monday October 02, 2023 @06:54AM (#37736529)
Respectfully, I believe you are in the wrong here.

Covid and climate science denial can be strengthened by having a 'discussion'.

This is because conspiracy thinking is actually immune to evidence. The denialist will subvert your evidence in a way that it proves the conspiracy. In here they will probably complain that 'correlation is not causation' or some other methodology 101 trope, whereas the audience will think "oh, yeah, this is complicated, smart people are debating it, I guess the jury is still out and we don't know for certain if climate change is real or not, and the vaccines are not a silver bullet either, lets just wait until the debate is over'.

But, in fact, the debate is over.

So no, in this case the onus is one the person attacking a vast body of scientific literature proving beyond reasonable doubt that vaccines are effective to come up with something supporting those wild claims. It is not up to me to provide a literature list that nobody will ever read anyway, and anyone who is even remotely interested in finding the truth can google such a list in 5 min.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by kuerbel on Monday October 02, 2023 @08:49AM (#37737420)
Thank you for your post. And I mean it. I've fallen into this trap so often myself, because nothing grinds my gears as conspiracy theorists do. I think next time I'll stop before I answer, think of your post and maybe copypaste it.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by sod on Monday October 02, 2023 @08:52AM (#37737437)
All I did was asking for information. After all, science is about studies and data, not about opinion.

It would just be nice to get a finger pointing in a direction, not the middlefinger.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @08:59AM (#37737494)
At this point, anyone still "asking for information" knows full well where to find it. It's not March 2020 any more.

"Actual data from US prisons" took me about 20 seconds to find a reputable source for (https://news.ycombinator.com/item?id=37736396), likely less time than your comment asking for it took to type.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by sod on Monday October 02, 2023 @09:15AM (#37737650)
> At this point, anyone still "asking for information" knows full well where to find it. It's not March 2020 any more.

Do you really think that behavior will improve the knowledge gap?

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @09:41AM (#37737973)
I don't think any behavior will help the willfully ignorant.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by empath-nirvana on Monday October 02, 2023 @09:50AM (#37738091)
Re:Nobel Price in Medicine goes to development of mRNA vaccines by fabian2k on Monday October 02, 2023 @06:24AM (#37736287)
The vaccines massively reduced mortality and severe disease in the vulnerable populations. That is a big win.

They also could have stopped the spread for the early variants, but the later ones were simply too contagious. There simply was no chance to keep transmission fully down at that point.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by koolba on Monday October 02, 2023 @06:41AM (#37736433)
> The vaccines massively reduced mortality and severe disease in the vulnerable populations. That is a big win.

That’s changing the goalposts. The vaccines were not necessary for the vast majority of the population or society as a whole to “open up”.

That’s assuming you analyze only physical harm from the spreading virus. After months of brainwashing, they were definitely required for large swathes of the population to given them a mental protection to come out of their shells.

> They also could have stopped the spread for the early variants, but the later ones were simply too contagious. There simply was no chance to keep transmission fully down at that point.

There was never a chance to keep transmission fully down. It was like trying to prevent a cold or the flu from spreading.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by fabian2k on Monday October 02, 2023 @06:46AM (#37736486)
The criteria for the original license were the reduction in deaths and disease. Transmission wasn't even tested in the original phase III trials. The vaccines achieved their primary purpose, they prevented death and severe disease.

COVID was a major threat to a significant part of the population. The vaccines were effective and reduced the threat to those people enormously.

It would have been very nice and useful to stop transmission and achieve herd immunity. But even without that the vaccines were a huge win and saved a lot of lives.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by somenameforme on Monday October 02, 2023 @10:37AM (#37738714)
This is false. Moderna seems to have moved, or removed, their initial testing results but you can still find an archive here. [1] The pharmaceutical industry was initially claiming that vaccination would completely prevent infection, as it typically does, let alone spread:

"There were 11 COVID‑19 cases in the Moderna COVID‑19 Vaccine group and 185 cases in the placebo group, with a vaccine efficacy of 94.1% (95% confidence interval of 89.3% to 96.8%)."

It's easy to create false memories because the politicians and pharma industry simultaneously swapped the narrative to stopping hospitalization and death once it became completely clear the vaccines were not stopping infection, but that is not what their initial purpose was.

