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Re:Polio Detected in US by qbasic_forever on Friday July 22, 2022 @12:13PM (#32193687)
What's most concerning IMHO is that this appears to be from community spread with no known recent travel history (polio apparently incubates in 7-21 days so they would have caught it in the last few weeks).

Even more troubling is that they were paralyzed which means they were one of the less than 1% of polio cases that turn into a severe event like being paralyzed. The vast majority of cases are asymptomatic or just give you diarrhea.

How many people could be out in the community and spreading it without anyone knowing?

Re:Polio Detected in US by jefftk on Friday July 22, 2022 @12:20PM (#32193761)
> How many people could be out in the community and spreading it without anyone knowing?

I wonder whether anyone has checked Rockland county wastewater? This kind of testing recently detected it in London: https://www.science.org/content/article/poliovirus-in-london...

Re:Polio Detected in US by michaelcampbell on Sunday July 24, 2022 @08:39AM (#32212860)
I presume you mean here as an indicator, not a cause?
Re:Polio Detected in US by jefftk on Sunday July 24, 2022 @09:24AM (#32213260)
That's right: wastewater is a good signal for what's happening inside the people upstream
[dead]
Re:Polio Detected in US by voz_ on Friday July 22, 2022 @01:23PM (#32194578)
Absolutely loony take. How does an engineer get like this?
Re:Polio Detected in US by NikolaNovak on Friday July 22, 2022 @03:09PM (#32195922)
Some of the most intelligent, knowledgeable, respected-in-their-field distant family members of mine are like that. I've spent decade trying to figure it out, because selfishly it's terrifying and I don't want it happening to me.

One thing that seems to be common and is my working hypothesis, is that they're so smart and so respected in their field (or, in subset of cases, arrogant), that they simply trust themselves more than anybody else. There is nobody in their family and friends who can truly "slap some sense into them"; provide perspective, course-correct, nudge into objective reality or mainstream story, whatever we call it. I've actually asked a couple of them point blank - and they admitted, nope, there's nobody that they trust more than themselves. Couple of them even said - if you don't have trust and faith in yourself, you're weak.

So I'm hoping I'm somewhat inoculated against going off the deep end by having at least 3 people in my life (wife, sister, and one good friend) who can, and have, slapped some sense into me when I was going off the rails.

Re:Polio Detected in US by Swizec on Friday July 22, 2022 @03:42PM (#32196270)
I was reading a book on cognitive biases recently and the part that really stuck for me was: The smarter you are, the more likely you are to fall prey to the Narrative Bias/Fallacy.

Super smart people are so good at constructing plausible narratives that they can convince themselves of almost anything. You have to actively look for ways to disprove your own narratives. This is hard because they sound so plausible.

Re:Polio Detected in US by pklausler on Friday July 22, 2022 @04:43PM (#32196884)
So smart people don't know when they're wrong because they're smart enough to convince themselves that they're right, and dumb people don't know when they're wrong, because they're too dumb to see how dumb they're being. We can't win.
Re:Polio Detected in US by Swizec on Friday July 22, 2022 @06:30PM (#32197875)
Yes, I think the lesson to take away is that you want not only to be smart, but also wise and humble. Wise enough to realize you need to poke holes in your ideas, humble enough to fix your hypothesis when facts change.
Re:Polio Detected in US by unclebucknasty on Saturday July 23, 2022 @12:23AM (#32200339)
>wise and humble...you need to poke holes in your ideas...

But where does critical thinking come in? Seens there should be a heuristic or generalized approach for deciding what to believe. Epistemology, I suppose.

And this should all preface the formation of our ideas in the first place.

Re:Polio Detected in US by pps on Friday July 22, 2022 @06:38PM (#32197942)
> You have to actively look for ways to disprove your own narratives

Socratic Method is one way, I can recommend "The Socratic Method - A Practitioners Handbook" by Ward Farnsworth.

Re:Polio Detected in US by NikolaNovak on Friday July 22, 2022 @04:01PM (#32196459)
Perfect; that sounds like exactly what I've observed - in others as well as myself - but I did not have a name, so now I can google better, thx :)

(any recommendations on that specific book?)

Re:Polio Detected in US by naniwaduni on Friday July 22, 2022 @04:49PM (#32196958)
protip: you can do this without being overwhelmingly smart, too. You need only be smart enough to convince yourself
Re:Polio Detected in US by troutwine on Friday July 22, 2022 @03:58PM (#32196428)
What book was that? I'd be interested in giving it a read.
Re:Polio Detected in US by Swizec on Friday July 22, 2022 @06:29PM (#32197865)
Looking at my Audible history it was either Think Again by Adam Grant or Super Thinking by Gabriel Weinberg. Can't remember exactly.
Re:Polio Detected in US by troutwine on Thursday July 28, 2022 @01:39PM (#32267717)
Much obliged.
Re:Polio Detected in US by somenameforme on Friday July 22, 2022 @04:01PM (#32196455)
I'd argue that there is no nobody you should trust more than yourself. This does not mean disregarding expertise or imagining that you know, or can know, everything. But the moment that you grant final primacy over your own thoughts to somebody other than yourself is the moment that that person can make you believe, and consequently act, in nearly any way. And, at scale, that's quite a disconcerting thought.

When people trust themselves above all it means we'll never have a utopia because we all can't help but believing some pretty stupid stuff at times. But at the same time we'll never have an absolute dystopia, because the diversity of thought ensures we'll never all fall off the deep end, or be pushed off it, together.

Re:Polio Detected in US by NikolaNovak on Friday July 22, 2022 @08:42PM (#32198965)
It's not binary; it's not like I'm promoting being in a cult and surrendering your rights to thoughts and opinions :->

On a daily and regular basis, I trust myself, my thought process, experience, rationale, etc. I spent decades consciously honing my analytical and logical skills and I will spend lifetime continuing to do so. And it serves me well.

But, I believe, there needs to be a "safety valve". A "who watches the watchmen", somebody to provide a sanity check on your own rationale and story and narrative and thought process, which left alone can take you from first principle to lala-land, one seemingly logical step at the time, over years if needed. There needs to be an external influence/person who can, if situation calls for it, help you see things from an external yet trustworthy perspective, when your internal narrative, the "personal story of your life", starts strongly diverging from objective consensus reality.

(on a deeply personal note, I'll freely admit my sister did that for me ~15 years ago - after for a year or so I spun an increasingly personal internal narrative about something in my life, with a short but incisive comment, she momentarily enabled me to see myself through her eyes, and not love what I saw, and get that instant split-vision of my narrative and external narrative of what and why and how and whence I am where and how I am. Anybody else, I would've discarded or been defensive or otherwise ignored it. And I see many people around who desperately need a "grounding" or "reality check" or "slapping sense into" or "righting the boat" or whatever we choose to call it, but don't have anybody that can reach them. )

Re:Polio Detected in US by pstuart on Friday July 22, 2022 @11:54PM (#32200185)
A key element should be the willingness to accept that one could be wrong when the evidence supports that conclusion.

And I'd take this a step further -- the ability to unlearn/reprogram is a mark of intelligence, but ego definitely factors in as well.

Re:Polio Detected in US by AlexandrB on Friday July 22, 2022 @06:05PM (#32197659)
Science, as a discipline, is all about not trusting yourself because you can fool yourself easily if you're not careful.
Re:Polio Detected in US by kelnos on Friday July 22, 2022 @07:50PM (#32198567)
This is kinda a weird take to me, because I don't see "trust someone else more than yourself" as equivalent to "grant final primacy over your own thoughts to someone else".

I trust myself very little when it comes to many topics, because I have next to zero expertise in them, and I know that "common sense" often does not lead us to good decisions on topics where we have little understanding. That doesn't mean I'm going to outsource decision-making to others who are experts on those topics, but I am probably going to most often do what they say, after applying their information to my own situation and determining what seems reasonable and doable.

