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Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:00PM (#29826128)
I have omicron right now (4-5 months after 2nd jab, so pretty much no effect from that) and it's just like a common cold (certainly wouldn't call it "battling omicron"). I have zero problems with getting this each year.
Re:Omicron at 100% Prevalence, Colorado by shrikant on Thursday January 06, 2022 @12:33PM (#29826654)
Congratulations.

Both my wife and I (double vaxxed for 5 months, not boosted yet although were just about to do so) caught Omicron-flavoured Covid in the lead-up to Christmas and it wiped us out each for 2-3 days each, with a combination of fatigue, aches, fever, and violent coughing. Certainly worse than any cold or flu we've had up until that point.

I still have a pretty nasty cough and a throat inflammation.

Aren't anecdotes fun?

Re:Omicron at 100% Prevalence, Colorado by steelstraw on Thursday January 06, 2022 @01:00PM (#29827148)
Congratulations. You haven't had a bad cold or flu before. It's not uncommon for the flu to knock someone out for a good week. Or for a cold to leave a lingering cough for weeks.
Re:Omicron at 100% Prevalence, Colorado by smileysteve on Thursday January 06, 2022 @04:53PM (#29830818)
> It's not uncommon for the flu to knock someone out for a good week.

This is why it has a vaccine. That prevents it, prevent seriousness of symptoms, and deaths. (yet a large percent of the population doesn't get it, and so 50k us citizens die each year)

Re:Omicron at 100% Prevalence, Colorado by JPKab on Thursday January 06, 2022 @07:56PM (#29833157)
I have gotten a flu vaccine every year since I was 18. The worst flu I ever had was in January 2020. (I was tested and positive for influenza)

Fever for 4 days, horrible coughing, vomiting, barely able to get out of bed. Flu vaccines certainly provide some cross-immunity when the vax isn't matched to the strain, but not too much. That's what my doctor told me when I complained to her (when she told me I had tested positive for flu) that I'd gotten the annual flu vaccine the preceding October. Depending on the strain vs the vaccine for that year and how big of a mismatch it is, it can really whip your ass despite the vaccine. That being said, the flu shot is a good idea for anyone, and crucial for seniors.

Re:Omicron at 100% Prevalence, Colorado by uhtred on Thursday January 06, 2022 @02:16PM (#29828461)
You are the gatekeeper on feeling sick, now?
Re:Omicron at 100% Prevalence, Colorado by bingohbangoh on Thursday January 06, 2022 @02:50PM (#29828962)
We've been under threat of lockdown, under lockdown, or under restrictions for ~2 years now.

It's understandable that some are very concerned after or about getting sick but many of us, for our own sanity and psychological health, need to move on.

Re:Omicron at 100% Prevalence, Colorado by landemva on Friday January 07, 2022 @03:27AM (#29836500)
And the front line critical infrastructure are out doing their jobs. Change your career and get outside!
Re:Omicron at 100% Prevalence, Colorado by tablespoon on Friday January 07, 2022 @12:29PM (#29841909)
> We've been under threat of lockdown, under lockdown, or under restrictions for ~2 years now.

> It's understandable that some are very concerned after or about getting sick but many of us, for our own sanity and psychological health, need to move on.

WWII lasted longer, and IIRC the US was under a restrictive civilian rationing regime that whole time.

I understand that people can get annoyed with various measures required for the public good, but that's not good reason to "move on" from whatever challenge that motivates them.

Re:Omicron at 100% Prevalence, Colorado by crocodiletears on Thursday January 06, 2022 @03:13PM (#29829334)
Caught a bad flu in late 2018. Lingered for two months. Cough so bad, I dislocated a rib. Had X-rays taken, and everything. Took about a year for the the rib to stop slipping whenever I exerted myself. In the end, it was a period of discomfort that set me back a spell, but which I ultimately got over. Probably wouldn't try to shut down society over it, or use it as proof that people should fear the flu. Just that sometimes you get sicker than usual.
Re:Omicron at 100% Prevalence, Colorado by clairity on Friday January 07, 2022 @04:18AM (#29836931)
i had a similarly bad flu bout winter 2017-18. the worst of it literally had me at the edge of death one night. would have stopped breathing had i not willfully forced myself to, through all the congestion and soreness (also had a rib issue like you). the flu is no joke, and yet i also wouldn’t try to shut down the world, let alone my city, for the flu.
Re:Omicron at 100% Prevalence, Colorado by jsight on Thursday January 06, 2022 @03:03PM (#29829182)
No, but he's fundamentally right. The symptoms described are no worse than a moderate flu.
Re:Omicron at 100% Prevalence, Colorado by throwaway64643 on Thursday January 06, 2022 @04:27PM (#29830455)
People forget that it knocks so many people down at once in a short time, and with quarantine rules in force. It is more contagious than flu/cold. Imagine what would happen every year in winter if this becomes the new normal.
Re:Omicron at 100% Prevalence, Colorado by throwoutway on Thursday January 06, 2022 @08:13PM (#29833321)
Imagine what would happen if we go in lock down every year. And keep making kids learn remote. And keep letting governments gain more authority without the reasonable discussion
Re:Omicron at 100% Prevalence, Colorado by abletonlive on Thursday January 06, 2022 @03:21PM (#29829468)
Pointless post. We could ask the same of you.
Re:Omicron at 100% Prevalence, Colorado by dougmwne on Thursday January 06, 2022 @12:47PM (#29826893)
It’s terrible to feel terrible, but getting over the worst part of Covid in 3 days is an enormous improvement from how unvaccinated people fared in the initial waves. Even for people not hospitalized, they dealt with pneumonia and shortness of breath for weeks. I think we can celebrate the progress we are making in reducing the average severity of this disease and there are more tools coming soon with Pfizer’s new pill and newer multivalent vaccines.
Re:Omicron at 100% Prevalence, Colorado by Miner49er on Thursday January 06, 2022 @01:07PM (#29827268)
Your comment makes it out like everyone with Covid had pnuemonia and shortness of breath for weeks, when really it was a small minority.
Re:Omicron at 100% Prevalence, Colorado by dougmwne on Thursday January 06, 2022 @01:52PM (#29828044)
According to the CDC, 30% to 40% of symptomatic people get shortness of breath, which is a significant share. That is a signal that the infection has reached the lower respiratory system.

https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us-setting...

