News for hackers. Stuff that matters.
Re:San Francisco decriminalizes psychedelics by pessimizer on Thursday September 08, 2022 @03:21PM (#32770673)
Because it's often true, and was universally true for late-Xers, early-Millennials?

https://en.wikipedia.org/wiki/William_Leonard_Pickard

Back then (the 90s), LSD was $2/hit.

Re:San Francisco decriminalizes psychedelics by cammikebrown on Thursday September 08, 2022 @03:33PM (#32770851)
The wholesale price of LSD is currently under $2/hit.
Re:San Francisco decriminalizes psychedelics by pessimizer on Thursday September 08, 2022 @03:41PM (#32770960)
That was retail in the 90s, but considering inflation that sounds like we're finally getting back to Pickard pricing. My local sources run an order of magnitude higher.

edit, for anyone curious about 90s wholesale: "Government informant Skinner testified that Petaluma Al and the largest wholesale customers of Pickard paid 29 cents per 100 µg dose, which would put the cost at around $2.97 million for a kilogram of LSD."

edit: I'm annoyed by the math used in this quote. They couldn't say $2.9 million or "around" $3 million?

Re:San Francisco decriminalizes psychedelics by chasd00 on Thursday September 08, 2022 @04:32PM (#32771697)
A kg of pure lsd would be a site to behold. I don’t know how you could even handle it in any semi-safe way.
Re:San Francisco decriminalizes psychedelics by boltzmann-brain on Thursday September 08, 2022 @04:52PM (#32771940)
somehow I can't reply to djhn's comment, but what makes large amounts of LSD unsafe is how readily it gets absorbed into the blood stream through the skin in amounts that are metabolically massive. Look up "thumbprinting"
Re:San Francisco decriminalizes psychedelics by loves_mangoes on Thursday September 08, 2022 @05:01PM (#32772033)
That's mostly a myth, it's not very well absorbed through the skin at all.

For a thumbprint, you still put your thumb on your tongue and lick it. But it's important to keep in mind that only very rarely have people actually done thumbprints. Those are mostly stories, legends, and artistic works of fiction and falsehood. Only a fool would take them as fact.

Re:San Francisco decriminalizes psychedelics by pengaru on Thursday September 08, 2022 @06:29PM (#32772883)
Albert Hoffman discovered LSD by accidentally absorbing it through his fingertips. [0]

> While re-synthesizing LSD, he accidentally absorbed a small amount of the drug through his fingertips and discovered its powerful effects.

[0] https://en.wikipedia.org/wiki/History_of_LSD#Discovery

Re:San Francisco decriminalizes psychedelics by notch656a on Thursday September 08, 2022 @07:27PM (#32773422)
How much was Hoffman working with though? The absorptivity needn't be high when the potency is so high.
Re:San Francisco decriminalizes psychedelics by pengaru on Thursday September 08, 2022 @09:26PM (#32774216)
From LSD - My Problem Child, pt. "Discovery of the Psychic Effects of LSD":

"Nevertheless, in the spring of 1943, I repeated the synthesis of LSD-25. As in the first synthesis, this involved the production of only a few centigrams of the compound."

"In the final step of the synthesis, during the purification and crystallization of lysergic acid diethylamide in the form of a tartrate (tartaric acid salt), I was interrupted in my work by unusual sensations."

...

"But this led to another question: how had I managed to absorb this material? Because of the known toxicity of ergot substances, I always maintained meticulously neat work habits. Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin. If LSD-25 had indeed been the cause of this bizarre experience, then it must be a substance of extraordinary potency."

Re:San Francisco decriminalizes psychedelics by notch656a on Thursday September 08, 2022 @10:45PM (#32774713)
Enjoyed the excerpts and thank you!

I take a few to mean more than 2 centigrams. So 30mg minimum. Thats 300x the 'normal' dose.

Re:San Francisco decriminalizes psychedelics by bryanrasmussen on Friday September 09, 2022 @04:23AM (#32776741)
so Hoffman doesn't actually know how he absorbed it

>Possibly a bit of the LSD solution had contacted my fingertips during crystallization, and a trace of the substance was absorbed through the skin.

that's a possibly, I suppose if that possibly exists then possibly some got on object X and then after leaving lab object X came in contact with his mouth or even nose when he touched his face.