As an example, I will most likely get the Omicron-tuned COVID vaccine when it becomes available, assuming the relevant experts I trust say that it's a good idea. I have no idea if I really need it, but the non-zero threat of long COVID, coupled with the fact that we still know fairly little about the long-term effects of having contracted COVID, means I would rather face the very low risk of vaccine complications than increase my risk of getting COVID, with the attendant risk of it being something that causes lingering health problems for some significant part of my life. I won't be outsourcing my decision-making to a third party, but I recognize that I do not trust my expertise in this field (since I do not have any), and will allow those with expertise to heavily inform my decision.

Re:Polio Detected in US by GauntletWizard on Friday July 22, 2022 @05:10PM (#32197161)
You shouldn't need someone you trust more than yourself to slap sense into you. You should view someone whom you trust strongly (but less strongly than your own thoughts) arguing hard as an indicator, even if you disagree with them. You should be able to ask "Why do we disagree", and trace that back to (hopefully) some simple but core value difference, like "I like hotdogs and they like hamburgers".
Re:Polio Detected in US by jakelazaroff on Friday July 22, 2022 @06:36PM (#32197926)
Your trust in someone also doesn't need to apply equally on all topics. I'm much likelier to trust a virologist over myself about virology than about the best way to cook pasta.
Re:Polio Detected in US by Aperocky on Friday July 22, 2022 @01:32PM (#32194691)
It's some interesting psychology.

I've had discussion with a guy in lab of a top university and they believed 911 was an inside job. steel beams and all that.

It doesn't seem to correlate to technical ability, there are something in psychology that draws a certain type of people towards conspiracy and in which they go into a mental state where normal explanations are removed from their logic and they go seek outlandish explanations or slightly hard to explain things and turn a twist into it. I don't understand why but I think a pretty decent amount of people subscribe to this kind of thinking.

Neurology researchers here, please give us answers.

Re:Polio Detected in US by krisoft on Friday July 22, 2022 @02:28PM (#32195475)
> they believed 911 was an inside job. steel beams and all that.

911 is definietly a conspiracy. A bunch of telecom engineers acting in unison with dispatchers and first responders. There is no other explanation how else police/emt/fire brigade shows up when you dial that number and tell them about an emergency. But what it has to do with steel beams I don’t know. \s

Joking aside: I have noticed that sometimes when I preceive that everyone around me thinks X i feel an urge to think the opposite of it. I only had mild and inconsequential cases of this (opinion about shows, products, etc), but I can imagine that this type of contraryness in edge cases can convince people that everyone is wrong about some important historical event. And it seems once they convinced themselves their belief is stable enough to make them stick with it.

Obviously hating Game of Thrones when everyone was raving about it feels very different from subscribing to conspiracy theories, but maybe the phenomena is similar, just one latches on to a different subject?

Re:Polio Detected in US by tshaddox on Friday July 22, 2022 @03:36PM (#32196200)
Funny that that's the conspiracy you reach for to make the joke. Not the one where people planned in secret to send people to the United States to learn how to fly airplanes so that they could hijack commercial airlines and commit suicide attacks.
Re:Polio Detected in US by Fnoord on Friday July 22, 2022 @02:51PM (#32195740)
> Joking aside

Good thing you mention or I fell for it (that you meant it seriously, not that I believed in the conspiracy). Poe's law in effect.

But that's the thing. People who believe in conspiracies are susceptible to them. For example, they could've lost their trust in society, or smoke a lot of pot, or have a friend or two who are into it. Very much like a cult.

And I am saying that as person who was into conspiracies, who lost faith in society, who used drugs (psychedelics, mostly), and had a severe psychosis (not at all related to the previously mentioned though but stress from another factor).

Re:Polio Detected in US by mcguire on Friday July 22, 2022 @03:54PM (#32196386)
Hating Game of Thrones is perfectly justified. :-)
Re:Polio Detected in US by ThePowerOfFuet on Saturday July 23, 2022 @05:43AM (#32201819)
It's a shame they ended it after seven seasons and left most of the plot lines hanging.
Re:Polio Detected in US by overrun11 on Friday July 22, 2022 @01:54PM (#32195012)
Was their argument rigorous or obviously irrational? On the spectrum of plausibility from lizard people to JFK, 9/11 doesn't strike me as especially delusional. I believe we sometimes don't differentiate well enough between abnormally suspicious people that act rationally from the clearly deranged. Non-consensus views could be a sign of either but a failure mode a different set of smart people have is to write off anything non-consensus merely because it's low status.
Re:Polio Detected in US by Aperocky on Friday July 22, 2022 @08:25PM (#32198837)
Clearly not rigorous as the main point (steel beam don't melt) they talked about has already been debunked by approximately 200 articles.
Re:Polio Detected in US by tekknik on Sunday July 24, 2022 @08:25AM (#32212762)
> steel beam don't melt

you should probably reword that, “steel beams don’t melt at the temperature jet fuel burns at”.

Re:Polio Detected in US by galangalalgol on Friday July 22, 2022 @01:36PM (#32194749)
Not a neurology researcher, but always seems to be people with really good pattern recognition intell. They connect dots well, blessing and curse etc.
Re:Polio Detected in US by rjbwork on Friday July 22, 2022 @01:50PM (#32194960)
Indeed. As someone with experience of extreme manic psychosis, it is the pattern recognition/dot connection algorithm kicked into absolute overdrive. Spurious correlation abounds when afflicted with such a condition.

Thankfully my experience was acute and triggered by drugs, so a few years of anti-psychotics and refraining from anything other than cannabis and alcohol in moderation have let me stop taking the anti-psychotics and at worst I experience cyclothymia, which I've decided to just live with and not medicate.

Re:Polio Detected in US by pintxo on Friday July 22, 2022 @02:22PM (#32195379)
I'd say they may connect dots quickly, but not necessarily well.
Re:Polio Detected in US by bredren on Friday July 22, 2022 @02:07PM (#32195222)
This sounds like ~the plot of the film Pi.
Re:Polio Detected in US by birdyrooster on Friday July 22, 2022 @02:18PM (#32195326)
steel beams don't melt jet fuel
Re:Polio Detected in US by fortran77 on Friday July 22, 2022 @07:07PM (#32198200)
First of all, he's probably not an engineer. He's a computer programmer.

For some reason, Computer Programmers think they're experts in every subject.

Re:Polio Detected in US by designium on Friday July 22, 2022 @01:46PM (#32194903)
Engineers are just human as others. Engineers is not equal to be rational in other areas of life.
Re:Polio Detected in US by corrral on Friday July 22, 2022 @02:22PM (#32195380)
They're very prone, in my experience, to believing that their explanations are ultra-rational, though, reality be damned. And to falling for arguments with the trappings of rationality, but deeply flawed premises or early steps slyly skipped so the castle's built on sand but looks like a perfect castle with all these crazy-tall minarets reaching for the sky (ahem, like a certain popular-online political & economic philosophy) and then treating everyone who doesn't agree that the castle's beautiful as irrational, probably-emotion-driven morons.
Re:Polio Detected in US by mistermann on Friday July 22, 2022 @03:59PM (#32196430)
> They're very prone, in my experience, to believing that their explanations are ultra-rational, though, reality be damned.

Like for example, their analyses of "conspiracy theorists" (when what they are actually analyzing is their own incredibly flawed semi-conscious representation of conspiracy theorists). It's quite funny that the world is this way if you think about it deeply, because it could be otherwise.

Re:Polio Detected in US by corrral on Friday July 22, 2022 @04:36PM (#32196823)
How many exchanges building on this before we reach a particularly helpless flavor of solipsism, you think? I'd say about three more posts.
Re:Polio Detected in US by mistermann on Saturday July 23, 2022 @03:06AM (#32201095)
You are free and welcome to play the solipsism card to avoid epistemic soundness. I'd even say it is the most popular approach.

Alternatively, you could desire to know what is true, at least in theory.

Consider what is going on from an architectural perspective - do you believe that what I say is incorrect?

Re:Polio Detected in US by woodruffw on Friday July 22, 2022 @02:11PM (#32195259)
And beyond this: engineers, particularly programmers, are particularly susceptible to flawed "first principles" thinking.

Not every factoid in every field can be derived from a small set of first principles, particularly when that field is primarily empirical in nature.