[1] - https://web.archive.org/web/20210202223626/https://www.moder...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @10:52AM (#37738902)
Your quote: "Some of the vaccine group still got infected."

Your summary: "They claimed vaccination would completely prevent infection."

Perhaps you just can't read?

Re:Nobel Price in Medicine goes to development of mRNA vaccines by somenameforme on Monday October 02, 2023 @11:05AM (#37739092)
The efficacy rate was not being measured based on death/sickness, but on any infection at all. It was supposed to be 94.1% effective in terms of completely preventing infection.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @11:09AM (#37739134)
Again, I think you're having trouble reading. From your link:

> The median length of follow up for efficacy for participants in the study was 9 weeks post Dose 2. There were 11 COVID‑19 cases in the Moderna COVID‑19 Vaccine group and 185 cases in the placebo group, with a vaccine efficacy of 94.1% (95% confidence interval of 89.3% to 96.8%).

> Cases of COVID‑19, starting 14 days after Dose 2, were defined as symptomatic COVID‑19 requiring positive RT-PCR result and at least two systemic symptoms or one respiratory symptom.

A SARS-CoV-2 infection and a COVID-19 case aren't the same thing, for the same reason a HIV infection is not the same as having AIDS. The 94.1% number comes from counts of actual sickness, despite your assertions to the contrary.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by somenameforme on Monday October 02, 2023 @11:22AM (#37739311)
Feel free to change the above to claim they stated it would create a negative PCR test or a PCR test with less than 1 one respiratory symptom or 2 systemic symptoms. It does not meaningfully change the issue whatsoever. The asterisk by infection went, without skipping a beat, from a 'PCR test and symptoms' to 'hospitalization/death.' These are very different things.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by fabian2k on Monday October 02, 2023 @03:49PM (#37743522)
The virus the vaccine was first tested is quite different than the version we faced later. The virus is not a static target, but a quickly evolving one. And the later variants were far, far more contagious than the initial one.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by Lutger on Monday October 02, 2023 @06:59AM (#37736566)
> That’s changing the goalposts.

You complain about that, but proceed to doing it yourself, and you don't even address the point unlike the person you responded to.

> It was like trying to prevent a cold or the flu from spreading.

Which is funny, because even the very mild measures we had here in the Netherlands totally succeeded in preventing the flu from spreading. Haven't had a cold or flu in 1.5 years whereas normally would be sick at least 2-3 times. One strain of the flu was completely eradicated.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by empath-nirvana on Monday October 02, 2023 @09:48AM (#37738060)
> After months of brainwashing

When you say stuff like this, it makes me think you have the wrong idea about who was the victim of brainwashing.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by somenameforme on Monday October 02, 2023 @11:03AM (#37739054)
It sounds hyperbolic but look at any poll on how deadly people thought COVID was compared to how deadly it actually was. This study [1] found people believing that, on average, about 16% of people infected (diagnosed or not) with COVID died. In reality, there were a measured total of around 700 million cases and 7 million deaths. And vast numbers of cases went undiagnosed and so would never have ended up being tracked. In any case, the real IFR was well less than 1%. Brain washing is an unnecessarily loaded and divisive term, but it is safe to say that the media (and politicians) actively went out of their way to make people believe things that were not true, and they succeeded.

[1] - https://www.frontiersin.org/articles/10.3389/fpsyg.2021.6191...

Re:Nobel Price in Medicine goes to development of mRNA vaccines by jf22 on Monday October 02, 2023 @11:55AM (#37739795)
Public perception and reality are often at odds, but it doesn't mean the difference in perception is because of brainwashing, it's because humans are bad at measuring risk.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by koolba on Monday October 02, 2023 @01:11PM (#37741203)
If the ones who are supposed to be informing the masses are deliberately feeding them information that leads them to inaccurately measure said risk, then that’s brainwashing.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by somenameforme on Monday October 02, 2023 @01:29PM (#37741519)
I'd argue you're creating a bit of a false dichotomy there. I completely agree that the public is bad at measuring risk. But do you disagree that the media/politicians were actively working to exaggerate the impact of the disease? And really this even applied to organizations like the CDC. Read this [1] page and tell me how long you think it'd take the average person to realize they're talking about child hospitalizations with COVID and not child hospitalizations from COVID?

