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Re:How long til we're all on Ozempic? by mrshadowgoose on Friday October 11, 2024 @05:07PM (#41813758)
> Why do we find it acceptable to help people who struggle with alcohol abuse, or nicotine addiction, or opioid addiction, but not to help people who struggle with food abuse?

"Getting fit and staying fit" is a form of social capital, because it's extremely hard and only within reach of a small portion of the population. "Being fit" is strongly aligned with "being attractive" which confers all sorts of cross-cutting social benefits.

Some people feel cheated when medication allows others to "effortlessly" join this social club, and then become vile and hateful in response.

Re:How long til we're all on Ozempic? by unclad5968 on Friday October 11, 2024 @05:39PM (#41814035)
In what ways is fitness not within reach for a large portion of the population?
Re:How long til we're all on Ozempic? by timeinput on Friday October 11, 2024 @06:14PM (#41814371)
Something like 15% of the world lives in extreme poverty. This is darn near the best it's been in the history of the world (there used to be much more poverty by percentage), but this group would likely have trouble being fit. They might be skinny, but surely not fit.

Ignoring that extreme the questions maybe different: How many hours does a median person have free from work, commute, and sleep? How much time must be spent managing exercise and diet to achieve fitness?

I think if you took the time to answer those questions for the median or modal non-impoverished person in the world you might find that fitness is actually quite difficult to achieve.

It seems really hard in the US.

Re:How long til we're all on Ozempic? by itsoktocry on Friday October 11, 2024 @09:37PM (#41815615)
I don't understand, impoverished people aren't taking Ozempic, either.
Re:How long til we're all on Ozempic? by laeri on Saturday October 12, 2024 @01:49AM (#41816758)
Parent poster wasn't referring to Ozempic but a general healthy lifestyle. Which requires resources many people do not have such as time, money, education etc.
Re:How long til we're all on Ozempic? by cashsterling on Saturday October 12, 2024 @02:07AM (#41816835)
The work-life balance & climate in some areas of the US (and other areas of the world) does make it hard to exercise... but that's only part of the story.

Eating healthier requires very little extra time: perhaps 2-3 hours a week for shopping and meal prep.

- making a salad take 5 minutes.

- baking 10 meals worth of chicken takes 30-45 minutes, with about 5-10 minutes of actual prep time.

- baking a few meals worth of salmon, or some other fish is about the same as chicken.

- cutting up an apple takes 1-2 minutes. Bananas, peaches are ready to go, almost no prep required.

- steaming fresh broccoli takes 3-5 min of prep... and about 15-20 minutes total.

- Equally important is making small decisions to avoid or limit less healthy foods, which requires no time at all and often saves us money [that we can spend on healthier foods instead].

Exercising: 30-60 minutes a day, most days, is ideal but anything is better than nothing. A morning and evening 20 minute walk is great place to start (and can be so relaxing). If a person spends time on Hacker News, they could instead allocate that time to exercise. There are free 15 minutes yoga videos on Youtube. A set of push ups requires 60 seconds. Sometimes I do body weight squats at my desk at work (especially during Teams calls, camera off of course).

Sleep: get at least 7 hours of sleep a night... ideally starting to bed before 11pm. more sleep gives us more energy to put towards being awesome during the day and more energy for exercise and doing the extra work to eat better.

I think almost everyone can set aside 6-10 hours in their week towards building their health. It is a matter of priorities... a person's health should be one of their top priorities.

Re:How long til we're all on Ozempic? by mrshadowgoose on Friday October 11, 2024 @05:54PM (#41814188)
Studies have repeatedly shown that lifestyle modification does not result in sustained weight loss for most.

Not going to waste my time providing sources to remedy your ignorance. You are more than capable of doing this research yourself.

Re:How long til we're all on Ozempic? by zamadatix on Friday October 11, 2024 @07:31PM (#41814949)
Proving a negative is a hard and sometimes annoying in itself ask plus you're probably frustrated with the general attitude to this kind of conversation (especially if your main expectation/experience is others don't like the pill answer out of spitefulness) but that doesn't make this kind of response any more okay here.