Re:Polio Detected in US by pessimizer on Friday July 22, 2022 @02:26PM (#32195435)
But many people are not rational in any part of their lives, so irrational arguments are not surprising from them. Some people don't actually know what a rational argument is - it's something that you learn in school, not something that is intuitive. They think that argumentation is when you make the other person shut up, rather than when you make a step by step case to get to a point from a set of agreed upon (at least provisionally) premises. You can recognize these people because they have a tell of repeating the same sentence over and over again to drown out the other person speaking. They're not trying to lay out a convincing case, they're trying to survive. If they trusted you, you could absolutely teach them argumentation and reason.

Engineers do know how to argue rationally, because they have to remember why things work to a pretty intense depth. The question is how people can wall off that ability instead of applying it to other things that are important to them.

Being "human" isn't an explanation, though. That's just saying that humans are frail, and this is a failure, therefore it should be expected from humans.

Re:Polio Detected in US by sangnoir on Friday July 22, 2022 @02:35PM (#32195557)
> How does an engineer get like this?

There's nothing special about engineers that makes them less prone to human weaknesses. I had a (software) engineer colleague who believed in overunity energy, and was so into it they traveled to paid conferences.

Re:Polio Detected in US by rajup on Friday July 22, 2022 @05:18PM (#32197239)
I think this is something barfed up by a GPT-3 model trained on OANN, Fox News and 4chan.
Re:Polio Detected in US by bigbillheck on Friday July 22, 2022 @02:43PM (#32195644)
An awful lot of cranks are engineers (electrical seems to be the variety most prone to it).
Re:Polio Detected in US by fifafu on Friday July 22, 2022 @01:24PM (#32194580)
Oh my.

Stefan Lanka could keep his money due to a formality. The judges even said that it was clearly proven the measle virus exists.

Re:Polio Detected in US by tshaddox on Friday July 22, 2022 @03:38PM (#32196232)
Also no legitimate method of inquiry works by someone saying "I'll give you a reward if you prove me wrong!" and then having that promise of reward settled in court.
Re:Polio Detected in US by cies on Sunday July 24, 2022 @06:44AM (#32212103)
Well, it does prove a point.

If Lanka said "there is no proof that gravity makes things fall down" he'd loose the 100k. That proof is really well supported by hard evidence.

At this point viruses are simply not proven by hard-science and Lanka was made to pay up based on non-hard-science papers, that are now vetted by a court case to be just that: no hard scientific proof.

Re:Polio Detected in US by cies on Friday July 22, 2022 @08:25PM (#32198835)
Here's the case:

http://lrbw.juris.de/cgi-bin/laender_rechtsprechung/document...

I dont think that counts as "a formality". It simply is not hard-scientifically proven.

The measles virus may still exist and make people sick, but to me that is a theory as the proof is still outstanding.

> The judges even said that it was clearly proven the measle virus exists.

Do you have a source for that?

Re:Polio Detected in US by jefftk on Friday July 22, 2022 @09:07PM (#32199156)
Machine translation gives me the following for point 20: "In addition, the submission of a single publication was required, in which both the proof of the existence of the measles virus and the determination of its diameter were provided, so that it was not sufficient if - as advocated by the expert - merely the combination of the scientific statements in the six submitted professional articles prove the existence of the measles virus and at least two of these articles contain sufficient information on the diameter of the measles virus."

I would count that as a "formality": the bet required the proof to be in a single publication, but as it was instead split across several it didn't count.

On the latter question the machine-translated text is hard enough to read that I can't reliably tell what the defendant is claiming and what the court is declaring, but I think maybe the court is saying they're not convinced the submitted papers constitute proof?

Re:Polio Detected in US by cies on Sunday July 24, 2022 @07:30AM (#32212398)
That is a formality in my book too.

But if you read on from where your citation stops (i.e. after "...on the diameter of the measles virus"), you find:

"Furthermore, the content of the publications submitted did not meet the requirements for proof. The phenomena presented therein as measles viruses are actually transport vesicles (bubbles) of the cell itself. None of the documentation submitted is based on attempts where the pathogen - as required - had previously been isolated and biochemically characterized or even such an isolation had been scientifically documented. [... (cut out some more things that are formalities to me)...] The determination of the diameter was also not well-founded. The size range of 300 to 1000 nm given in one of the publications presented already refutes the thesis of the virus, since viruses are characterized by a small variation in their diameter between 15 and a maximum of 400 nm. Incidentally, information from the RKI dated January 24, 2012 states that the diameter of measles viruses is said to be 120-400 nm and often contain ribosomes inside, although the latter contradict the existence of a measles virus."

What I get from this is:

1. The virus was not properly "isolated and biochemically characterized" and "isolation had been scientifically documented"

2. The diameter established by the evidence provided was not well founded, and greatly contradict other findings.

What Lanka's main point to me is, is that in order to scientifically establish the existence of a (sub-)microscopic infectious disease carrier, you need to first truly isolate it.

Not "claiming to have isolated it in virologist terms", that is: claiming to have it contained in a concoction monkey kidney tissue, bovine fetal serum, and more; thus in a soup with other DNA carriers. Because this "redefinition of isolation" makes it impossible to say we actually found it. Also we cannot sequence the DNA/RNA of the virus in order to establish it's identity, when we are testing a soup that has other DNA/RNA in it. (That's why virologists use "in silico" sequencing, which is not trustworthy either: especially not when other DNA/RNA is present in the sample)

Since the theory of viruses has become widely accepted, we have learned a lot about other sub-cell biological things with DNA/RNA in them, like exosomes. We have truly isolated them, and truly sequenced their genetic material.

But somehow for viruses with still cannot do that.

I hence hold the position that the hard-scientific evidence on the existence of viruses is very thin, or just not there. It's merely a theory at this point.

Only once the existence is established we can meaningfully establish contagiousness.

For instance with polio it is claimed by "the horrific anti-vaxxers" that the vaccine was introduced when the wave of polio-like symptoms was on the decline. And that polio-like symptoms are since also, conveniently, characterized as other diseases. So there are other reasons than the effectiveness of the vaccine to the disappearance of symptoms in the population.

Hence we need to establish first the virus exists and is contagious, or we end up with the vaccine's effectiveness being the proof of the existence of the virus. Which is basically what I believe is where we currently are. And a decline of the wave of polio-like symptoms for other reasons can then easily be mistaken for effectiveness of the vaccine.

Therefor hard-scientific evidence is so important. Especially if states enact laws based on it, like we saw with covid measures and all state run vaccination programs.

Thanks for sticking to the discussion btw, I really appreciate you take the time to respond to my points that --i also know-- seem ridiculous from a mainstream viewpoint. Have a great day.

Re:Polio Detected in US by jefftk on Sunday July 24, 2022 @08:59AM (#32213050)
I know less about measles, but the broader question of how to identify viruses by DNA sequencing is what I'm now doing professionally.

You write: "Also we cannot sequence the DNA/RNA of the virus in order to establish it's identity, when we are testing a soup that has other DNA/RNA in it." That is generally not correct. When you sequence, what you get are subsequences ("reads") of around 200 base pairs. Generally a very large number of them. Then you try to figure out what genetic sequences could have led to you observing those reads, through a process called "assembly". The idea here is that if I have one read that looks like ABCDE and another like BCDEF, it's very likely that these were generated from an original sequence of ABCDEF. If your reads were drawn from a sample that has multiple things in it you will piece each one together separately, and as long as you took enough reads you'll be able to get the genetic sequence for each.

I've been working on wastewater recently, which is a huge mixture of many different things, but we see some extremely common genetic sequences. When you look up these sequences with BLASTN they turn out to be ones people have previously identified as plant viruses from vegetables people commonly eat, such as tomatoes, peppers, and cucumbers. [1] You can download the data and play with it yourself if you want?

Here's an approach that should let you replicate the identification of these sequences and is simple enough that you could code yourself:

1. Download one of the 180 FASTQ files the authors published

2. Extract the nucleotide sequences ("grep '^[ACTG]' fname.fastq")

3. Write a little program that emits all subsequences of length 40. Short enough not to get too many read errors, long enough that mismatches are unlikely.

4. Sort those subsequences. (Unix sort will do it, even though this will exceed the memory available on your machine unless you have a much better machine than I do.)