Re:San Francisco decriminalizes psychedelics by cwkoss on Thursday September 08, 2022 @06:30PM (#32772890)
idk, the rainbow family (lsd distribution network) requiring inductees to take a thumbprint to test that they aren't cops and see if they can handle the inevitable accidental dosing that can occur when laying blotter makes a lot of sense to me.

I wouldn't assert that it's 'fact' but seems very plausible. (A full 'thumbprint' is probably uncommon, but ingesting a visible amount of crystal from a fingertip seems believable)

Re:San Francisco decriminalizes psychedelics by effingwewt on Thursday September 08, 2022 @06:13PM (#32772742)
Oh it's very well absorbed through the skin, and not a myth at all, and can be easily searched many places online.

We would routinely put this to the test.

Not only is it absorbed through the skin, but it takes longer to start and end the trip. We would do it on purpose for a longer/more intense trip if we were say camping for the weekend.

Re:San Francisco decriminalizes psychedelics by goatsi on Thursday September 08, 2022 @07:29PM (#32773437)
You would solely take LSD by putting it on unbroken skin? Multiple LSD chemists have confirmed this is a myth.

An esteemed underground LSD chemist arrested in '05, Donnie Shackelford, is quoted in an unfinished book on black market LSD production by Tim Scully. Here's an excerpt from the interview.

>Tim Scully said, "Did you ever get dosed through your skin in the lab". Donnie Shackelford replied, "No, I have accidentally dosed myself while laying sheets, I either touched my eye, or mouth. But the answer to your question is no, you cannot be dosed through the skin. I never wore gloves in any procedure unless lye is used and it isn’t in this procedure. I learned the hard way dropping a flask with 20g of LSD in it. I was extremely upset. I’ve had it all over my hands many, many times. I was there when Dr. Nichols basically called bullshit on the good doctor at Mindstates 60th anniversary".

This is the Mindstates talk by David Nichols https://erowid.org/general/conferences/conference_mindstates...

>"Another fact: I've made LSD in my lab on many occasions for research purposes, possibly in not so meticulous a manner as Albert Hofmann. Nothing ever happened. I had several graduate students who made LSD as an intermediate for projects. No accidental ingestion of LSD ever occurred. A technician in my lab makes it routinely because we use it as a drug to train our rats. He's learned by experience that he never gets high, nothing ever happens. And yesterday I was talking to Nick Sand, and Nick said, "I made a solution of LSD in DMSO…" -- DMSO (dimethyl sulfoxide) is a chemical that greatly enhances absorption of other chemicals through the skin -- he says, "…I painted it on my skin. Nothing happened." A concentrated solution and nothing happened!"

Re:San Francisco decriminalizes psychedelics by djhn on Thursday September 08, 2022 @04:41PM (#32771792)
Chemistry and LSD newbie question: what would make it unsafe?
Re:San Francisco decriminalizes psychedelics by loves_mangoes on Thursday September 08, 2022 @04:49PM (#32771905)
A kilogram is a lot, considering LSD is active at microgram doses, although in practice there are labs producing and handling kilograms of it.

LSD in powder form is readily available on the black market. Expensive (because you don't just go and ask to buy only 1mg of LSD powder), but not exceptionally unsafe or rare.

Now the people who handle Fentanyl and Fentanyl analogues, those probably want to triple check their gloves and mask before putting them on.

Re:San Francisco decriminalizes psychedelics by elevaet on Thursday September 08, 2022 @08:35PM (#32773921)
> in practice there are labs producing and handling kilograms of it.

Really? I doubt it. 1kg is about 10 million doses (@100ug each). I don't think there are enough people gobbling acid for there to be labs producing on that scale per batch. The cost of making a mistake with a batch that big would be quite high.

Re:San Francisco decriminalizes psychedelics by herbst on Friday September 09, 2022 @02:32AM (#32775987)
You would be surprised but there are reputable online shops who offer exactly that.
Re:San Francisco decriminalizes psychedelics by elevaet on Friday September 09, 2022 @06:00AM (#32777367)
Do you think they actually have that in stock, and if they've ever fulfilled a 1kg order? I don't mean that facetiously, but I am skeptical that it's just a marketing stunt!
Re:San Francisco decriminalizes psychedelics by herbst on Friday September 09, 2022 @06:48AM (#32777670)
I am not gonna name drop anyone, but there is one reputable seller that is online for 10+ years and is resold in all colours on all popular platforms. If they announce that bulk stock is available and shortly after the announcement it's sold out. It's either really smart marketing or just the reality of how big the market actually is :) However 1g Gramm is available too, maybe it's more like 1000 people buying 1g?