For others open to listening to why it's often out of reach: Outside the go-to "motivation" type discussion gravitation (and, keep in mind, not everyone can just 'motivate themselves past their addictions' in the first place or they wouldn't be addictions) it is also disproportionately hard for those struggling in other ways of life (financially, mentally, physically/genetically). Some of these can be cascaded effects, like support systems (e.g.not everyone's partner is willing or able to go all in on it like above). Others can be that it is medically not as easy for some people to lose weight at a given intake amount which makes it just that much harder.

Most people would like very VERY much to be fit. That most still aren't fit should be a good indicator it's out of most's reach to "just eat less" independently. All this said as a person who is not overweight themselves but has been around many people in different situations, abilities, and luck that have left them unable to be so as well.

Re:How long til we're all on Ozempic? by JamesBarney on Friday October 11, 2024 @06:31PM (#41814493)
Yeah the problem with providing a study is that proving a negative is so hard. Everyone assumes there exists a successful RCT with a 5-10 year time horizon for weight loss via lifestyle interventions. And there just isn't one, and the only way to know that is to search for one.
Re:How long til we're all on Ozempic? by artursapek on Friday October 11, 2024 @07:23PM (#41814913)
How does "burning more calories than you consume" not result in weight loss for most people, lmao?
Re:How long til we're all on Ozempic? by sethammons on Saturday October 12, 2024 @09:30AM (#41818928)
How do people not realize that the digestive system is dynamic and that as you change the calories in (and the type of calories) that the body changes the out.

You can't outrun thermodynamics. But your body will change its efficiency.

Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @11:19AM (#41819728)
Because your metabolism changes. If you ate 700 calories per day it would be harder for you to lose weight than if you ate 1400 and worked out.

You’d still be eating less, but retaining more weight. Why? Because your metabolism slows down significantly if you don’t fuel it, and that makes it harder to lose weight, not easier.

Most things in life are not binary, and are affected by more than just a single choice.

Re:How long til we're all on Ozempic? by artursapek on Saturday October 12, 2024 @02:21PM (#41821203)
Yeah. So that's why working out is the solution lol. How is this controversial?
Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @02:24PM (#41821232)
Because working out, alone, is not the solution. You could work out all day and still not lose a pound. Plenty of studies have shown this.

Moreover, have you ever tried to work out at 450 lbs? No? It is an immense effort, often literally impossible for most people at that weight, and the best they can manage is a walk around the block before their cardio can’t keep up.

What then?

See above, where I reminded people (which includes you) that things are rarely binary.

Re:How long til we're all on Ozempic? by artursapek on Saturday October 12, 2024 @08:00PM (#41823886)
they could like roll around idk
Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @08:47PM (#41824159)
Cool. Let me know if you figure out a solution.

Otherwise, perhaps let people get healthy instead of admonishing them to get healthy the way you think they should, which turns out to be… the same way they have always tried and has not worked.

Re:How long til we're all on Ozempic? by artursapek on Sunday October 13, 2024 @09:06AM (#41827700)
Bringing up mortally obese 450lb people (a tiny fraction of the population) is not a good faith argument against my position that it's a travesty Ozempic and other "weight loss drugs" are being prescribed to people en masse when most of them actually are very capable of just eating more healthy diets and exercising more. What we actually need to do is un-fuck our food supply and encourage healthier lifestyles... not give big pharma yet another chokehold over the population.
Re:How long til we're all on Ozempic? by borski on Sunday October 13, 2024 @12:00PM (#41829100)
Fine. I was 265. Not morbidly obese, just obese.

The rest of my argument still holds if you change that.

Your contention of “most of them actually are very capable of just eating more healthy diets and exercising more” is a nonsensical assumption, based on no data, and a prejudiced assumption that they are lazy and haven’t tried, ever.

