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Re:Study: Electroshock therapy more successful for depressio... by engined on Sunday October 23, 2022 @09:00PM (#33311875)
After dealing with depression myself, I dove deeply into this world, and actually ended up founding a ketamine and esketamine treatment startup in the Boston area (lumin.health). We've seen pretty amazing results with patients who have otherwise failed antidepressants and/or ECT and TMS (Transcranial Magnetic Stimulation). The reality is that ketamine/esketamine are much more accessible from a patient perspective, and while considered "new" by many in the medical community, offer faster results and carry less stigma for patients than ECT in particular. If ketamine/esketamine don't work, patients typically know within 2-3 sessions, and can walk away with no long term side effects. With ECT, patients generally have to complete a whole course before they see effect, and then are stuck with some of the potential mid/long-term side effects.

The space is also at the precipice of a whole new class of psychedelics coming online - MDMA, psilocybin, and more are all 1-5 years out (working through FDA drug trials), and hold promise of both faster results (versus 6-8 months of trialing traditional antidepressants) and fewer downside risks (versus weight gain, sex drive, etc. issues with antidepressants and memory loss, headaches, etc. with ECT and TMS).

Bottom line, if you're suffering and considering those treatments, I highly recommend finding a local center and at least learning more about options available to you.

Re:Study: Electroshock therapy more successful for depressio... by boredtofears on Monday October 24, 2022 @01:49AM (#33313320)
One rumination I have had about the medical application of psychedelics is to wonder how lasting the effects of all these initial studies will be over the long term.

The effects of psychedelics are profound to a person who hasn't experienced them, which is the vast majority of people today. I think, when a person goes through a powerful experience they've never had, it makes them a lot more suggestive, which in turn makes therapies more effective. Will this still be the case if psychedelics usage is normalized? When a person knows what to expect out of the drug will they still remain as suggestible to therapy?

My own experience with psychedelics tells me no: once you become familiar with the effects the "high" loses some of it's properties that make it a useful tool for introspection.

I haven't done psychedelics in a purely therapeutic setting so there may be something to my observation that I'm missing completely.

Re:Study: Electroshock therapy more successful for depressio... by sneak on Monday October 24, 2022 @02:05AM (#33313392)
Ketamine’s effects on depression are not caused by the hallucinations or psychedelic effects.

I can’t speak to other hallucinogens but I would imagine the situation is the same there. The day after an acid trip isn’t a new neurochemical environment because of the powerful hallucinations the day before, it is something else.

> My own experience with psychedelics tells me no: once you become familiar with the effects the "high" loses some of it's properties that make it a useful tool for introspection.

My own experiences run directly counter to this assertion.

Re:Study: Electroshock therapy more successful for depressio... by boredtofears on Monday October 24, 2022 @03:58AM (#33314025)
> The day after an acid trip isn’t a new neurochemical environment because of the powerful hallucinations the day before, it is something else

What is a "new neurochemical environment" exactly? I've had many acid comedowns, and they have all been affected by how the high was - emotionally, mentally, and physically. What do you mean by "its something else"?

Re:Study: Electroshock therapy more successful for depressio... by tekknik on Monday October 24, 2022 @08:55AM (#33316023)
I’m far from an expert here, but as I understand it there is no repeated, or daily dose of the psilocybin. Instead it physically changes your brain. Here’s one study:

https://www.mdpi.com/1422-0067/22/2/835/htm

Re:Study: Electroshock therapy more successful for depressio... by novok on Monday October 24, 2022 @02:06PM (#33320178)
IMO I think it is still a new neurochemical environment, much like how the body is different after intense exercise for the next few days, as it recovers. It gets sore, weaker, etc. There is definitely a training & depletion effect for the brain.
Re:Study: Electroshock therapy more successful for depressio... by tomcam on Monday October 24, 2022 @04:28AM (#33314181)
Thank you. Any help for insomnia or overeating?
Re:Study: Electroshock therapy more successful for depressio... by sshine on Monday October 24, 2022 @05:02AM (#33314364)
Insomnia: Have you heard Andrew Huberman’s podcast episode on sleep?

https://hubermanlab.com/sleep-toolkit-tools-for-optimizing-s...

