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Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Thursday October 31, 2019 @09:48PM (#21415619)
I've been dealing with a hormonal issue that's been negatively impacting my deep sleep for almost two years.

There was a week in early February this year, right after surgery, where I felt like a million bucks. Normally, I have a pretty low-grade chronic headache (yeah, it's as horrible as it sounds). However, that week, my head felt "clear". I don't know how else to explain it other than I felt like my brain had been washed. I was going to bed at 9-9:30pm, and waking up at 5am, and felt incredible. I reverted not long afterwards, and believe I recently figured out the root of the issue (fingers crossed!), but I 100% believe that you need deep sleep to function well. IMO, it's not sufficient to get light and REM sleep; deep sleep is when true brain recovery occurs. I feel like I should know; before I started treatment, I would go to bed at 9-9:30pm and sleep until 8 and still feel exhausted. You need quality sleep in addition to quantity.

Wrist-based sleep trackers are basically useless, FWIW. I've been using one pretty consistently since before my health issues started and they really can't discern the difference between light/REM/deep sleep phases. If there's anything which mirrors how I feel after waking up in the morning, it's HR dip, but even that isn't 100% reliable.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by icotyl on Thursday October 31, 2019 @11:31PM (#21416068)
> I've been dealing with a hormonal issue that's been negatively impacting my deep sleep for almost two years.

Also, not getting enough sleep can wreak havoc on your hormones.

"Men who sleep 5 hours a night have significantly smaller testicles than men who sleep 7 hours or more. Men who routinely sleep 4-5 hours a night will have a level of testosterone of someone 10 years their senior."

https://www.youtube.com/watch?v=5MuIMqhT8DM

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @10:48AM (#21419387)
> Also, not getting enough sleep can wreak havoc on your hormones.

Yep, and that was a part of my problem. Unbalanced hormones lead to poor sleep, and poor sleep leads to unbalanced hormones. My pituitary just stopped working correctly, and no matter how many hours I spent in bed, my body just wasn't doing what it needed to dial up the deep sleep requirements. Horrible negative feedback loop.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by ASalazarMX on Friday November 01, 2019 @12:56PM (#21421000)
My god, popular wisdom right here. In my country, a good-for-nothing, lazy person is called 'huevón', which means 'someone with big testicles' in Spanish. It's applied to both men and women, though.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by gpas on Saturday November 02, 2019 @09:15AM (#21427505)
Same as boludo in Argentina
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by ASalazarMX on Sunday November 03, 2019 @12:32PM (#21435253)
¡Gracias! No estaba seguro de si eran equivalentes.
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Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by jakswa on Friday November 01, 2019 @02:25AM (#21416626)
Up late depriving yourself of sleep? While watching a video arguing for deeper, more healthy sleep? Ya me too.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by pvaldes on Friday November 01, 2019 @06:21AM (#21417439)
> Men who sleep 5 hours a night have significantly smaller testicles than men who sleep 7 hours or more

Seems logic. I wonder what this men could do to kill time in all of those extra hours in the bed.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by steve19 on Thursday October 31, 2019 @10:46PM (#21415862)
> I recently figured out the root of the issue (fingers crossed!

Don't leave us hanging, what is the root cause?

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @10:39AM (#21419313)
> Don't leave us hanging, what is the root cause?

This is somewhat conjecture, but bloodwork indicates that my pituitary gland completely shut down at the beginning of 2018, following multiple viral infections and a year of intense triathlon training. My hormone levels were just completely out of whack. I've been getting shots from my endocrinologist, and a week and a half later, I'm feeling like a different person. Hopefully I just need it temporarily as a kick-start, and can then wean off.

Otherwise, my sleep habits are functionally pretty close to perfect.

* No food or blue light after 6pm

* I only use my bed for sleep (no reading)

* No caffeine of any kind after noon

* Black-out curtains

* In bed by 9pm

Falling asleep and staying asleep has never been an issue for me; it's just getting good sleep that's been the problem.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by throwaway_law on Friday November 01, 2019 @11:01AM (#21419527)
>I've been getting supplementation

Can you expand on this. Is this something like melatonin to help reset your circadian rhythm for sleep? Or supplements to jump start your pituitary gland?