> What we actually need to do is un-fuck our food supply and encourage healthier lifestyles...

Great. We should do that. I completely agree. It will definitely help our kids.

That won’t help anyone get healthy in this lifetime. It takes too long. Obesity would kill you first.

But you’re right, that’s probably better than taking a medication that is clearly helping people change their habits and get healthy, because you feel it would be better if they didn’t have the problem in the first place.

Nicotine gum and patches help curb smoking and change people’s habits. Why? Why not just force everyone to quit cold turkey, like my dad did? Should we just change the way we talk about smoking and produce fewer cigarettes? Sure.

But nicotine patches and gums saved lives and helped people quit that had never been able to before them, and not for a lack of trying.

GLP-1 meds are an aid. The alternative isn’t fixing the food supply, but dying from obesity.

Re:How long til we're all on Ozempic? by artursapek on Sunday October 13, 2024 @08:50PM (#41833119)
Cool, I hope you are on your way to a healthier weight. I can see why medication could help in the short-term for someone who has dug a deep hole. My reaction of disgust is towards the premise of "how long until we're all on Ozempic?" and the current state of affairs, where far too many people in the US are being medicated for that and various other things.
Re:How long til we're all on Ozempic? by borski on Monday October 14, 2024 @12:30AM (#41834198)
> ... where far too many people in the US are being medicated for that and various other things.

What, precisely, does this mean? If medication is appropriately prescribed, by well-educated and well-trained doctors who have, upon actually meeting the patient which neither of us has done, decided that this patient could benefit from said medication... why is that bad?

39.6 percent of U.S. adults are obese. If all of them were prescribed GLP-1 meds (which would definitely never be true, for lots of reasons), and if all of them got healthy because of it... that's bad? Simply because they used medication to help?

Clarify for me, please, why medication is somehow not allowed to be used as a tool to fight illness or injury. Because people should somehow be "stronger" and able to fight it more on our own, despite not having been able to in the past?

Re:How long til we're all on Ozempic? by artursapek on Monday October 14, 2024 @08:22AM (#41836848)
GLP-1 is not a get out of jail free card. It will have long-term side effects.

Mass medication is an undesirable state of the world because it doesn’t address the root of any problem. It simply negates or masks some of the effects. The Ozempic situation is just like how kids are now being prescribed Adderall in the millions, when really the problem is they are just given iPads too much and fed unhealthy food that causes ADHD. Adderall doesn’t address the cause. Then you end up with a slave population that needs this medication to function. which is only good for the pharma companies making money on those meds.

Re:How long til we're all on Ozempic? by borski on Monday October 14, 2024 @08:39AM (#41836960)
> GLP-1 is not a get out of jail free card. It will have long-term side effects.

Source? Because so far it seems like you and others really want it to have long-term negative effects, but that the evidence for that is made up and entirely in your head, to date.

> The Ozempic situation is just like how kids are now being prescribed Adderall in the millions, when really the problem is they are just given iPads too much and fed unhealthy food that causes ADHD. Adderall doesn’t address the cause.

Ah, finally, the mask comes off. Your issue is with people getting help for disorders and illnesses they have, period.

The trope that ADHD is caused by iPads is nonsense. ADHD is caused by an underdeveloped pre-frontal cortex. Plenty of kids actually have it. I did, for sure. I wish I had found out what ADHD was, instead of holding my preconception about what it was, much earlier in life. I didn’t need that struggle against a thing I could never beat, because your brain controls everything you do.

> Then you end up with a slave population that needs this medication to function. which is only good for the pharma companies making money on those meds.

Do you? Show me a “slave population” that “needs adderall to function.”

Re:How long til we're all on Ozempic? by artursapek on Monday October 14, 2024 @09:40AM (#41837430)
I think we can just agree to disagree lol. Yeah all of these problems are just naturally occurring and humans were screwed until Ozempic and Adderall were invented. Thank God for the pharma companies!
Re:How long til we're all on Ozempic? by borski on Monday October 14, 2024 @01:19PM (#41839631)
That isn’t what I said. You are conflating multiple things.

