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Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @10:25AM (#21639046)
Not to be facetious but why is the legal status of these drugs preventing you from trying them?

Ketamine, LSD, shrooms are all accessible, and recreational varieties are not expensive.

Re:Psilocybin for major depression granted Breakthrough Ther... by astura on Tuesday November 26, 2019 @10:56AM (#21639356)
This is a ridiculous question, the answer is because they are illegal, of course.

Most of us aren't willing to risk a criminal record.

I wouldn't know where I could obtain such items even if I wanted to buy them. If I can't buy something off the shelf at a retail store I'm simply not going to bother.

Sketchy/unknown supply chain.

Tons of us have jobs (or whole careers!) that we could lose for using illegal drugs, many of those jobs include random drug tests. I'm not risking my entire fucking livelihood without a damn good reason.

Re:Psilocybin for major depression granted Breakthrough Ther... by jddj on Tuesday November 26, 2019 @11:48AM (#21639980)
What a world. It feels like this is one of those topics where one side of the tracks has a vastly different worldview to the other.

During the UK conservative party leadership contest earlier this year I thought it was pretty telling that all or most of the main candidates admitted to using illegal drugs at some point.

But sometimes I forget that there are people out there who are significantly more risk-averse or perhaps more generally obedient and who see the world very differently.

I guess my point is that I didn't think it was a ridiculous question.

I'd also point out that your use of "most" here might be unwarranted. There are surveys which demonstrate more than half of respondents admitting to the use of illicit drugs [1].

[1] https://www.drugabuse.gov/national-survey-drug-use-health

Re:Psilocybin for major depression granted Breakthrough Ther... by alwillis on Tuesday November 26, 2019 @04:38PM (#21643012)
> But sometimes I forget that there are people out there who are significantly more risk-averse or perhaps more generally obedient and who see the world very differently.

The criminal justice system treats people very differently, depending on who you are.

In my lived experience, for middle class white kids, using cocaine, heroin, LSD, etc. was just a right of passage, that for the most part, didn’t effect their future prospects for college or a career.

Meanwhile, black and brown kids caught with a dime bag ended up going to jail.

In the US, white and black people use drugs at about the same rate, but black people are convicted at much higher rates and with longer sentences: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614457/

Re:Psilocybin for major depression granted Breakthrough Ther... by Reelin on Tuesday November 26, 2019 @09:22PM (#21644757)
Possibly controversial view, but I think that these differences are largely socioeconomic in nature. The US justice system does not treat poor people kindly, regardless of their skin color or ethnicity. "Justice for all who can afford it" and whatnot.

(Of course there's also the odd case of a racist judge, but my impression is that it's by far the exception.)

Edit: The paper you linked does raise some very interesting questions about the motivations behind various government policies, however.

Re:Psilocybin for major depression granted Breakthrough Ther... by alwillis on Thursday November 28, 2019 @12:06AM (#21654728)
>The US justice system does not treat poor people kindly, regardless of their skin color or ethnicity. "Justice for all who can afford it" and whatnot.

Yes, income is a factor, but that still doesn't explain why blacks are 13% of the population but the prison population is nearly 40% black.

Nobody seriously disputes the clear racial bias in the criminal justice system.

Re:Psilocybin for major depression granted Breakthrough Ther... by kharak on Thursday November 28, 2019 @02:20AM (#21655263)
I guess my reaction to your post is the closest I'll ever come to the feeling of envy.

IRL, I don't know a single drug user or way how to get them. I looked it up online several times in different countries. Result always the same, a good likelihood of your delivery getting intercepted and you getting fucked as a result. Everyting about this annoys me.

Re:Psilocybin for major depression granted Breakthrough Ther... by Integrape on Tuesday November 26, 2019 @02:40PM (#21641843)
Try considering the notion that some of us value our mental well-being greater than we value our careers, and that what we do in the privacy of our own dwellings is our business and no one else's.
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @10:59AM (#21639388)
Hardly ridiculous. Marijuana is still illegal at the federal level but might as well be considered legal at this point.

No one is going to go to jail because you purchased a small amount of drugs. If you are the seller it's a different story.

