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Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by modeless on Thursday October 02, 2025 @09:38PM (#45457838)
Never thought I'd see so many people rooting for death here on HN. What a dour, pessimistic place this has become.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by drooby on Thursday October 02, 2025 @10:05PM (#45458074)
There is plenty of reason to welcome death. And be optimistic about its presence.

As Max Planck observed: "Science progresses one funeral at a time".

And really, the same can be said for political beliefs.

Humans are stubborn creatures that stratify power. Death has always been the great equalizer. But perhaps soon, no longer.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Thursday October 02, 2025 @10:23PM (#45458190)
Science progresses because it makes a disciplined study of the world with numerical predictions that are checked for accuracy.

Politics is treated by most people as essentially a religion. And religion does not progress with death. It just cycles through periods of greater fundamentalism and less fundamentalism.

There aren't enough people studying political science and studying it rigorously enough for the Planck observation to apply.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by mhb on Thursday October 02, 2025 @11:49PM (#45458775)
It's even worse than that. When people who have experience die, new people arise to repeat their mistakes. Witness the NYC mayoral race.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by judahmeek on Friday October 03, 2025 @12:48AM (#45459085)
When I think of repeated mistakes, I think of populists embracing fascism.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by mhb on Friday October 03, 2025 @12:56AM (#45459138)
There's no shortage of mistakes to support the counterargument to the proposition that the death of experience is the best path to a better world.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by scoopdewoop on Thursday October 02, 2025 @10:40PM (#45458314)
That is a really naive epistemology. Science as an objective methodology that churns out truth doesn't exist. Its a human endeavor full of interests.

Religion is also a human endeavor full of interests, and can also ascertain certain truths. Often people who subscribe to scientism gloat that even in the farthest reaches of space, other aliens will arrive at the same equations. Similarly, I think at the farthest reaches of space aliens will have to reckon with wickedness, duty, hospitality, forgiveness, etc. It can even make numerical predictions like "there will always be the poor". So far so true.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Thursday October 02, 2025 @11:25PM (#45458625)
This is just a bunch of cold-war style anti-science critique stuff. It's frankly not worth responding to.

There are reasonable things to say about science, but the anti-objectivity bit was an attempt to undermine science and reduce opposition to political rule by fiat. The rise in authoritarian rhetoric and beliefs is why we're seeing the anti-science and anti-expert ideas become fashionable again.

Notice that the anti-expert/anti-intellectual/anti-science people always have something else they're selling you that conflicts with the experts/intellectuals/science.

Anyway, good luck.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by scoopdewoop on Thursday October 02, 2025 @11:53PM (#45458793)
This isn't an anti-science critique. It's a philosophical argument about how science actually operates. I'm not coming at this from a populist authoritarian angle! (Literally my views were influenced by Feyerabend, an academic and leftist anarchist)

The tobacco-funded studies that failed to prove cigarettes harmful? Those were scientists doing "objective methodology." Pharmaceutical companies suppressing unfavorable trials? Scientists. The replication crisis? Scientists following the same process.

These aren't exceptions. They show that science is a human practice embedded in institutional and economic contexts.

Acknowledging that science involves human interests doesn't undermine it. It's how you maintain critical perspective when bad actors claim scientific authority. Or should I trust the current experts that Tylenol causes Autism?

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by illiac786 on Friday October 03, 2025 @01:13AM (#45459234)
I agree. People stop changing their mind at some point. Social progress is only possible when old generations die. To think scientists are some sort of truth seeking machines, unbiased, isolated from society, is naive.

Also I really dislike the categorisation into scientists and non-scientists, this really makes science sound like a dogma. I prefer inventors, pioneers, or simply curious people.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by arcwhite on Friday October 03, 2025 @07:57PM (#45469138)
Or do people stop changing their minds because they're worn down, their brains no longer as capable of making space and joy for new ideas?

Which these stem cells, if they pan out, very specifically fix

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by illiac786 on Saturday October 04, 2025 @01:57AM (#45470870)
Possible, but many concepts and principles are frozen by the age of 30 already.

I have never seen someone which is left on the political spectrum at 30 become a Keynesian by 50.