I agree we created many of these problems (food being unhealthy, for example).

I also agree fixing many of them would be good.

I don’t agree that that is the only way to help people, and I don’t agree with the implication that “all pharma is bad,” because I don’t make outlandish binary statements like that.

Re:How long til we're all on Ozempic? by antifa on Sunday October 13, 2024 @07:53PM (#41832796)
> What we actually need to do is un-fuck our food supply

Seems like something you could lead with instead of moronic gut reactions...

Re:How long til we're all on Ozempic? by artursapek on Sunday October 13, 2024 @08:51PM (#41833127)
There's nothing moronic about the argument that calorie deficits can cause weight loss. Most people using Ozempic have never tried multi-day fasting as an alternative. There are plenty of ways to lose weight that don't require taking medicine that might be fucking up your digestive system long-term.
Re:How long til we're all on Ozempic? by borski on Monday October 14, 2024 @01:24PM (#41839680)
> There's nothing moronic about the argument that calorie deficits can cause weight loss.

That’s not the argument you are making, and that is one I’d agree with.

> Most people using Ozempic have never tried multi-day fasting as an alternative.

Source? This is an assumption that requires data, because it is intuitively not true; and anecdotally, it is also not true.

This is purely a prejudiced assumption.

> There are plenty of ways to lose weight that don't require taking medicine that might be fucking up your digestive system long-term.

Or it might not, and hasn’t, at any meaningful scale, since 2005. Seems like you really want it to, though, and that seems like more a problem with you than it or them.

Re:How long til we're all on Ozempic? by paulddraper on Friday October 11, 2024 @06:30PM (#41814482)
Nor will I waste time proving the opposite.

Until next time we meet on the internet. :salute:

Re:How long til we're all on Ozempic? by wiseowise on Saturday October 12, 2024 @03:04AM (#41817040)
Oh well, back to my unhealthy lifestyle because study of some thousand something in one country said it’s impossible to change!
Re:How long til we're all on Ozempic? by unclad5968 on Saturday October 12, 2024 @01:47PM (#41820952)
I didn't ask if lifestyle modification resulted in sustained weight loss. I asked in what ways is fitness not accessible to the majority of people.
Re:How long til we're all on Ozempic? by aucisson_masque on Friday October 11, 2024 @07:04PM (#41814756)
Fitness require making efforts and determination.

Taking a pill doesn't.

That's why it will always be out of reach of some people.

Re:How long til we're all on Ozempic? by beeboobaa3 on Friday October 11, 2024 @06:59PM (#41814715)
just look around outside
Re:How long til we're all on Ozempic? by cashsterling on Saturday October 12, 2024 @01:40AM (#41816709)
Fitness is in reach for almost everyone on Hacker News. There are folks who have serious health issues or disabilities that preclude exercise... but the rest of us [the majority?] can walk more, do body weight squats, some form of incline push ups, and so forth and build larger successes on top of smaller ones. We can start by taking a morning and evening walk.

We all can make healthier decision about what food we put into our bodies (a lot could be done to make our food supply healthier, as well). I find I have to be more strict about eating right as I get older to maintain my health.

I feel like folks saying 'fitness' isn't in reach [for most/many of us] is a cop out. This is anecdotal, but i know people who have lost 100+ lbs in their 40's and 50's and completely turned their life around; I know people who have reversed Type-2 diabetes through diet and exercise. These people have busy lives with a lot of responsibility... some of these people live in city areas where access to gyms or outdoor spaces for walking, etc. is not convenient.