The "summary" of the article is that "COVID-19 can cause severe illness in children and adolescents" followed by numbers talking about a shocking increase in rates. The fact it's talking about people hospitalized with COVID is hidden in a wall of text written in language that most people wouldn't be able to decipher. That more people tested positive for a more contagious variant, in any setting, is the most unremarkable news imaginable - spun into a terrifying headline, by the CDC no less.

I see no way to imagine that article was written in good faith. And it's been the absolute norm for the past 3 years now.

[1] - https://www.cdc.gov/mmwr/volumes/70/wr/mm7036e2.htm

Re:Nobel Price in Medicine goes to development of mRNA vaccines by kibbi on Monday October 02, 2023 @07:44AM (#37736920)
> The vaccines massively reduced mortality and severe disease in the vulnerable populations.

By how much, in numbers?

Re:Nobel Price in Medicine goes to development of mRNA vaccines by Lutger on Monday October 02, 2023 @06:43AM (#37736455)
Any sources or data to back that up? Or is this just your own hypothesis you came up with yourself?

There is an enormous body of knowledge proving vaccines did reduce transmissions, you can easily find them online. So a claim that goes counter to the outcome of hundreds of studies should have some backup, otherwise it no better than saying 'here is a snowball that proves 100% of climate scientists are wrong'

Re:Nobel Price in Medicine goes to development of mRNA vaccines by goodluckchuck on Monday October 02, 2023 @09:02AM (#37737524)
You also are not providing any sources or data…
Re:Nobel Price in Medicine goes to development of mRNA vaccines by d0100 on Monday October 02, 2023 @10:26AM (#37738567)
From my time of internet arguing about vaccines, most "reduce transmission" claims started at 70% and last I remember ended up being only 30%
Re:Nobel Price in Medicine goes to development of mRNA vaccines by someuser2345 on Monday October 02, 2023 @11:31AM (#37739424)
Here is a paper that claims that there was no correlation between vaccination rates and an increase in covid cases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481107/
Re:Nobel Price in Medicine goes to development of mRNA vaccines by usrusr on Monday October 02, 2023 @07:09AM (#37736645)
What would have been the alternative? Go endemic Bergamo-style? Remain in soft lockdown for a decade or two in order to go endemic at a very slow pace? At the time vaccines were widely available, chances of making the virus die out had already been at exactly zero for quite a while (well, zero, plus wherever the chances are for a sudden all life ending meteor strike). It was vaccines that allowed us come to where we are now with the amount of inconvenience we had on the way. Any path without vaccines would have been worse, one way or the other.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by amelius on Monday October 02, 2023 @08:06AM (#37737082)
Re:Nobel Price in Medicine goes to development of mRNA vaccines by dekhn on Monday October 02, 2023 @10:46AM (#37738837)
Are you a scientist, or otherwise qualified to make judgements like this?

I see a lot of armchair quarterbacks making statements about public health, but it ussually ends up being poorly informed speculation.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by forgetfreeman on Monday October 02, 2023 @10:47AM (#37738852)
Oh there's certainly moral hazard for all of the muppets that fell in line with the interlocking "reopen" astroturf campaigns that cropped up during the lockdown, but it isn't due to false or misleading claims about vaccine efficacy. It was made clear from jump that 1. the vaccines did not confer perfect immunity and 2. continuous mutation meant the goalposts for protection were moving. Individuals that chose to accept either the narrative that we were all perfectly safe once vaccinated or that there was nothing to worry about in the first place because it was all a giant conspiracy are collectively responsible for Covid making the transition from pandemic to endemic.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by astrange on Monday October 02, 2023 @02:37PM (#37742515)
It's impossible that covid could ever have not become endemic. It can transmit through animals, we're not going to vaccinate or kill all the animals, and we haven't found the source it actually came from.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by forgetfreeman on Monday October 02, 2023 @06:46PM (#37745495)
Bullshit. There was a window of time where hard quarantine could have prevented it. Instead we got politics.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by astrange on Monday October 02, 2023 @07:34PM (#37745920)
Only if no person or animal ever left China ever again.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by forgetfreeman on Tuesday October 03, 2023 @07:31PM (#37758977)
Bullshit. We have the ability to screen individuals before travel.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by astrange on Wednesday October 04, 2023 @06:40AM (#37763251)
No you don't, covid is infectious before it's symptomatic. Australia and China tried the closest working thing to that (incoming quarantine) and it was extremely expensive and eventually failed.