I know such people exist, but they are the exception.

Personality psychology shows personality does not change much after 30.

And there is even some theories such as the “impressionable years” (15-25) which are even more extreme in that respect, stating that basically very little changes after 25.

Overall this makes me doubt stem cells can change any of this.

But I am myself way past my impressionable years, my mental flexibility is lessened, I may be wrong and not open to new ideas.

It would feel sad though, having civilisation lead by the same people over hundreds of years if not more, somewhat stratified, predictable, dull.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Friday October 03, 2025 @08:20AM (#45462103)
> Feyerabend, an academic and leftist anarchist)

Yes that was obvious in your first post.

Feyerabend was writing during the cold war and was influenced by Marx (an authoritarian) and Marxist critiques of science promoted by the Soviets at the time. You get the same threads running through people like Kuhn and Popper.

The backdrop of these ideas is that the authoritarian Soviet state wanted to undermine faith in science within the US for the same reason it wanted to undermine democracy. They also wanted to promote the idea of alternative views of science at home because Soviet science was constrained by needing to be consistent with Marx. These ideas percolated for a few decades as propaganda before people like Feyerabend gussied them up and tried to publish them as academic works.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by scoopdewoop on Friday October 03, 2025 @09:33AM (#45462826)
This is ahistorical conspiracy theory.

First, state communists kill anarchists. That's history.

Second, the Soviets were incredibly dogmatic about science because they used it to justify their materialist ideology. They promoted Lysenkoism (fake genetics) to conform to Marxist doctrine. That's literally the opposite of epistemological questioning.

Third, claiming Kuhn and Popper were Soviet mouthpieces is unhinged. Popper wrote "The Open Society and Its Enemies" as an anti-communist text. Kuhn taught at Harvard, MIT, and Princeton. They were Western academics, not agents.

You've gone from defending naive scientism to claiming anyone who critiques it is a communist propagandist. That's McCarthyism, not an argument.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Friday October 03, 2025 @01:02PM (#45465095)
No, it's not. Like I said this isn't worth responding to, but people who actually look into the history will understand what I'm saying.

The problem you're facing is you don't believe in any sort of objective reality so you're acting as if ideas are about which team you're on instead of how they relate to the truth.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by scoopdewoop on Friday October 03, 2025 @02:58PM (#45466480)
Whoever you are imagining has nothing to do with me. Enjoy debating your spooky stalinist strawmen.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Friday October 03, 2025 @04:32PM (#45467470)
The difference between you and me is I've focused on what you've written and you've called me every name in the book despite not knowing what you're talking about.

We see your other posts where you're asking why murdering your enemies isn't okay and promoting conspiracy theories. I don't have to imagine who you are, you've told us.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by Karrot_Kream on Friday October 03, 2025 @04:00PM (#45467155)
> (Literally my views were influenced by Feyerabend, an academic and leftist anarchist)

Sigh this is the most annoying thing on the internet. It's like every online debate a leftist post-structuralist has to say "nuh uh actually everything is relative because it's all about structure and there's no objective truth man." It's a lazy critique. You can aim post-structuralist critique at literally anything. You're right, science is an artifact of the society it's in, and actually society is based on the Wim Hof breathing technique so really science is in service of Wim Hof Breathing. You can't argue with me because everything is relative and based on structures and Wim Hof breathing is the root of all social structure.

If you're going to trot out a post-structuralist critique, build an alternate theory, don't just pick an argument apart. I'm hardly the first person to note this continental Leftist weakness. Zizek has written about this extensively. I don't need to believe in Soviet conspiracy theories to think your argument is weak.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by A4ET8a8uTh0_v2 on Sunday October 05, 2025 @01:27PM (#45483463)
Zero disagreement. I will only add that I am patiently waiting for transmetropolitcan prediction of postneoredereconstructionism to become true.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by jibal on Saturday October 04, 2025 @05:49AM (#45472097)
> These aren't exceptions.

It's furious cherry picking. The scientific consensus is that cigarettes are harmful, the globe is warming, Tylenol DOES NOT cause autism, etc.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by inglor_cz on Friday October 03, 2025 @05:34AM (#45460915)
"This is just a bunch of cold-war style anti-science critique stuff. It's frankly not worth responding to."

