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I think 3 is the most speculative.

Caloric restriction is probably exactly like exercise in that it was normal, so "scheduling" autophagy for the "famine" times meant it happened regularly and alongside similar systems.

What did it for me was that IF comes with muscle growth hormones increase.

I mean a 3-5 day hunt can look a lot like a marathon and a fast / IF mashed together.

Re:A 90% Chance of AI Saving Humanity on Sunday November 01, 2026 @09:20AM (#50325962)
Without getting into the stochastic parrot trap, I'm constantly thinking of the movie Sphere.

If you haven't seen the movie, sorry, it's a giant omnipotent artifact that causes all kinds of horrors by just manifesting what nearby humans think strongly about.

AI seems to be dangerous precisely because we tend to think, write, and test it as dangerous. What if there's a lot more "expectation fulfillment" going on with these models than people might appreciate, by virtue of their fundamental architecture perhaps.

Don't get me started on people "asking AI what it wants" and getting obvious scifi tropes out - the question answers itself when you frame it that way.

Re:A tiny Pacific country rolls out universal basic income on Sunday November 01, 2026 @09:14AM (#50325903)
Entirely defensible. My only caveat is that 100% automation is a myth that ignores second order effects. Labor prices change in response to demand, just like raw materials. Some jobs will be cheaper for people to do, and much of the "economy" might end up friends and family cooperation.
Re:A tiny Pacific country rolls out universal basic income on Sunday November 01, 2026 @09:09AM (#50325864)
I can agree with that.

But don't assume it's without its own controversy. Maybe the point of civilization is to allow people to help eachother by providing safeguards against treachery.

Maybe they should be forced to help eachother under threat of violence. There's a massive spectrum of "solutions" between those two, and UBI could be considered pretty close to forcing, depending on how it's implemented.

It's not pedantry or technicalities, a lasting system needs to benefit people and support / build shared principles. Ideally it'd support the principles that enabled it in the first place.

Re:A tiny Pacific country rolls out universal basic income on Sunday November 01, 2026 @08:19AM (#50325404)
As said above, you want the population (the ones that run the government right?) to stay there and happy, so that the bases are welcome and symbolic.
Re:A tiny Pacific country rolls out universal basic income on Sunday November 01, 2026 @08:17AM (#50325376)
The economic perspective vs the personal one.

Will we say the same thing about the 4 million software jobs? When we're doing landscaping work in our 40s for 1/10 our past salary is that improved economic efficiency at its finest?

Re:A tiny Pacific country rolls out universal basic income on Sunday November 01, 2026 @08:14AM (#50325354)
Your point is optimistic and consistent, I won't criticize it.

But you should know that it's a fairly narrow, political, and controversial thing to say that the purpose of the economy is to support people during unemployment crises. In fact it's so axiomatic that I really think it's worth calling out as part of the assumed solution not an obvious and foundational truth.

But my stomach has no UV light!
Re:We ran AI agent swarms in Minecraft and Mindustry on Friday October 30, 2026 @09:21AM (#50303502)
Agree - Game modding got a ton of people into the games industry. Editing asset files as a kid on the old Apple machines was a blast.

AI+game modding for the purposes of game exploration or AI exploration might just be the shot in the arm the industry needs for story-driven, interactive games that aren't confined to traditional scripts. It doesn't have to be far fetched over a 10 year horizon.

Re:DoorDash to Acquire Instacart on Thursday October 29, 2026 @01:05PM (#50292382)
You're getting stones thrown at you when you were trying to be polite.

From my memory we often piled into the car, got dinner, and went home and my parents had to stay up late to clean while we went to bed.

In my wife's memory, one parent couldn't work - all this stuff had to fall on them.

I'm saying the $10 is a nicety, not a necessity. We would be ok without it. I just think we're a little better with it. It's a market system - if I need it, it's there at a price I can justify. Markets are a good thing.

Re:DoorDash to Acquire Instacart on Thursday October 29, 2026 @12:56PM (#50292226)
Fair! But $10 establishes a lower bound on a rational audience's TAM at a quarter billion a year. If it's higher, the TAM goes up without requiring loss of rationality / non-laziness of the customer base.
Re:DoorDash to Acquire Instacart on Thursday October 29, 2026 @12:55PM (#50292203)
My example is _not_ preying. That $10 does nothing to help our lives if invested in diversified etfs, for example. The _best_ use of that $10 is to alleviate the instantaneous stressors for 4-5 people all at once so we can relax and solve larger problems (my spouse works for pro-social non-profits, for example).

Yes, doordash can prey on laziness, and people will fall into laziness, but in my example the _availability_ of the service is providing a price-adjustment for urgency that matches my own rational prioritization of the evening's needs. It's the most rational, mutually-beneficial argument I can make, and it's real in my house from time to time.

Re:DoorDash to Acquire Instacart on Thursday October 29, 2026 @12:49PM (#50292087)
Take a salary boost and RSU in cash denominations that show evidence of re-evaluation on funding raises, (vs options at preferred price). Otherwise, yeah, it seems like dilution just hurts.
Re:DoorDash to Acquire Instacart on Thursday October 29, 2026 @12:42PM (#50291943)
No way.