Re:Psilocybin for major depression granted Breakthrough Ther... by astura on Tuesday November 26, 2019 @01:15PM (#21640992)
I'm sorry but "why does something being illegal prevent you from doing it?" is a ridiculous question.

Even if you start with the premise nobody is going to jail (which is blatantly untrue - I personally know people with possession charges), getting caught with small amounts of drugs can ruin the careers of some people, including my own career. Think people who must hold a professional licence, people who are subject to background checks (including coders who work at medium to large companies), people who work with children, people who work in certain safety critical industries, people who hold security clearances, etc. There was an FBI agent who was fired recently for testing positive for thc from using CBD oil, the federal government's position is there's no legitimate reason to test positive for thc.

Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @01:24PM (#21641101)
You're referring to your own risk tolerance that is unfounded in most modern workplaces. If you work in tech absolutely no employer does drug tests for employment. People talk about microdosing LSD openly.

Michael Pollen wrote a best selling book about his experience with psychedelics earlier this year. Tim Ferris funded a research institute at John Hopkins and talks about it on his podcast all the time.

Unless you work for the federal gov't you're catastrophizing the risk.

Re:Psilocybin for major depression granted Breakthrough Ther... by jabits on Tuesday November 26, 2019 @05:16PM (#21643312)
I don't know where you get this, maybe start-up land. I have been a dev since the early '90's and all kinds of enterprises do drug testing. Most utilities, health-related organizations, defense contractors, transportation businesses and even many large manufacturers routinely drug test potential employees. Most only test for pre-employment screening, but random testing is still used in many places.

Most recently, three years ago, I was tested for a contracting gig at a Wisconsin power company for a web dev job.

Re:Psilocybin for major depression granted Breakthrough Ther... by astura on Tuesday November 26, 2019 @06:21PM (#21643754)
Sometimes I think startup land is a different planet, around here pretty much every company who would hire a software developer drug tests AND background checks unless maybe it's a really, really small company. Some even do the hair drug test instead of the piss test.

I've ALWAYS been drug tested before starting a software job. I've been drug tested working for the most benign of industries. I actually had a friend who quit weed so she could get a better paying job.

Re:Psilocybin for major depression granted Breakthrough Ther... by Analog24 on Tuesday November 26, 2019 @09:57PM (#21644887)
That sounds like a different planet to me. I don't know of any big tech company, let alone startups, that drug test. I wouldn't be surprised if this was the case for dev jobs in older industries but it doesn't seem to be the norm any more.
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @05:35PM (#21643466)
modern tech cos do not drug test
Re:Psilocybin for major depression granted Breakthrough Ther... by metalchianti on Tuesday November 26, 2019 @02:11PM (#21641556)
There is still some risk. I think you're forgetting that (1) illegal drugs are hard to obtainn--no walking into CVS--and (2) illegal drugs are not reliably sourced--I trust mass manufactured marijuana far more than I do from the sketchy guy on the corner.
Re:Psilocybin for major depression granted Breakthrough Ther... by LostJourneyman on Tuesday November 26, 2019 @03:20PM (#21642262)
That's not necessarily true, especially in consulting firms. I am drug tested somewhat regularly.
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @04:20PM (#21642830)
"If you work in tech"
Re:Psilocybin for major depression granted Breakthrough Ther... by astura on Tuesday November 26, 2019 @06:31PM (#21643818)
You think there are no tech jobs in consulting firms?
Re:Psilocybin for major depression granted Breakthrough Ther... by galangalalgol on Tuesday November 26, 2019 @09:47PM (#21644853)
What is tech? If you mean sv startups perhaps. But pretty much any embedded sw shop will at least test at hire on.
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Wednesday November 27, 2019 @02:04AM (#21645899)
google, amazon, fb, netflix, apple...these are not "startups"
Re:Psilocybin for major depression granted Breakthrough Ther... by fiblye on Tuesday November 26, 2019 @05:18PM (#21643333)
> No one is going to go to jail because you purchased a small amount of drugs.

