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Re:Infection fatality rate of Covid-19 inferred from seropre... by morsch on Saturday October 17, 2020 @10:55AM (#24810409)
Here's another recent meta-study (preprint) on the same topic: Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications https://www.medrxiv.org/content/10.1101/2020.07.23.20160895v...

Abstract: This paper assesses the age specificity of the infection fatality rate (IFR) for COVID-19 using results from 29 seroprevalence studies as well as five countries that have engaged in comprehensive tracing of COVID-19 cases. The estimated IFR is close to zero for children and younger adults but rises exponentially with age, reaching 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85. We find that differences in the age structure of the population and the age-specific prevalence of COVID-19 explain nearly 90% of the geographical variation in population IFR. Consequently, protecting vulnerable age groups could substantially reduce the incidence of mortality.

I think those results are in the same ballpark as what Ioannidis calculates. This isn't good news, really, not for middle-aged-adults anyway.

IFR(age) = 0.1 x 10^((age-82)/20)

Re:Infection fatality rate of Covid-19 inferred from seropre... by rndgermandude on Saturday October 17, 2020 @11:15AM (#24810576)
>This isn't good news, really, not for middle-aged-adults anyway.

Or for anybody who knows middle aged and older people, especially if you spend time with them. I am honestly more concerned about killing my parents than dying myself of covid-19. This is why I skipped my mom's birthday for example, because I had pretty mild cold-like symptoms... or maybe mild covid-19.

Re:Infection fatality rate of Covid-19 inferred from seropre... by onecommentman on Saturday October 17, 2020 @08:49PM (#24814745)
BTW, for those substantially younger than dirt. You may be wondering why your elder elders aren’t particularly frightened by this, but folks 40 to 60 are more sensitized.

After a certain age momento mori, a reminder that you will die, start coming at you fast and furious. This is just one more. They probably care more about seeing you than this next scheduled flight to Heaven.

What unique about the shutdowns and social isolation, for the 40s-60s, are this is a momento senesci (if I have the Latin right). It’s a reminder that they will mostly likely enter a stage in life called old age, the slo-go/no-go stage of old age. A time when there will be fewer friends to visit, or the logistics become too difficult. A time when they will stay at home much more, and wouldn’t it be nice to have a comfortable home to be in. A time when that next flu won’t be so easy to shake, so maybe they skip that concert. The grim reaper isn’t knocking at the door, but rather an older, frailer version of themselves. These shutdowns and social distancing are a disconcerting trial run.

My take on things...

Re:Infection fatality rate of Covid-19 inferred from seropre... by joe_the_user on Sunday October 18, 2020 @05:06PM (#24821137)
That older people aren't frightened by this seems like a gross generalization. Plenty of the people disturbed by the rather poor and haphazard against Covid are older people who feel personally threatened.

Everyone experiences aging but in this highly individualized culture, how one interprets the experience is also individualized - varying from welcoming to acceptance to various fitness/health measures aimed to stave it off - plus there's denial and anger.

Someone looking forward to enjoying old age might not want life to end in middle age, etc...

Re:Infection fatality rate of Covid-19 inferred from seropre... by agapon on Monday October 19, 2020 @03:49AM (#24824124)
I think it's "memento" not "momento".
Re:Infection fatality rate of Covid-19 inferred from seropre... by nradov on Saturday October 17, 2020 @02:07PM (#24811885)
That was always a risk even before COVID-19. Regular seasonal influenza can be deadly, especially to the elderly. Patients can transmit it to others when they are asymptomatic or presymptomatic. COVID-19 has a longer incubation period and a significantly higher fatality rate but the same fundamentals still apply.

Any of us could have inadvertently killed someone by giving them the flu without even realizing it.

Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @03:32PM (#24812509)
This is all true, but COVID hysteria has taken hold across the entire world, and HN is no exception unfortunately.

You are being reflexively down voted because people view any comparison to Influenza as illegitimate, not realizing that you are making a broader point about risk management and attribution of blame for infection as opposed to saying that SARS-2 and Influenza are literally the same viruses.

Personally I find it fascinating that I was never told it was my fault if I gave someone the flu in the course of both of us living our normal lives, but if I go to a grocery store and an elderly person does too and they get COVID-19 from me (imagine in this hypothetical there is no doubt that I gave them the virus) then somehow it’s my fault and I’m guilty of any harm that befalls then.

Incredibly dangerous precedent. I hope people see where it leads. And I hope they learn from the history of public health, such as when “public health officials” used to shut down gay bars “for the greater good”.

Re:Infection fatality rate of Covid-19 inferred from seropre... by jointpdf on Saturday October 17, 2020 @04:04PM (#24812794)
I can only speak for myself here, but COVID-19 has increased my awareness of the impact of flu season and I will endeavor to mitigate the risk of infecting others in the future. In the past, I hardly gave it a second thought—it never occurred to me that I could kill or harm someone by being careless (e.g. riding the metro to/from the climbing gym during flu season and indiscriminately spreading germs). Masks, giving people space, combining shopping trips, biking or driving, etc.—all are super easy ways to reduce potential harm to myself or others, so I’m more than happy to do these things as necessary going forward. There is no sense of fear or guilt, since I know I’ve done what I can reasonably do.

