E.g. MDMA was a widely used substance in psychoterapy before 1980 (they used it to "open" patients before sessions), but it got banned and almost nobody could carry on with their research. Without research, you cannot claim practical uses and be taken seriously. And pharmas are not interested in spending on some product that they can't market anyway.
https://maps.org/news/media/playboy-ecstasy-was-legal-in-198...
What do you mean? That pharma companies only develop drugs that don't require prescriptions? As far as I know at least that's kind of their main business.
Just look at the history of ketamine: known since 1970, it's controlled until 2000's when finally is found to work better than anything against depression. But even today it isn't marketed, unlike hundreds of antidepressants known to have worse secondary effects and be less effective. Reason? Some people might have fun with it.
Just because some medicines have kind of happy or fun or hallucinating effects don't make them more or less controlled.
And your argument about MDMA, it's already a developed medicine which is available under subscription. Why do you talk about delays?
And most medicines take more than 5 years to develop and release to market (also those without funny side effects sought after by drug abusers).
It's funny how you talk about ketamine being not 'marketed'. Why should a drug be marketed? It's a medical doctor who should subscribe it to patients he sees has a need for it. For sure medical companies might market it to doctors, but overall drugs should not be 'marketed'. Just see the issue with Purdue Pharma and the opioid crisis in the US.
Turns out MDMA is on list I, despite being used medically for a decade without problems. Currently there's no MDMA available, at least in the USA, under subscription nor prescription. It seems that is being researched, with extreme difficulties for being in list I, as a remedy for PTSD.
I'm done with this thread.
He had a Harley motorcycle that he accidentally dropped while moving it for street cleaning, and injured his back trying to pick up.
Sadly, after a very risky surgery to fix the injury, that was completely botched, he got addicted to oxycontin and eventually took his life.
There are a lot more stories there, but I'll leave it as that for now.
RIP Marcello.
Supposedly one of them works with a prof at Berkeley to make their product
https://en.wikipedia.org/wiki/William_Leonard_Pickard
Back then (the 90s), LSD was $2/hit.
edit, for anyone curious about 90s wholesale: "Government informant Skinner testified that Petaluma Al and the largest wholesale customers of Pickard paid 29 cents per 100 µg dose, which would put the cost at around $2.97 million for a kilogram of LSD."
edit: I'm annoyed by the math used in this quote. They couldn't say $2.9 million or "around" $3 million?
For a thumbprint, you still put your thumb on your tongue and lick it. But it's important to keep in mind that only very rarely have people actually done thumbprints. Those are mostly stories, legends, and artistic works of fiction and falsehood. Only a fool would take them as fact.
> While re-synthesizing LSD, he accidentally absorbed a small amount of the drug through his fingertips and discovered its powerful effects.
"Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25. As in the first synthesis, this involved the production of only a few centigrams of the compound."
"In the final step of the synthesis, during the purification and crystallization of lysergic acid diethylamide in the form of a tartrate (tartaric acid salt), I was interrupted in my work by unusual sensations."
...
"But this led to another question: how had I managed to absorb this material? Because of the known toxicity of ergot substances, I always maintained meticulously neat work habits. Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. If LSD-25 had indeed been the cause of this bizarre experience, then it must be a substance of extraordinary potency."
I take a few to mean more than 2 centigrams. So 30mg minimum. Thats 300x the 'normal' dose.
>Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin.
that's a possibly, I suppose if that possibly exists then possibly some got on object X and then after leaving lab object X came in contact with his mouth or even nose when he touched his face.
I wouldn't assert that it's 'fact' but seems very plausible. (A full 'thumbprint' is probably uncommon, but ingesting a visible amount of crystal from a fingertip seems believable)
We would routinely put this to the test.
Not only is it absorbed through the skin, but it takes longer to start and end the trip. We would do it on purpose for a longer/more intense trip if we were say camping for the weekend.
An esteemed underground LSD chemist arrested in '05, Donnie Shackelford, is quoted in an unfinished book on black market LSD production by Tim Scully. Here's an excerpt from the interview.
>Tim Scully said, "Did you ever get dosed through your skin in the lab". Donnie Shackelford replied, "No, I have accidentally dosed myself while laying sheets, I either touched my eye, or mouth. But the answer to your question is no, you cannot be dosed through the skin. I never wore gloves in any procedure unless lye is used and it isn’t in this procedure. I learned the hard way dropping a flask with 20g of LSD in it. I was extremely upset. I’ve had it all over my hands many, many times. I was there when Dr. Nichols basically called bullshit on the good doctor at Mindstates 60th anniversary".