What world are you living in? Drug possession is one of the most common reasons for being arrested.

https://www.bjs.gov/content/dcf/enforce.cfm

Re:Psilocybin for major depression granted Breakthrough Ther... by lazyasciiart on Tuesday November 26, 2019 @12:45PM (#21640639)
> An estimated 137,000 people are in prison today on a basic drug-possession charge. Approximately 65% of them sit in local jails, and most of them have yet to actually be accused of a crime. These unfortunate individuals may have to wait months to get their day in court because of their inability to post bail. https://www.marijuanabreak.com/going-to-prison-for-marijuana...
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @12:56PM (#21640743)
It isn't risk-free, but the risk is low.

Michael Pollen literally wrote a best selling book about taking LSD, eating shrooms, etc. earlier this year.

Re:Psilocybin for major depression granted Breakthrough Ther... by lazyasciiart on Thursday November 28, 2019 @01:23AM (#21655038)
The risk has a pretty high relationship with the color of your skin.
Re:Psilocybin for major depression granted Breakthrough Ther... by givinguflac on Tuesday November 26, 2019 @11:58AM (#21640096)
I’ve been to jail for a small amount of MJ. The chain of custody and the purity/contamination of a plant is much easier to track, then something like a powder a pill or liquid. There is literally no circumstance where I would trust something that wasn’t a plant on the black market
Re:Psilocybin for major depression granted Breakthrough Ther... by throwaway837373 on Tuesday November 26, 2019 @04:04PM (#21642676)
Ehrlich's reagent will tell you if you have something in at least the same chemical family as LSD, which rules out almost all of the dangerous substances that are sometimes sold as "LSD."
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @12:56PM (#21640755)
Everyone has a different risk tolerance. People use LSD, ketamine, and shrooms all the time.
Re:Psilocybin for major depression granted Breakthrough Ther... by dfalfndfk on Tuesday November 26, 2019 @12:43PM (#21640604)
If you are a person of colour in America you're definitely at risk.
Re:Psilocybin for major depression granted Breakthrough Ther... by wallace_f on Tuesday November 26, 2019 @11:45AM (#21639947)
That's obnoxiously ignorant. Even in high school one of my friends had their house raided and electronics, other valuables consfiscated. A dealer scapegoated him, and he had been searched and found with a pipe with resin in it. He carried the pipe to be cool. He had smoked weed less than 5 times at that point. I have other friends with criminal records for minute quantitites of personal use marijuana.
Re:Psilocybin for major depression granted Breakthrough Ther... by ghostbrainalpha on Tuesday November 26, 2019 @12:29PM (#21640447)
I consider myself extremely risk averse, and would probably agree with you on most things.

But with unbeatable Major Depression you are dealing with a significant suicide risk, and the risk to your legal status may be worth the benefit to your overall happiness.

People who want to replace a little Prozac with Psilocybin can afford to wait 10-15 years for treatments to become standardized, legal and affordable.

I spent 15 years assuming that I would kill myself someday, and basically all of life was a delaying action to put suicide off as long as possible. So for me taking the plunge into illegal self treatment was worth it. A yearly Ayahusca session for me does more to combat depression that years of therapy and legal medications.

Re:Psilocybin for major depression granted Breakthrough Ther... by empath75 on Tuesday November 26, 2019 @02:06PM (#21641507)
> People who want to replace a little Prozac with Psilocybin can afford to wait 10-15 years for treatments to become standardized, legal and affordable.

Be very careful making that transition, you can get serotonin shock.

Re:Psilocybin for major depression granted Breakthrough Ther... by CryoLogic on Tuesday November 26, 2019 @01:34PM (#21641184)
Supply chain is a definite concern with LSD, and other synthetic drugs. They are often incorrectly dosed and sometimes laced with other chemicals.

Naturally grown drugs like marijuana, mushrooms, even peyote and it's cousins are easy to identify, easy to dose safely and there is almost no risk of supply chain tampering.

Re:Psilocybin for major depression granted Breakthrough Ther... by tasty_freeze on Tuesday November 26, 2019 @01:50PM (#21641357)
Counterpoint: the amount of psilocybin in a mushroom can vary by 5x, even of the same strain, depending on growing conditions and time of harvest.