Re:Omicron at 100% Prevalence, Colorado by artificialLimbs on Thursday January 06, 2022 @03:46PM (#29829872)
Had I reported to the CDC (I didn't), I would have reported that I woke up in the middle of the night unable to take a deep breath, went nearly immediately back to sleep, and was free of all symptoms the next day. This would have counted toward the total (had I reported), and such counting needs a wider perspective before such things as say, creating lockdown policies based on these figures.
Re:Omicron at 100% Prevalence, Colorado by rlpb on Thursday January 06, 2022 @02:14PM (#29828410)
According to https://www.bbc.co.uk/news/health-59895598, over 500,000 people in the UK are still suffering health issues a year after catching Covid, and nearly 900,000 are still suffering after 12 weeks. The UK population is around 70 million, so that's around 1% of the entire population. If you take into the fact that many people in the UK have managed to not catch it at all yet, or exclude children who suffer far less (if at all), then the percentage would be higher.

I don't think 1% is "a small minority".

Re:Omicron at 100% Prevalence, Colorado by kcplate on Thursday January 06, 2022 @09:07PM (#29833849)
The problem with a statistic like that is that it is pretty much devoid of almost all data that would make it truly meaningful and valuable. That stat tells us nothing of their health pre-Covid, and I’d bet a very large portion of that number were already dealing with health issues (which we already know significantly increases severe Covid). The meaningful number is how many formerly healthy people are battling Covid caused health issues a year later. My guess is that it is a pretty small number, likely small enough that it would be considered even by you to be a “small minority”.
Re:Omicron at 100% Prevalence, Colorado by rlpb on Friday January 07, 2022 @07:04AM (#29838117)
Previous health condition status is part of the dataset, so you don't need to guess. If you want to take that into account, then use the data to make your point.
Re:Omicron at 100% Prevalence, Colorado by kcplate on Friday January 07, 2022 @08:54AM (#29839097)
Thanks for the tip! I’ll let the dataset speak for itself:

“7. Health/disability status is self-reported by study participants rather than clinically diagnosed. From February 2021 study participants were asked to exclude any symptoms related to COVID-19 when reporting their health/disability status. However, in practice it may be difficult for some participants to separate long COVID symptoms from unrelated exacerbation of pre-existing conditions, so these results should be treated with caution. “

Re:Omicron at 100% Prevalence, Colorado by shrikant on Thursday January 06, 2022 @02:11PM (#29828362)
Yeah absolutely, I count ourselves reasonably lucky that we only caught the disease after vaccinations.

I have absolutely non-zero desire to go through this every year, unlike my parent commenter though.

Would I be of a similar opinion as parent if I had a similarly asymptomatic-to-mild case? I don't know for sure, but I would hope not, because I wouldn't want to draw conclusions or base policy from just my anecdotal experience.

Other replies to me appear needlessly partisan jibes: I neither said nor implied anything about continued lockdowns and any such inference is pure projection.

Re:Omicron at 100% Prevalence, Colorado by markkanof on Thursday January 06, 2022 @03:31PM (#29829621)
Your parent commenter wasn't saying that they have a desire to get this every year, just that if the worst case outcome is getting what they had every year, they would find that an acceptable trade-off for getting society back to normal.
Re:Omicron at 100% Prevalence, Colorado by slibhb on Thursday January 06, 2022 @04:36PM (#29830597)
> I have absolutely non-zero desire to go through this every year, unlike my parent commenter though.

Many people get sick every year or every other year. Their illness is like you described: 2-3 days of being "knocked out" and about a week to fully recover.

It's not that I "desire" to go through that every year or two, it's just life. I expect that's why people responded incredulously to your post: for them, getting sick occasionally is normal.

Re:Omicron at 100% Prevalence, Colorado by cloverich on Friday January 07, 2022 @02:00PM (#29843233)
to add on — before i had kids i rarely got sick. at one point i went maybe seven or eight years. now, every couple months. and at least one a year that puts me down a few days or more. And those aren’t even the flu, typically. There are many kinds of colds that can knock you out.

Each is likely an endemic version of something that was far more serious and deadly historically. Now it’s a minor or major annoyanace that is part of normal life. i bet eradicating covid would fall into the same bucket S eradicating any of the others. Something to aspire towards, but until then something to simply accept as normal and move on with our lives.

Re:Omicron at 100% Prevalence, Colorado by dwaltrip on Thursday January 06, 2022 @04:06PM (#29830151)
By saying “I don’t want to experience this every year” without any caveats, there is an implication we should do something to prevent it. Especially given the broader context of the pandemic thus far. Surely you can see how many readers might feel that implication.
Re:Omicron at 100% Prevalence, Colorado by gilbetron on Thursday January 06, 2022 @01:08PM (#29827288)
That sounds like a fairly typical cold, maybe edging to "bad" in my experience. I'm double vaxxed plus a booster about 1 month ago, and currently have Omicron. I have roughly the same experience as you, although less on the coughing, which is odd because I usually get a lot more coughing with colds.
Re:Omicron at 100% Prevalence, Colorado by uhtred on Thursday January 06, 2022 @02:19PM (#29828512)
> That sounds like a fairly typical cold

No, it doesn't. I've never felt "wiped out" from a typical cold.

Re:Omicron at 100% Prevalence, Colorado by drusepth on Thursday January 06, 2022 @03:16PM (#29829389)
I regularly feel "wiped out" from a typical cold, often for 4+ days in a row.

This whole thread is full of anecdotes from people implicitly claiming that their experience applies to everyone, when in reality everyone's going to have different experiences with everything from colds to covid. Unfortunately, the latter has a much higher prevalence of seriously-worse side-effects (long-haul, ageusia, anosmia, death, etc) compared to the former.

