There are reports in medical journals of people accidentally taking hundreds of doses of LSD, and they all were sober within 24 hours.

This is a famous case from the 70s: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129381/?page=1

Summary: 8 people at a party in SF “accidentally” (having mistook it for cocaine, as one does) snorted at least two lines each of powdered LSD. Somehow, they made it to the hospital 10 minutes later. 5 of them were in a coma by the time they were seen, and 3 had to be intubated. One person had a temperature of 107F + 200BPM pulse. One of the comatose patients discharged himself after 12 hours, and they all seemingly recovered fully. But without prompt medical care…probably not.

Conclusion: Do not snort a 1000x dose of LSD.

I read the paper and I think there's another explanation. They say the seized material was "almost pure" LSD- 80 - 90%. But "almost pure" LSD is 99.9% or more. Seems more likely the material was contaminated with something else that caused the reaction.

In my experience, double the dose lasts the same amount of time, but the peak is more intense. It seems the brain just gets used to the sensation after a while.

I think "they all were sober within 24 hours" is too strong of a statement - LSD's half life is 3.6 hours, so after 24 hours blood concentration should be reduced to ~1/64th. Sober within 2-3 days is probably accurate, but I bet anyone who took a 100x dose doesn't feel "normal" for at least a couple weeks, perhaps months - more from PTSD-like effects from the intensity of the experience rather than acute LSD intoxication.

You're talking about the half-life of the molecule in the bloodstream, which is different from the half-life of the intensity of the effects. Serotonin receptors begin to downregulate as soon as the effects start, causing tolerance which lasts (to some extent) for several weeks. Taking a massive dose of LSD, or any other classical psychedelic for that matter, wouldn't significantly extend the trip. The brain just refuses to stay in that state for long.

Three case reports for LSD overdoses: https://www.researchgate.net/publication/339234169_LSD_Overd...

LOL. Overdoses which cure people of their mental illness for 20 years:

"first case report documents significant improvements in mood symptoms, including reductions in mania with psychotic features, following an accidental lysergic acid diethylamide (LSD) overdose, changes that have been sustained for almost 20 years."

Maybe lsd has changed since the 90s but 2 or 3 hits lasts longer than 24hrs. I don’t see how “hundreds” would be survivable. You would probably just die of exhaustion, there’s no sleeping on lsd and the harder you try fight it the worse it gets.

If 2 or 3 hits was lasting longer than 24h, there's a good chance it was something other than LSD (like DOM) or you have an idiosyncratic reaction.

I've met a couple people who took 100+ hits at once and survived to tell the tale. One fellow took what what was around 1000. The psychological aftershocks took him months to process, but at the time we met he was normal (well as normal as you'd expect from a person brave enough to intentionally ingest that much) and healthy.

To overshare, 2 or 3 hits wouldn't even hit me hard enough to stop me from doing Anki or reading, except for the relatively short time I'd be peaking. I could definitely sleep on it after the peak (but wouldn't at current prices.)

2-3 hits don’t last longer than 24 hours for the vast majority of people.

Likely you’ve been taking something else.

Nobody in this world, is taking "hundreds of doses" of LSD and sober within 24 hours.

That case report notes a 10x dose, a 5x dose (these are pretty standard), and a very loose description of snorting 55mg of powdered LSD, which I don't buy. I've seen enough folks eat a sheet or down a 10k mic vial and trip for a week+ to know better. Possibly the dose report was well off, or snorting it and fortunately they didn't get much of it or it wasn't pure LSD-25.

The linked reported "massive overdose from the 70's case" is also fairly bogus, in my opinion. Look deeper in the report and see the serum levels quoted and one of the highest of one of 7 patients recorded was 26ng/ml? That's effectively like taking 6-7 hits of LSD at approximate dosage of 200 microgram per dose. So what's "massive," and what does that mean then, if that person was comatose off only 6 medium sized doses of LSD, right? That is not anywhere near hundreds of doses.

I also have a lot of doubt about the last one. The first two are light users having strong emotional reactions to amounts that would be an un-notable recreational amount for others. 55mg is nuts. Five hits won't really even make you hallucinate.

As old hippies used to tell me in the 90s, pot is 100x stronger than it was in the 60s, and LSD is 100x weaker.