This is the Mindstates talk by David Nichols https://erowid.org/general/conferences/conference_mindstates...
>"Another fact: I've made LSD in my lab on many occasions for research purposes, possibly in not so meticulous a manner as Albert Hofmann. Nothing ever happened. I had several graduate students who made LSD as an intermediate for projects. No accidental ingestion of LSD ever occurred. A technician in my lab makes it routinely because we use it as a drug to train our rats. He's learned by experience that he never gets high, nothing ever happens. And yesterday I was talking to Nick Sand, and Nick said, "I made a solution of LSD in DMSO…" -- DMSO (dimethyl sulfoxide) is a chemical that greatly enhances absorption of other chemicals through the skin -- he says, "…I painted it on my skin. Nothing happened." A concentrated solution and nothing happened!"
LSD in powder form is readily available on the black market. Expensive (because you don't just go and ask to buy only 1mg of LSD powder), but not exceptionally unsafe or rare.
Now the people who handle Fentanyl and Fentanyl analogues, those probably want to triple check their gloves and mask before putting them on.
Really? I doubt it. 1kg is about 10 million doses (@100ug each). I don't think there are enough people gobbling acid for there to be labs producing on that scale per batch. The cost of making a mistake with a batch that big would be quite high.
Edit:// having more acid than you could ever need is somewhat a novelty in this scene
IMO it's wonderful to know that this substance won't disappear anytime soon.
It's a darknet vendor btw and their name contains small mythical creatures. No personal experience with them, but I know their product and have a morbid interest for the market :)
of course, many things are not safe on the skin and that's not uniquely dangerous, really
Summary: 8 people at a party in SF “accidentally” (having mistook it for cocaine, as one does) snorted at least two lines each of powdered LSD. Somehow, they made it to the hospital 10 minutes later. 5 of them were in a coma by the time they were seen, and 3 had to be intubated. One person had a temperature of 107F + 200BPM pulse. One of the comatose patients discharged himself after 12 hours, and they all seemingly recovered fully. But without prompt medical care…probably not.
Conclusion: Do not snort a 1000x dose of LSD.
"first case report documents significant improvements in mood symptoms, including reductions in mania with psychotic features, following an accidental lysergic acid diethylamide (LSD) overdose, changes that have been sustained for almost 20 years."
I've met a couple people who took 100+ hits at once and survived to tell the tale. One fellow took what what was around 1000. The psychological aftershocks took him months to process, but at the time we met he was normal (well as normal as you'd expect from a person brave enough to intentionally ingest that much) and healthy.
Likely you’ve been taking something else.
As old hippies used to tell me in the 90s, pot is 100x stronger than it was in the 60s, and LSD is 100x weaker.
Unlike cannabis, you can’t smoke it, so ingestion is an obvious choice. I suppose pills could be an answer but kids eat pills all the time too. Granted, perhaps less enticing than chocolates but still a problem.
The better option would be to forgo purchase of these substances until you're ready to consume them. Legalization makes this a reality. I could go to the store, buy the drugs, then drive straight home and consume them in a safe environment.
The prohibition we have currently is what tempts people to stock up all at once and ultimately leads to higher risks for children finding/consuming them while mommy and daddy are at work.
Whenever someone says something like that, you know they don't have much experience trying to get hold of illegal drugs! It's rarely easy, and often falls through.
As this is a public record, I'm in total agreement with you. I have zero experience acquiring illegal drugs, none.
To not distinguish psychedelics from "illegal drugs" however, especially in the context of San Francisco, suggests to me you don't have much experience with the city.
Also, the chocolate brownies are pretty good and even sometimes have drug-free versions too!
https://mushroomoneupbars.com/
IDK, people cheaply deliver these politely, promptly and dependably to your door where I live, and I don't live in CA.
If you live in the EU, you can even acquire a legit derivative legally on the 'clearnet'.
https://en.wikipedia.org/wiki/Berwyn_Heights,_Maryland_mayor...
Been doing this for years too. It ain't even new.
This is San Francisco we're talking about, psychedelics already weren't a priority for the police in any practical sense.