In that sense, I think comparing COVID-19 to the flu is helpful.

Re:Infection fatality rate of Covid-19 inferred from seropre... by dabbledash on Saturday October 17, 2020 @04:45PM (#24813212)
This is something I really worry about: that people are so risk averse and so invested in the COVID response that society is going to permanently become more cold, more closed off, and less human. 2020 life is no way to live long term, and I don’t even want to take a step in this direction. If I found out tomorrow that there would never be a cure or vaccine for COVID, I would just go back to living like I lived before.
Re:Infection fatality rate of Covid-19 inferred from seropre... by supernovae on Saturday October 17, 2020 @06:01PM (#24813753)
People need to read history. History shows this isn't our first rodeo with a pandemic. History shows that social distancing works. History shows that society thrived after.

In fact, cities that didn't socially distance had things much worse and took longer to recover.

Humans are resilient creatures. We're not going to lose our social capabilities just because we're also evolved enough to be smart to stay safe for survival.

Re:Infection fatality rate of Covid-19 inferred from seropre... by jointpdf on Saturday October 17, 2020 @05:58PM (#24813736)
I disagree strongly with the notion that mitigating risk of harm to others via awareness and simple action somehow makes society less human. I live in DC, a notoriously cold and closed off city as far as social interaction goes. Mask usage (even outdoors) is close to 100% here. When I see someone wearing a mask, I’m filled with a sense of warmth and camaraderie—that person cares about me and others. Someone else may see the same scene and think, “look at all these petrified sheep”. I sort of understand, but I’d challenge those people to shift their perspective.

If kinship isn’t your thing but sober analytical thinking appeals to you, wearing a mask is a no-brainer: positive benefit with effectively zero cost (the only negative thing that can happen to you is that someone might think you’re a terrified dweeb, but they’d be wrong).

Re:Infection fatality rate of Covid-19 inferred from seropre... by dabbledash on Saturday October 17, 2020 @06:11PM (#24813812)
It goes far beyond masks. No hugging. No shaking hands. No singing. No bars. Masks and plexiglass for kids who are lucky enough to actually get school. Not having funerals for the dead. We can put up with these things in the short term to protect the vulnerable, and you’re right that people’s concern for others speaks well of them.

But the logic some people use to support these things veers into territory where it sounds like they would be willing to make (or demand) any sacrifice for literally any increase in safety. I worry about how that will play out long term.

But that’s just my fear. Hopefully it’s overblown (and it probably is).

Re:Infection fatality rate of Covid-19 inferred from seropre... by gruez on Saturday October 17, 2020 @08:04PM (#24814503)
>But the logic some people use to support these things veers into territory where it sounds like they would be willing to make (or demand) any sacrifice for literally any increase in safety. I worry about how that will play out long term.

Seems like you're strawmanning/shifting the goalposts, considering your initial comment says "I would just go back to living like I lived before", which would suggest you would take zero protective measures.

Re:Infection fatality rate of Covid-19 inferred from seropre... by dabbledash on Saturday October 17, 2020 @08:14PM (#24814577)
Yeah, I think that was an overstatement of my position and unnecessarily provocative.

I probably would mostly go back though. Overall, I’d rather accept a more dangerous world with normal human contact than continue the kind of things we’re doing now indefinitely. But I’m sure I’d be more cautious about visiting a nursing home than I was pre-Covid. I’d be a lot more likely to isolate at the first sign of a fever than I used to be. I’d wear a mask when I’m sick. But I’d probably stop avoiding gatherings, masking when I’m well etc.

Re:Infection fatality rate of Covid-19 inferred from seropre... by sterlind on Saturday October 17, 2020 @04:57PM (#24813296)
I sure hope that sick people continue to wear masks once this is all over. It's basic human decency to avoid spreading germs - even the flu - to others, especially elders. This is the norm in Asia.

After COVID ends, I won't wear a mask if I'm healthy but I sure as hell will if I have a cough or fever.

Re:Infection fatality rate of Covid-19 inferred from seropre... by dabbledash on Saturday October 17, 2020 @05:07PM (#24813378)
Might be reasonable, but would you wear one all flu season just to make sure you don’t unwittingly infect someone while you’re asymptomatic? Might save a life.

If everybody comes out of this more careful about handwashing, I can’t argue that that’s bad. But I worry it’s going to go way past that.

I’m probably wrong though, judging by the number of people who already can’t be bothered with the one way aisles at the grocery store.