Edit:// having more acid than you could ever need is somewhat a novelty in this scene

Re:San Francisco decriminalizes psychedelics by elevaet on Friday September 09, 2022 @08:00PM (#32786320)
Very amazing. I wonder if you're talking about a clearnet analogue vendor or a darknet one.. regardless it brings me joy to consider that there are multi 1kg stashes around the planet and that the well will likely not run dry in any foreseeable future.
Re:San Francisco decriminalizes psychedelics by herbst on Saturday September 10, 2022 @06:23AM (#32789330)
Some of my friends grand parents still have a bottle sandoz LSD around from back then when Hoffmann shared the love aggressively.

IMO it's wonderful to know that this substance won't disappear anytime soon.

It's a darknet vendor btw and their name contains small mythical creatures. No personal experience with them, but I know their product and have a morbid interest for the market :)

Re:San Francisco decriminalizes psychedelics by jet_32951 on Thursday September 08, 2022 @09:15PM (#32774136)
That's been thoroughly debunked by Derek Lowe: https://www.science.org/content/blog-post/fainting-fentanyl-...
Re:San Francisco decriminalizes psychedelics by KarlKode on Friday September 09, 2022 @07:27AM (#32777888)
I think OP didn't mean that you can absorb fentanyl through the skin but rather that you'd have trace amounts of fentanyl (or even the more powerful analogues such as carfentanyl) on your hands and then touch your mouth or eyes. That can certainly kill you.
Re:San Francisco decriminalizes psychedelics by fitch321 on Thursday September 08, 2022 @09:45PM (#32774344)
May I debunk that debunking ?

https://en.wikipedia.org/wiki/Kolokol-1

Re:San Francisco decriminalizes psychedelics by paulmd on Thursday September 08, 2022 @05:35PM (#32772394)
it'll go through skin, and if you spilled a bunch on an ungloved hand you're going to be going for a ride, which is of course the origin of the 'bicycle day' itself and the discovery of LSD.

of course, many things are not safe on the skin and that's not uniquely dangerous, really

Re:San Francisco decriminalizes psychedelics by xvedejas on Thursday September 08, 2022 @04:48PM (#32771886)
LSD is extremely potent at small quantities (dozens of micrograms); exposure to even a small fraction of this (a few grams, say) could be enough to put someone into a non-responsive state for a few days. I don't think it'd cause permanent damage, but still not something to underestimate.
Re:San Francisco decriminalizes psychedelics by kirsebaer on Thursday September 08, 2022 @05:16PM (#32772197)
There are reports in medical journals of people accidentally taking hundreds of doses of LSD, and they all were sober within 24 hours.
Re:San Francisco decriminalizes psychedelics by jointpdf on Thursday September 08, 2022 @07:14PM (#32773321)
This is a famous case from the 70s: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1129381/?page=1

Summary: 8 people at a party in SF “accidentally” (having mistook it for cocaine, as one does) snorted at least two lines each of powdered LSD. Somehow, they made it to the hospital 10 minutes later. 5 of them were in a coma by the time they were seen, and 3 had to be intubated. One person had a temperature of 107F + 200BPM pulse. One of the comatose patients discharged himself after 12 hours, and they all seemingly recovered fully. But without prompt medical care…probably not.

Conclusion: Do not snort a 1000x dose of LSD.

Re:San Francisco decriminalizes psychedelics by dekhn on Thursday September 08, 2022 @08:01PM (#32773689)
I read the paper and I think there's another explanation. They say the seized material was "almost pure" LSD- 80 - 90%. But "almost pure" LSD is 99.9% or more. Seems more likely the material was contaminated with something else that caused the reaction.
Re:San Francisco decriminalizes psychedelics by nattmat on Thursday September 08, 2022 @06:07PM (#32772697)
In my experience, double the dose lasts the same amount of time, but the peak is more intense. It seems the brain just gets used to the sensation after a while.
Re:San Francisco decriminalizes psychedelics by cwkoss on Thursday September 08, 2022 @06:36PM (#32772958)
I think "they all were sober within 24 hours" is too strong of a statement - LSD's half life is 3.6 hours, so after 24 hours blood concentration should be reduced to ~1/64th. Sober within 2-3 days is probably accurate, but I bet anyone who took a 100x dose doesn't feel "normal" for at least a couple weeks, perhaps months - more from PTSD-like effects from the intensity of the experience rather than acute LSD intoxication.
Re:San Francisco decriminalizes psychedelics by deadbeeves on Thursday September 08, 2022 @07:29PM (#32773442)
You're talking about the half-life of the molecule in the bloodstream, which is different from the half-life of the intensity of the effects. Serotonin receptors begin to downregulate as soon as the effects start, causing tolerance which lasts (to some extent) for several weeks. Taking a massive dose of LSD, or any other classical psychedelic for that matter, wouldn't significantly extend the trip. The brain just refuses to stay in that state for long.
Re:San Francisco decriminalizes psychedelics by radicaldreamer on Thursday September 08, 2022 @06:03PM (#32772669)
Re:San Francisco decriminalizes psychedelics by kvetching on Thursday September 08, 2022 @08:35PM (#32773917)
LOL. Overdoses which cure people of their mental illness for 20 years:

"first case report documents significant improvements in mood symptoms, including reductions in mania with psychotic features, following an accidental lysergic acid diethylamide (LSD) overdose, changes that have been sustained for almost 20 years."

Re:San Francisco decriminalizes psychedelics by chasd00 on Thursday September 08, 2022 @06:13PM (#32772746)
Maybe lsd has changed since the 90s but 2 or 3 hits lasts longer than 24hrs. I don’t see how “hundreds” would be survivable. You would probably just die of exhaustion, there’s no sleeping on lsd and the harder you try fight it the worse it gets.
Re:San Francisco decriminalizes psychedelics by elevaet on Thursday September 08, 2022 @09:11PM (#32774118)
If 2 or 3 hits was lasting longer than 24h, there's a good chance it was something other than LSD (like DOM) or you have an idiosyncratic reaction.

I've met a couple people who took 100+ hits at once and survived to tell the tale. One fellow took what what was around 1000. The psychological aftershocks took him months to process, but at the time we met he was normal (well as normal as you'd expect from a person brave enough to intentionally ingest that much) and healthy.

Re:San Francisco decriminalizes psychedelics by pessimizer on Thursday September 08, 2022 @08:09PM (#32773752)
To overshare, 2 or 3 hits wouldn't even hit me hard enough to stop me from doing Anki or reading, except for the relatively short time I'd be peaking. I could definitely sleep on it after the peak (but wouldn't at current prices.)
Re:San Francisco decriminalizes psychedelics by ada1981 on Friday September 09, 2022 @01:27AM (#32775627)
2-3 hits don’t last longer than 24 hours for the vast majority of people.

Likely you’ve been taking something else.

Re:San Francisco decriminalizes psychedelics by BTCOG on Thursday September 08, 2022 @05:41PM (#32772456)
Nobody in this world, is taking "hundreds of doses" of LSD and sober within 24 hours.
Re:San Francisco decriminalizes psychedelics by BTCOG on Thursday September 08, 2022 @06:15PM (#32772754)
That case report notes a 10x dose, a 5x dose (these are pretty standard), and a very loose description of snorting 55mg of powdered LSD, which I don't buy. I've seen enough folks eat a sheet or down a 10k mic vial and trip for a week+ to know better. Possibly the dose report was well off, or snorting it and fortunately they didn't get much of it or it wasn't pure LSD-25.
Re:San Francisco decriminalizes psychedelics by BTCOG on Thursday September 08, 2022 @07:41PM (#32773524)
The linked reported "massive overdose from the 70's case" is also fairly bogus, in my opinion. Look deeper in the report and see the serum levels quoted and one of the highest of one of 7 patients recorded was 26ng/ml? That's effectively like taking 6-7 hits of LSD at approximate dosage of 200 microgram per dose. So what's "massive," and what does that mean then, if that person was comatose off only 6 medium sized doses of LSD, right? That is not anywhere near hundreds of doses.
Re:San Francisco decriminalizes psychedelics by pessimizer on Thursday September 08, 2022 @06:43PM (#32773015)
I also have a lot of doubt about the last one. The first two are light users having strong emotional reactions to amounts that would be an un-notable recreational amount for others. 55mg is nuts. Five hits won't really even make you hallucinate.

As old hippies used to tell me in the 90s, pot is 100x stronger than it was in the 60s, and LSD is 100x weaker.

Re:San Francisco decriminalizes psychedelics by ROTMetro on Friday September 09, 2022 @01:44AM (#32775716)
I'm used to him having a long wizard looking beard.