I have a few doctors and other medical professionals in my family... knowing what I know, I am 'almost terrified' of becoming metabolically unhealthy and overweight. Many of the maladies that afflict us are metabolic disorders (in whole or in part) due to the long term effects of poor diet, lack of exercise & quality sleep (high stress doesn't help either). Poor metabolic health tremendously increases risk of almost every disease and malady: diabetes, heart disease, heart attack, dementia & Alzhiemer's, many cancers, stroke, depression and other mental illnesses, sleep apnea, susceptibility to infectious disease, etc. Poor metabolic health also indirectly leads to higher likelihood of issues causing chronic pain: e.g., herniated discs in the spine, ankle/knee/hip problems, migraine headaches.

I'm glad Ozempic exists but it is not a cure... it is an aid towards building a healthier life. Use Ozempic as a tool, by all means!!, to start your journey and get yourself into a better situation physically. But please use that good start to pursue the 'best/healthy you'... do it for yourself.

Re:How long til we're all on Ozempic? by unlikelytomato on Friday October 11, 2024 @08:58PM (#41815439)
I would say my concerns are far more in the range of downstream effects from the medication. Specifically, I am concerned with muscle retention. Concerns aside, it's a little hard of an argument to swallow having visited many other countries where these things are simply not an issue. How can it be argued that the cause is anything other than behavior when so many others are doing just fine? There is more to this story than painting people as evil.
Re:How long til we're all on Ozempic? by bozleh2 on Friday October 11, 2024 @09:55PM (#41815692)
> How can it be argued that the cause is anything other than behavior when so many others are doing just fine?

Aren’t you are ignoring the way western society influences behavior? eg lack of walkability of suburbs, massive price difference between fresh and processed foods, constant advertising of junk food & alcohol.

Re:How long til we're all on Ozempic? by wiseowise on Saturday October 12, 2024 @03:01AM (#41817030)
How do people move around cities? They teleport?

Where there’s a will there’s a way.

> constant advertising of junk food & alcohol.

Nobody is forcing you to eat those.

Re:How long til we're all on Ozempic? by ruraljuror on Saturday October 12, 2024 @07:47AM (#41818424)
> Nobody is forcing you to eat those.

No, I think force feeding junk food is pretty rare but that seems like a straw man.

Consider children. Their brains are not fully developed and they have little agency in determining the food they have access to. Childhood obesity is on the rise. So blame the children’s choices?

Ok, sure, blame the parents. I agree of course it is the parents responsibility, but the cards are often stacked against parents by big corporations with government subsidies (in the us).

It’s really weird to me to argue that this is completely a problem at the individual level and not a social one—and I see no other way to interpret your comment.

Re:How long til we're all on Ozempic? by wiseowise on Saturday October 12, 2024 @09:53AM (#41819089)
> Consider children. Their brains are not fully developed and they have little agency in determining the food they have access to. Childhood obesity is on the rise. So blame the children’s choices?

Been there. It’s always bad parenting. I had to fix shitton of issues myself, because of idiot parents.

Re:How long til we're all on Ozempic? by unlikelytomato on Tuesday October 15, 2024 @08:08AM (#41847689)
The point is that the isn't some mysterious force we cannot comprehend. If the odds are stacked against us, change the odds instead of medicating everyone.

At the same time, we are all still individuals. We agency to make life decisions. I generally don't subscribe to the notion that people are helpless even in the face of a big scary corporation. There are two competing ideas. Either 1 there is some unknown force creating this problem(but doesn't extended to the entire human population for some reason) or 2 we know there are environmental causes. For #2, why systemically stack a drug on top if we know what the boogy man is? #1 we need to seriously buckle down on research on what the environmental/behavior factor is so we can bring everyone back to human baseline. Using drugs for people already in great suffering is one thing, but that is very different from widespread distribution as a preventative.

Re:How long til we're all on Ozempic? by ruraljuror on Tuesday October 15, 2024 @03:22PM (#41852153)
I think you lost the thread (literally the context of threads I was responding to), because much of what you’re saying aligns with my point. OP was mocking the idea that environmental factors should be taken into account and advocating a no-excuses policy of individual responsibility.