Re:Omicron at 100% Prevalence, Colorado by technothrasher on Thursday January 06, 2022 @03:22PM (#29829490)
My 15 yo son got Covid about three weeks ago, symptoms matched what the parent poster described, including feeling "wiped out". Oh wait, no he didn't. Testing all came back negative. Diagnosis from his pediatrician: common cold.
Re:Omicron at 100% Prevalence, Colorado by gilbetron on Thursday January 06, 2022 @04:00PM (#29830088)
Ah, yeah, you're right. It was probably just the cold that myself, my son, and my wife got after being exposed to someone that had symptomatic, PCR tested Covid. I'm sure it was just a coincidence that we then all three tested positive for covid.
Re:Omicron at 100% Prevalence, Colorado by kcplate on Thursday January 06, 2022 @08:54PM (#29833731)
Wow…You definitely missed the entire point of that comment.
Re:Omicron at 100% Prevalence, Colorado by gilbetron on Thursday January 06, 2022 @10:39PM (#29834541)
Did I? If I did ... sigh. But I'm not convinced! But I also wouldn't be surprised :)
Re:Omicron at 100% Prevalence, Colorado by josephcsible on Sunday January 09, 2022 @03:39PM (#29867104)
technothrasher wasn't doubting that you had COVID, but rather making the point that the common cold and COVID now have the same symptoms and severity, and that getting a test is now the only way to tell which one you have.
Re:Omicron at 100% Prevalence, Colorado by not_really on Thursday January 06, 2022 @06:54PM (#29832491)
Whoosh
Re:Omicron at 100% Prevalence, Colorado by gilbetron on Thursday January 06, 2022 @10:40PM (#29834550)
I'm not convinced it wooshed! But I also wouldn't be surprised :)
Re:Omicron at 100% Prevalence, Colorado by spurgu on Friday January 07, 2022 @09:42AM (#29839616)
Joint pain and being mentally "out" (not being able to hold complex structures in my mind = unable to code) are two hallmarks of common colds for me and why I always take ~2 days off work when I have one - I'd just get frustrated trying. Sore throat is another one.

Omicron now is no different. Ended up taking 3 days off work and am now back to normal capacity.

Re:Omicron at 100% Prevalence, Colorado by sanderjd on Thursday January 06, 2022 @03:15PM (#29829375)
FWIW: To me, it sounded like an atypical cold or a typical flu. I've been "wiped out" by colds before, though rarely, and I'm always "wiped out" by flus, though I catch them a lot less often than once a year.
Re:Omicron at 100% Prevalence, Colorado by peder on Thursday January 06, 2022 @02:05PM (#29828264)
This is one of the most privileged takes I've ever read. OH GOOD HEAVENS. You were sick for a whole 2-3 days. Best lockdown the country to avoid what most people experience 1+ times per year.
Re:Omicron at 100% Prevalence, Colorado by jollybean on Thursday January 06, 2022 @02:39PM (#29828797)
? It's killed 800 000 people.

The 'privileged' comment is 'I got COVID it was just like a cold, I can do this every year ... so there's no more pandemic'.

Conflating their personal anecdote with the range of outcomes.

For now, we're still in a pandemic. Hopefully it will get better.

Re:Omicron at 100% Prevalence, Colorado by lovecg on Thursday January 06, 2022 @02:54PM (#29829032)
Omicron didn’t kill 800 000 people. There’s also vastly more immunity (whether through vaccines or previous infections). Let’s wait and see but there’s hope it’s a different, milder disease.
Re:Omicron at 100% Prevalence, Colorado by thomasmg on Thursday January 06, 2022 @04:08PM (#29830190)
(You are right of course. With the data we have now, we are quite certain that Omicron is much milder. Hopefully no lockdown is needed.)

But, personally, I would like to avoid getting Omicron, as long term effects are still unclear: does "long Omicron" exist, does it affect vaccinated, and if yes how common and severe is it. There are some recent news about long Covid: it could be micro-clots.

Re:Omicron at 100% Prevalence, Colorado by lovecg on Friday January 07, 2022 @01:32AM (#29835755)
There’s some evidence that most “long covid” symptoms (everything except loss of smell) in most people who claim to have it are not due to covid:

https://jamanetwork.com/journals/jama/fullarticle/2787741

Specifically, reporting long covid symptoms correlates with thinking you had covid, and not as much with actually having had covid.

Of course this doesn’t mean there aren’t some real severe cases out there, but it’s probably not nearly as widespread as it seems.

Re:Omicron at 100% Prevalence, Colorado by nradov on Thursday January 06, 2022 @09:54PM (#29834212)
Unless you live as a hermit you are unlikely to avoid getting Omicron. A more rational approach would be to take steps that will maximize your odds of survival when you do get it.

https://www.medpagetoday.com/opinion/vinay-prasad/94646

Re:Omicron at 100% Prevalence, Colorado by jollybean on Friday January 07, 2022 @09:46AM (#29839664)
Yes, like taking a vaccine. And also social distancing and avoiding others so that the peak of cases doesn't coincide with an overflow of Medical facilities resulting in your inability to get proper medical attention if needed.
Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:46PM (#29826869)
> Aren't anecdotes fun?

Anecdotes was precisely the reason why I posted it. See whom I'm replying to.

Re:Omicron at 100% Prevalence, Colorado by parthdesai on Thursday January 06, 2022 @01:34PM (#29827761)
so the answer is to stay locked down and screw over small businesses and tons of workers every winter because a subset of people have harsher symptoms?
Re:Omicron at 100% Prevalence, Colorado by lukifer on Thursday January 06, 2022 @02:04PM (#29828249)
Every policy has tradeoffs. We could save around 20,000 lives per year (in the US) with a simple policy change: just cap all speed limits at 45 mph.

I think it's a fair critique that some lockdown measures go too far (particularly those with low efficacy, or "safety theater"), but it's more helpful to take about specifics, rather than "lockdowns good" or "lockdowns bad".

At some point (and maybe it's now?), we'll need to shift our thinking from "pandemic" to "endemic". COVID is going to be with us from now on, and will start to look more like flu season (viruses tend to evolve to be less deadly over time). And I don't say that to trivialize it; COVID has given me much greater awareness of the impact of the seasonal flu on the elderly and the immuno-compromised.