China also claims they've found it in fomites (inanimate objects) like frozen food shipments. Though, I dunno if I believe that one.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by forgetfreeman on Wednesday October 04, 2023 @04:29PM (#37771273)
Closest working thing is an interestingly loaded phrase
Re:Nobel Price in Medicine goes to development of mRNA vaccines by thehappypm on Monday October 02, 2023 @11:24AM (#37739348)
Ultimately, none of the societal restrictions really helped reduce the portion of the population that caught covid -- given enough time, it ended up rounding up to 100%, almost worldwide. Restrictions and masking really just bought us some time and slowed the process of getting to "everyone got infected". Even China, New Zealand, Australia, etc failed at zero-covid given enough time, and covid raged once it got out. Different states in the US with vastly different policies ended up with the same final outcome. According to the NY Times, Florida and New York both have 35k cases cases per 100k population -- obviously there are substantial differences in data quality, but we are clearly not looking at an order-of-magnitude difference between these two massively different responses.

Given that lens, the ultimate outcome of the pandemic is "almost everyone eventually gets covid." As a result, the vaccines -- in reducing mortality -- saved an absolutely immense amount of lives.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by lumb63 on Monday October 02, 2023 @06:22AM (#37736263)
I think it’s worth mentioning that COVID wasn’t what caused the world to shut down, and vaccines weren’t what caused the world to open up. These were both incredibly authoritarian policy choices by governments.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by xxs on Monday October 02, 2023 @06:26AM (#37736304)
So the millions of death cases were a welcome purge?
Re:Nobel Price in Medicine goes to development of mRNA vaccines by prohobo on Monday October 02, 2023 @06:35AM (#37736381)
I suppose so, if you look at the exacerbation of economic inequality, starvation (+15 million worldwide), and deaths of despair caused by the lockdowns and associated interventions. Seemingly no one minds that.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @06:41AM (#37736431)
In the US, pandemic mitigation dropped poverty numbers drastically.

https://www.nytimes.com/2022/09/13/business/economy/income-p...

Going back up now.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by logicchains on Monday October 02, 2023 @06:33AM (#37736361)
Sweden never locked down and has one of the lowest covid death rates overall now.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by aredox on Monday October 02, 2023 @06:41AM (#37736436)
They just had a very sparse population and the highest rate of single-occupancy housing...

And socialized medicine.

Really, what a fine example for e.g. New York to follow!

Re:Nobel Price in Medicine goes to development of mRNA vaccines by DiogenesKynikos on Monday October 02, 2023 @06:43AM (#37736454)
Sweden has twice the death rate as its closest neighbors (both geographically and culturally), Norway and Denmark. Note that the differences in policy between Sweden and other European countries were largest early on in the pandemic, and the differences in Sweden's death rate then were even more extreme.

In a broader international comparison, Sweden (and Europe generally) did not fare well. Countries that took a zero-CoVID approach, such as China, Taiwan, Australia, New Zealand, Vietnam and Singapore ended up with much lower death rates, because most of them vaccinated their populations before allowing the virus to spread.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by jacquesm on Monday October 02, 2023 @06:44AM (#37736469)
I think you've made this point at least 50 times in as many COVID threads and you've been refuted at least as many times, why do you keep doing this?
Re:Nobel Price in Medicine goes to development of mRNA vaccines by Lutger on Monday October 02, 2023 @07:07AM (#37736634)
I highly recommend everyone who wonders why people do this to read the 'Conspiracy Theory Handbook'. Unlike what the title suggests, it is a very brief primer into the psychological research done by Cook and others on conspiracy thinking, mostly from the perspective of climate science denial: https://www.climatechangecommunication.org/handbook/the-cons...