If you think I am advocating medication or implying that “people” are helpless against corporations, read again. I agree with most of what you say although I am not sure we need more research (although of course I don’t discourage it). Maybe one day we’ll prove that the government subsidizing corn so that big corporations (spun off from former tobacco companies as another comment pointed out) can super cheaply mass produce syrup which our evolutionary biology finds difficult to resist and market directly to children turns out to be bad for health outcomes and good for profits (for the medical industrial complex as well). Oh wait, we already know that.

Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @11:12AM (#41819685)
> Where there’s a will there’s a way.

Yeah? Even if I’m disabled, I should got for a walk, just because I want to?

Pretending the world is binary is a fun exercise, but it is always untrue.

Re:How long til we're all on Ozempic? by wiseowise on Saturday October 12, 2024 @03:23PM (#41821700)
We’re talking about people who are able but unwilling to make the effort.
Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @05:54PM (#41823031)
Are we? Because most people have this conversation and talk about people they think are able and unwilling, when in reality the vast majority are willing and unable, for one reason or another.
Re:How long til we're all on Ozempic? by partomniscient on Saturday October 12, 2024 @08:47PM (#41824164)
>Nobody is forcing you to eat those.

No, but social conditioning normalises it and those in the lower socioeconomic areas of living buy the cheapest rather than most nutritional food and are way less likely to read informative articles or posts about healthy eating. It really is heavily influenced by a lack of supply of healthy affordable food.

Re:How long til we're all on Ozempic? by ruraljuror on Saturday October 12, 2024 @07:35AM (#41818365)
Not sure why you are downvoted. I had the same question about who’s behavior we are referring to. Attributing obesity simply to individual behavior and choices is pretty myopic. Just look at government subsidies for corn. There are larger forces than the individual at play. This is a social problem.
Re:How long til we're all on Ozempic? by onionisafruit on Friday October 11, 2024 @11:32PM (#41816180)
Are you saying that us fatties should move to those other countries where our “behavior” will be kept in check?
Re:How long til we're all on Ozempic? by unlikelytomato on Saturday October 12, 2024 @04:06AM (#41817343)
I don't understand the hostility. I am attempting to discuss the topic on a discussion site. My point is not too instruct any one person on what the exact correct solution is. However, I find the selective vision with this topic to be dishonest and ultimately damaging to the conversation(and progress by extension). One can still come to the conclusion that drugs tip the balance positivity enough to use them without sweeping other realities under the rug.
Re:How long til we're all on Ozempic? by billyjmc on Friday October 11, 2024 @09:42PM (#41815637)
The “more to this story” is likely endocrine disruptors in addition to (and associated with) the other “behavior” issues you’re alluding to.

And our answer to it is… another endocrine disruptor. But this time we’ll call it something else (GLP-1 agonists) and laugh all the way to the bank.

Re:How long til we're all on Ozempic? by pizza on Friday October 11, 2024 @10:50PM (#41815992)
It seems the article is now behind a paywall (can only get a reddit link w/ a screenshot atm [0]) but there was a study that showed body composition after 25% weight loss in terms of fat mass and fat-free mass (and the portion of fat-free mass that was skeletal muscle mass) after traditional several interventions, and also compared the breakdown of weight lost in terms of FM and FFM for several GLP-1 medications:

- diet alone

- diet + extra protein

- diet + exercise

- retatrutide

- tirzepatide

- semaglutide

tldr is that, despite some muscle loss, muscle as a percentage of body composition is higher (~50% FFM at start, whereas weight lost with GLP-1 meds ranged from 25%-39% of muscle). It also seems like the muscles will likely function better with less insulin resistance:

> Intentional weight loss causes a greater relative decrease in body fat than FFM or SMM, so the ratio of FFM/SMM to fat mass increases. Accordingly, physical function and mobility improve after weight loss despite the decrease in FFM/SMM, even in older adults with decreased FFM and SMM at baseline. In addition, weight loss improves the “quality” of remaining muscle by decreasing intramyocellular and intermuscular triglycerides and increasing muscle insulin sensitivity

https://www.reddit.com/r/tirzepatidecompound/comments/1dtzr2...