I guess am curious is the pituitary shut down was caused by the lack of sleep, and getting the good sleep will reactivate the gland, or if the gland is an issue you are addressing with the supplements directly.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @11:08AM (#21419614)
> Can you expand on this. Is this something like melatonin to help reset your circadian rhythm for sleep? Or supplements to jump start your pituitary gland?

Shots. I'm seeing an endocrinologist. OTC supplements did nothing for me.

> I guess am curious is the pituitary shut down was caused by the lack of sleep, and getting the good sleep will reactivate the gland, or if the gland is an issue you are addressing with the supplements directly.

My sleep habits were fantastic prior to my illness. The issues started after I got two bad viruses in succession. In early 2018 I got the Flu followed by Hand, Foot, and Mouth. I just never really recovered; my body just kind of sputtered out. Hormone production tanked, which led to poor sleep, which further messed up my hormone production, etc.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by throwaway_law on Friday November 01, 2019 @11:48AM (#21420045)
Sorry to hear all this, but glad it seems to be improving now.

I had a similar issue (and like you I was engaged in serious endurance training). I would also go to sleep early, wake up at 4AM without an alarm and knock out a 2 hour run. I ended up with pityriasis rosea (which is kind of a medical mystery in terms of cause but linked to viruses), and thereafter some sleep/hormone disruptions.

In addition to what you are currently doing to address the sleep issue, consider testing your microbiome. Often bacterial infections and viruses change the makeup of the microbiome which also has significant negative influences on hormone production/regulation. In my case gut health helped break the negative feedback loop.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by IanSanders on Friday November 01, 2019 @08:24AM (#21417987)
Probably personal. (unless crossed fingers is the cause)
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @10:41AM (#21419326)
Hah! Just answered above. :)
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Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by steve19 on Friday November 01, 2019 @02:47AM (#21416685)
Obviously we are asking the parent what was preventing deep sleep.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by ianai on Friday November 01, 2019 @07:13AM (#21417659)
He said an HR dip which I think means heart rate. That might be achieved by daily exercise, I think?
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @10:44AM (#21419349)
> He said an HR dip which I think means heart rate. That might be achieved by daily exercise, I think?

Unfortunately exercise didn't help me either; I'm convinced it's just body chemistry (although, if you're already somewhat healthy, I think daily exercise can influence that). I was at a point where exercise had no effect.

My theory is that HR dips lead to what the article suggests; lower blood flow in the brain opens up space for cranial fluid to flush things out.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by alanfalcon on Thursday October 31, 2019 @10:31PM (#21415799)
Similarly, my CPAP changed my life for the better. I went from constantly tired to being a productive member of society again.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by etagobla on Friday November 01, 2019 @01:04AM (#21416411)
Or just sleep on your side like other primates
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by teej on Friday November 01, 2019 @01:30AM (#21416497)
I was always a side sleeper. My CPAP has made a significant difference in the quality of my sleep.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by beaner on Friday November 01, 2019 @01:49AM (#21416545)
Genuine question, can you elaborate on the supposed relationship between sleep orientation and CPAP?
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by DoingIsLearning on Friday November 01, 2019 @02:38AM (#21416662)
Parent is being facetious about this but is also overly simplifying the issue.

You can think of your airway as tube of cartilage and soft muscle. As we age (there are also other contributing factors) this tube may be narrowed or collapse under the weight of adjacent tissue. Excess weight (more adjacent tissue), alcohol consumption (more tube muscle relaxation) also contribute to the narrowing/collapsing of this tube.

The airway tube has the least amount of pressure from adjacent tisue when you are on your side. And the highest amount of pressure when lying on your back.

What parent is dismissing is that Positional Sleep Apnea is a fraction of all sleep apnea cases. I.e. his solution of sleeping on the side would 100% resolve sleep apnea for a fraction of all sleep apnea patients but certainly not everyone.

Source: Did contract work for a sleep apnea startup.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by beaner on Friday November 01, 2019 @11:53AM (#21420127)
Thanks!
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by DoingIsLearning on Friday November 01, 2019 @12:23PM (#21420551)
To keep with the 'tube' analogy, a CPAP machine creates a positive air pressure in the airway, which in practice pushes the tube's inner walls outwardly and prevents a collapse or narrowing of the tube.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by Miserlou57 on Friday November 01, 2019 @01:03AM (#21416404)
Can you please elaborate? This describes what I have suffered from consistently for years but I haven’t been able to identify
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @11:15AM (#21419687)
I'm so sorry. Have you had full blood work done? My PCP had labs ordered that he normally only does for 70+ year olds. This was after more than a year and a half of suffering. I had plead with him to run everything. Pituitary, testosterone, etc.