Re:Infection fatality rate of Covid-19 inferred from seropre... by anoncake on Saturday October 17, 2020 @06:29PM (#24813942)
You can cough and sneeze into a mask if you want. I think it's disgusting.
Re:Infection fatality rate of Covid-19 inferred from seropre... by ficklepickle on Saturday October 17, 2020 @07:10PM (#24814162)
More or less disgusting than coughing and sneezing all over everyone around you?
Re:Infection fatality rate of Covid-19 inferred from seropre... by anoncake on Sunday October 18, 2020 @07:24AM (#24817037)
My elbow hasn't complained so far.
Re:Infection fatality rate of Covid-19 inferred from seropre... by EliRivers on Sunday October 18, 2020 @01:52PM (#24819735)
You just dump snot and mucus into your own elbow? What, like, onto the skin or does it just soak into the clothes you're wearing? For someone throwing around the word "disgusting" you're not exactly an exemplar.
Re:Infection fatality rate of Covid-19 inferred from seropre... by anoncake on Sunday October 18, 2020 @09:07PM (#24822520)
Re:Infection fatality rate of Covid-19 inferred from seropre... by EliRivers on Tuesday October 20, 2020 @03:20PM (#24841332)
Nope. I think sneezing into your elbow is pretty gross. You telling me it's better than your hand doesn't suddenly make it nice.
Re:Infection fatality rate of Covid-19 inferred from seropre... by anoncake on Wednesday October 21, 2020 @12:52PM (#24849644)
Of course it isn't nice. It's just the least bad option when other people are around.
Re:Infection fatality rate of Covid-19 inferred from seropre... by BlewisJS on Saturday October 17, 2020 @04:01PM (#24812759)
If you know you have the flu (or COVID-19), surely you know you are likely contagious and can spread it to more vulnerable people. Yes, it is your fault and you deserve blame if you knowingly spread it to others through negligence. Stay home if you're sick.
Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @04:14PM (#24812891)
I agree those who are symptomatic should stay home. But for COVID we go further and tell asymptomatic people to perform (flawed) transmission control measures. Where do we do that with Flu?

The point is if I don’t know I have COVID and spread it to Grandma at the grocery store, in your eyes I’ve killed Grandma. I wonder why we don’t apply that logic everywhere.

Re:Infection fatality rate of Covid-19 inferred from seropre... by kvez on Saturday October 17, 2020 @04:45PM (#24813204)
The influenza vaccine is a flawed transmission control measure and is the best we have available, same as masks. We do blame people who skip those, although it doesn't show on their faces like the absence of a mask does.

The spreadability of the flu is also much lower than that of COVID-19 (largely thanks to the vaccines), which is really why people never regarded masks as necessary for the flu.

Re:Infection fatality rate of Covid-19 inferred from seropre... by amelius on Saturday October 17, 2020 @03:39PM (#24812558)
I don't see the point. There are rules now, so not following them would indeed make it your fault if someone gets sick because of your actions that were not in accordance with the rules.
Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @03:49PM (#24812637)
Because if I go out into the world and get infected with a disease, that’s one of the risks of living life, and we have always understood that. That’s why if you catch the flu nobody blames the man next to you at the grocery store.

For COVID we throw this out the window.

When you take the approach to its logical conclusion you end up in a very scary place.

Re:Infection fatality rate of Covid-19 inferred from seropre... by amelius on Saturday October 17, 2020 @05:04PM (#24813358)
> That’s why if you catch the flu nobody blames the man next to you at the grocery store.

I would if he wasn't sufficiently careful about it.

Re:Infection fatality rate of Covid-19 inferred from seropre... by amanaplanacanal on Saturday October 17, 2020 @10:14PM (#24815044)
One of the risks of sex is venereal disease. I probably shouldn’t bother with condoms though, it’s just one of the risks of living life. Is this the same logic you are using, or am I misunderstanding you?
Re:Infection fatality rate of Covid-19 inferred from seropre... by nobody9999 on Sunday October 18, 2020 @01:56AM (#24815800)
>Personally I find it fascinating that I was never told it was my fault if I gave someone the flu in the course of both of us living our normal lives, but if I go to a grocery store and an elderly person does too and they get COVID-19 from me (imagine in this hypothetical there is no doubt that I gave them the virus) then somehow it’s my fault and I’m guilty of any harm that befalls then.

You ignore an important factor. Those who are vulnerable to serious complications/death from influenza can and should be inoculated with the latest influenza vaccine. That significantly mitigates the risk for the vulnerable.

There is no corresponding vaccine for Sars-Cov2. As such, the similar group who are vulnerable can't mitigate the risk.

That's why I (and many others) are trying to be much more careful. I'd also add that while the IFR for those under 55 are quite low, they aren't zero.

Re:Infection fatality rate of Covid-19 inferred from seropre... by sjg007 on Saturday October 17, 2020 @06:58PM (#24814110)
Wear a mask and stay 6 feet away.
Re:Infection fatality rate of Covid-19 inferred from seropre... by ianlevesque on Saturday October 17, 2020 @02:50PM (#24812206)
Thankfully the flu has an effective enough vaccine.
Re:Infection fatality rate of Covid-19 inferred from seropre... by nradov on Saturday October 17, 2020 @05:17PM (#24813458)
Effective enough for what? In some recent years seasonal influenza vaccine effectiveness was as low as 19%. That's still much better than nothing and I encourage everyone to get vaccinated, but let's be realistic about the level of protection.

https://www.cdc.gov/flu/vaccines-work/past-seasons-estimates...