This is, ironically, an absurd echo of every autocrat's self-defense. "It is just the commies/right-wingers who hate our Dear Leader and want to undermine his benevolent authority for their own nefarious purposes."

Scientists are humans, prone to every vice that plagues humanity: jealousy, lust for power, greed, willingness to bend data to make their theory work, plagiarism, and, lately, blatant misuse of AI without even acknowledging it aloud.

The scientific community absolutely needs both internal self-policing, external policing, and mechanisms that limit abuse of power by the elders against their subordinates, or it will lose the necessary integrity and thus also any trust of the outsiders.

If you deny this, you basically deny humanity of everyone involved. And I say this as a former young scientist with a PhD from algebra. I have seen enough, with my own eyes.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Friday October 03, 2025 @08:25AM (#45462154)
I just want to draw everyone's attention to the fact that you're saying science needs a lot of policing to keep it in line. The rest is just rhetoric.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by inglor_cz on Friday October 03, 2025 @08:36AM (#45462256)
Science needs exactly as much policing as every other human activity: airlines, accounting, agriculture etc.

I have no problem with you "drawing everyone's attention" to the fact that I think so. Indeed I consider the above to be self-evident, because humans aren't angels.

Maybe you confuse policing with censorship or political pressure? That is not the same thing.

"The rest is just rhetoric."

Nope, you just prefer to ignore the 800 pound gorilla in the room whose name is "replication crisis". Partly caused by outright fraud.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by CyberDildonics on Friday October 03, 2025 @09:50AM (#45463023)
By definition things that are true are science and things that have no evidence are religion.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by mediaman on Thursday October 02, 2025 @10:48PM (#45458375)
That understanding of what science is, in its de facto form of practice to date, is remarkably ungrounded from the history of science.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ants_everywhere on Thursday October 02, 2025 @11:18PM (#45458576)
Nope it's remarkably consistent with the history of science, which I've studied pretty extensively.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by eamag on Sunday October 05, 2025 @03:27AM (#45479577)
do you have any result of this study, like an essay or a video? Would be curious to read too
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by sho on Thursday October 02, 2025 @11:09PM (#45458528)
This just sounds like rationalization to me, just-so stories we tell ourselves to feel better about something we can't change anyway, so isn't it lucky that everything is perfect just the way it is!

I think it's nonsense. Society is the way it is because of the prevailing conditions. We haven't really had to deal with getting rid of dead wood in science because death always did that anyway, if death goes away then we'll just adapt. That witticism from Planck is just an observation of the times, not some universal, uh, constant.

> There is plenty of reason to welcome death

Maybe we should welcome it even faster then! If death speeds up science so much, then maybe society shouldn't provide health care to scientists at all. In fact maybe we should euthanize all scientists at age 50 - or earlier. Right?

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ethbr1 on Thursday October 02, 2025 @11:22PM (#45458608)
Ask yourself if most older people reliably update their beliefs as the world changes.

If the answer is "No, they don't," then it follows that part of progress is newer generations moving into positions of authority and bringing their new ideas with them.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by modeless on Friday October 03, 2025 @12:22AM (#45458955)
Part of curing aging would be restoring youthful brain characteristics such as openness to change. Which honestly seems like a small and easy task when compared to the whole endeavor of curing aging.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @02:57AM (#45459867)
It's not that old people are not open to change, they just very reasonably disregard all the bullshit that contradicts their experience. To achieve plasticity of beliefs people will have to forget stuff.

Which closes the circle, nature already invented all that: your kids are a version of you that's free from both the baggage of harmful mutations and the baggage of harmful presuppositions.

Not at all clear to me why we want to reinvent an inferior version of this process, it works remarkably well.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ben_w on Friday October 03, 2025 @03:33AM (#45460116)
> Not at all clear to me why we want to reinvent an inferior version of this process, it works remarkably well.

That sounds like something that someone who is not open to change would say.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @04:15AM (#45460375)
Absolutely. Progress is a delicate balance of accepting change and being conservative.