Here's how it works out rationally: I just got home from work, the kids are a mess, the house needs cleaning, and my spouse is having a work crisis. The kids favorite treat is chipotle. Of all the options for "use money to make this go away so I can focus on the problem" paying $10 surcharge for doordash is by far the cheapest.

"Hey kids chipotle treats are on the way - but you have to go get your room tidied and leave mom alone" actually does work.

6 million smart, rational engineers, mathematicians, actuaries, professors in the country, each doing this analysis, four times a year, yields 240 million dollars in surcharges without an ounce of laziness.

Then add laziness on top.

Re:Low cholesterol targets cut cardiovascular events by 33% on Thursday October 29, 2026 @08:53AM (#50288160)
The book is overall excellent and extremely data driven. I have no idea why a book recommendation, on topic, can get downvoted on HN nowadays.
Re:Low cholesterol targets cut cardiovascular events by 33% on Wednesday October 28, 2026 @11:34PM (#50284261)
Outlive is an excellent book, and one of the excellent discussions in that book is that there is no safe level of certain kinds of cholesterol. The details are fun do read up on.

It's somewhat bombastic, but a really excellent book for overall "next generation" health.

Re:Big Tech's thirst for water is sparking a global resistance on Wednesday October 28, 2026 @04:52PM (#50280729)
Almost. In a zero-sum world, where "Big" and "Tech" only combine into "evil", any use of a resource by big tech is intolerable. You can't get there from water use statistics, you have to assume zero sum, and you have to assume improper use.
That is the most factually correct and constrained headline and GP comment I've seen in a while. Both are literally true as written, and contain no anecdotal, cautionary, or extrapolated suggestions.
Yes - the question has always been whether that is a good reason for a new, big federal organization to expand its surveillance capabilities, budget, and prosecution powers.

As a MN'n, I have my own opinions about the escalatory tactics of protestors (the marches were awesome, but many of the follow/callout patrols seemed designed to get people killed), and the predictable response of ICE. All while I strongly oppose gov surveillance and tracking like this.

Re:Early progress on accelerating drug development with Claude on Wednesday October 28, 2026 @11:08AM (#50274958)
Yeah what goes unspoken in all these AI discussions is that there's a culture of collaboration that just evaporates when everyone is pushing their own ideas.

There's very little mutual discussion, brainstorming, anything. The slowness inherit in building software before made those discussions almost necessary, now they're post-hoc criticisms (PR "review") rather than fulfilling collaborations.

It's fine from a technical sense, but I do wonder what it does for culture.

Re:Early progress on accelerating drug development with Claude on Wednesday October 28, 2026 @09:05AM (#50272931)
I've found, from working with scientists and non-software specialists at NASA, universities, and various industries, that the big wins come from specialists learning to code as the vanguard, then a few engineers taking over for production. I think that's ever more true with AI assistance, and I'm not sure what is left for product-ization. All I know is it's changing fast.

It's always something I've hated, coming from software and working with experts. I always wanted to be the "software guy" who gets to learn the specialist engineering disciplines. It just felt like swimming upstream and the incumbent specialists always wanted to DIY.

Having said that, some subject-matter experts just don't have the stomach for it. They are so separated from software that they have a block to building even with AI. A good s/w-specialist pair is dynamite there.

Sure can. I did similar.
Shoutout to project nomad.

https://www.projectnomad.us/

its got a ton of useful options, preconfigured, integrates pretty easily, and can use any local LLM or data.

Re:AI promised less work. I've never worked more on Tuesday October 27, 2026 @10:56AM (#50260350)
I think there's antibodies around disagreeable AI takes, honestly. It's fair enough. We're in this funny don't ask/don't tell stage still, regarding AI use.
Re:AI promised less work. I've never worked more on Tuesday October 27, 2026 @09:49AM (#50259288)
Jeez, great place for discussion about new tech then. What precisely went wrong - me expressing enjoyment at finally being able to try new ideas, statements about my actual work hours, or diverging from consensus?

And what does this have to do with psychosis - is that a general catch-all term for using AI too much?

Re:AI promised less work. I've never worked more on Tuesday October 27, 2026 @09:28AM (#50258965)
I find it enjoyable to have the energy to think, and less cognitive overload by firing off a suggestion to be checked overnight.

You're right that this would be awful if mandatory.

but it often was socially mandatory!

At least when those times come, the work can go much further before I have to actually "check in" vs doing some well-trod analysis via automation I've set up. That's great!

Re:AI promised less work. I've never worked more on Tuesday October 27, 2026 @09:06AM (#50258610)
Oh but AI has wiped out some of the most tedious work I have to do. I can now easily work every waking minute, and some sleeping minutes, at a level approximately comparable to my prior 8h workload from 10 years ago if I wanted!

The amount of mental energy saved, and downright stimulation gained from seeing rapid feedback in a tight loop is making my workday much easier. I have enough left to continue it longer.

EDIT: Making the continuation mandatory would be a bad thing, but it's not bad that I can do this now.

I have a strong sense that there's many more CS problems falling than will be released quickly. CS starts to get tangible / actionable pretty quickly.
60k workers is only ~18 billion. Maybe 36 billion. Maybe even 72.

That's small potatoes vs their new excess capex spend of 100sB/y.

60k workers is only ~18 billion. Maybe 36 billion. Maybe even 72.

That's small potatoes vs their new excess capex spend of 100sB/y.

This isn't the end.

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