On the other hand, if you buy 250mg of powdered psilocin or psilocybin from a reputable vendor, you know exactly how much you are getting.

Re:Psilocybin for major depression granted Breakthrough Ther... by hutzlibu on Tuesday November 26, 2019 @08:04PM (#21644396)
"there is almost no risk of supply chain tampering"

Hell no. There are sadly a million ways to increase the weight of hash with neutral to very harmful chemicals.

Also just the buds of marijuhana can be poisened. Low quality ganja mixed with artifical thc(or something else for example happened quite a lot in recent times)

Fortunately, you do can grow your own ...

Re:Psilocybin for major depression granted Breakthrough Ther... by rojobuffalo on Tuesday November 26, 2019 @12:19PM (#21640332)
Psilocybin mushrooms were decriminalized in Denver, CO this year.
Re:Psilocybin for major depression granted Breakthrough Ther... by WalterSear on Tuesday November 26, 2019 @01:51PM (#21641364)
Also Oakland CA.
Re:Psilocybin for major depression granted Breakthrough Ther... by 19793378 on Tuesday November 26, 2019 @09:36PM (#21644814)
> Tons of us have jobs (or whole careers!) that we could lose for using illegal drugs, many of those jobs include random drug tests. I'm not risking my entire fucking livelihood without a damn good reason.

It is ridiculous how "square" things have gotten in 2019 when you read things like this on a forum called "Hacker News." Have you ever heard of Mondo 2000? Or that time The San Francisco Examiner sent a reporter to SIGGRAPH because they could not believe the claims that so many people in computer graphics were doing LSD? Things were different in the Valley in the early 1990s.

Re:Psilocybin for major depression granted Breakthrough Ther... by funkjunky on Wednesday November 27, 2019 @10:01AM (#21648381)
Seriously, the responses in this thread are just embarrassing. It's like listening to purity-ring wearing adolescent virgins talk about sex.

Most of the people I know wouldn't think twice about dropping some l or shrooms on a weekend with some ketamine and a hit of DMT, and we all have respectable jobs and families. It's just not that big of a deal.

Re:Psilocybin for major depression granted Breakthrough Ther... by givinguflac on Wednesday November 27, 2019 @12:24PM (#21649854)
"It's like listening to purity-ring wearing adolescent virgins talk about sex."

You're an ignorant jerk. Anyone who hasn't been caught won't think it's a big deal. Anyone sitting in jail because of it would disagree. Seriously, fuck off with your holier-than-though "adolescent virgins" schtick because some people don't want to just have a bender with illicit substances that aren't standardized.

This has absolutely nothing whatsoever to do with people who want to do shrooms or acid on a weekend, it's about people looking for therapeutic relief! I can't fathom the ignorance that leads to someone like you conflating medical treatment with nonchalant recreational drug use. They aren't the same, and I'm not looking to get high and have a fun weekend. I'm looking to relieve mental illness you ignorant ass.

Re:Psilocybin for major depression granted Breakthrough Ther... by JPKab on Tuesday November 26, 2019 @05:54PM (#21643581)
A buddy of mine, who rarely drinks and dislikes marijuana, grows his own psilocybin mushrooms. It wasn't difficult for him to learn, and he bought kits online. The legal risk is minimal to non existent unless you are dumb enough to sell them.

The health risks aren't bad either. Psilocybin mushrooms have distinct properties which can be tested for with a white sheet of paper in a super simple test.

In other words, fortune favors the bold.