Not all change is worth accepting, but if I'm wrong about this one my death will eventually put an end to me being wrong.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @04:49AM (#45460611)
That's an inversion of Pascal's wager. Pascal says if I'm right about this my death will reward me, therefore I believe, and you've come up with if I'm wrong about this my death will criticise me, therefore I believe.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @06:15AM (#45461167)
Do you agree with the Pascal's wager then? I don't and if mine is an inversion, I don't see a problem with it.

It's not scary to make a mistake if any decision you make is temporary anyhow. Knowing that I die no matter what I do with my life gives me so much more freedom in how I can live it.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @06:58AM (#45461423)
I think it's the same kind of idea, because it shuts down any duty to worry about whether you are right. You get to be a dogmatist, since dogmatists die eventually.

The second sentence deserves some response, but I don't know what to make of it. Mistakes are good, surely? More mistakes faster. Well, I suppose you mean something like life-ruining mistakes, but in the first place I'm not sure there really can be any - unless you have a low threshold for "ruined" - and in the second place, immortality gives you endless hope of staging a comeback.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @07:17AM (#45461563)
I don't really see an issue with it either, though it depends on what exactly you mean by a dogmatist.

Literally everyone operates within some framework of unprovable dogmas to be able to tell good from evil and to decide how to act. Accepting that fact is a IMO a better path than striving for some sort of non-existent objective skepticism (but that's only better within my framework of what better is, of course).

And surely I worry whether I'm right, and all the time. It's just that when I worry and estimate the expected value of my decisions, I don't get NaNs and INFs. My life is not infinitely valuable to me, engaging in activities that involve possible loss of my life is often a good decision because the upside is good. That's largely true because I die anyway, I'm not sure the same calculations would hold if I were immortal.

UPD to respond to the second part that was added later

> Well, I suppose you mean something like life-ruining mistakes, but in the first place I'm not sure there really can be any - unless you have a low threshold for "ruined" - and in the second place, immortality gives you endless hope of staging a comeback.

It's remarkably easy to ruin your life by dying or getting a permanent disability. Would you climb a mountain with a risk of avalanches and rockfalls if you were otherwise immortal? Even commuting to work by bicycle becomes questionable, chances of getting hit by a car on a crossing are pretty high compared to taking the metro.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @07:46AM (#45461779)
I almost completely disagree with "everyone operates within some framework of unprovable [moral] dogmas", but I don't completely disagree. I think the potential for mind-changing debate about moral matters - some of it inexplicit, but still rational - is enormous: and that the dogmatic cores of almost everyone's moral worldviews are, in modern times, practically identical, or close enough to be compatible.

More to the point, you can refrain from being unnecessarily dogmatic. As I'm sure you do really. But that means anticipation of death, to wipe out your ideas, shouldn't diminish your will to filter them through argument or thought. It just acts as a safety mechanism against your possibly losing your grip on rationality and becoming an intransigent old nuisance, I suppose.

So the second point is that self-sacrifice is less expensive for the mortal. I guess that could be seen as a rather cold fact that a mortal person is less valuable. But immortal people could be hindered by being all neurotic about risks to their lives, if that even is how we make decision about self-sacrifice and mortal danger (however mild - germs?) ... but I suspect that isn't a calculation we'd do, even if immortal. I suspect the basis for these decisions is something different. This makes me scratch my head, I may come back to it.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by _DeadFred_ on Friday October 03, 2025 @11:50AM (#45464315)
Yes. Older people are much more flexible as they have had to adopt new thinking, been exposed to much more new ideas, realized the mistakes dogmatic young them did. Young people seem much more rigid and dogmatic to their much shorter held and therefore often much lesser informed positions.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @02:50AM (#45459824)
> In fact maybe we should euthanize all scientists at age 50 - or earlier. Right?

I understand you're trying to perform reductio ad absurdum but I would like to point out that the proposition is less absurd than you make out.

