CTO of Microsoft wrote 6 books on molecular gastronomy named Modernist Cousine [1]. There are lots of pages in first book about managing environmental fecal matter (hint: there is a LOT of it around you and in the food you eat).
Another idea I’m curious about would be to preserve fecal samples from a young mouse and transplant back to their older selves to see if that also shows the same effect.
Is that (primarily) because high fiber food takes so long to digest that it gives more time for "stuff" to propagate in your gut?
Fixing microflora (and hence influencing metagenome) however, is not that simple. You wont feed good bacteria only, but pathogenic too if you have them overpopulated, which will make things worst. You can't easily replace those with new ones coming from food because of the acid barrier. You might think that lowering it down is good idea, but its totally not, because you will soon find new neighbor h. pylory which can cause all kinds of shit, along with having less nutrientes available by stealing and unoptimal pH environment. Regular probiotics are usually meaningless (influencing environment like fart in the wind).
Eating carnivoir diet makes your acid stronger which further strenghtens your defences (only great if you don't have invaders).
Then, this is dynamic - good guys can become bad in specific context.
The best way to improve your microbiome health is to find FT surogate, some great probiotic like Visbiome or VSL3, eat fermented foods, use prebiotics, and obviously dont use antibiotics in relaxed manner (save them for emergencies, like once in decade, and even then help flora repopulation and good luck with fungi proliferation) and do not remove your apendix just for the sake of it.
Funny thing nobody mentiond antibiotics and how harmful they are. Yes, they can save your life but poping them every now and then borders to malpractice.
I am a software architect, not a doctor, but machine is a machine.
Another study [1] I just found showed that older women who had been exposed to antibiotics for => 2 months had increased risk of all-cause mortality and cardiovascular mortality (hazard ratio 1.49). Interestingly, if they had also been exposed to antibiotics in middle-adulthood, their mortality rate was even higher; which may suggest that antibiotic exposure permanently impairs the microbiome. Paper's conclusion: "Long-term use of antibiotics in late adulthood may be a risk factor for all-cause and cardiovascular mortality. The unfavorable effect of antibiotic exposure for subsequent risks of deaths due to chronic diseases needs to be considered."
That seems like a very obvious case of correlation vs causation (people who need medicine are more likely to die than those who dont)
It's almost trite to say it at this point but correlation is not causation.
- https://pubmed.ncbi.nlm.nih.gov/35027429/
- https://pubmed.ncbi.nlm.nih.gov/35243408/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879739/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8000835/
- https://pubmed.ncbi.nlm.nih.gov/33676528/
Note, some of these are studies of humans and some are on mice
And I’m pretty sure one of the human studies does establish causation, although I don’t have time to see which one
Still, I hope that my post was received by the poster as informational, despite its somewhat harsh tone. No matter your background, knowing how to present your ideas in a non-confrontational way will surely make more people listen to you.
Please, this should be primary school knowledge nowadays.
From a doctors perspective prescribing antibiotics encourages people to show up with minor illness, it’s bad medicine but good business practice.
Let me guess you’re going to move the goalpost.
Uh huh
> some great probiotic like Visbiome or VSL3
Sure are a lot of "you watered down the product" and false advertising lawsuits against these guys.
This should have been one of the mandatory COVID prevention methods.
Can supplementation be an effective substitute for fiber derived from real foods? If so, are there any particular kinds of supplements you'd recommend?
Whatever psyllium you choose, be careful of lead content. https://www.consumerlab.com/reviews/psyllium-supplements/psy... has reviews and analysis of 8 products, including lead content.
I’ve been using this stuff almost daily for many years.
“ALA, the most common omega-3 fat, is an essential fatty acid that is converted into EPA and DHA. However, this conversion process is inefficient in humans. On average, only 1–10% of ALA is converted into EPA and 0.5–5% into DHA”
It would be like trying different gasoline additives instead of taking your car to the car wash.
Along these lines, are there any potential health benefits to penis in butt sex? Or does the poop need to enter my butt?
1) A critical experiment to determine that it is bacteria (or fungal/virus) per se and not a host effector would be the transfer of contents from aged germ-free control mice (mice without microbes of any type). The authors mention a transfer protocol that could be optimized for fungal commensals, but don't address the more important germ-free control.
2) It is hard to characterize individual immune metabolites/signals (e.g. IL-10, IL-6, etc.) as either good or bad. The context determines the effect and they show changes in at least 20 cytokines in Fig 3E. While they focus on IL-6 and TNF, it's not immediately clear those are necessarily a part of pathogenic inflammageing. LBP conversely, seems pretty hard to interpret as anything but evidence of barrier permeability and this result seems strong.
3) It's not clear how much of this effect would sustain over the long term. The amount of time between fecal transplant and mouse sacrifice/result generation was only 18 days. Experiments with such a short duration seem like they might capture an unrelated effect due to some other coincident factor.
Overall, a well done paper with a lot of interesting things, but also reasons to be very skeptical of the magnitude of this effect. As usual, I will end with: you can dramatically improve your microbiome health (whatever that term actually means) by eating a high fiber diet like most humans did for most of evolutionary time.