5. uniq -c

6. sort -nr

7. At this point the data should all fit in memory. Write a program where you make a map from the first 39 characters in a sequence to the last character, and from the last 39 characters to the first. Take the most frequent subsequence in the data and attempt to extend it using those two maps. You should end up with a sequence about 6k long.

8. Enter that sequence into https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastn&BLAS... It will probably identify it as Tomato brown rugose fruit virus.

I don't know how I would explain this if viruses didn't exist?

[1] https://journals.asm.org/doi/10.1128/AEM.01448-21

Re:Polio Detected in US by cies on Monday July 25, 2022 @07:12AM (#32222898)
I'll need a bit more time to look into this. But I will. Thanks.
Re:Polio Detected in US by colineartheta on Friday July 22, 2022 @01:20PM (#32194549)
I just want to clarify for my own understanding - are you making an argument that this individual, that has been tested for and is known to have the polio virus in their body (one of the most widely understood viral infections we have), is actually not afflicted with polio because…the symptoms are comparable to other, potentially unknown, diseases or causes?

Additionally, are you claiming that virologists, an area of study that has proven, repeatedly (through the very apparent efficacy of countless vaccines for diseases that ravaged humanity for millennia) to be one of the most remarkably successful scientific endeavors in human history, is somehow…not scientifically rigorous?

(I’m going to take a lot of karma damage for this, but I believe it has to be said)

Re:Polio Detected in US by lurquer on Friday July 22, 2022 @02:47PM (#32195694)
(Meanwhile, on other threads, there are discussions about the lamentable fraud that may have tainted Alzheimer/“brain plaque” research for the past 20 years, another thread about recent studies showing seratonin may have squat to do with depression, and you can always count on occasional thread regarding the Theranos debacle that deluded some very educated people. Greater harm, it seems, comes from lack of skepticism than too much of it.)
Re:Polio Detected in US by nemothekid on Friday July 22, 2022 @06:13PM (#32197744)
There's a super strange trend I've been seeing, since COVID, where science is no longer allowed to be wrong. Even though the very discipline is about making hypothesis and proving them wrong; I'm seeing a lot of arguments that kind of boil down to "Science is a liar sometimes"[1].

Do you have the same opinion on particle physics? Scientists have spent the better part of 80 years on an obviously wrong standard model - has that caused you to doubt Maxwell's equations or how the circuits in your computer works?

More seriously, "lack of skepticism" is bunk when the "skeptics" don't provide equal or greater research and reasoning. People have started to think of themselves as nobel laureates because they can say "no, I don't think so", and have 0 data to back them up.

[1] https://www.youtube.com/watch?v=U3Ak-SmyHHQ

Re:Polio Detected in US by triyambakam on Friday July 22, 2022 @08:57PM (#32199069)
This reminds me of weird it is to hear about the "scientific consensus" - it is such an oxymoron and meant to mean "anyone who disagrees is crazy"
Re:Polio Detected in US by colineartheta on Friday July 22, 2022 @03:05PM (#32195891)
I have followed that thread, and the Alzeimer "story" with great interest over the couple years I've been aware of it - in no way was my comment above meant to be a reflection on the possibility of a "taint" or lack-of scientific rigor (to bring in another example - the lack of repeatability in, oh, nearly every(?) social psychology experiment, etc. etc.) in the scientific and medical-science fields. The rise in administration at academic levels at the expense of science, the growing discontent in scientific funding being tied to results rather than curiousity, all very important - and very important to keep a skeptical mind about it all! Absolutely, that, to me, is the core of the scientific excercise.

I only meant that, in this particular case of polio detection, the cause and origin of the case is fairly cut-and-dry (there are other articles that have been published about it that give additional information), and introducing skepticism of the manner I responded to initially is likely to do more harm than good. Disinformation often begins with a distortion of a grain of truth, and the effects of that public skepticism and, dare I say it, ignorance (ironically?) breeds the environment that causes the reemergence of, for example, polio, amongst a public that is just being "skeptical" of vaccines.

Re:Polio Detected in US by lurquer on Friday July 22, 2022 @04:20PM (#32196652)
I hear you.

In regard to Polio vaccines, there is some head-scratching to be done if you go down that rabbit-hole. It’s all ancient history now, but the numbers of polio cases was dropping even before the vaccine roll-out. I don’t know enough about it to comment beyond that. But, I do know human nature: polio outbreaks were terrifying to parents, and there would be every reason not to be a bit skeptical when a solution to the problem was found… that is, it wasn’t a time for clear thinking in the midst of the panic. It’s precisely times like that when people are prone to overlook things.

For instance, imagine the chaos that could ensue if a disease that was overwhelmingly trivial and asymptomatic was advertised as possibly being 10 or 20 percent lethal? Heck, I bet folks would be so scared that they’d shut down entire countries, weld people into their apartments, gulp down horse de-wormer, mandate experimental drugs, etc. Of course, I exaggerate. I doubt something like that could happen in modern times. But, if it did, the skeptics back when it was going on and even after the panic had died down, would most likely be pilloried and accused of being unthinking idiots. Just saying.

Re:Polio Detected in US by mrguyorama on Friday July 22, 2022 @03:00PM (#32195839)
Except unlike that Alzheimers research, vaccines work. They often work astonishingly well. If you want to pretend viruses don't exist, you need to provide alternative reasons for why these vaccines work so well, and especially now that we have shown mRNA vaccines work, this alternative explanation also has to work in cases where only a tiny subset of that virus exists in the vaccine.

Quite simply, not understanding something, or not liking the consequences of it, is not skepticism, it's ignorance. Skepticism requires having good reasons to reject good models/research/outcomes etc. In the Alzheimers case, the reason for skepticism, which many people in the field had, was difficulty reproducing results, and lack of positive outcomes from therapies using that working hypothesis.

Blind skepticism makes you beyond stupid, and eventually turns you into an idiot who watches Alex Jones and thinks your own son is a crisis actor

Re:Polio Detected in US by cies on Friday July 22, 2022 @07:52PM (#32198587)
I'm not saying viruses do not exist. I'm saying that they are merely a theory that is not proven with the same scientific rigor that bacteria infections have been proven. In fact I find the science on the existence of viruses rather thin.

https://rumble.com/v13jt4t-science-pseudoscience-and-the-ger...

> especially now that we have shown mRNA vaccines work

Right, they dropped from 100% effective to 30% effective in the first weeks, then requiring boosters. They totally lied/oversold them. And everyone got "it" anyway. How does that mean "they work"?

Re:Polio Detected in US by aaaaaaaaaaab on Friday July 22, 2022 @08:55PM (#32199055)
You realize that viruses are visible via electron microscopy?
Re:Polio Detected in US by cies on Sunday July 24, 2022 @07:58AM (#32212581)
Are they? EM changes the sample, it can destroy cells.

Also they do not look at truly isolated samples of viruses: they look at concoctions of monkey kidney cells, bovine fetal serum and more with the supposed virus in there. When looking at a concoction like that, what certainty you have you see the virus and not another small biological particle (like exosomes, or dead cell debris)?

Last thing, it seems that with many of these EM photos of viruses, is that the control group was omitted. You also need to bring a concoction that does not have supposed virus in there and somehow show that does not contain the visual element that ARE seen in the sample with supposed virus. Virologists disagree and are okay with going ahead without control groups in these cases.

Re:Polio Detected in US by tekknik on Sunday July 24, 2022 @08:43AM (#32212894)
> When looking at a concoction like that, what certainty you have you see the virus and not another small biological particle (like exosomes, or dead cell debris)?

Because a virus looks nothing like cells that would make up any of those organs. When you examine enough samples and suddenly see some cells that don’t look like they belong that’s a pretty good indicator of a foreign body.