One of the key traits of conspiracy thinking is immunity-to-evidence:

"Conspiracy theories are inherently self-healing, evidence that counters a theory is re-interpreted as originating from the conspiracy. This reflects the belief that the stronger the evidence against a conspiracy (e.g., the FBI exonerating a politician from allegations of misusing a personal email server), the more the conspirators must want people to believe their version of events (e.g., the FBI was part of the conspiracy to protect that politician)"

Re:Nobel Price in Medicine goes to development of mRNA vaccines by AndrewDucker on Monday October 02, 2023 @06:50AM (#37736506)
Re:Nobel Price in Medicine goes to development of mRNA vaccines by K0SM0S on Monday October 02, 2023 @07:21AM (#37736759)
Most discussions around depopulation get bogged down in emotional or ethical arguments. To clarify, ethical considerations aren't distractions; they drive the pragmatic actions of all parties involved. It's even feasible to consider the most ethical—perhaps fully democratic—means of implementing such plans. However, it's worth noting there's a historical tolerance limit beyond which future generations may not be kind to the architects of such initiatives.

The real crux isn't whether some advocate for lower populations—clearly, many do—but the operational aspect: who executes, under what authority, and how? For instance, if a group of biologists and engineers aim to reduce Earth's population to 4 billion by 2400, the implications—like fewer children and potential space colonization—are vastly different than a group of anthropological philosophers striving for the same population count by 2033, which could necessitate more drastic measures.

These logistical issues, whether it's stealth tactics versus open methods or the necessity of opportunistic partnerships, remain conspicuously underexplored.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by DiogenesKynikos on Monday October 02, 2023 @06:36AM (#37736390)
Governments could have avoided shutting down if they had been willing to accept much larger numbers of deaths. In the US, that would have meant somewhere around a million more deaths.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by logicchains on Monday October 02, 2023 @06:39AM (#37736424)
That's absolutely untrue; the data shows that lockdowns did not reduce deaths: https://onlinelibrary.wiley.com/doi/full/10.1002/hec.4737 .

>Using an event study approach and data from 43 countries and all U.S. states, we measure changes in excess deaths following the implementation of COVID-19 shelter-in-place (SIP) policies. We do not find that countries or U.S. states that implemented SIP policies earlier had lower excess deaths. We do not observe differences in excess deaths before and after the implementation of SIP policies, even when accounting for pre-SIP COVID-19 death rates.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by aredox on Monday October 02, 2023 @06:46AM (#37736476)
Yes, we should have saturated hospitals even more, it would have had no effect on mortality!

https://youtu.be/0P8KyaYuaTg?si=emkhsme03r9shDxE

Re:Nobel Price in Medicine goes to development of mRNA vaccines by TMWNN on Tuesday October 03, 2023 @02:49AM (#37748663)
Italian and New York hospitals were overwhelmed because a) both places put sick elderly into old age homes. (42% of US COVID19 deaths in 2020 occurred in old age homes!) b) Like elsewhere early on, doctors put everyone serious onto ventilators in a mistaken belief that they should treat patients like they do ARDS cases based on blood oxygen levels. This damaged healthy lung sacs and caused long-term dependence on mechanical respiration that doctors found almost impossible to wean patients from, and other side effects like deep vein thrombosis; Nick Cordero is an example. (This article from April 2020 <https://www.statnews.com/2020/04/08/doctors-say-ventilators-...> was completely vindicated in retrospect.) Neither happened after the first few months.

And no, none of those field hospitals built in parking lots and stadiums everywhere were used, either. In Wales, for example, Millennium Stadium was converted into a temporary field hospital with 300 beds and capacity to expand to 2000 beds. It was such a big deal that a public contest was held to name it Dragon's Heart Hospital <https://en.wikipedia.org/wiki/Dragon%27s_Heart_Hospital>. However, said hospital never had more than 46 patients at one time, and was closed in six weeks for lack of use!

Even in NYC, which really did see overloaded hospitals briefly in March-April 2020, USNS Comfort treated a total of 179 patients. USNS Mercy treated a total of 77 patients in LA.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by DiogenesKynikos on Tuesday October 03, 2023 @04:14AM (#37749196)
You left out (c) cases were rising exponentially, so even if doctors could have handled X number of patients, they would become overwhelmed a few days later when that turned into 2X. Virtually no one in the population had immunity to SARS-CoV-2, so the only way to stop the exponential rise was a dramatic reduction in face-to-face contact between people. That could occur through spontaneous change in public behavior (e.g., everyone avoiding public places as much as possible, or everyone wearing then-unavailable N95 masks in public), from public policy ("lockdowns"), or from both. But continuing on as normal would have led to hospitals being overwhelmed, no matter how efficiently they were run and how skillfully they treated the patients.