Re:How long til we're all on Ozempic? by jvanderbot on Saturday October 12, 2024 @06:20AM (#41818047)
How will the person have less insulin resistance when GLP-1 medications stimulate the release of insulin?

It seems to me we're curbing eating by flooding with insulin, when one of the big damaging effects of overeating is insulin floods. (Or perhaps I'm misreading, perhaps insulin floods are only bad b/c they cause insulin resistance which causes more overeating?)

Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @11:04AM (#41819607)
You aren’t being flooded with insulin with the GLP-1 meds. You have food in your body, but my insulin levels, on average, are possibly lower than yours (if I’m in need or a GLP-1 med) despite eating the same amount.

A GLP-1 med stimulates the release of insulin slowly over a sustained period of time, not just as a massive spike when I eat.

Everyone (that isn’t diabetic) has a massive insulin spike when they eat something that spikes their glucose. GLP-1 meds don’t make that better in any way.

Re:How long til we're all on Ozempic? by edanm on Saturday October 12, 2024 @02:10AM (#41816847)
> Concerns aside, it's a little hard of an argument to swallow having visited many other countries where these things are simply not an issue.

Which countries? As far as I know, most Western countries have roughly similar issues with obesity, at least directionally.

Re:How long til we're all on Ozempic? by Veen on Saturday October 12, 2024 @04:24AM (#41817439)
It can be quite eye-opening to travel from say, the UK to Hungary. Walk down a busy street in London and you'll see many overweight people. Walk down a similar street in Budapest, and you'll see very few.
Re:How long til we're all on Ozempic? by cco on Monday October 14, 2024 @04:21PM (#41841508)
The numbers don't seem to bear out your impression, Hungary has higher rates overall than the UK. Perhaps there is more social mixing in the neighborhoods you visit in London vs Budapest.
Re:How long til we're all on Ozempic? by jvanderbot on Saturday October 12, 2024 @06:17AM (#41818034)
This is the essence of the moral argument: Someone chooses to abuse a substance, they become a more frequent abuser, and the abuse piles up damage, which the person ignores to continue abusing.

The essence of the argument against drug interventions is that the root cause is personal choice, and therefore a drug is a shortcut or crutch and does not address the root cause.

Many people feel that the real cause is the structural changes to the person's brain, body, and daily routine that reinforce, and are reinforced by the initial tiny over-consumption, which compounds over time. It's like a debt where you are stuck paying interest, no matter how much you'd like to pay off the debt. Addiction is a system in which the person's willpower goes against everything they have set up over decades. It's unreasonably challenging for nearly everyone to walk it all back. Insulin resistance is one of the most pernicious effects of even small over-eating over time. The body and mind do not feel satiated even though enough calories have been consumed. It's not "I would enjoy another slice of pizza", it can be "I am still starving".

And yes, the environment in which we live, where it is less stigmatized to overeat, and food is treated a certain way, more like a drug than fuel, is part of that system.

Re:How long til we're all on Ozempic? by scotty79 on Saturday October 12, 2024 @07:33PM (#41823714)
I think some of the observed muscle loss might be just burning the fat tissue embedded inside muscles (marbling).
Re:How long til we're all on Ozempic? by room500 on Tuesday October 15, 2024 @09:09AM (#41848189)
Some, but sarcopenia caused by rapid weight loss is a well known phenomenon. I think the tie to ozempic is a little overblown, but is is a real issue.

In a “traditional” weight loss strategy, you paired calorie deficit with an increase in physical activity (cardio, resistance training, etc). This increased physical activity helped protect you from muscle loss (your body tended to recognize that muscle was important so it burned fat at a higher rate)

With ozempic, people can lose weight without changing their sedentary lifestyle. Since your muscles are not needed, your body is free to grab energy from wherever it can. In some studies, almost half of weight loss can come from lean tissue.