Re:Polio Detected in US by scifibestfi on Friday July 22, 2022 @03:02PM (#32195869)
I would have completely agreed with this until Covid, when many (not all) virologists completely threw scientific rigor out the window. It will take generations to rebuild the trust they burned.
Re:Polio Detected in US by erulabs on Friday July 22, 2022 @03:18PM (#32196030)
I would be cautious of making group generalizations like that. If a couple idiots who call themselves physicists publish a terrible paper -- that doesn't indict all of psychics. Covid made every amateur virologist and wanna-be-scientist come out of the woodwork. Don't throw the baby out with the bathwater!
Re:Polio Detected in US by jefftk on Friday July 22, 2022 @03:41PM (#32196258)
Why would a terrible paper by physicists indict all of psychics?
Re:Polio Detected in US by chihuahua on Friday July 22, 2022 @06:57PM (#32198112)
because of autocorrect
Re:Polio Detected in US by scifibestfi on Saturday July 23, 2022 @11:15AM (#32204056)
That's why I said "not all". But it was enough of them, and enough of them in positions of authority, that it damaged the entire field.
Re:Polio Detected in US by dougmwne on Friday July 22, 2022 @01:12PM (#32194468)
Wow, that’s quite a take. How do you explain the effectiveness of measles and polio vaccines if they were not viral illnesses?
Re:Polio Detected in US by Jwarder on Friday July 22, 2022 @01:50PM (#32194953)
I don't want to put works in cies's mouth, but it possible to read the comment in a reasonable way. It is not necessarily a claim that polio isn't real, but rather that patient's signs and symptoms can overlap with other medical issues. Stefan Lanka doesn't pass my sniff test, but reference to him and to test contamination can be read as examples that these sorts of tests are not always clear.
Re:Polio Detected in US by tekknik on Sunday July 24, 2022 @08:45AM (#32212908)
> but rather that patient's signs and symptoms can overlap with other medical issues

This is pretty well true with all illnesses though, so that’s a bad indicator.

Re:Polio Detected in US by cies on Friday July 22, 2022 @08:06PM (#32198685)
I found the roll-outs of these vaccines only came when the numbers of sick people were already well on the decline. I think polio is likely related to use of certain --now forbidden-- pesticides.
Re:Polio Detected in US by dougmwne on Monday July 25, 2022 @02:17PM (#32228607)
Animal testing played a significant role in development of a Polio vaccine. I understand you are making a point that correlation is not causation, but there are actual animal trials where they purposefully infected monkeys and watched the disease progression. There are plenty of things we may not understand in the world, but we do understand some science well enough to prove beyond reasonable doubt causal relationships in certain kinds of experiment design.
Re:Polio Detected in US by Induane on Friday July 22, 2022 @01:33PM (#32194707)
HN is generally okay with dissenting viewpoints.

I didn't know scurvy was considered contagious; that's pretty cool. I did know people used to cure it by drinking tea made from Arborvitae trees - or at least its European counterpart (I think they have the same common name).

I find the stance a little baffling though; if Measles isn't a virus, why can it's spread by halted by vaccination? Aside from the general usage and success thereof, sometimes it's easy to wonder just because the major outbreaks in the US happened a fairly long time ago. But a couple years back I had a coworker from Nigeria - I guess they still have outbreaks there?... anyway he scrambled to help get them money for MMR vaccines (I don't know if they're usually free via the WHO but supply wasn't abundant so - I guess bribes are a thing there moreso than here). And lo-and-behold none of his family got sick at all, but most of their smaller town did -- including their neighbors; a few had persistent physical problems (I don't recall what now) and a few people died. That's anecdotal, but goes very well with existing evidence and provides a nice microcosm for observation.

The MMR vaccine isn't a nutrient cocktail and I find it quite hard to conjure a Occam's razor explanation that doesn't involve a known virus (or maybe I severely lack imagination or am too tainted by existing knowledge). To make the vaccines (at least ones like the MMR vaccine) they culture viruses - letting them replicate in cells - and then weakening or killing them. Do the vaccines just happen to have a weakened form of a virus that doesn't cause Measles and it's protective quality merely a startling coincidence?

I mean, the virus can be viewed under a microscope https://www.ncbi.nlm.nih.gov/pmc/articles/PMC375751/ - if that isn't responsible for the preventative effects of the vaccine, then what actually is?

Sometimes science gets used badly and misconceptions abound or bad routes are taken for a while until they prove untenable; sometimes prevailing wisdom lasts a thousand years and then a Copernican revolution happens. They tend to be most useful to question though when there is a better alternative explanation that better fits the observations than the current prevailing wisdom.

Anyone can "question" anything - but what is the better fitting explanation exists for observations about Measles than the prevalent wisdom and evidence that it is a virus?

Re:Polio Detected in US by tshaddox on Friday July 22, 2022 @03:40PM (#32196251)
> I find the stance a little baffling though; if Measles isn't a virus, why can it's spread by halted by vaccination?

I mean surely anyone making the first claim would also make the claim that the measles vaccine is bogus. That second claim is already infamously popular enough in areas of the U.S. that there have been measles outbreaks among unvaccinated children.

Re:Polio Detected in US by cies on Friday July 22, 2022 @08:16PM (#32198754)
> if Measles isn't a virus, why can it's spread by halted by vaccination?

I say that viruses are still a theory. To truly scientifically prove it they need to isolate (truly isolate) the virus, and they never did that. Always there was cell materials in the concoction the virologists call an "isolated" virus.

> I mean, the virus can be viewed under a microscope https://www.ncbi.nlm.nih.gov/pmc/articles/PMC375751/ -

They looked at an concoction with lots of other biological particles: cells, decaying cells, cell parts, etc. There is simply no way to know they EM-photo'ed a virus or one of the other things.

And all the while they have not been able to truly isolate viruses, they were able to isolate all kinds of other small biological particles. Some carrying DNA. They managed to properly sequence that DNA. So far they never manage to truly sequence the DNA of a virus , but instead virologists do an "in silico" sequencing, which is more guesswork than actual sequencing.

Re:Polio Detected in US by projektfu on Saturday July 23, 2022 @08:37AM (#32202745)
A lot of what you're saying sounds smart but is devoid of meaning. I'm wondering if you have done any bench top research in biology. It's a humbling experience.

Viruses clearly exist. You can observe them infecting and lysing cells in real time. You can do controlled experiments where only the cultures containing viruses you've added get lysed. You can purify antibodies against them. You can prove that the antibodies inactivate the virus. As there are viruses that affect everything from bacteria to plants and animals, proving Koch's postulates for at least one virus is trivial.

None of that depends on EM. Microscopy merely gave us a picture of these things which lets us understand their structure better.

It doesn't depend on genome sequencing. That just helps us understand what proteins they make and why they vary.

However, both those techniques are substantially more valid than you give them credit for and are always used in the context of other tests to assure you're studying the right thing.

You talked about bovine serum and monkey cells. While both can be used in virology, the trend is for serum-free media and generally you want to use human cells when studying human viruses. In any event, if both the control culture and the test culture use the same media and cell type, anything different between them is likely due to the test. That's kind of fundamental to how science works. After all, human cells may contain dormant viruses or viral genomes, so you want to make sure that your controls are identical such that your intentionally infected cells are the only ones that show viral activity.

I used to joke that mouse deer didn't actually exist. That they were just jackelopes that the taxidermists made up for the museum of natural history. I bet that I could have made that very convincing with a lot of rhetoric. A visit, however, to a zoo with said ungulates alive and in the flesh would quickly prove me wrong. I think you're relying on the fact that you won't have to put your ideas to the test and nobody in your real life will be sophisticated enough to show you the reality. In that case, perhaps you'd be better served asking what you can do to prove that viruses exist? Otherwise you'll just go on like this.

Re:Polio Detected in US by cies on Sunday July 24, 2022 @08:17AM (#32212705)
> You can observe them infecting and lysing cells in real time.

Where? How?

> proving Koch's postulates for at least one virus is trivial.

I thought Koch's postulates were too strict for virologists... And hence were relaxed. (lol)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182102/

Can you show a somewhere the old postulates are all met for a virus?

> It doesn't depend on genome sequencing. That just helps us understand what proteins they make and why they vary.

And, not totally unimportant, to ID the particle we're looking at.

> While both can be used in virology, the trend is for serum-free media and generally you want to use human cells when studying human viruses.

Nice trend. Now can they also truly isolate (that is without other DNA/RNA carrying particles present) a virus? Like biologists have done with other biological particles of similar size?