To your point (a), old-age homes should have been much better protected, but it's virtually impossible to shield them off when the virus is raging outside. The most effective way to protect the elderly would be to reduce transmission of the virus in society as a whole.

To your point (b), that's what happens in a pandemic. There's a completely new disease, and doctors don't know how to treat it effectively. Everyone is trying to do what they can, based on experience with treating other diseases. You can't base public health policy around a belief that doctors will instantly know the correct way of treating a pandemic disease. You have to take dramatic measures to reduce transmission in a situation like New York faced in early 2020.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by DiogenesKynikos on Monday October 02, 2023 @06:51AM (#37736514)
This is a garbage-in, garbage-out analysis, akin to saying, "We analyzed 100 cities, and found that those with levies were more prone to flooding. Thus, we conclude that levies offer no protection against flooding." We know mechanistically why levies work: they block water. We know mechanistically why lockdowns work: they reduce transmission. Less transmission means fewer infections means fewer deaths.

You can see this most clearly in the zero-CoVID countries, which had dramatically lower death rates during the pandemic. Taiwan and China had virtually zero deaths for much of the pandemic, because they traced literally every infection chain and capped it off. They reopened after vaccinating most of their populations, which means that most people in those countries had a primed immune system when they first got infected. As we know from numerous studies, that dramatically reduces mortality.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by kybernetyk on Monday October 02, 2023 @06:42AM (#37736450)
If governments cared about dead people they would regulate the fast food and processed food industry. McDonald’s kills more people than covid ever could.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by misnome on Monday October 02, 2023 @06:45AM (#37736475)
I applaud the sheer scale of this whataboutism, to the point I am unsure if it is a parody.

The distance between topics has to be somewhere close to a world record!

Re:Nobel Price in Medicine goes to development of mRNA vaccines by oldgradstudent on Monday October 02, 2023 @09:30AM (#37737813)
Almost everyone got vaccinated and almost everybody got Covid, regardless of vaccination.

This would not be accepted with any other type of vaccine (with the notable exception of influenza).

Re:Nobel Price in Medicine goes to development of mRNA vaccines by lawn on Monday October 02, 2023 @09:33AM (#37737860)
Vaccination was never about "not getting it".
Re:Nobel Price in Medicine goes to development of mRNA vaccines by oldgradstudent on Monday October 02, 2023 @09:40AM (#37737959)
>Vaccination was never about "not getting it".

What do you base this bizarre claim on?

From the package insert for the Pfizer vaccine:

> COMIRNATY is a vaccine indicated for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals 12 years of age and older. (1)

A single indication, "not getting it". This is what the clinical trials tested and this is what the FDA approved.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by empath-nirvana on Monday October 02, 2023 @09:57AM (#37738196)
> to prevent coronavirus disease

You can be infected with a pathogen without developing the disease associated with the pathogen.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @10:03AM (#37738295)
You'll note that insert doesn't say "to prevent infection".

As with HIV (SARS-CoV-2) versus AIDS (COVID-19), the disease you can get from the virus is not the same thing as the infection itself.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by oldgradstudent on Monday October 02, 2023 @10:18AM (#37738483)
The trials were never powered to even test for infetion or transmission. It is quite clear now the vaccine prevented neither.

It was supposed to prevent the disease - basically postive test + symptoms. It didn't.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @10:22AM (#37738520)
> The trials were never powered to even test for infetion or transmission.

You called that very statement a "bizarre claim" upthread.

Try this: "Seatbelts prevent injury and death in car accidents."

They don't prevent every single one of them, but no one calls the above statement a lie. Your standard - requiring a vaccine be perfect at its purpose - is an invented one in bad faith to win an argument.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by oldgradstudent on Monday October 02, 2023 @10:35AM (#37738687)
> You called that very statement a "bizarre claim" upthread.

The discussion was about Covid. Covid is the disease (infection+symptoms). The vaccine was supposed to prevent you from "getting it".

Re:Nobel Price in Medicine goes to development of mRNA vaccines by ceejayoz on Monday October 02, 2023 @10:46AM (#37738841)
We have evidence of it reducing transmission: https://www.cidrap.umn.edu/covid-19/covid-shots-previous-inf...

That alone demonstrates the vaccine can help you not get it.