Re:Omicron at 100% Prevalence, Colorado by parthdesai on Thursday January 06, 2022 @02:41PM (#29828809)
I agree, that is my point is exactly. At a certain point, we need to learn to live with it. Majority of us on HN are in an extremely privileged position where we can WFH and infact for a lot of us, pandemic led to more savings. But that is not the case for an average person out there. There are families out there have been ruined financially for life because their business had to shut down. Kids very much might have life long repercussions from the school shut down. At a certain we have to take all this into account before just initiating a province wide lockdown every winter (which is what is happening in the country I live in, Canada).
Re:Omicron at 100% Prevalence, Colorado by perydell on Thursday January 06, 2022 @02:33PM (#29828705)
I am curious how you know it was Omicron. Was it sequenced and they told you that?
Re:Omicron at 100% Prevalence, Colorado by phonypc on Thursday January 06, 2022 @12:04PM (#29826190)
Hmmm... mild symptoms after being vaccinated. It's almost like the vaccine worked or something. How weird.
Re:Omicron at 100% Prevalence, Colorado by JPKab on Thursday January 06, 2022 @12:59PM (#29827127)
My brother had mild symptoms after being unvaccinated. So did my kids. So did my neighbors whose kids play at my house all the time.

So did the vast majority of South Africans who aren't vaccinated.

I push the vaccine onto all my high-risk family members. I recommend it to anybody as a tool to introduce your immune system to the virus.

But let's be honest about this:

The vaccines in circulation were created to stop the Alpha variant. The immune system response is too targeted to antigens on the spike protein that are no longer present in the newly evolved, vaccine escaping variants. The vaccine is a useful tool for mitigating severe disease, but it's an outdated vaccine for a variant that no longer exists. Just like the a flu shot for the wrong strain tends to have some positive benefit when you catch a mismatched strain via some cross immunity, that's what we get from this vaccine. And guess what? We get it from infection induced immunity as well.

Re:Omicron at 100% Prevalence, Colorado by MrMan on Thursday January 06, 2022 @01:43PM (#29827917)
an honest, but wrong, take in your final paragraph.
Re:Omicron at 100% Prevalence, Colorado by JPKab on Friday January 07, 2022 @10:34AM (#29840297)
Feel free to state counter arguments. I'd like to hear what statements I said conflict with your understanding of the science.
Re:Omicron at 100% Prevalence, Colorado by jaywalk on Thursday January 06, 2022 @12:09PM (#29826269)
Plenty of unvaccinated (the vast majority, in fact) also experience mild symptoms. It's almost like you've got an unfalsifiable way to always say "it worked!"
Re:Omicron at 100% Prevalence, Colorado by stormbrew on Thursday January 06, 2022 @12:17PM (#29826388)
> Plenty of unvaccinated (the vast majority, in fact) also experience mild symptoms.

This is true of essentially all diseases except some very very rare exceptions that also tend to burn out very quickly. That's just how disease spread works, mild cases help the virus propagate. It's not like the virus is a mustache twirling villain that wants to murder you, it takes a fairly specific balance to obtain long term survival.

> It's almost like you've got an unfalsifiable way to always say "it worked!"

There's plenty of evidence to support the idea that "it works", and actually quite a lot of evidence to contradict the idea that "it doesn't work". Severe outcomes are blatantly more common, per capita, in people who are not vaccinated. The only way you get to any other conclusion is if you just plain don't trust any evidence presented, in which case there is literally nothing that is falsifiable for you and you may as well believe covid-19 is evil unicorns or something.

Re:Omicron at 100% Prevalence, Colorado by jaywalk on Thursday January 06, 2022 @12:38PM (#29826716)
> Severe outcomes are blatantly more common, per capita, in people who are not vaccinated.

With omicron? I have not seen any data to support that.

Re:Omicron at 100% Prevalence, Colorado by stormbrew on Thursday January 06, 2022 @12:41PM (#29826784)
I mean, it's pretty early to be drawing conclusions about this with omicron. Especially since it hit right as people in most of the vaccinated world were hitting 5-6mo since their second shots. That doesn't mean it's "unfalsifiable" it just means it hasn't been yet.

That said, I don't think the null hypothesis is suddenly "vaccines do nothing" for some reason. It's clear enough it spreads more easily but that doesn't suddenly invalidate all prior assumptions about the vaccines' effectiveness against severe outcomes.

Edit: I'm very happy to be proven wrong about this but I feel like people should direct some of these replies more to the person I was replying to? I'm not the one who thinks vaccines do nothing here. :P

Re:Omicron at 100% Prevalence, Colorado by JPKab on Thursday January 06, 2022 @01:03PM (#29827205)
It's only too early if, like our public health authorities, you are too bigoted and self-important to trust South African medical scientists because they aren't from a mostly white country. That's my take on why the CDC ignored their scientists, as did the media.

From the very beginning, the South African medical authorities were screaming that this variant was producing far fewer hospitalizations OVERALL (despite higher case numbers) than the delta/alpha did.

But because they are a third world country, and the news media in the West is biased towards bad news, they chose to treat this positive data as suspect. It the SA scientists had talked about how horrible it was, they would have taken it as gospel.

Those of us who were looking at the data knew otherwise.

Re:Omicron at 100% Prevalence, Colorado by amanaplanacanal on Thursday January 06, 2022 @06:37PM (#29832270)
I thought the issues were more about the younger population than in Europe and the US. And the unknown number of folks that had already been exposed to previous waves. Not the racial makeup of the people living there.
Re:Omicron at 100% Prevalence, Colorado by JPKab on Thursday January 06, 2022 @07:36PM (#29832948)
> already been exposed in previous waves

I was amused at the sudden acknowledgement of natural immunity from previous infection in the very publications that have constantly claimed it doesn't exist, the minute it supported their need to keep fear mongering. Same with the younger population point, considering these very organizations have gone out of their way to obfuscate the vast risk stratification by age for most of the pandemic. The terrified 20-somethings wearing respirators in TikTok videos are a result of this.

Re:Omicron at 100% Prevalence, Colorado by stormbrew on Thursday January 06, 2022 @09:58PM (#29834244)
> I was amused at the sudden acknowledgement of natural immunity from previous infection in the very publications that have constantly claimed it doesn't exist

Can you cite some of these alleged claims?

Re:Omicron at 100% Prevalence, Colorado by MrMan on Thursday January 06, 2022 @01:40PM (#29827869)
agreed
Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @01:59PM (#29828172)
> I mean, it's pretty early to be drawing conclusions about this with omicron.