Is it better to for an obese person to lose weight vs not lose weight? Absolutely. But it would be even better if they also changed their lifestyle to protect their muscle mass.

Re:How long til we're all on Ozempic? by scotty79 on Wednesday October 16, 2024 @05:43AM (#41857231)
I'm curious how is lean mass measured and why do we think what we measure is actually lean.

I'm not denying that under some circumstances like in the case of severely obese patients their bodies might think protein is better energy source than fat but in people with normally functioning bodies it shouldn't happen a lot especially if they get enough protein in their weight loss diet.

Re:How long til we're all on Ozempic? by zero-sharp on Friday October 11, 2024 @10:09PM (#41815773)
>Some people feel cheated when medication allows others to "effortlessly" join this social club, and then become vile and hateful in response.

Nice one. I think it's a bad idea to be dependent on drugs for something you can achieve on your own, especially if the drugs don't have a long term safety profile. Pretty sure I read somewhere that they don't. If you're going to use them for a short period of time, that's fine. Don't say nobody warned you if that doesn't pan out though (or worse, you have a bad drug response).

Re:How long til we're all on Ozempic? by l2silver on Friday October 11, 2024 @10:44PM (#41815949)
> Some people feel cheated when medication allows others to "effortlessly" join this social club, and then become vile and hateful in response.

I don't think this is just about a social club. Battling weight loss and habits is foundational to the human experience from the most recent centuries. Be it drugs, or anything else really that changes the nature of these challenges, people are going to feel discomfort because it's an attack on their understanding of the world, and in some ways, their beliefs.

Re:How long til we're all on Ozempic? by cromka on Saturday October 12, 2024 @04:42AM (#41817565)
The idea is this drug kick starts people to form new habits going forward. As witnessed by other commenters I. This thread as well.
Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @11:14AM (#41819697)
Precisely. It doesn’t do the work for you.
Re:How long til we're all on Ozempic? by jajko on Saturday October 12, 2024 @03:49AM (#41817258)
This is funny how black & white some folks here want the world to be painted if it suits them.

You know by far the biggest benefit of doing hard workouts or doing extreme sports? Its not muscle mass nor how much they lift. Its about how it changes your personality, resilience to mental or physical suffering and ease of overcoming it. You know, hardest part of doing anything is winning the mental resistance game and just start it. Keep doing this every day in various forms for decades... A very strong resilient personality under various circumstances is almost an unavoidable result if you are putting in enough effort.

If somebody can't even stop themselves buying and paying for junk food at grocery store or has to overeat constantly otherwise getting anxious, that part of personality is missing and another, less desirable is present.

Who would you prefer to have as a close colleague you depend on, life long partner, a close dependable friend? Who do you think women would prefer subconsciously? Societies have always some form of castes, even hardcore communists have/had them, in US one of very popular is based on career/income/wealth. And this is just another dimension or caste, so let's not act like we are not humans with flaws and subjective preferences, we don't give our respect out for free.

These medication help with none of above, in fact they strongly reinforce such behavior and personality traits. But to each their own. One benefit I can see that they could start / help with movement from former to the latter, but that's rarer than people like to admit.

Re:How long til we're all on Ozempic? by borski on Saturday October 12, 2024 @11:23AM (#41819761)
That’s cute. You know nothing about me, but assume I’m not resilient.

I have achieved much, largely due to my resilience. It would be very difficult to argue, after growing up very impoverished and getting to where I am today, that I am not resilient.

I played sports, lots. I competed in martial arts. Resilience isn’t my issue.

But thanks for telling me I have a moral problem I don’t have, instead of perhaps considering that what people are telling you might be the truth.

You don’t always know better, even if it flies in the face of what it is you do know.

Re:How long til we're all on Ozempic? by user3939382 on Saturday October 12, 2024 @04:29AM (#41817481)
It’s only within reach of a small portion because of industrialized food. Look at a graph of obesity rates in the US over several decades. Find literally any picture of people at any beach in the US in the 60s or 70s versus now.