Because without true isolation you could always be looking at "dead cell debris" or other stuff that is there and is not the virus, but may look like one.

> After all, human cells may contain dormant viruses or viral genomes, so you want to make sure that your controls are identical such that your intentionally infected cells are the only ones that show viral activity.

Bingo! So as long as you put "culture" cells in the sample and call that an isolate, it is polluting the sample.

> you'd be better served asking what you can do to prove that viruses exist?

Isolate them. Truly isolate them.

> I used to joke that mouse deer didn't actually exist. That they were just jackelopes that the taxidermists made up for the museum of natural history. I bet that I could have made that very convincing with a lot of rhetoric. A visit, however, to a zoo with said ungulates alive and in the flesh would quickly prove me wrong.

Because in the zoo you can see the animal all by itself. Now if you say you can only see deer mouse when they are in a soup with 50 other species of mouse, and you make a crummy black white pictures of the soup claiming some provide proof of your deer mouse: should I take you seriously?

Re:Polio Detected in US by projektfu on Monday July 25, 2022 @11:57AM (#32226248)
It's amazing how you so rapidly made my point. You display no interest in the subject at all, you're just trying to win what you think is a rhetorical argument. Nature doesn't care about arguments.
Re:Polio Detected in US by tekknik on Sunday July 24, 2022 @08:51AM (#32212974)
What looks like a virus that isn’t a virus? Why does this debris in multiple samples look similar if they’re random collections of other matter?

Why is it so hard to believe viruses exist?

Re:Polio Detected in US by cies on Monday July 25, 2022 @07:10AM (#32222881)
> What looks like a virus that isn’t a virus?

So what does it look like? We only have crummy black-white EM images, that look like any dead cell debris to me.

> Why is it so hard to believe viruses exist?

It was easy, I did it most of my life. It's much harder to question my beliefs, but maybe that's something you have less experience with.

> Why is it so hard to believe viruses exist? (2)

Because they have never been truly isolated. While other bio particles of similar size have.

Re:Polio Detected in US by tekknik on Wednesday July 27, 2022 @11:38PM (#32260231)
If you question electron microscopy then why do you not question your own eyesight? Eyes are just as susceptible to EM radiation no?
Re:Polio Detected in US by twawaaay on Friday July 22, 2022 @03:18PM (#32196029)
> HN is generally okay with dissenting viewpoints.

No, it is not. HN is for more or less like-minded people and if you stay too far from the beaten path you risk the ire of moderators regardless of whether you are right or not.

Apparently this is the price of keeping it civilised.

Re:Polio Detected in US by mike_d on Friday July 22, 2022 @04:08PM (#32196534)
The abundance of straight up looney anti-vaxx stuff that ends up in the HN comments proves this is not true.
Re:Polio Detected in US by tekknik on Sunday July 24, 2022 @08:53AM (#32212993)
Which looney anti-vax stuff? Polio or COVID, as there’s a huge difference
Re:Polio Detected in US by triyambakam on Friday July 22, 2022 @09:00PM (#32199096)
One comment on a thread of hundreds is an abundance?
Re:Polio Detected in US by rgrieselhuber on Friday July 22, 2022 @01:08PM (#32194406)
> (I'm going to take a lot of karma damage for this, but i believe it has to be said)

I don't think you have anything to worry about, HN is well-known to be highly tolerant of a variety and even dissenting opinions.

Re:Polio Detected in US by joeyh on Friday July 22, 2022 @05:13PM (#32197197)
He did travel, to Poland and Hungary. The AP originally had an article claiming no travel, but later updated it.

Vincent Racaniello covers this and other details, recommended: https://www.youtube.com/watch?v=P-5KGHzHTsI

Re:Polio Detected in US by qbasic_forever on Friday July 22, 2022 @05:50PM (#32197520)
He didn't travel in the last 30 days I read, and the incubation time is shorter than that. I.e. he caught it after coming home.

Vincent has been a very bad source of information for the COVID pandemic. He has famously been against vaccine boosters, and even declared he didn't think he needed one. Even now as the need for second boosters is clear (and the need for first boosters completely justified and verified) he still says they aren't necessary. This is on top of him downplaying every variant like Omicron and saying they wouldn't be a problem (and then they went on to be huge problems). He should not be platformed IMHO.

Re:Polio Detected in US by claytongulick on Friday July 22, 2022 @10:53PM (#32199832)
Based on your opinions, I don't think you should be platformed.

Kind of stinks when it's used against you, doesn't it?

The solution to bad ideas is more ideas, not "deplatforming" or whatever mealy-mouthed word is currently being used to make censorship marketable these days.

Re:Polio Detected in US by pstuart on Friday July 22, 2022 @11:41PM (#32200116)
So would you consider @dang to be some mealy-mouthed censor when he admonishes and possibly removes content here that goes against community guidelines?
Re:Polio Detected in US by ls15 on Friday July 22, 2022 @11:57PM (#32200203)
That fully depends on the content of the guidelines.
Re:Polio Detected in US by pstuart on Saturday July 23, 2022 @12:18AM (#32200313)
https://news.ycombinator.com/newsguidelines.html

My question is simple: is there any speech that should not be tolerated here? Yes, or no?

Re:Polio Detected in US by ls15 on Saturday July 23, 2022 @11:21AM (#32204113)
I am totally fine with banning verbal attacks on others, just like physical attacks are typically banned IRL too.

Basically the same rules can be applied, for example a counter attack in defense is a lighter offense than an unprovoked attack.

I think that this does not particularly limit someone's ability to express their opinions, ideas and beliefs.

Re:Polio Detected in US by pstuart on Sunday July 24, 2022 @02:31PM (#32216250)
Outright incitement to violence against others is easy to recognize as speech not worth tolerating.

But here it gets interesting: hate speech wrapped up as "opinions, ideas, and beliefs". At the risk of downvotes (what ev er), I posit that Fox News engages in high level hate speech (not every minute but enough for it to count).

Case in point: Tucker Carlson's "The Great Replacement" agenda. It's thinly veiled white nationalism -- basically arguing that white people are under attack from non-whites. Yes, it gets discussed by him as "what if" and "how come" but it has an agenda that is prepared to be enforced by violence by those who are spooked by it.

I don't have an answer for how to deal with this, but it is in the end hate speech and is not healthy for society as a whole.

Re:Polio Detected in US by teakettle42 on Saturday July 23, 2022 @02:17AM (#32200872)
Manner restrictions are different than content restrictions.

There’s speech that doesn’t fit the community’s guidelines in terms of the manner it is expressed, but I don’t believe there are any ideas that should not be tolerated here.

Re:Polio Detected in US by Fargoan on Saturday July 23, 2022 @02:33AM (#32200940)
Hitler did nothing wrong.

Do you still stand by your statement? Should that idea be tolerated on this forum?

Re:Polio Detected in US by teakettle42 on Saturday July 23, 2022 @02:44AM (#32200988)
Sure. Why not? Make a cogent argument for the idea.

I’ll disagree, of course, but in the exceedingly unlikely event that you present a strong argument, it’s still an opportunity to hone my own counter-argument.

Re:Polio Detected in US by claytongulick on Saturday July 23, 2022 @11:43PM (#32210119)
Good to see that Godwin [1] holds.

The answer is yes, absolutely.

And I'd happily engage you to try to convince and educate you, in a respectful way, why I believe that's incorrect.

Because that's how we raise ourselves up.

Censoring, reviling, shutting down and abandoning people who hold these sorts of beliefs only serves to reinforce them and drive them into echo chambers of radicalization.

So yes, by all means. Express any thoughts, ideas, opinions or dreams you have.

By actively participating in the marketplace of ideas, we can let the best ones rise, and the worst ones defeat themselves.

Through discussion and debate, not force or cooersion, of which censorship is an insidious form.

[1] https://en.m.wikipedia.org/wiki/Godwin's_law

Re:Polio Detected in US by pstuart on Sunday July 24, 2022 @02:33PM (#32216274)
Why not try something along the lines of:

"We need to kill all the ** to keep our race pure"

Is that speech that should be tolerated? Karl Popper would say no, and I agree with his reasoning.