The most frustrating thing was that doctors doubled down on their initial diagnosis of clinical depression. Surely there's no way that a young, "healthy" male could actually have a problem!

I hope you feel better soon.

I elaborate in more detail here: https://news.ycombinator.com/item?id=21419313

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by teddyuk on Friday November 01, 2019 @07:09AM (#21417641)
What do you think about meditation? I feel if I mediate regularly then I feel on top of the world
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @10:49AM (#21419407)
> What do you think about meditation? I feel if I mediate regularly then I feel on top of the world

Love it! Do it twice a day for 20 minutes. Sadly it had no positive benefit on sleep. :(

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by anonuser123456 on Thursday October 31, 2019 @11:15PM (#21415991)
>I've been dealing with a hormonal issue that's been negatively impacting my deep sleep for almost two years.

How do you know this? Are you going to bed with an EEG every night?

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @11:18AM (#21419724)
> How do you know this? Are you going to bed with an EEG every night?

I had a sleep study done which indicated I get very little deep sleep, but no apnea.

Another data point is that I remember almost all of my dreams; I could literally write a few short stories if I wanted to every morning. Frequent dream recall is not a good sign since it indicates that REM is getting disrupted. REM is the precursor to deep sleep, so if REM is getting disrupted, you're probably not making it to Phase 3.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by joveian on Friday November 01, 2019 @02:57PM (#21422496)
I agree that particularly strong and extended dream recall is a bad sign (that kind of thing is supposed to be blocked during sleep), but REM sleep is not a precursor to deep sleep. They are independent and usually deep sleep is entered most early in the night and REM later. REM episodes soon after getting to sleep are a sign of narcolepsy. Some medications (including some antidepressants) reduce or nearly eliminate REM sleep. Dreaming has been connected to dopamine that can also be affected by many medications and a variety of other things (like exercise). There are a bunch of sleep realted substances that still have unknown function so I'm sure there are a bunch of things that can go wrong completely outside the realm of current medical science.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @03:39PM (#21422890)
Err. I made a typo. You're correct. Non-REM deep sleep comes first and REM comes second.

https://youtu.be/bEbtf7uS6P8?t=6790

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by julian_digital on Friday November 01, 2019 @04:56AM (#21417140)
> Wrist-based sleep trackers are basically useless

Have you found any good sleep trackers that aren't wrist-based? Any recommendations?

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @11:16AM (#21419693)
> Have you found any good sleep trackers that aren't wrist-based? Any recommendations?

Unfortunately not. :(

Whoever can crack that nut is going to be very wealthy.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by Discombulator on Saturday November 02, 2019 @12:55AM (#21425965)
I am using the Dreem 2 (dreem.com, use my referral code for a discount: UEXBFMANU). I do not have a certified reference device but those aspects of the recordings that I can assess (start and end of sleep, awakenings, onset of sleep, position) match my experience and are more accurate than the other devices I am using (Withings Sleep, Garmin Fenix 3). There are several in depth reviews on the web comparing the device output with state of the art polysomnogram recordings.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by guiambros on Sunday November 03, 2019 @12:48AM (#21432255)
I'm dying to test Dreem 2, but having burned by so many gadgets that went out of business, including a very similar Zeo Sleep Tracker[1] almost 10 years ago, I'll hold for a while more to see if the company will survive.

Their recent research comparing Dreem to a regular PSG [2] is pretty impressive, but I'm skeptical of their business model, and am concerned they won't survive for long.

[1] https://www.mobihealthnews.com/20772/exclusive-sleep-coach-c...

[2] https://www.biorxiv.org/content/biorxiv/early/2019/06/10/662...

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by greenhatman on Saturday November 02, 2019 @11:03AM (#21428049)
Peter Attia recommends Oura Ring.

https://peterattiamd.com/members/discounts/

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by bbernoulli on Thursday October 31, 2019 @10:20PM (#21415753)
What do you think was the issue?!

