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Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ethbr1 on Thursday October 02, 2025 @11:22PM (#45458608)
Ask yourself if most older people reliably update their beliefs as the world changes.

If the answer is "No, they don't," then it follows that part of progress is newer generations moving into positions of authority and bringing their new ideas with them.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by modeless on Friday October 03, 2025 @12:22AM (#45458955)
Part of curing aging would be restoring youthful brain characteristics such as openness to change. Which honestly seems like a small and easy task when compared to the whole endeavor of curing aging.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @02:57AM (#45459867)
It's not that old people are not open to change, they just very reasonably disregard all the bullshit that contradicts their experience. To achieve plasticity of beliefs people will have to forget stuff.

Which closes the circle, nature already invented all that: your kids are a version of you that's free from both the baggage of harmful mutations and the baggage of harmful presuppositions.

Not at all clear to me why we want to reinvent an inferior version of this process, it works remarkably well.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by ben_w on Friday October 03, 2025 @03:33AM (#45460116)
> Not at all clear to me why we want to reinvent an inferior version of this process, it works remarkably well.

That sounds like something that someone who is not open to change would say.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @04:15AM (#45460375)
Absolutely. Progress is a delicate balance of accepting change and being conservative.

Not all change is worth accepting, but if I'm wrong about this one my death will eventually put an end to me being wrong.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @04:49AM (#45460611)
That's an inversion of Pascal's wager. Pascal says if I'm right about this my death will reward me, therefore I believe, and you've come up with if I'm wrong about this my death will criticise me, therefore I believe.
Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @06:15AM (#45461167)
Do you agree with the Pascal's wager then? I don't and if mine is an inversion, I don't see a problem with it.

It's not scary to make a mistake if any decision you make is temporary anyhow. Knowing that I die no matter what I do with my life gives me so much more freedom in how I can live it.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @06:58AM (#45461423)
I think it's the same kind of idea, because it shuts down any duty to worry about whether you are right. You get to be a dogmatist, since dogmatists die eventually.

The second sentence deserves some response, but I don't know what to make of it. Mistakes are good, surely? More mistakes faster. Well, I suppose you mean something like life-ruining mistakes, but in the first place I'm not sure there really can be any - unless you have a low threshold for "ruined" - and in the second place, immortality gives you endless hope of staging a comeback.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by alexey-salmin on Friday October 03, 2025 @07:17AM (#45461563)
I don't really see an issue with it either, though it depends on what exactly you mean by a dogmatist.

Literally everyone operates within some framework of unprovable dogmas to be able to tell good from evil and to decide how to act. Accepting that fact is a IMO a better path than striving for some sort of non-existent objective skepticism (but that's only better within my framework of what better is, of course).

And surely I worry whether I'm right, and all the time. It's just that when I worry and estimate the expected value of my decisions, I don't get NaNs and INFs. My life is not infinitely valuable to me, engaging in activities that involve possible loss of my life is often a good decision because the upside is good. That's largely true because I die anyway, I'm not sure the same calculations would hold if I were immortal.

UPD to respond to the second part that was added later

> Well, I suppose you mean something like life-ruining mistakes, but in the first place I'm not sure there really can be any - unless you have a low threshold for "ruined" - and in the second place, immortality gives you endless hope of staging a comeback.

It's remarkably easy to ruin your life by dying or getting a permanent disability. Would you climb a mountain with a risk of avalanches and rockfalls if you were otherwise immortal? Even commuting to work by bicycle becomes questionable, chances of getting hit by a car on a crossing are pretty high compared to taking the metro.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by card_zero on Friday October 03, 2025 @07:46AM (#45461779)
I almost completely disagree with "everyone operates within some framework of unprovable [moral] dogmas", but I don't completely disagree. I think the potential for mind-changing debate about moral matters - some of it inexplicit, but still rational - is enormous: and that the dogmatic cores of almost everyone's moral worldviews are, in modern times, practically identical, or close enough to be compatible.

More to the point, you can refrain from being unnecessarily dogmatic. As I'm sure you do really. But that means anticipation of death, to wipe out your ideas, shouldn't diminish your will to filter them through argument or thought. It just acts as a safety mechanism against your possibly losing your grip on rationality and becoming an intransigent old nuisance, I suppose.

So the second point is that self-sacrifice is less expensive for the mortal. I guess that could be seen as a rather cold fact that a mortal person is less valuable. But immortal people could be hindered by being all neurotic about risks to their lives, if that even is how we make decision about self-sacrifice and mortal danger (however mild - germs?) ... but I suspect that isn't a calculation we'd do, even if immortal. I suspect the basis for these decisions is something different. This makes me scratch my head, I may come back to it.

Re:Anti-Aging Breakthrough: Stem Cells Reverse Signs of Agin... by _DeadFred_ on Friday October 03, 2025 @11:50AM (#45464315)
Yes. Older people are much more flexible as they have had to adopt new thinking, been exposed to much more new ideas, realized the mistakes dogmatic young them did. Young people seem much more rigid and dogmatic to their much shorter held and therefore often much lesser informed positions.