Re:Polio Detected in US by ls15 on Saturday July 23, 2022 @11:37AM (#32204304)
Context matters in my opinion. If you say this to a person whose jewish family has survived the Holocaust, then I would say this statement is an indirect verbal attack. You could as well say "Your family should have been killed". Verbal attacks are an attempt to hurt people, just like physical attacks are, and therefore in my opinion it is fair to ban them to some extent.

I don't even think this has anything to do with free speech, as in freedom to express your thoughts. The key with free speech is that everyone is entitled to that. Verbal attacks are often an attempt to stop others from expressing their thoughts, so I think they are fundamentally an action against free speech.

That being said, as a German, I don't agree with the German blanket bans of certain expressions. Context and intentions always matter, I think.

Re:Polio Detected in US by claytongulick on Saturday July 23, 2022 @11:52PM (#32210160)
I think that I don't agree with this, entirely.

Most, if not all, meaningful speech risks offending someone.

Framing uncomfortable beliefs as attacks grants a form of "victim power" by which anyone can claim to be a victim of your "attack" as a means of shutting down speech.

This isn't a hypothetical, I see the technique used frequently.

Re:Polio Detected in US by ls15 on Sunday July 24, 2022 @01:02AM (#32210473)
I agree that this is a possibility and a risk, but I think that a bit of common sense goes a long way. One of my classmates tried to frame everyone who disagreeed with him as nazi, but nobody fell for it, because it was obvious that he just tried to evade criticism. There also needs to be some leeway - for example a German court has ruled that a public service worker could not be fired for calling his boss an "old asshole", because they've known each other for very long. Context matters.
Re:Polio Detected in US by dennis_jeeves1 on Saturday July 23, 2022 @07:58AM (#32202525)
At a broader level I think the solution is simple. Any person must be able to decide who he/she personally wants to listen to. in forums this can be implemented by a feature that allows you to hide certain people's comments based on your own judgement. At HN and most other forums the moderator or others decide if a person's comments are to be visible to others.

I really have a hard time understanding what the drama is about.

[dead]
Re:Polio Detected in US by jeromegv on Friday July 22, 2022 @07:09PM (#32198209)
The vaccine is vastly effective to prevent hospital stays and death by a very high margin.

Yes, it is true, it does not prevent spread, as we thought it might. But it prevents the worse outcome of it, which is a big win.

Re:Polio Detected in US by claytongulick on Saturday July 23, 2022 @11:59PM (#32210198)
There's a lot of nuance here.

In what population? With what comorbiditities?

What are the other associated risks?

Based on that I've seen, in certain populations the risks of vaccination are close to, or outweigh the risks posed by covid infection.

This is why medical decisions are personal and should be made in consultation with a doctor.

Re:Polio Detected in US by kelnos on Friday July 22, 2022 @07:36PM (#32198437)
If you're less likely to get COVID if you are vaccinated (which seems to be the case; at least in my city, two-thirds of the case rate is coming from unvaccinated people), then it absolutely does reduce spread. Not "prevent", but that was never a realistic outcome.
Re:Polio Detected in US by mwint on Friday July 22, 2022 @07:14PM (#32198253)
Please confirm: this means the people saying the vaccine should be a strictly personal decision were correct?
Re:Polio Detected in US by blamestross on Friday July 22, 2022 @07:37PM (#32198439)
One judges decisions based on available information. All the then available information indicated that mass vaccination was the best means of reducing transmission, especially because such large portions of the population were unwilling (or unable) to lock down to prevent spread. Even then, it still has been shown to prevent spread, just not as effectively as hoped.

From a public health perspective mass vaccination was definitely the right approach.

Re:Polio Detected in US by mwint on Friday July 22, 2022 @08:56PM (#32199062)
Certainly one cannot judge a decision by its outcome, but we can perhaps learn something if the skeptics we were banning from social media ended up being correct.

Whether they were following proper reasoning or not, if they were right it’d be good to take a step back and figure out if anything in the “proper reasoning” system needs adjusted.

Re:Polio Detected in US by blamestross on Saturday July 23, 2022 @02:05PM (#32205847)
That I agree with. A lot of bad assumptions were revealed, but not the ones I think you are alluding to.

- If the market and the government disagree on the value of human lives, the market wins. (Basically the government should just consign more people to die, especially vulnerable populations to avoid drama)

- A nontrivial portion of the population reacts to government intervention with spiteful noncompliance (we need to be using a softer and more coercive hand than 'authority says X is the best plan')

- If we have to fall back on socialized medicine whenever there is a crisis, maybe we should just do it all the time.

- There will be more pandemics, more often, until the forces permitting them change.

As somebody who immunocompromised, this pandemic taught me exactly how little my life is valued by my civilization and government.

Re:Polio Detected in US by ajkjk on Friday July 22, 2022 @07:33PM (#32198403)
There is plenty of data to establish exactly what the vaccine does, and how effective it is (very), so we don't have to guess or infer from weird anecdotes.
Re:Polio Detected in US by stjohnswarts on Friday July 22, 2022 @03:23PM (#32196071)
surely they are testing sewage to see if there is more of the polio virus in the drainage. I thought the CDC had started using that a lot more often. On the left you have nuts who think vaccines are unnatural and therefore awful, and on the right you have nuts who say the government is injecting nanites for 5G mind control. It's a crazy world out there.
Re:Polio Detected in US by ajsnigrutin on Friday July 22, 2022 @07:55PM (#32198611)
I mean... the crazy nuts also predict a lot of stuff that ends up being true.

I got vaccinated because "if you get vaccinated, you won't get covid"... and then the narrative changed. 5G (well, every technology from 2g onwards) also enables a lot more precise tracking of users (their location).

Re:Polio Detected in US by Fatnino on Friday July 22, 2022 @08:37PM (#32198930)
If you get the vaccine, you won't get (and this detail is important) the ALPHA VARIANT of covid. And indeed, I'd bet dollars to donuts you did not end up catching Alpha.

The vaccine was never going to be great against variants (though some people did claim it would be just as good with little evidence) and the more removed the variants get (ie, variant of a variant) the less chance those older vaccines have of resisting them.

So it's not exactly that the "narrative changed" so much as that the virus changed and the narrative didn't keep up fast enough.

Re:Polio Detected in US by seoaeu on Friday July 22, 2022 @09:07PM (#32199153)
Pedantic: the alpha variant is B.1.1.7 previously known as the UK variant. The original strain didn’t get a Greek letter
Re:Polio Detected in US by origin_path on Saturday July 23, 2022 @09:14AM (#32203026)
Almost nobody caught Alpha or the original strain the vaccines actually targeted because they had naturally disappeared before the vaccines were even available.

The fact that the virus would change was obvious from the start. Coronaviruses always do mutate fast, it's why nobody bothered making vaccines for then before. The narrative changed not because the emergence of yet another variant was unexpected but because the narrative was always and everywhere whatever would convince people to take shots, not what was true.

Re:Polio Detected in US by vorpalhex on Friday July 22, 2022 @09:02PM (#32199113)
You can still get the alpha variant.

For what it's worth, we knew really early that the vaccine reduced severe illness primarily. People continued to be, and still are, inaccurate.

Re:Polio Detected in US by origin_path on Saturday July 23, 2022 @09:17AM (#32203050)
The rampant historical revisionism about vaccines is absurd. It's 1984 level stuff.

The trials didn't even measure "severe illness", so no, we definitely didn't know that by any definition of early. Actually that claim only came to the fore as effectiveness against infection collapsed and a new justification was required.

Re:Polio Detected in US by ajsnigrutin on Friday July 22, 2022 @11:01PM (#32199883)
https://thehill.com/homenews/sunday-talk-shows/553773-fauci-...

> “So even though there are breakthrough infections with vaccinated people, almost always the people are asymptomatic and the level of virus is so low it makes it extremely unlikely — not impossible but very, very low likelihood — that they’re going to transmit it,” Fauci said.

So, very few get it at all, and the ones who get it, can't spread it, even without masks. This (well, similar, from our local agencies) was the info I got when i went to get vaccinated.

Re:Polio Detected in US by vorpalhex on Saturday July 23, 2022 @02:01AM (#32200793)
I'm going to repeat my claim.