No it's not. Late November was too early. In mid-December we could start drawing conclusions. At this point things are becoming quite clear - we see similar trends everywhere, not just South Africa.

Re:Omicron at 100% Prevalence, Colorado by MrMan on Thursday January 06, 2022 @01:40PM (#29827864)
its not early, omicron is declining already in places it hit a few weeks ago
Re:Omicron at 100% Prevalence, Colorado by dahinds on Thursday January 06, 2022 @01:00PM (#29827139)
https://www.webmd.com/lung/news/20220105/hospitalization-omi...

"The data suggests that three doses of vaccine provided an estimated 68% drop in the risk of being hospitalized with Omicron compared with people who were unvaccinated."

Re:Omicron at 100% Prevalence, Colorado by beebmam on Thursday January 06, 2022 @12:27PM (#29826547)
When you look at individuals, you'll never be able to truly say any treatment "worked" with certainty for virtually anything. It's same with nearly all medical treatments. Humans, very often, get better on their own with time, and time can't ever be rewinded to test the alternative.

The way we know a medical treatment works is by looking at large scale data, controlling for variables, understanding mechanisms of action, and by approaching this science in good faith and not cherry picking data to fit one's own conclusions. There's a concept known as "Number Needed to Treat" that is probably relevant to your concerns here.

Vaccinations have historically been extremely effective for many diseases, and COVID is no exception. It's accurate to say (most) "COVID vaccines are highly effective at preventing severe disease caused by the SARS-CoV-2 viruses". Omicron is so new that it's hard to be certain of anything regarding it right now, but we'll have a better picture in a few weeks. I do know that we're seeing many hospitals get overwhelmed across the US currently, and many medical workers are out sick with a COVID infection.

Re:Omicron at 100% Prevalence, Colorado by Buttons840 on Thursday January 06, 2022 @12:43PM (#29826815)
I have some skeptical family members who like to talk about 3rd party anecdotes. "A nurse told me she saw blah blah blah happen". As you say, stories like this are not a way to know a thing, but I can't get them to understand.

It's like we rolled a die once, and it came up 6, and now we're all forming our own special opinions on whether or not the die is fair. We just can't know. Of course, if someone rolled the dice 30,000 times and reported what they found, that would be great (wink wink).

Instead of using Calc 1 as a filter course, we should use Statistics instead.

Re:Omicron at 100% Prevalence, Colorado by virgilp on Thursday January 06, 2022 @12:50PM (#29826948)
Well you can look at this: https://cdn.substack.com/image/fetch/w_1100,c_limit,f_auto,q...

(it's recent data, from NY, so - likely a lot of omicron)

Re:Omicron at 100% Prevalence, Colorado by betterunix2 on Thursday January 06, 2022 @12:49PM (#29826921)
Yet it is predominantly the unvaccinated who are overwhelming hospitals with more severe cases. In NYC it is something like 15x difference -- 30 per 100000 unvaccinated versus 2 per 100000 vaccinated people wind up requiring hospital care. Those may be small numbers, but with omicron clearly being both more contagious and evading prior immunity it rapidly becomes problematic.
Re:Omicron at 100% Prevalence, Colorado by cmrdporcupine on Thursday January 06, 2022 @12:44PM (#29826825)
It's almost like hospitalization statistics might just back this assertion up with actual irrefutable data.
Re:Omicron at 100% Prevalence, Colorado by dwaltrip on Thursday January 06, 2022 @04:08PM (#29830180)
For crying out loud… Go look up the frickin statistics. The vaccines are very effective.
Re:Omicron at 100% Prevalence, Colorado by spurgu on Sunday January 09, 2022 @03:05PM (#29866835)
Really?

See https://vinayprasadmdmph.substack.com/p/vaccine-effectivenes...

Those "frickin" statistics? Or which ones?

Re:Omicron at 100% Prevalence, Colorado by dwaltrip on Monday January 10, 2022 @07:59PM (#29885614)
From own your link:

> [The] vaccines likely (and evidence shows they) still have great protection against severe disease; …

This exactly what we were talking about above.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Monday January 10, 2022 @10:25PM (#29887071)
Like 15% effective, after 2 jabs, for me personally?
Re:Omicron at 100% Prevalence, Colorado by ceejayoz on Tuesday January 11, 2022 @09:04AM (#29891550)
On a personal level it's gonna be either 100% or 0%. You either got severe disease, or you didn't.

You can't extrapolate a population-level percentage from a single data point. Luckily, we've got information on hundreds of thousands of deaths, millions of hospitalizations, and billions of shots.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Tuesday January 11, 2022 @09:15AM (#29891649)
That doesn't make any sense. If the immune response didn't wane on a personal level we wouldn't be needing any boosters.
Re:Omicron at 100% Prevalence, Colorado by ceejayoz on Tuesday January 11, 2022 @09:32AM (#29891818)
You can't get 15% of a case of severe COVID. At a personal level, the vaccine either worked at preventing it, or it didn't. We can compute a population-level probability of those two scenarios for you, but you can't really say "15% effective, after 2 jabs, for me personally".
Re:Omicron at 100% Prevalence, Colorado by spurgu on Tuesday January 11, 2022 @09:50AM (#29892035)
> You can't get 15% of a case of severe COVID.

Getting Covid or not is binary, yes, but the severity of the disease is on a spectrum. I can surely get a 15% less severe disease thanks to a 4-5 month old vaccination. Just like the severity of the disease depends on the viral load you're exposed to.

Of course there's no way of knowing what the exact percentage is for me personally, so in that sense you're right - it's just an average. But it's surely indicative, which is why you should be getting boosters after a specific amount of time, if you're in a risk group.

Re:Omicron at 100% Prevalence, Colorado by jollybean on Thursday January 06, 2022 @02:41PM (#29828811)
"Plenty of unvaccinated (the vast majority, in fact) also experience mild symptoms. It's almost like you've got an unfalsifiable way to always say "it worked!""

Yes, it's called 'Science'.

The vaccine absolutely helps to reduce symptoms, hospitalizations and death, even 5 months in.

There are millions of Omicron cases around the world measure up against various vaccinated and unvaccinated populations.