Re:Infection fatality rate of Covid-19 inferred from seropre... by DangerousPie on Saturday October 17, 2020 @03:28PM (#24812476)
Flu is about 1/10 as deadly as coronavirus. And there’s a vaccine.
Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @03:43PM (#24812598)
This is a debunked claim that arose from conflating IFR vs CFR. Please source your claim.

In terms of overall IFR Influenza and COVID-19 appear to be comparable. Influenza kills at least an order of magnitude more children, and for those in between roughly 35-55 they both kill about the same, and for the very elderly COVID-19 is multiple times more deadly.

The overall IFRs are very comprable except COVID-19 preferentially kills the very old. This also means when you calculate YLL (years of life lost) Influenza takes more life-years away.

I’d say at most if you take a .1% IFR of Influenza then COVID-19 is about 3x as deadly. Note however that we fundamentally classify Influenza deaths differently than with COVID-19. Almost any country considers any PCR-positive person who dies to be a COVID-19 death regardless of whether it’s a baby born with intestines outside of its body, or a young man in Orange County who died in a motorcycle accident, or George Floyd. All 3 of those examples I gave are real individuals who were PCR-positive at time of death. I know for a fact that the first two were initially labelled COVID-19 deaths, not sure about Floyd.

There’s a concept I call the pathological vs physiologixal distinction that is crucial to understand and has been totally violated with COVID—19. The short of it is that it is a mistake to confuse a virus with a disease. (This is also why the phrase “asymptomatic COVID-19” is an oxymoron; if you have no symptoms you have a virus but not a disease)

I have acne; if you culture my skin you will find the bacteria C. Acnes, which is naively believed to “cause” acne. Yet if you culture the skin of a healthy individual without acne, they also have C. Acnes. The question then is what combination of factors leads C Acnes to be pathogenic in one case (me) and not for another. The answer like most things is complicated, some combination of lipid peroxidation compromising the skin barrier, genetic skin turnover rates, etc, but most pop-sci articles will simplify it to “bacteria cause acne”.

Similarly, it is a mistake to assume that if someone dies and has a positive SARS-2 PCR test that they died of COVID. First of all due to egregiously absurd cycle thresholds, you stay PCR-positive months after infection (again, see George Floyd’s hennepin county autopsy, he “had COVID” despite having recovered from it over a month prior to his death). But more importantly even if you truly have active, replicating SARS-2 in you at time of death, you didn’t necessarily die from COVID.

I really got off on a tangent there but to wrap up, even if you take the official COVID-19 numbers - which I believe are grossly inflated - at most COVID-19 is 3x as lethal. To say it is an order of magnitude more deadly means you’re still stuck in April. It’s October now, please follow the new developments in the field. There was actually a paper released recently that traces the origins of the 10x deadly meme, debunked it and attributed its genesis to conflating CFR vs IFR. I’m on mobile travelling now without my laptop so I don’t have my megalist of research articles at my fingertips but if you search around maybe you can find it.

Re:Infection fatality rate of Covid-19 inferred from seropre... by TheOtherHobbes on Saturday October 17, 2020 @04:29PM (#24813028)
This is trivially disproven by the excess mortality figures from earlier in the year.

By the start of the Summer the UK had around 60,000 excess deaths above the five year median - which included at least one fairly severe flu season.

Later in the Summer when lockdown was still in place and/or infection rates were still very controlled, the number of excess deaths dipped slightly below the median - as you would expect it to, given that people weren't commuting and there were far fewer road accidents.

The figures also disprove the usual talking point that other deaths had increased dramatically because hospital care and chronic medical attention were hard to access. There were certainly some extra deaths, but not on the scale of COVID itself.

Unless you're going to claim that some other lethal illness was stalking the land and no one had noticed, COVID is the only remotely plausible explanation for those excess deaths.

Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @04:39PM (#24813150)
> COVID is the only remotely plausible explanation for those excess deaths.

I personally know someone whose father likely died due to being unable to access health care in a timely fashion, as well as someone else who died of cancer after their chemotherapy was postponed. And I also know of two suicides in my extended social group in the past few months. It's tough to pin specific blame on lockdown for things like that. But it's certainly plausible that deaths like that would lead to excess deaths.

In the UK specifically the health authorities were estimating in late July that around 21,000 people had died due to lack of access to health care during lockdown: https://www.telegraph.co.uk/news/2020/07/29/lockdown-has-kil...

In the US there are a lot of concerns that dementia patients in particular are dying due to the isolation caused by lockdown measures: https://www.washingtonpost.com/health/2020/09/16/coronavirus...

Re:Infection fatality rate of Covid-19 inferred from seropre... by notahacker on Saturday October 17, 2020 @06:54PM (#24814083)
> I personally know someone whose father likely died due to being unable to access health care in a timely fashion, as well as someone else who died of cancer after their chemotherapy was postponed. And I also know of two suicides in my extended social group in the past few months. It's tough to pin specific blame on lockdown for things like that. But it's certainly plausible that deaths like that would lead to excess deaths.

Sure, but we can look at when the excess deaths happened. Instead of being evenly distributed across the lockdown period, or peaking towards the end when people had longer without access to support, they came exactly when you'd expect deaths from an epidemic wave to peak before plummeting to normal levels towards the end of the lockdown period. Undoubtedly, individual deaths have resulted from lockdown, but the pattern of excess deaths matches COVID rather than lockdown being behind the aggregate increase.

Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Sunday October 18, 2020 @12:24AM (#24815536)
...but why would excess lockdown deaths happen in a uniformly distributed way? Lockdown itself wasn't applied in a uniform fashion: hospitals figured out pretty quickly that lack of care was killing people and modified policies to mitigate that damage. My own advice to friends and family was "probably best not to go to the hospital for that" in March, and back to normal in April when I realized that the numbers weren't as bad as portrayed. Anecdotally, all of the deaths I mentioned happened close to the beginning of lockdown in their respective countries.

Again, this isn't idle speculation: genuine mainstream health authorities believe lockdown has killed significant numbers of people. This is not a controversial position.

Re:Infection fatality rate of Covid-19 inferred from seropre... by notahacker on Sunday October 18, 2020 @08:04AM (#24817220)
> ...but why would excess lockdown deaths happen in a uniformly distributed way?

No, the question is why does the excess deaths distribution perfectly align with the expected and recorded COVID death spike and drop so sharply afterwards when lockdown was still in place.

It's uncontroversial that lockdown has killed and saved significant numbers of people for reasons other than COVID, but similarly it is entirely uncontroversial that the aggregate increase in excess deaths was caused by COVID. The idea that the inflection point COVID-time-to-death days after the start of lockdown is better explained by unannounced changes in policy or your personal advice to friends and family, on the other hand is about as scientifically credible as blaming 5G.

Re:Infection fatality rate of Covid-19 inferred from seropre... by lemming on Saturday October 17, 2020 @07:12PM (#24814168)
Here in New Zealand where very few people died of COVID, overall mortality dropped significantly during lockdown. This seems to have mostly been due to a lack of traffic deaths, air pollution improvements, as well as a massive reduction in non-COVID respiratory illnesses. This article actually posits a reduced number of complications from elective surgeries as a factor in the reduced death rate: https://blogs.otago.ac.nz/pubhealthexpert/2020/07/10/weekly-...:

For example, around 40% of Wellington ICU patients are typically from elective procedures and around 10% of all Wellington ICU patients die.

Re:Infection fatality rate of Covid-19 inferred from seropre... by mrb on Sunday October 18, 2020 @12:17PM (#24818913)
«I personally know someone whose father likely died due to being unable to access health care in a timely fashion, as well as someone else who died of cancer after their chemotherapy was postponed»

Without lockdowns these people would probably not have been able to access health care either, because of, well, the pandemic.

Re:Infection fatality rate of Covid-19 inferred from seropre... by thu2111 on Monday October 19, 2020 @08:43AM (#24825787)
That's not correct. Sweden, which did not restrict healthcare access, and has one of the lowest ICU capacities in Europe, did not see hospital overload or healthcare rationing at any point.

Lockdowns have certainly created a death toll, that is by now mainstream consensus. The debate is about whether it's most of the excess death or only a large chunk of it.

But it's worth remembering that even then excess death numbers are low in absolute terms. A lot of people can't see that because for some reason it's standard for statistical agencies to only give a few years of data in convenient graphs on their websites, but older data is there, and it puts things in proportion. In the UK for example, which has one of the worst excess death rates in Europe, 2020 is so far a bit less deadly than 1999/2000 and the gap is widening [1]. But nothing remarkable happened in the UK in 1999/2000, nobody talks with sadness about those who were lost at the millennium. Nobody noticed anything at all. The idea that we've had some sort of terribly high or remarkable levels of excess death isn't the case: it's being noticed because people were told to expect enormous levels so started tracking the data with a microscope, and then it went up partly due to lockdowns.

In many other countries excess death is even less remarkable than that. Germany and Switzerland have seen years no different to the previous years for example. Cumulative death in Switzerland for 2020 is by now completely average, for example. There was no plague in Switzerland at any point.

[1] http://inproportion2.talkigy.com/

Re:Infection fatality rate of Covid-19 inferred from seropre... by mrb on Tuesday October 20, 2020 @03:03AM (#24834595)
«did not see hospital overload or healthcare rationing at any point.»

They did ration healthcare. This was the object of multiple news articles last week: https://time.com/5899432/sweden-coronovirus-disaster/ «the country’s hospitals were implementing a triage system» The triaging was so severe that «Only 13% of the elderly residents who died with COVID-19 during the spring received hospital care» Get your facts right.

«Lockdowns have certainly created a death toll, that is by now mainstream consensus. The debate is about whether it's most of the excess death or only a large chunk of it.»

This is laughably inaccurate. On the contrary, lockdowns are largely credited for overall having averted cases and deaths. I maintain a list of peer-reviewed studies (and some preprints) on the subject, and the vast majority agree: https://twitter.com/zorinaq/status/1307723024523616257 There isn't a single peer-reviewed study that suggests lockdowns are responsible for a "large chunk" of excess deaths. You are victim of misinformation.