E.g. if Ancel Keys died at 50 then health risks of sugar consumption would have been accepted by the scientific community decades earlier saving tens of millions of lives. I certainly don't suggest to euthanize anyone however I'm glad he died eventually. In fact I'm glad everyone dies eventually me included.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @04:05AM (#45460306)
So you advocate a traditional, orderly, socially acceptable form of killing everybody, by maintaining traditional death against possible ways to overcome it.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @04:16AM (#45460380)
Correct
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @04:19AM (#45460398)
It's got a certain appeal, but I'm undecided. Will I be allowed to opt out?
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @06:08AM (#45461137)
It's a bit far, but I think countries and societies will be split around this question if or when such a technology comes. You'll definitely find a place to opt out, I would stick/move to a country where immortality is illegal.

Now if my world model is correct, the immortal societies will see a decline akin to the Byzantine empire (which never actually declined, just progressed slower than it's neighbors). As the result they will either succumb and integrate into their mortal counterparts or perhaps continue existing like some sort of native tribal reservations. If I'm wrong, the inverse will happen.

In the end the more effective and stable socioeconomic model wins because it's the only thing that matters in the long run. It may take a while to reach the equilibrium though.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @07:00AM (#45461436)
Very good! This sounds groovy, let the competition pan out how it will.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by m463 on Thursday October 02, 2025 @11:14PM (#45458558)
code reviews could go much quicker...
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by manmal on Friday October 03, 2025 @03:26AM (#45460066)
I don’t know where I saw that number, but supposedly the mean age of an immortal human will be 500 years due to accidents. True immortality is not a thing.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by pas on Friday October 03, 2025 @10:22AM (#45463350)
mind uploading and backups
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by cmccart on Friday October 03, 2025 @02:24PM (#45466076)
Maybe 500 years by today's behavioral standards. I assume that if people were told you could live ~forever barring an accident leading to your death, many people in society would behave VERY differently. The risk profile of you or me getting in a car to drive to the store is VERY different than someone with age-and-sickness-proof-but-accident-vulnerable immortality.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by kevlened on Friday October 03, 2025 @10:50PM (#45470110)
It also increases the cost of martyrdom.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by nojs on Saturday October 04, 2025 @01:13AM (#45470680)
Incidentally this is one reason why people in the past seemed braver than now and did crazier things. When your life expectancy is 25, you take a lot more risks.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ben_w on Friday October 03, 2025 @03:27AM (#45460073)
> There is plenty of reason to welcome death.

Only when painfully ill, this reverses old age symptoms correlated with some of those painful conditions.

> As Max Planck observed: "Science progresses one funeral at a time".

If the aphorism was causally true, Spanish Flu, the Nazi's death camps, and Pol Pot's Cambodia would've created a lot more science than they did.

Even for politics: the Holodomor didn't end Stalin; the deaths in WW1 didn't change the world order enough to prevent WW2.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by inglor_cz on Friday October 03, 2025 @05:23AM (#45460848)
You don't understand the aphorism if you think that death in itself causes scientific progress.

It means something else. When old, entrenched scientists die, they lose their ability to prevent younger scientists from studying topics they personally don't like. Dead people cannot deny the living use of labs, grants etc.

Plenty of otherwise impeccable great minds died "stuck" on bad ideas. For example, the great German pathologist Rudolf Virchow utterly rejected the idea of archaic humans existing, and did his best to slow down the research on the Neanderthals etc.

Einstein himself rejected the quantum theory, though, to his credit, he didn't prevent others from studying it.

Ancel Keys, who lived to be almost 100, tried to destroy career of every nutritional scientist who toyed with the idea that saturated fats may not be the killers he pronounced them to be, and defended sugar from more scrutiny.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by kiba on Friday October 03, 2025 @07:47AM (#45461799)
I distrust aphorisms, not without having read the literature on the evidence or lack thereof behind the aphorism.

For example: History is written by the winner.

Certainly not true on its face. The South managed to convince people that the confederacy cause was noble. It certainly wasn't. They managed to reshape popular narrative.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by inglor_cz on Friday October 03, 2025 @08:18AM (#45462089)
History is written by the winner. does not mean that everybody trusts what is written by the winner. It has also become somewhat weaker in the era of digital communication, when censorship of sources becomes harder.