Re:Omicron at 100% Prevalence, Colorado by eli_gottlieb on Thursday January 06, 2022 @01:44PM (#29827923)
Yeah we have this thing called a clinical trial. I volunteered in it. Did you?
Re:Omicron at 100% Prevalence, Colorado by HNDen21 on Thursday January 06, 2022 @01:43PM (#29827910)
I have 5 people in the house, 1 vaccinated, 4 not.. the ones that were not had a 2 day fever... the one vaccinated (me) had no fever but just a cough for 3-4 days. All in all just like a mild flu
Re:Omicron at 100% Prevalence, Colorado by twox2 on Thursday January 06, 2022 @02:04PM (#29828240)
Anecdotal stories don't paint an accurate picture. I live in NYC and had Covid xmas week. It was ROUGH. (I'm double jabbed.) I also know unvaxxed people (0 shots) that just had a little sniffle and bounced back in 2 days. I also know of a seemingly healthy young lady that tested positive and died 3 days later.
Re:Omicron at 100% Prevalence, Colorado by time_to_smile on Thursday January 06, 2022 @02:46PM (#29828888)
> Anecdotal stories don't paint an accurate picture

You would have thought that after 800,000+ deaths in the US people would have learned the importance of understanding statistics when dealing with these issues, especially on a place like HN, but pandemic has melted people's brains and now people are arguing anecdotes about what constitutes a "bad cold" and a "mild flu".

The funny part is that it doesn't really matter because it's not like we get to collectively vote whether the pandemic will end or not. It's pretty clear that, even given how extremely contagious omicron is, people don't care as much as the used to about a seasonal flu.

Even supposing covid sticks around and becomes "only" as bad as the flu, 10 years ago if your said it was fine to double the annual cases of flu and flu death people would have said that was insane.

Sadly if people haven't learned to reason about these problems correctly now, it means they very likely never will.

Re:Omicron at 100% Prevalence, Colorado by brandonmenc on Thursday January 06, 2022 @04:05PM (#29830146)
> 10 years ago if your said it was fine to double the annual cases of flu and flu death people would have said that was insane.

And if you told them that things like lockdowns and vaccine mandates were still in effect at that point, they'd say that was insane too.

Re:Omicron at 100% Prevalence, Colorado by time_to_smile on Thursday January 06, 2022 @05:01PM (#29830922)
> vaccine mandates were still in effect at that point, they'd say that was insane too.

No, that one is particularly weird right now. Vaccines are essentially mandated for many parts of life, and have been for my entire life. At multiple points throughout my development I've had to get required vaccines to do things. I had never even heard of antivaxxers until my late 20s. They used to be laughed at as an insane fringe group on HN.

Nobody in 2011 would have thought it was weird that vaccines would be mandated. I suspect if I predicted on HN that there would be strong resistance to a vaccine in the event of a global pandemic people would have laughed at me as ridiculous.

People don't like vaccines because they don't like the reality we're in and they strangely think resisting wearing masks and resisting vaccines somehow makes it less real. Unfortunately it has made things much worse.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Friday January 07, 2022 @10:02AM (#29839874)
> Vaccines are essentially mandated for many parts of life

Not ones requiring multiple jabs per year, seemingly forever (unless something like Omicron comes along).

Also not experimental ones rushed out with an EUA. Would you accept a mandate of the Chinese or Cuban vaccine, twice per year, for your whole family, for the whole foreseeable future?

> Nobody in 2011 would have thought it was weird that vaccines would be mandated.

You'd be very wrong. I remember very well that people were highly vocal against the H1N1 vaccine a decade ago and would've (rightfully so) lost their minds with mandates. Turned out the vaccine caused narcolepsy in kids[0], among other things. I never had that vaccine. My pregnant partner did (which turned out to be a lucky gamble).

> resisting wearing masks

Barring N95/FPP2+ masks it's mainly theater. It will be interesting to read all about this in a year or three once the heated political agendas have subsided.

[0] https://en.wikipedia.org/wiki/2009_swine_flu_pandemic_vaccin...

Re:Omicron at 100% Prevalence, Colorado by brandonmenc on Thursday January 06, 2022 @09:07PM (#29833846)
Mandated vaccines for adults in the United States actually is weird and unprecedented in the modern era.

It's so unprecedented and unpopular an idea that everyone - including Biden - were falling all over themselves assuring us they would under no circumstances mandate the Covid vaccine.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:21PM (#29826469)
4-5 months..... even against Delta that would've been close to 50% efficacy. With Omicron probably non-existent.

Also, see most of South Africa.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Sunday January 09, 2022 @03:04PM (#29866827)
Have a look here:

https://vinayprasadmdmph.substack.com/p/vaccine-effectivenes...

tl;dr Vaccine effectiveness around 15% for me at this point. So it was the natural immune response (gasp!), combined hospitalization rates across the world reflects this.

Re:Omicron at 100% Prevalence, Colorado by potatoman22 on Thursday January 06, 2022 @12:10PM (#29826288)
That's the point. It's often a mild cold for the vaccinated
Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:22PM (#29826488)
It's mild for non-vaccinated South Africans as well.

The same still applies as always: Vaccinate the risk groups.

Re:Omicron at 100% Prevalence, Colorado by mullingitover on Thursday January 06, 2022 @12:32PM (#29826640)
SA had very high numbers of previous infections, so there was a ton of pre-existing immunity.
Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:48PM (#29826903)
Which some would see as a partial argument against lockdowns.
Re:Omicron at 100% Prevalence, Colorado by mullingitover on Thursday January 06, 2022 @03:56PM (#29830034)
Comparing death rates in Australia, which actually did pretty major lockdowns, to South Africa[1], I don't know that this is a great argument against them. South Africa definitely paid for that infection-based immunity in human lives.

[1] https://ourworldindata.org/explorers/coronavirus-data-explor...

Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @04:18PM (#29830338)
Of course heavy and complete lockdowns are effective (at delaying the spread of the virus) - if no one is in contact with anyone else there's no way for the virus to spread. A more apt comparison would be made between countries/states with slight or "normal/average" lockdown to ones without, but that's very difficult to do in practice. And then measure the financial and societal impacts (which is also difficult/impossible).
Re:Omicron at 100% Prevalence, Colorado by the_doctah on Thursday January 06, 2022 @02:16PM (#29828463)
So if everyone gets Omicron, we will have a ton of pre-existing immunity?
Re:Omicron at 100% Prevalence, Colorado by mullingitover on Thursday January 06, 2022 @03:48PM (#29829904)
We already have a great deal of pre-existing immunity. The big question we're answering right now is whether vaccine-based immunity (which we have more of in AU, UK, and the US) is as robust as immunity from infection (main source of immunity in SA). It's still too early to say with certainty, but it's looking like the vaccines are working if you're not immunocompromised.
Re:Omicron at 100% Prevalence, Colorado by lovecg on Thursday January 06, 2022 @02:59PM (#29829113)
Seems that we don’t have much choice in the matter so we will find out pretty soon. That wouldn’t be the worst outcome.
Re:Omicron at 100% Prevalence, Colorado by kcplate on Thursday January 06, 2022 @09:12PM (#29833886)
According the the CDC, natural immunity is not be named or acknowledged.
Re:Omicron at 100% Prevalence, Colorado by betterunix2 on Thursday January 06, 2022 @12:45PM (#29826853)
Yet the unvaccinated are still overwhelmingly more likely to wind up requiring hospital care than the vaccinated.
Re:Omicron at 100% Prevalence, Colorado by ifyoubuildit on Thursday January 06, 2022 @01:23PM (#29827568)
The seronaive are. The unvaccinated with a prior infection are unlikely to require hospital care: https://www.nejm.org/doi/full/10.1056/NEJMc2108120
Re:Omicron at 100% Prevalence, Colorado by brutal_chaos_ on Thursday January 06, 2022 @12:07PM (#29826241)
Granted this still needs peer review...but you may want to look into this:

https://www.researchsquare.com/article/rs-1139035/v1

I hope your recovery goes well and you truly have zero issues.

Re:Omicron at 100% Prevalence, Colorado by PraetorianGourd on Thursday January 06, 2022 @12:26PM (#29826530)
That also covers only previous, more virulent variants. Omicron does not seem to infect areas outside of upper respiratory so it is a tad overzealous to spread such fear over a preprint of a different variant. It would be like comparing a mild flu strain to H1N1 original.
Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:26PM (#29826532)
Keep up the fear-mongering... I'm healthy, I'm not worried about that at all. Neither am I afraid of drowning while boating.
Re:Omicron at 100% Prevalence, Colorado by brutal_chaos_ on Thursday January 06, 2022 @06:05PM (#29831875)
One might want to pay attention if the boat had a leak...

I do apologize if you took that as fear mongering, I have a nephew in a similar situation as you and we are keeping an eye on him just in case anything does come up, not that we expect anything will.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @06:24PM (#29832110)
Lots of things to be aware of when boating. The best is of course to use a structurally sound vessel. Then your main concern will simply be to keep a lookout as to not hit other boaters. With a leaky old brittle boat you need to make sure to have various backups plans and means of repairs for when things go wrong. The better shape your boat though, the less you have to worry outside of basic precautions. But if your boat is old and frail it would be of prudence to get the Pfizer Hull-Restoration kit and apply it thoroughly before heading out. And remember to apply twice per year!

Best wishes to your nephew.

Re:Omicron at 100% Prevalence, Colorado by gotoeleven on Thursday January 06, 2022 @12:32PM (#29826643)
Remember all the articles claiming covid gave you brain damage? What ever happened to that?
Re:Omicron at 100% Prevalence, Colorado by betterunix2 on Thursday January 06, 2022 @12:43PM (#29826810)
Not very hard to find the current, best understanding of the phenomenon:

https://www.ninds.nih.gov/Current-Research/Coronavirus-and-N...

Re:Omicron at 100% Prevalence, Colorado by gotoeleven on Thursday January 06, 2022 @01:51PM (#29828038)
Compare the nih link above to the hysteria from here:

https://news.ycombinator.com/item?id=27975514

Re:Omicron at 100% Prevalence, Colorado by CharlesW on Thursday January 06, 2022 @12:37PM (#29826703)
What happened is that we have a better understanding of the kind of brain damage it does, and how it does it.
Re:Omicron at 100% Prevalence, Colorado by kadoban on Thursday January 06, 2022 @12:44PM (#29826843)
There was some initial fear that anosmia might be related to brain damage (since basically ruled out I believe).

One of the common long covid symptoms is "brain fog" though. Which I _think_ is probably metabolic or circulatory or something, but definitely affects the brain whatever the actual cause is.

Re:Omicron at 100% Prevalence, Colorado by nicoburns on Thursday January 06, 2022 @12:39PM (#29826746)
It's not a high percentage of cases. But there are significant number of people reporting long-term issues with brain fog post-covid. Whether that's actually caused by a brain issue I don't know. But it certainly seems to be able to effect your ability to think.
Re:Omicron at 100% Prevalence, Colorado by swader999 on Thursday January 06, 2022 @12:12PM (#29826318)
That's pretty terrifying.
Re:Omicron at 100% Prevalence, Colorado by rblatz on Thursday January 06, 2022 @12:18PM (#29826424)
Eventually it’s going to do what all other viruses have done. Mutate into another flu or common cold. We already have l seasonal coronavirus outbreaks. We call it cold and flu season; except it’s numerous coronaviruses and influenza viruses and one or two “win” that year.
Re:Omicron at 100% Prevalence, Colorado by lovecg on Thursday January 06, 2022 @03:02PM (#29829172)
Some part mutation, some part immunization so that future infections are milder. In the absence of perfect vaccination this involves killing millions of people. Let’s not forget about this.
Re:Omicron at 100% Prevalence, Colorado by causality0 on Thursday January 06, 2022 @12:10PM (#29826292)
I'm happy it's not a battle for you, but it is for my wife.
Re:Omicron at 100% Prevalence, Colorado by JPKab on Thursday January 06, 2022 @12:54PM (#29827016)
I hope your wife is ok. Unfortunately, infection with Omicron is inevitable and not preventable, without living in a bubble. It's too infectious, and the vaccine, unlike with previous variants, does basically nothing to stop transmission. Combine that with an R0 equivalent to measles, and avoiding infection was never possible. She probably took every precaution she could reasonably take, and still got infected. That was my experience as well.