Your comparison to 1999/2000 flu death is invalid: there were delays in reporting deaths that caused many deaths to be reported on the week after Xmas, hence the artificially high peak of that week of 2000. If you compare monthly excess deaths (to smooth artificial peaks) you will see covid excess deaths in April 2020 surpass flu excess deaths of January 2000.

And yet, this comparison would still miss the point: covid is such a serious disease that despite (effective) lockdowns, it still managed to kill more than he most severe flu seasons of the last 20+ years. That alone should make you stop and think...

There is in fact a government report that found «in comparison with the deaths due to influenza and pneumonia occurring in the year to 31 August 2020, deaths due to COVID-19 have been higher than every year monthly data are available (1959 to 2020).» https://www.ons.gov.uk/peoplepopulationandcommunity/birthsde...

Germany and Switzerland have implemented particularly effective lockdowns, hence little to no excess deaths.

Re:Infection fatality rate of Covid-19 inferred from seropre... by thu2111 on Tuesday October 20, 2020 @08:09AM (#24836382)
The triaging was so severe that «Only 13% of the elderly residents who died with COVID-19 during the spring received hospital care»

You're seeing what you want to see. It is normal for elderly patients in nursing homes to die without being in a hospital. You're claiming that Swedish hospitals were so overloaded they turned away patients they would normally have seen, but there is no evidence of that and the paper TIME cited as support actually doesn't give any. Rather, it says:

"Swedish ICU use rates remained lower than predicted, but a large fraction of deaths occurred in non-ICU patients. This suggests that patient prognosis was considered in ICU admission, reducing healthcare load at a cost of decreased survival in patients not admitted."

The latter sentence doesn't follow logically from the first in any way. They are assuming that all COVID patients should have ended up in ICU and if they didn't, that can only be due to evil doctors turning them away at the door despite having spare beds (which Sweden always did have). That is an absurd assumption, unsupported by any direct evidence, which is why they have to rely on invalid statistical inferencing.

What happened is that PCR testing labelled a whole lot of people who were about to die anyway as "COVID deaths". COVID symptoms are so mild in virtually all cases that many patients will have simply got a little bit sick but not enough to rush them to hospital, which can at any rate be quite dangerous for the very elderly and frail, and then they died. Was it COVID that pushed them over the edge? Was it just old age? Who can really say when it gets right to the edge of a life - something has to give.

lockdowns are largely credited for overall having averted cases and deaths

By the people who recommended them in the first place. Many other people without obvious conflicts of interest have looked at this and concluded the opposite.

There isn't a single peer-reviewed study that suggests lockdowns are responsible for a "large chunk" of excess deaths. You are victim of misinformation.

The UK Government's own reports say otherwise. In fact here's an article on the BBC today: "Between March and September 2020, there were 24,387 more deaths in England than expected in private homes, and 1,644 in Wales. The large majority did not involve COVID-19."

https://www.bbc.com/news/health-54598728

Lockdowns have obviously killed people in the UK. Hospital admissions halved at the start, do you really think that would have had no impact on mortality? There is now a massive cancer backlog. The death toll of COVID is a handful of people per day in the UK, but the death toll from telling people to avoid hospitals during 2020 is going to be racking up for years, perhaps decades.

Why do lockdown supporters so often believe other people are the victims of misinformation? I've read a lot of papers coming out of epidemiology and the academic research establishments this year, many of them are atrocious. They mis-use logic and statistics every third paragraph, scientists mis-represent their own papers in press releases, their code sometimes just doesn't work. The standards in academia are incredibly low and they pump out "misinformation" at a shocking rate. If you simply believe peer reviewed studies without double checking them, you're the one being misled, not me.

Germany and Switzerland have implemented particularly effective lockdowns, hence little to no excess deaths.

I live in Switzerland. It had a rather mild lockdown, quite incomparable to many other countries thank god. It's astonishing you believe these were "particularly effective". But if you get your information from TIME, well, it's less of a surprise.

Re:Infection fatality rate of Covid-19 inferred from seropre... by throwaway_pdp09 on Saturday October 17, 2020 @04:56PM (#24813292)
I believe what you're talking about ("...likely died due to being unable to access health care in a timely fashion" etc). is is exactly what contributes to an excess death. That's why excess deaths are important, they take into account exactly those deaths caused indirectly. (a bit unclear, but you get me I hope).
Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @05:13PM (#24813427)
But it's quite critical to know what % of excess deaths were caused by unreported COVID-19 infections, vs lockdown. The fact is, lockdown will kill people. It's really important to figure out how many it will kill, so we can balance that against lives saved, especially with COVID-19 proving to be much less deadly than originally feared.

As an extreme example, for some poorer countries without much healthcare infrastructure, you can definitely make the case that given the inevitability of the virus spreading, in some situations the right thing to do is give up early, accept that you'll have a wave of deaths, and move on. The alternative is a slow motion disaster with about as many direct COVID deaths, and additional deaths due to lockdown. If you don't have healthcare infrastructure to begin with, overloading it doesn't change much.

Re:Infection fatality rate of Covid-19 inferred from seropre... by Izkata on Saturday October 17, 2020 @09:39PM (#24814928)
You're not taking into account the denominator - the number of people getting infected.