There are so many small things you can do, and they get summarised here. Drugs are just one dimension.

Re:Study: Electroshock therapy more successful for depressio... by tomcam on Monday October 24, 2022 @05:09AM (#33314391)
Thanks . Love Huberman. Done almost everything to no avail! One thing I haven’t done is sauna and I just got one.
Re:Study: Electroshock therapy more successful for depressio... by joelrunyon on Monday October 24, 2022 @07:03AM (#33315116)
If you're struggling with sleep and "turning the lights off" around bed time - we made a custom natural sleep product for high performers focused on quality, restful sleep - https://impossible.co/products/sleep

Shoot me a DM if you want to try it out - happy to send one your way.

Re:Study: Electroshock therapy more successful for depressio... by victor106 on Monday October 24, 2022 @07:47AM (#33315491)
> Why Melatonin is Bad For You (coming soon).

I am curious to read why this is bad. My doc thinks this is perfectly fine

Re:Study: Electroshock therapy more successful for depressio... by KMnO4 on Monday October 24, 2022 @09:24AM (#33316297)
Going out on a limb here, but I’m assuming it’s meant to be “why [exogenous] melatonin is bad for you”.

Melatonin is naturally secreted by the pineal gland, which like other hormones gets downregulated when taken exogenously over long periods of time.

There’s also studies showing a downregulation in dopamine and seratonin with long term use of melatonin.

Re:Study: Electroshock therapy more successful for depressio... by joelrunyon on Tuesday October 25, 2022 @01:05AM (#33326458)
Re:Study: Electroshock therapy more successful for depressio... by danielfoster on Monday October 24, 2022 @11:08PM (#33325704)
This is just magnesium and l-theanine
Re:Study: Electroshock therapy more successful for depressio... by joelrunyon on Tuesday October 25, 2022 @01:07AM (#33326467)
Yes - they're both great compounds for helping improve sleep performance - (which unlike knockout pills you can improve over time). Most of our customers tracking their sleep with an Oura ring, Whoop band, or Eight sleep see improvements in both their scores and energy levels when adding our product to their nightly routine.

- https://impossible.co/blogs/health/magnesium-and-sleep - https://impossible.co/blogs/health/l-theanine-for-sleep

Re:Study: Electroshock therapy more successful for depressio... by IndySun on Monday October 24, 2022 @07:18AM (#33315240)
Overeating might be helped by knowing your own body's blood sugar response to carbs. Take a browse through Tim Spectors ZOE. Hope you get some progress.
Re:Study: Electroshock therapy more successful for depressio... by engined on Monday October 24, 2022 @09:23AM (#33316290)
(This is not medical advice and I am not a doctor) I don't think ketamine is directly indicated overeating, and I know esketamine isn't for insomnia or overeating. That said, There do seem to be a handful of papers studying the use of ketamine in things that affect sleep, like circadian rhythm [0][1]. In general, ketamine causes sedation in about 70% of those treated with it. Though that is short acting (hours) it may help set an individual for a good sleep, and to the extent that insomnia or overeating are caused by or co-occurrent with depression, ketamine could likely help.

[0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866161/ [1] https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1423

Re:Study: Electroshock therapy more successful for depressio... by bergenty on Monday October 24, 2022 @08:43PM (#33324698)
What about developing a system that people can use to administer ECT to themselves. Obviously it will have to be sold as something else.
Re:Study: Electroshock therapy more successful for depressio... by waste_monk on Monday October 24, 2022 @10:55PM (#33325616)
As I understand ECT is basically just having a seizure while under some heavy-duty muscle relaxants and/or general anaesthetic (?), so you don't flail around and hurt yourself.

Seems way too dangerous for home use.