"The South managed to convince people that the confederacy cause was noble. "

A certain percentage of people will believe in anything. Putin is a virtuous peacemaker, Nazis didn't murder people in industrial ovens, Stalin was a good person, the American Civil War wasn't about slavery, you name it.

That still does not negate the overall observation expressed in the aphorism: winners have a lot more clout when determining how the war will be seen by future generations. The percentage of Confederacy supporters in the Western civilization is fairly small. They may be visible, but the vast majority of the Western population, to the extent that they think of ACW at all, don't support the cause of continuing enslavement of blacks.

Anyway, aphorisms shouldn't be treated like mathematical theorems. Their validity isn't as "hard" as that of maths, but in human society, nothing is. Aphorisms are the sort of model which is "wrong, but sometimes useful".

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by kiba on Friday October 03, 2025 @09:22AM (#45462718)
Anyway, aphorisms shouldn't be treated like mathematical theorems. Their validity isn't as "hard" as that of maths, but in human society, nothing is. Aphorisms are the sort of model which is "wrong, but sometimes useful".

I am not treating them as mathematical statement, I just don't take it for granted that these "aphorism" are in fact historical truth.

Cursory search of "winners write history" already reveal to me a far more complex and nuanced reality. Indeed, such a statement is considered harmful.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ben_w on Friday October 03, 2025 @06:44AM (#45461344)
If (and to the extent that) the aphorism isn't causal, then it is irrelevant to a hypothetical where we solve death.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by inglor_cz on Friday October 03, 2025 @08:04AM (#45461959)
You still don't understand what is being said, and what precisely is the line of causality there.

Maybe someone else can explain it better than I can.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by pas on Friday October 03, 2025 @10:39AM (#45463541)
there's no need to understand it, as being healthy well after being alive for hundreds of years would incentivize a lot of people to do more with their life than clutching their academic pearls.

even if not, the aphorism is not a necessity. scientific progress is a very soft thing anyway in most fields (medicine for example), and just because nowadays when the old guard dies off a new paradigm takes over doesn't necessarily mean that were the old guard alive there wouldn't be paradigm shifts!

simply accumulating the necessary data to convincingly be able to claim that the new model is better takes decades ... which conveniently coincidences with some old dog dying.

sure, likely if the old guard would be alive for a few more decades maybe they would insist on even more convincing data.

but that would at least help us to have better science!

and no one is prohibited from exploring applications of the new models before they became de facto dogma!

... and so on.

most of the time progress is limited by methods (data collection, precision - repeatability, and of course replicability), but those are usually limited by engineering, culture, funding, etc.

see the whole story with Alzheimer's and the first mouse model problem, and the failed clinical trials of various treatments, and ... despite all this how still we have no better idea, despite decades of effort!

https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...

https://www.astralcodexten.com/p/your-review-of-mice-mechani...

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by UltraSane on Friday October 03, 2025 @03:53PM (#45467090)
Science might progress faster if people can spend hundreds of years becoming experts in multiple fields.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @12:47AM (#45459075)
Many people here have kids, it changes the way you see life and death quite a bit.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by AndrewDucker on Friday October 03, 2025 @04:31AM (#45460485)
Yes, it's made me determined to live as long as possible, so that I can see more of my kids' lives.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by munksbeer on Friday October 03, 2025 @07:28AM (#45461641)
I have kids. I want to live much longer.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by subscribed on Friday October 03, 2025 @11:55AM (#45464370)
I have kids. The current crop of the politicians in the most important/impactful countries is frankly terrifying.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by Terr_ on Friday October 03, 2025 @03:23AM (#45460037)
I think the last several months have been very un-optimistic for quite a lot of us. Especially when it comes what's being done by aged people that have also accumulated power.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by inglor_cz on Friday October 03, 2025 @04:52AM (#45460627)
I don't particularly like death, but the potential societal stasis caused by longer lives is a problem as well.

Already when living to our 80s and 90s, we can see the top strata of the society (CEO level, Parliaments) overflowing with very old people who don't want to relax their grip on power. The current US Senate is older than the Brezhnev politburo, widely considered a gerontocracy, once was. It is the same elsewhere. Few powerful people are as self-aware as Benedict XIV. was, or their lust for power is simply too big.