You can still get it.

You are agreeing with me.

If you want people to trust you, you have to be honest. If you make obvious lies then you get caught and trust is destroyed. The CDC repeatedly lied and misled the American public and now is having trust issues leading to people not getting vaccinated like they should.

If you want to be trusted, don't lie.

Re:Polio Detected in US by seoaeu on Friday July 22, 2022 @09:04PM (#32199139)
> if you get vaccinated, you won't get covid

Literally no one reputable ever said this given that original studies showed 95% effectiveness at preventing wild-type Covid…

Re:Polio Detected in US by ajsnigrutin on Friday July 22, 2022 @09:33PM (#32199303)
https://thehill.com/homenews/sunday-talk-shows/553773-fauci-...

> “So even though there are breakthrough infections with vaccinated people, almost always the people are asymptomatic and the level of virus is so low it makes it extremely unlikely — not impossible but very, very low likelihood — that they’re going to transmit it,” Fauci said.

So, almost noone vaccinated will get it, and those who do, won't spread it.

So, people literally died, because they though they coudln't get it, and went out, and other people who though they couldn't spread it, spread it around.

Re:Polio Detected in US by seoaeu on Saturday July 23, 2022 @12:23PM (#32204755)
> if you get vaccinated, you won't get covid

[…]

> So, almost noone vaccinated will get it

That’s a pretty clear case of moving the goalposts if I ever saw it.

Re:Polio Detected in US by bazzert on Saturday July 23, 2022 @05:45AM (#32201829)
President Biden said it.
Re:Polio Detected in US by azinman2 on Friday July 22, 2022 @05:16PM (#32197219)
I’d like to see a strong new center.
Re:Polio Detected in US by mcguire on Friday July 22, 2022 @03:51PM (#32196359)
This whole thing is very concerning.

"According to the New York State Health Department, a person was found to be infected by a vaccine-derived poliovirus type 2 (VDPV2), aka revertant polio Sabin type 2 virus."

"Vaccine-associated paralytic polio" (https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-p...) is "a rare adverse event" following immunization with the Oral Polio Vaccine. "The United States exclusively has used IPV since 2000."

I doesn't seem likely that a "young adult" who hasn't travelled outside the US would be exposed to the OPV. Possibly, from some of the other cases mentioned in the CDC article, someone the young adult interacted with had been exposed to it, though.

The original article doesn't mention if the young adult was immunocompromised, which seems like a requirement for a secondary OPV infection.

Re:Polio Detected in US by Fomite on Friday July 22, 2022 @05:55PM (#32197556)
This does indeed seem like the unfortunate confluence of being exposed to someone shedding the vaccine-strain and community transmission. Which is exceedingly rare in the U.S., but is entirely foreseeable in low vaccination rate enclaves, which are growing more common.
Re:Polio Detected in US by mike_d on Friday July 22, 2022 @04:22PM (#32196675)
The risk of spread from weakened virus is completely eliminated under a proper vaccination program. You go into a community, vaccinate everyone, and you have zero risk.

The fact the patient was unvaccinated was effectively their "immunocompromise" that allowed the virus to spread to them.

Re:Polio Detected in US by makomk on Friday July 22, 2022 @04:49PM (#32196949)
Unfortunately, vaccinating everyone is not actually zero risk. A small proportion of people who recieve the oral polio vaccine develop vaccine-associated paralytic polio which is exactly what it sounds like - full-on paralytic polio caused by receiving the vaccine. It's a rare complication, somewhere around one in a million, but back when polio had been eradicated in most of the world it was the main cause of paralytic polio. So we'd really like to fully eradicate polio and then stop using that vaccine.

This is made harder by another similar but subtly different problem - circulating vaccine-derived polioviruses. They come from the oral vaccine too, but instead of affecting vaccinated people they spread amongst the unvaccinated population and evolve to regain the virulence and high rate of paralyzation of wild polio. It's one of those viruses that was found in New York. This poses a problem for eradicating polio and stopping vaccination, because once you're no longer vaccinating people they can catch and spread the virus from the oral vaccine and it can evolve into something dangerous. The current VDPV problem traces back to an attempt to finally finish eradicating the type 2 poliovirus, which no longer exists in its wild form, by removing it from the oral vaccine and stamping out any subsequent VDPV spread. This failed badly.

Re:Polio Detected in US by oneoff786 on Friday July 22, 2022 @05:45PM (#32197477)
Wikipedia states

> A potential, adverse effect of the OPV is its known ability to recombine to a form that causes neurological infection and paralysis.[27] This genetic reversal of the pathogen to a virulent form takes a considerable time (at least 12 months) and does not affect the person who was originally vaccinated. The vaccine-derived attenuated virus is normally excreted from vaccinated people for a limited period. Thus, in areas with poor sanitation and low vaccination coverage, the spontaneous reversal of the vaccine-derived virus to a virulent form and its spreading in the environment can lead to unvaccinated people becoming infected.

Which boils down to no, you cannot get polio from the polio vaccine but potentially some others could get polio from you for a short period a year later if they’re not vaccinated.

Re:Polio Detected in US by makomk on Friday July 22, 2022 @07:40PM (#32198480)
A couple of paragraphs up in the Wikipedia article: "Oral polio vaccine results in vaccine-associated paralytic poliomylelitis in about three per million doses". I've also seen one in two million doses quoted elsewhere, but it's somewhere around the one in a million mark. You coupld probably quibble about whether that really counts as getting polio, but it's paralysis caused by infection with poliovirus and there is "no clinical difference between the paralysis caused by wild poliovirus, OPV, or VDPV" according to the CDC's FAQ on the topic so that's not a particularly interesting semantic quibble to me.
Re:Polio Detected in US by oneoff786 on Saturday July 23, 2022 @06:56AM (#32202183)
But NOT to the person who was vaccinated
Re:Polio Detected in US by mike_d on Friday July 22, 2022 @05:01PM (#32197070)
One in 200 infections leads to paralysis. So yes it is effectively zero risk compared to non-vaccination.

If you eliminate the unvaccinated population, vaccine-derived infections are a non-issue. Which is how we addressed the problem prior to 1979 - largely due to the fact that everyone saw first had what the virus did and there was no vaccine hesitancy.

But we haven't used weakened virus vaccines for polio in the last 20 years, so it's kinda moot.

Re:Polio Detected in US by robocat on Friday July 22, 2022 @04:43PM (#32196890)
> zero risk

* if you live on a spherical planet with spherical people

Re:Polio Detected in US by xyzwave on Friday July 22, 2022 @06:47PM (#32198007)
[dead]
Re:Polio Detected in US by mike_d on Friday July 22, 2022 @04:33PM (#32196785)
> https://www.sciencedirect.com/science/article/pii/S027869152...

Which has been thoroughly debunked by the scientific community. "Food and Chemical Toxicology" is not a respected journal, and most famously published the "GMO foods cause cancer" paper that ended up being retracted.

Here is a good video on why the author is a quack: https://www.youtube.com/watch?v=YwoRsj7AE7A

Re:Polio Detected in US by Consultant32452 on Friday July 22, 2022 @05:06PM (#32197117)
The Lancet data shows the same conclusion through different means. Did you have any thoughts on that?
Re:Polio Detected in US by mike_d on Friday July 22, 2022 @05:56PM (#32197561)
No it doesn't? Maybe you have the wrong link?

The link you provided is just a standard vaccine efficacy over time study using data from Sweden. These are a dime a dozen and all show two things: 1) you are less likely to die when vaccinated, and 2) immune response reduces over time so you need boosters.

Re:Polio Detected in US by mooman219 on Friday July 22, 2022 @03:44PM (#32196295)
> [Rockland County residents], have some of the lowest vaccination rates in the state; Monsey's is the lowest in the state, at 17.8%, as of June 15, 2021

Rockland County from the article.

Re:Polio Detected in US by Izkata on Friday July 22, 2022 @04:03PM (#32196472)
That's not in the article, a different comment here got it from Wikipedia.
Re:Polio Detected in US by Fargoan on Friday July 22, 2022 @04:03PM (#32196471)
I don't trust anyone who refers to the COVID vaccines as "the jab"