We have loads of evidence of it lessening symptoms; for a non-zero amount of people, that'll mean going from symptomatic to asymptomatic, i.e. SARS-CoV-2 infection but not COVID-19.

Vaccines have never been expected to be perfect in this regard; some polio vaccines can give people polio, for example.

(The idea that "turns out it only prevents hospitalization and/or death, not mild symptoms" is a bad result is also lunacy from the start.)

Re:Nobel Price in Medicine goes to development of mRNA vaccines by oldgradstudent on Monday October 02, 2023 @11:47AM (#37739662)
Again, the debate started over the claim that

>>>> Vaccination was never about "not getting it".

Of course it was about whether the vaccine prevents you from "getting it" (it being Covid). The original claim was that it was 95% effective in preventing you getting it.

> We have loads of evidence of it lessening symptoms; for a non-zero amount of people, that'll mean going from symptomatic to asymptomatic, i.e. SARS-CoV-2 infection but not COVID-19.

We have loads of crappy evidence showing that (see below). Crappy means highly confounded observational data.

> Vaccines have never been expected to be perfect in this regard; some polio vaccines can give people polio, for example.

No one expects them to be perfect, but the original claims were they were supposed to be 95% effective in preventing Covid. Real world efficacy is no where near that. If there's any efficacy at all it is in the low teens.

[BTW, there's a huge debate about the oral Polio vaccine. The US stopped vaccinating with it two decades ago because of that risk]

> (The idea that "turns out it only prevents hospitalization and/or death, not mild symptoms" is a bad result is also lunacy from the start.)

It would be luncay if anyone actually claimed that.

The problem is that claiming that it prevents hospitalizations or deaths requires evidence. Reliable evidence.

A recent NEJM correspondence demonstrates quite vividly how terrible much of the evidence for that claim was:

https://www.nejm.org/doi/full/10.1056/NEJMc2306683

(the original author's response is especially hillarious)

Re:Nobel Price in Medicine goes to development of mRNA vaccines by empath-nirvana on Monday October 02, 2023 @09:55AM (#37738170)
I caught covid after getting vaccinated and I would not have even known I had it had a coworker not tested positive and I had to test to come back to the office. Symptoms were incredibly mild. A lot of people my age who weren't vaccinated ended up the in the ER. I never thought the vaccine would prevent disease, it was never claimed that the vaccine prevented catching covid, it always just reduced severity and mortality.
Re:Nobel Price in Medicine goes to development of mRNA vaccines by oldgradstudent on Monday October 02, 2023 @10:33AM (#37738654)
The vaccine was never approved for reduction of symptoms because there was no good evidence to make this claim. And there's no good evidence to make it now.

It was approved for the prevention of Covid (the 'D' stands for disease). It was supposed to prevent you from getting Covid, regardless of severity, and it didn't.

And if we're citing anecdotal evidence. I know of no one who got anything more than flu symptoms, and for most it was mild, regardless of vaccination.

That includes obese diabetic 80s year olds. I know of no one personally who went to the ER except for a vaccinated friend who panicked.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by someuser2345 on Monday October 02, 2023 @11:36AM (#37739490)
> it was never claimed that the vaccine prevented catching covid The president of the United States made that exact claim: https://apnews.com/article/joe-biden-business-health-governm...
Re:Nobel Price in Medicine goes to development of mRNA vaccines by AuryGlenz on Monday October 02, 2023 @11:43AM (#37739601)
I’m not saying it didn’t reduce your symptoms - it probably did. But there were plenty of people that caught COVID unvaccinated and had the same experience as you.

On the other hand, I had the wonderful experience of catching the first virus and the delta variant. I should have been more protected than with the vaccine by itself as the data clearly showed at the time but it still hit me, a 34 year old decently fit person, almost equally as hard. I had 2-3 weeks of incredibly high fever along with a bunch of other nasty symptoms.

We’re all different. My retirement age mom has never been vaccinated (even though I wish she would have) and she’s either never caught it, which I doubt, or it was so mild she didn’t realize it.

Re:Nobel Price in Medicine goes to development of mRNA vaccines by shrubble on Monday October 02, 2023 @10:09AM (#37738359)
The ability to do it (specification) is what is being rewarded, not the merits or not of what Pfizer/Moderna/Biontech did (implementation).