In autocracies, people like Putin, Erdogan, Khamenei and Xi built very resilient systems that could support them for decades, if not centuries, and death is the only way that can reliably get them out of the way.

I suppose that not even the Americans would like to see various replays of Biden vs. Trump for several election cycles, and the Supreme Court is a veritable gerontocracy as well. If longevity research succeeds, the younger justices like Gorsuch and Barrett may well stay on the bench until 2070 or even longer, shaping rules for a world they will no longer understand.

If we ever are to achieve very long lives, we need to expand into the universe as well, so that the younger generations can build their own domains somewhere else, unburdened by the dictates of the old.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by profstasiak on Friday October 03, 2025 @05:02AM (#45460701)
seriously, HN has gone mad recently. The amount of doom in commentators is just off the chart.

I always loved going into HN comments, because the insights you could read here were very often of better quality than linked sources.

Now it's mostly doom and despair

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by munksbeer on Friday October 03, 2025 @07:28AM (#45461635)
I've been reading HN for a number of years, I think I only discovered it around 2018. I didn't register at first. It felt better then, but that could be my wrong memory.

I really agree with you. I wish I could find somewhere with as many interesting people to discuss technology and/or science without so much pavlovian cynicism.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by dingdingdang on Friday October 03, 2025 @05:09AM (#45460754)
This is literally amazing research, just because we are getting closer to rejuvenating tissue does not imply that suddenly we will stop dying - it just means vastly increased health span which means less health care cost and more joy in life! Congratulations to the authors of this paper!
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by Larrikin on Friday October 03, 2025 @12:12PM (#45464574)
I expect if people use healthcare 2x less, then the insurance companies and other companies that make their money from the sick will simply charge 4x more when you need healthcare.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by AngryData on Friday October 03, 2025 @07:58PM (#45469143)
Im not sure this will reduce healthcare costs very much since age related care is already the largest bulk of healthcare costs and living longer at an advanced age, even if relatively healthy, gives more time to accrue costs and age related problems.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by WhereIsTheTruth on Friday October 03, 2025 @07:04AM (#45461468)
Death holds profound significance, it acts as a mental reset

Accumulating traumas across an eternity would harm society

And I think it's unfair to reserve that for the wealthy, if anything, eugenics should determine who gains access, only the most genetically advantaged should be allowed, in an effort to protect and strengthen humankind

But I don't think our society is ready to have this discussion, hence why, aging and death should not be frowned upon

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by bilsbie on Friday October 03, 2025 @09:27AM (#45462770)
It’s kind of new anti human belief system that a lot of people Here have.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by subscribed on Friday October 03, 2025 @11:50AM (#45464318)
Just imagine Putin, Netanyahu, Musk, Thiel and Trump living 2x longer in the great health.

Because this technology won't be available to these raising the humanity, but to those ruthless.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by tomhowsalterego on Friday October 03, 2025 @12:39PM (#45464874)
Yeah I’m imagining people living 2x as longer in the great health.

I don’t see any problems. If you want to kill someone, go ahead, that’s between you and them and your reasons for thinking they should die at a certain age. But I have no qualms about anyone living longer, healthier lives. This includes you.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by orionsbelt on Friday October 03, 2025 @01:23PM (#45465342)
I like it here but this place has always been dour and pessimistic.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by snapplebobapple on Friday October 03, 2025 @08:28PM (#45469355)
Really? I am surprised it is this low.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by jibal on Saturday October 04, 2025 @05:45AM (#45472066)
Equating realism to pessimism is intellectually dishonest.

I'm at an age where many of my friends have died and many more soon will. Even in the most optimistic scenario this technology will not become normalized in my lifetime--and if it does become normalized there will be many undesirable consequences. In any case, global warming will destroy human civilization and this technology will die with it.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by littlestymaar on Saturday October 04, 2025 @07:44AM (#45472613)
Tolkien didn't call death “The gift of Ilúvatar” for nothing.

In fact, even in our world, age-related death is an evolved trait, this isn't something obvious but that's something that arised through the natural selection because it improves fitness.