Re:Psilocybin for major depression granted Breakthrough Ther... by funkjunky on Wednesday November 27, 2019 @10:30AM (#21648652)
You realize that drug tests don't detect psychedelics. And it's ridiculously easy to grow your own psilocybin mushrooms (the spores for which are legal to purchase in all states except California, Georgia, and Idaho) if you're worried about the supply chain.
Re:Psilocybin for major depression granted Breakthrough Ther... by trianglem on Tuesday November 26, 2019 @02:52PM (#21641991)
That’s so interesting because it is so different from my experience. I find it incredibly easy to find access to these items and if I move to a new city all I end up doing is going to a local bar and chat up people to find new sources.
Re:Psilocybin for major depression granted Breakthrough Ther... by icelancer on Tuesday November 26, 2019 @03:42PM (#21642464)
This is not a ridiculous question. If you are just willing to suffer without exploring illegal alternatives, so be it. But it is not ridiculous to take a small risk to explore a compound that can alleviate suffering.
Re:Psilocybin for major depression granted Breakthrough Ther... by liquidify on Tuesday November 26, 2019 @11:19AM (#21639618)
I would imagine a lot of people don't want to take LSD because of difficulty guaranteeing that it is actually real LSD-25 and not some other derivative. I think the American CIA was responsible for spiking the LSD supply with more dangerous alternatives at one point. And now, there are plenty of variants that are either mixed in and then sold, or sold directly as LSD, when they are actually not.

Testing is difficult because the common tests only test for the presence of LSD-25, not the purity, and not for the presence of substitutes. Someone who mixed the pure substance with some more dangerous derivative would be impossible to detect without lab grade tools.

This has stopped me from trying LSD for my whole life. I assume there are many others that don't want to take mind altering substances with unknown purity.

Re:Psilocybin for major depression granted Breakthrough Ther... by collyw on Tuesday November 26, 2019 @11:23AM (#21639682)
There is plenty of information on the internet on how to grow mushrooms.
Re:Psilocybin for major depression granted Breakthrough Ther... by mml on Tuesday November 26, 2019 @07:46PM (#21644301)
I've read that street lsd-25 is vanishingly rare. it doesn't keep (degrades under UV), and it's hard to make (why make lsd when you can make meth instead?). I'm told much street lsd is other stuff. Dunno if true.
Re:Psilocybin for major depression granted Breakthrough Ther... by melq on Tuesday November 26, 2019 @01:12PM (#21640945)
What sort of impurities are you concerned with? Are there many drugs that are psychoactive at such low (microgram) doses?
Re:Psilocybin for major depression granted Breakthrough Ther... by adrusi on Tuesday November 26, 2019 @03:48PM (#21642514)
Fentanyl is active in a range very similar to LSD, it's the biggest concern.

25i-NBOMe is a drug similar in effect to LSD, but with a somewhat worse track record for safety. It's not likely to harm you, and unless you're fairly familiar with LSD, you might not notice the difference, but it has caused deaths due to severe vasoconstriction, which hasn't happened with LSD, even though many more people have used the latter. It's requires larger doses than LSD does, but it's still active at doses well under a milligram, and is usually sold on blotter paper just like LSD is.

Strychnine is also active in the LSD dose range. There was definitely some propaganda about strychnine-tainted LSD in the 70s, so it's hard to know if this has ever happened, or if it's just urban legend. But it's chemically plausible.

Fortunately, you don't have to just pray that your blotter doesn't have fentanyl in it. You can buy chemical test kits on the clear market and rule out all the culprits that should be cause for concern, and test that your blotter contains LSD (or at least a compound containing an indole group...). See https://www.reddit.com/r/ReagentTesting/ for links to vendors and more information.

Re:Psilocybin for major depression granted Breakthrough Ther... by cc-d on Tuesday November 26, 2019 @07:09PM (#21644060)
>Fentanyl is active in a range very similar to LSD, it's the biggest concern.

Not orally, the BA of actual fentanyl is abysmal orally (although some fentanyl analogs are definitely comparable). LSD is never contaminated with fentanyl to begin with. Some fentnayl analogs have been distributed in paper tab form by research chemical vendors, but LSD is never 'contaminated' with fentanyl. A test kit, or even just ingesting the tab slowly in pieces, eliminates this (non)risk entirely.

>25i-NBOMe is a drug similar in effect to LSD, but with a somewhat worse track record for safety

Thankfully this risk has decreased over the past few years, as real LSD is cheaper, and easier to find, than phenthylamine-based RCs being sold as LSD. You might encounter ALD-52, 1P-lSD, ETH-LAD, etc being sold as LSD, but these are just LSD analogs and have pretty much identical safety/effect profiles.