Statistically, people who are healthy and vaxxed developing severe symptoms from Omicron are outliers. That is no comfort to you, and I can assure you I know how you feel on that front when people like me tell you the stats. My mother-in-law suffered a very rare (statistically) adverse event from her second Pfizer shot in May, which killed her. She was in her early 60s, and healthy, but suffered cardiac arrest 3 hours after her second shot, in the midst of a fever. It was an exceedingly rare event, but it was no comfort to us to be told that.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:28PM (#29826566)
I'm sorry about your wife, hope she gets through it fine.

It's mainly that you provided a personal anecdote in one direction and I found it prudent to provide one in the other direction - one that echoes everything we've seen so far, cases skyrocketing, hospitalization rates barely nudging.

Re:Omicron at 100% Prevalence, Colorado by hedgehog on Thursday January 06, 2022 @12:47PM (#29826889)
Motivated anecdotes aren't prudent or useful. We know from the 2ish years of this we've had so far that the dynamics are tricky to pick apart. For example when young low-risk people are out at bars (very high exposure) and older or higher risk people stay home what happens is the hospitalizations lag because it takes some time for the first group to get sick, infect the second, and then some of those people to go on to the hospital. On the other hand older people are much more vaccinated so the relative risk between the groups will likely be different from previous waves.

That aside, hospitalizations are going up faster than they have at any point prior so not sure where your "barely nudging" comes from.

Re:Omicron at 100% Prevalence, Colorado by throwhauser on Thursday January 06, 2022 @12:13PM (#29826340)
Every year you'll be a year older though, which eventually results in being in a different (higher) risk category.
Re:Omicron at 100% Prevalence, Colorado by ajsnigrutin on Thursday January 06, 2022 @12:53PM (#29826998)
But this means, that we can reopen everything, let young people "live", and target the efforts towards old people (and other risk groups).

Atleast here in slovenia, most of the mandates affect mostly the young and healthy... yes, theoretically neither 20yo bobby nor his grandpa can enter nightclubs, due to them being closed, but with such data, we could reopen nightclubs, let bobby party and do all the stupid stuff we were free to do at 20yo, and focus the effort at grandpa, so he gets vaccinated, gets the masks, has somone bring him food, so he doesnt have to go to the stores, subsidize a plan for a smartphone to encourage more videoconferencing instead of live visits, give out free tests at home, to detect the infection early, etc.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @05:14PM (#29831132)
You're describing a sanity of focused protection which should've been in place since day one, but for some reason policymakers instead lost their minds. :| At least now with Omicron they will slowly realize that lockdowns make no sense. Right? Right? (looking at Finland and crying, my home country recently having gone into full lockdown mode for no good reason other than case numbers)
Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @12:28PM (#29826575)
Sure, and at some point I might even consider flu shots. So what?
Re:Omicron at 100% Prevalence, Colorado by atwebb on Thursday January 06, 2022 @02:35PM (#29828731)
Whew, I'm similar and it tanked me for about a week. I could feel every joint in my body and breathing was a conscientious decision for a few days due to the pain/discomfort. It has subsided a bit (and my family wasn't hit as hard) but I have 0 interest in experiencing it again. Currently hoping it doesn't impact me long term since I like to stay active.
Re:Omicron at 100% Prevalence, Colorado by brutal_chaos_ on Monday January 10, 2022 @05:36PM (#29883853)
You know what, I was unintentionally fear mongering. I'm glad you and others pointed that out. I did not make the connection between you having Omicron and the lack of Omicron in the paper (my nephew caught Delta...so that's where my concern lied). I hope you are still ok. :)
Re:Omicron at 100% Prevalence, Colorado by spurgu on Monday January 10, 2022 @10:36PM (#29887165)
I'm ok, tested negative today with a home test so I can finally go out and bother people again. ;)
Re:Omicron at 100% Prevalence, Colorado by r00fus on Thursday January 06, 2022 @04:40PM (#29830648)
> (4-5 months after 2nd jab, so pretty much no effect from that) and it's just like a common cold

So you have milder symptoms because you're vaxxed.

Re:Omicron at 100% Prevalence, Colorado by spurgu on Thursday January 06, 2022 @05:33PM (#29831416)
I'll let you know how I feel when I get it "unvaxxed" the next time, since I decided months ago already against getting a booster.

It also sounds like you're not aware of a) the vaning efficacy of the vaccine or b) how little it does against Omicron.

[dead]
Re:Omicron at 100% Prevalence, Colorado by nradov on Thursday January 06, 2022 @12:31PM (#29826629)
I encourage everyone eligible to protect themselves by getting vaccinated, but the current thinking is that new variants are most likely to evolve in immunocompromised patients who experience prolonged infections. The vaccines aren't very effective for them.

https://www.scientificamerican.com/article/covid-variants-ma...

It's also possible for new variants to evolve in animal hosts, then spread back to humans.

https://www.pbs.org/newshour/health/some-experts-suggest-omi...

Re:Omicron at 100% Prevalence, Colorado by CamperBob2 on Thursday January 06, 2022 @02:00PM (#29828179)
The vaccines would (probably) have been effective on whoever gave the immunocompromised patient the disease, though.

It's not all about the individual.

Re:Omicron at 100% Prevalence, Colorado by nradov on Thursday January 06, 2022 @02:05PM (#29828270)
Unfortunately there will be no significant herd immunity effect to protect the immunocompromised. They will all be exposed.

The main benefit of vaccines is in reducing symptom severity. They only produce a limited and temporary reduction in transmission risk.

https://www.medpagetoday.com/opinion/vinay-prasad/94646

https://www.nature.com/articles/d41586-021-02689-y

https://www.businessinsider.com/delta-variant-made-herd-immu...

Re:Omicron at 100% Prevalence, Colorado by PraetorianGourd on Thursday January 06, 2022 @12:28PM (#29826578)
You realize that in the United States, the so called “freedumb idiots” are not the bulk of the unvaccinated right? And you also must realize that Omicron did not start among a population of “freedumb idiots” right?

Leave the straw man out of this, disease is not a reflection of character.

Re:Omicron at 100% Prevalence, Colorado by chana_masala on Thursday January 06, 2022 @01:32PM (#29827723)
Vaccines can drive mutations, too. I don't know if that's the case here but it's been seen with other pathogens and vaccines