- fellow crappy-quality-sleeper

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by xeromal on Friday November 01, 2019 @12:58AM (#21416382)
I had dogshit slip that bordered insomnia for a while. I forced myself into a habit that triggered a sleep response.

For the past 4 or 5 years, I shower in the dark and walk to my room and pass out. I avoid "turning on" after that shower. No phones, no lights, no anything

Your body needs to know when its time to sleep. Texting, reading, and computer time in bed counters that.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by theli0nheart on Friday November 01, 2019 @11:20AM (#21419738)
I'm really sorry about that. I had full lab work done that indicated my pituitary was shot. I'm now getting hormone injections until we get my body functioning again. I'd recommend seeing your PCP; if they push a depression diagnosis on you, push back and ask to get full lab work. I was getting stuffed with SSRIs for more than 18 months until I couldn't take it any longer.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by myth_drannon on Thursday October 31, 2019 @10:27PM (#21415776)
Fitbit is pretty good at that I believe.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by fleetingmoments on Tuesday November 12, 2019 @06:07AM (#21513207)
Yes. They're the best of the commercial trackers, at least from what I have seen. I've worked in depth on this, and we were only able to subtly improve on Fitbit's published results using more advanced models. The best models have a Kappa (measure of agreement) compared to human polysomnography scorers of around 0.6. Where 0 would be random chance and 0.8 is the agreement between different human scorers.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by robodale on Saturday November 02, 2019 @10:44AM (#21427964)
I agree with this. I've been using a Fitbit for 4 years, and I can see the difference in my sleep on a good night compared to nights I've had alcohol, worked out too hard, been dehydrated, had too much caffeine late in the day...they all have measurable differences in my sleep.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by lsc on Friday November 01, 2019 @03:29AM (#21416852)
Do you have a source? Like, I'd pay money for good sleep tracking, (especially if it's fitbit-level money... I would pay more) but everything I've seen thinks that if I'm in bed and quietly, say, reading a book, I'm asleep until I move.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by jfim on Friday November 01, 2019 @03:50AM (#21416922)
I've been using the Oura ring for that and it works pretty well for me. Unlike the other fitness trackers, its primary focus is sleep. I don't know how well it would handle reading in bed, however.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by lsc on Friday November 01, 2019 @04:10AM (#21416980)
I'm mostly concerned about reading in bed 'cause I assume if it can't detect that, it can't detect, you know, staring at the ceiling. (though I guess I'm a lot more likely to fidget while staring at the ceiling.) I mean, I could get out of bed to read, but in my experience, that's even worse for sleep than reading in bed.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by brlewis on Friday November 01, 2019 @08:12AM (#21417905)
I work for Fitbit. I don't speak for Fitbit; this is my personal experience. If you get a Fitbit with heart rate tracking, which nearly all have now, it won't rely just on motion. For me it's worked great, showing an awake period at the beginning or end of my time in bed. More on how it works: https://help.fitbit.com/articles/en_US/Help_article/2163#Aut...

If you buy directly from Fitbit's website, the satisfaction guarantee is 45 days so you have plenty of time to try it out and see how well it works for you.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by ancientworldnow on Friday November 01, 2019 @09:33PM (#21425314)
I have a Withings sleep pad that sits under my mattress and I find it significantly more accurate than other decives I've tried.

It also easily tells between activities in bed (even motionless ones like reading or watching) vs sleeping (and all the assorted cycles). It also measures heart rate, breathing (and how many times you stop), and even snoring.

Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by lsc on Friday November 01, 2019 @04:13AM (#21416993)
huh. I will look more into the Oura ring. In budget, but not in "buy without research" budget.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by waivej on Friday November 01, 2019 @08:58AM (#21418197)
My Charge HR with “sensitive” sleep tracking setting was one of my favorite features. It always knew exactly how much sleep I got. I switched to a Garmin 935 and never look at the sleep data because it’s never accurate.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by chimpburger on Friday November 01, 2019 @12:29AM (#21416287)
Eliminate caffeine. Increase consumption of animal products. My sleep quality improved significantly after switching to a 90% carnivore diet.
Re:Deep Sleep May Help the Brain Clear Alzheimer's Toxins by sorenn111 on Thursday October 31, 2019 @10:26PM (#21415775)
please elaborate

signed, a shitty sleeper