Also, swallowing the tabs make some of the more common RC LSD imitators completely inactive, whereas LSD will still be absorbed perfectly. At the end of the day, if you're concerned about this, you can buy a $10 test kit.

>Strychnine is also active in the LSD dose range. There was definitely some propaganda about strychnine-tainted LSD in the 70s, so it's hard to know if this has ever happened, or if it's just urban legend. But it's chemically plausible.

This doesn't happen. Also, no it is not chemically possible. The amount of strychine required to seriously hurt somebody would be extremely obvious on LSD tabs. Like it actually isn't even possible to fit enough strychine to seriously hurt somebody on a lsd tab in a discreet manner . The choice of strychine here as a poison shows that whoever originally spread this nonsense has zero understanding of chemistry.

>Fortunately, you don't have to just pray that your blotter doesn't have fentanyl in it.

Once again, this isn't a serious risk. It's extremely rare to find fentanyl in this form now anyway, as most research chemical vendors no longer stock fentanyl analogs. And, again, just consuming the tab slowly or testing it makes this a non-risk.

Also generally there is a very little overlap in dealers who sell both fentnanyl and lsd, these drugs attract very different crowds.

Re:Psilocybin for major depression granted Breakthrough Ther... by selectodude on Tuesday November 26, 2019 @10:29AM (#21639076)
Not OP, but I wouldn't even know where to begin trying to source street drugs, nor am I particularly interested in learning.
Re:Psilocybin for major depression granted Breakthrough Ther... by boardwaalk on Tuesday November 26, 2019 @10:37AM (#21639169)
At least for shrooms, you can (legally) source the spores and grow your own (illegally). No worries about street drug impurities unless you don't trust your own tap water and fertilizer.
Re:Psilocybin for major depression granted Breakthrough Ther... by Integrape on Tuesday November 26, 2019 @11:42AM (#21639907)
Psilocybin mushrooms are not street drugs. These organisms grow wild in the southeastern United States, as well as other parts of the country, including the pacific northwest. You can purchase spores legally and grow your own easily and at low cost, if you have the mind and time.
Re:Psilocybin for major depression granted Breakthrough Ther... by givinguflac on Tuesday November 26, 2019 @10:33AM (#21639121)
Ultimately this is the answer. On top of that though, I have no guarantee that these are real compounds and not cut with something. The last thing I need while in search of mental health is brain damage or poisoning.
Re:Psilocybin for major depression granted Breakthrough Ther... by WhompingWindows on Tuesday November 26, 2019 @11:19AM (#21639610)
Brain damage or poisoning are much, much less likely than simply having a bad trip, which can have PTSD-like symptoms. But if set and setting are carefully controlled, bad trips are much less likely to occur, as you have no overly negative stimuli to induce a bad trip.
Re:Psilocybin for major depression granted Breakthrough Ther... by jschwartzi on Tuesday November 26, 2019 @11:00AM (#21639399)
It’s rare with LSD but occasionally they’ll substitute a research chemical with similar effects. You’re more likely to have that happen with “MDMA” that is actually methamphetamine or one of the analogues. Both are horrible.

There are places that sell home testing kits which are very useful since you don’t know what you’re getting by looking at it. People used to test for each other at raves until the police said it was a form of condoning drug use and shut it down. So now people still buy but it’s more dangerous.

Re:Psilocybin for major depression granted Breakthrough Ther... by selectodude on Tuesday November 26, 2019 @10:40AM (#21639192)
It's ludicrously expensive (I think I paid $3,000 for six sessions), but I've done a round at a local IV ketamine infusion center here in Chicago to great effect.
Re:Psilocybin for major depression granted Breakthrough Ther... by tempsy on Tuesday November 26, 2019 @10:54AM (#21639342)
there are test kits you can buy - buying on the darknet is similar to ebay - there are reviews and seller ratings etc

if you are really struggling, cost is prohibitive, and you think this might be an option then trying it once or twice at home is reasonable risk reward tradeoff, speaking from personal experience.