This new virus spread far and fast, while seasonal flu is significantly more blocked off by how many people have immunity or vaccines. Number of deaths is lower for seasonal flu because the number who get infected by those known viruses is also much lower. That's why the IFR is close yet for this year more people are dying.

Re:Infection fatality rate of Covid-19 inferred from seropre... by irq11 on Saturday October 17, 2020 @04:42PM (#24813175)
The numbers you cite aren’t 10x higher than median.

Observing that mortality is above median doesn’t prove that the virus is the cause of those excess deaths (e.g. we know that there were a lot of unreported heart attacks during a the same period), and it doesn‘t prove the specific claim that the IFR is 10x higher than the flu.

Re:Infection fatality rate of Covid-19 inferred from seropre... by tsimionescu on Saturday October 17, 2020 @05:47PM (#24813664)
All of your analysis falls apart at one crucial point: all of the data we have are for Covid19 IFR given the massive lockdowns and dedicated hospital infrastructure.

If you look at regions that were ineffective in handling the spread and had their hospital capacity overwhelmed, mortality jumps through the roof - I think it was higher than 10% in Lombardia before the lockdowns. And remember that hospitals can't work at anywhere close to 100% ICU occupancy for extended periods of time, so if the high inflow persists, mortality is likely to increase much more.

The vast difference between Covid19 and influenza is anyway plain to see if you look at ICU rates, even with all the lockdowns.

So even though your analysis sounds convincing at first read, it is a very bad interpretation of the data. The reality is that Covid19 is a much worse disease than Influenza, and that drastic measures are required to keep it under control (barely).

[dead]
Re:Infection fatality rate of Covid-19 inferred from seropre... by beagle3 on Saturday October 17, 2020 @07:29PM (#24814270)
It's not as simple as that.

Early on, people with low blood oxygen were put on ventilators quickly, which both took a great toll on the system, and didn't help (or even made things worse).

If you look at the graphs now (I looked at 30 countries just an hour ago), you'll see that many countries in Europe have a very visible "second wave", including Denmark, Austria, the UK, France, Spain and even Sweden - but almost no deaths; and unlike the first wave, despite more people diagnosed with SARS-COV-2, much less people need treatment, and there is no lack of beds anywhere (although there is a lot of fatigue, which is a more complicated discussion).

Given you know what to do, such as prawning, vitamin D, and more (and more importantly - what not to do - no early ventilation, for example) - then, we no longer have hospital ICUs stuffed full of people with COVID19 either.

A lot has changed since April, but when I look at arguments, some sides still hold the data from early April (assuming up to 5% IFR, and the Ferguson predictions), while some do not acknowledge that April happened and only look at the stats in Aug-Sep. Not surprisingly, such arguments aren't really converging and each side tends to assume the other side is an idiot or insane.

Re:Infection fatality rate of Covid-19 inferred from seropre... by matthewmacleod on Saturday October 17, 2020 @08:11PM (#24814550)
It's not as simple as that.

I don't know about that. Everything you say is reasonable and not at all an example of the effect I was talking about.

It's totally fine to say "hey it looks like the CFR/IFR is declining because we have better treatment methods". This is a good-faith point, backed up by some easily observable data, and something that can evolve into a discussion about how to effectively manage the disease. It's not a point that I've heard any rational person object to.

It is worth noting though – the UK, as an example, currently already has about 30% of the cases in hospital versus the peak in late April, and about 15% of the deaths. This is much better, but those numbers are increasing pretty rapidly and without careful management risks getting out of control.

Re:Infection fatality rate of Covid-19 inferred from seropre... by thu2111 on Tuesday October 20, 2020 @04:19AM (#24835012)
"hey it looks like the CFR/IFR is declining because we have better treatment methods"

It's a claim not many are making because it's not clear it's really true.

Firstly, the bulk of the falling IFR is due to more widespread testing driving up numbers of known infections and sero-surveys indicating that even more people than that may have been infected. It's not primarily driven by better survival rates, although they did get better.

At this point it seems clear that mass ventilation was a mistake. It was actually killing people rather than saving them because it's a last-ditch resort. COVID wasn't actually deadly enough to justify this and the large scale usage was driven more by the lack of reliable information, the somewhat unusual form of presenting pneumonia in early patients, the belief that it was an extremely deadly virus and the fact that ventilators force all air coming out of the patients lungs through high quality filters, so doctors are trained that ventilation stops infected patients pumping virus into hospitals.

But doctors are smart and pretty quickly figured out that the ventilation was making things worse, that they couldn't keep the hospitals virus-free anyway, and at any rate they were about to run out of the machines so their hands were forced and they had to try something new. After that usage of ventilation went back to more normal policies, with supplemental oxygen being deemed sufficient for even quite extreme cases, because of course almost all cases need little or no hospital treatment.

Meanwhile many drugs were tried and some were hailed as drugs that could help, e.g. remdesivir or hydroxychloroquine. But later on more controlled studies done under calmer conditions concluded they actually seemed to have no effect.