Re:Psilocybin for major depression granted Breakthrough Ther... by trashface on Tuesday November 26, 2019 @08:07PM (#21644409)
All of those are illegal in the US. And living there, you really, really, REALLY want to avoid the criminal justice system. Especially if you have anxiety/depression, which will trigger that system's "abnormal" profiling.
Re:Psilocybin for major depression granted Breakthrough Ther... by Beltiras on Tuesday November 26, 2019 @10:30AM (#21639096)
No regulatory body watching the production is one thing. You are buying from criminals. I'm all-in on the legalization of all drugs if only for the consumer protections it would introduce. Then there's the issue of harm-reduction for those that truly have a dependency/addiction problem AND generally freedom for freedoms sake.

The psilocybin treatment is also reported as way more effective when administered as part of therapy. You are supposed to trip under the guidance of a professional.

Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Tuesday November 26, 2019 @10:41AM (#21639204)
”You are supposed to trip under the guidance of a professional”

I don’t think that this statement is technically accurate - fortunately. Studies have shown that following a certain protocol or setting will increase the effectiveness. That framework is published science.

Re:Psilocybin for major depression granted Breakthrough Ther... by Beltiras on Tuesday November 26, 2019 @10:56AM (#21639361)
I'm speaking within the framework of what is sensible, given the science. If you want the trip to have more lasting effect then according to the research you should have someone guiding you along. It kinda makes sense too. You can spend a trip looking at butterflies and admiring them taking with you from the experience a certain wonder for the beauty of nature. It might even help you with your depression somewhat but will not substitute professional guidance that will help you confront what is an underlying psychological issue actually causing the depression.
Re:Psilocybin for major depression granted Breakthrough Ther... by xorfish on Tuesday November 26, 2019 @11:32AM (#21639781)
I think the point was that a sitter doesn't need to do it professionaly. A trusted, sober guide with some experience will work as well.
Re:Psilocybin for major depression granted Breakthrough Ther... by unR34L on Tuesday November 26, 2019 @11:52AM (#21640027)
Could you provide a link to the protocol or framework that you mentioned? I’m considering trying Psylocybin and would like to get informed beforehand.
Re:Psilocybin for major depression granted Breakthrough Ther... by AnthonBerg on Tuesday November 26, 2019 @04:24PM (#21642880)
Update: A downvoted post asked how to find that protocol or framework. I’d advise looking at MAPS’ site at http://maps.org/ - there are manuals and protocols there - as well as tracking back to the source studies that the FDA is basing its decisions on and searching on Google Scholar for papers.
Re:Psilocybin for major depression granted Breakthrough Ther... by fiblye on Tuesday November 26, 2019 @05:16PM (#21643313)
There’s a very real risk of getting a knock at your door and going to prison. That’s more than enough to scare some people.
Re:Psilocybin for major depression granted Breakthrough Ther... by kleer001 on Tuesday November 26, 2019 @06:22PM (#21643763)
The substance is only part of the equation, there's a lot of value in the skill and wisdom in an individual therapist's attention and work. And no licensed therapist is going to risk working with street pharm.
Re:Psilocybin for major depression granted Breakthrough Ther... by tyri_kai_psomi on Tuesday November 26, 2019 @10:28AM (#21639074)
Most people don't like to intentionally break the law.
Re:Psilocybin for major depression granted Breakthrough Ther... by collyw on Tuesday November 26, 2019 @11:30AM (#21639766)
I would be surprised if there were a driver out there who hadn't gone above the speed limit.
Re:Psilocybin for major depression granted Breakthrough Ther... by fabiomaia on Tuesday November 26, 2019 @11:20AM (#21639631)
Most people intentionally stream movies illegally. The moral aspect of breaking the law is not a very strong argument here.

I think the bigger moral issue with buying street drugs is that you are essentially funding organized crime.

Re:Psilocybin for major depression granted Breakthrough Ther... by tyri_kai_psomi on Tuesday November 26, 2019 @01:29PM (#21641138)
You mistakenly assume I mean strictly from a moral perspective. Assume a cost:benefit analysis, where the factors are, depending on the person, some combination of morality, desire to not face consequences (legal system, job, family), and perceived risk:reward ratio.