Given this progress of events it's hard to argue that treatment methods actually got better, except in a very technical sense that most people wouldn't really mean. They got better in the sense that they returned to normal for this kind of virus and stopped making the situation worse. If there had been no mass panic at the start it's likely treatments would never have got so extreme to start with.

the UK, as an example, currently already has about 30% of the cases in hospital versus the peak in late April, and about 15% of the deaths

The UK has also quadrupled its testing rate since April. The numbers aren't directly comparable.

without careful management it risks getting out of control

I don't believe that's been proven at all. The analysis was done many times by now: every government intervention tried so far has no correlation with the course of the disease. That means attempts at management have failed and it has in fact been out of control the whole time, but, fortunately for us, our bodies are generally pretty good at fighting diseases except in the last years of our lives or when immunocompromised in some way, so that hasn't led to disaster.

Re:Infection fatality rate of Covid-19 inferred from seropre... by beagle3 on Tuesday October 20, 2020 @04:38AM (#24835114)
I generally agree, though do note that vitamin D and prawning do seem to make a difference - and are practiced in many places even without local study and tracking (because the risk is negligible).
Re:Infection fatality rate of Covid-19 inferred from seropre... by spfzero on Sunday October 18, 2020 @01:28AM (#24815718)
Certainly in my county, many fewer people are dying even though many more are testing positive. Many more people are getting tested, for job requirements, travel, etc. It results in more positives, naturally. In a county of more than 3 million, we have around 50 in ICU, lowest in many months. As positive tests grow. Two things (at least) might be at work: better treatment is one, the other is that there were far higher numbers of people infected than known, earlier in the year. I’m sure treatment now is better, but I would not be surprised if many more people have been exposed, and have recovered, from this virus than is assumed.
Re:Infection fatality rate of Covid-19 inferred from seropre... by nradov on Saturday October 17, 2020 @08:36PM (#24814706)
As ghoulish as it may seem, I suspect another reason behind the declining fatality rate is that the earlier waves already killed some of the most vulnerable people.
Re:Infection fatality rate of Covid-19 inferred from seropre... by disgruntledphd2 on Sunday October 18, 2020 @08:56AM (#24817520)
Nah, it's a statistical artefact caused by testing policies.

In March, you needed multiple symptoms to get a test, which meant that conditional on having a test, your illness was much more serious.

Because this isn't an issue right now, it looks like the mortality rates have dropped when it's more likely that we are capturing a larger proportion of mild cases.

Re:Infection fatality rate of Covid-19 inferred from seropre... by beagle3 on Sunday October 18, 2020 @07:38PM (#24822033)
Obviously depends on where you look for this kind of reasoning, but I don’t think it is compatible with data in general.

Sweden’s death graph totally looks like “inventory of likely-to-die people exhausted”, regardless of testing (they have not changed recommendations or actions).

Israel had no first wave in April (it had a blip, which turns out was essentially limited to ultra orthodox religious which are about 15% of the population).

In September, the official 2nd wave but really 1st wave struck the entire population - and testing capacity was already high (about 0.7% of the population tested daily). And the stats looked way too similar to other countries’ first wave.

The US is a weakly connected network of hundreds of different repositories, which makes it really hard to observe similar processes - they are not visible on aggregate.

Re:Infection fatality rate of Covid-19 inferred from seropre... by Izkata on Saturday October 17, 2020 @09:52PM (#24814984)
When it comes to hospitalizations and fatality rates, people are talking past each other by only looking at part of the picture. The two main camps I see are:

1) Covid19 is far more deadly, look at all these excess deaths!

2) The IFR is low, about the same as the seasonal flu, so we really didn't need the lockdowns.

Both are half true.

Basically, we have decent herd immunity for existing viruses. Even with an identical IFR, the viruses are acting differently because we lack(ed) any real herd immunity for the new virus - so everyone was getting infected at once, which means everyone getting sick at once and risking overwhelming hospitals (this is the part people in camp 2 miss). On the flip side, because we do have decent herd immunity with existing viruses, either due to prior exposure or vaccine, seasonal flu doesn't spread nearly as far (this is the part people in camp 1 miss). A lot less people getting infected means a lot less people getting sick or dying, which explains the excess death despite the same IFR.

Re:Infection fatality rate of Covid-19 inferred from seropre... by watwut on Sunday October 18, 2020 @06:27AM (#24816795)
But IFR are not identical. That part is simply lie. It is not just taking part each other.

Seasonal flu has also much different spreading. You are spreading it for very short time and then you get clearly sick. Which makes limiting speed much easier.

Re:Infection fatality rate of Covid-19 inferred from seropre... by Izkata on Sunday October 18, 2020 @01:19PM (#24819410)
Yeah, that was a bit lazy of me, but I was primarily making a point about why the two groups don't seem to be able to agree. That said the IFR does keep getting revised downwards, and last I remember it was still higher, but the same magnitude as seasonal flu.
Re:Infection fatality rate of Covid-19 inferred from seropre... by thu2111 on Tuesday October 20, 2020 @04:08AM (#24834947)
That's not quite right either.

People in camp (2) don't miss the risk of overwhelmed hospitals. We remember that we were constantly told they were about to be overwhelmed back in April and they never were. Sweden has the lowest ICU capacity in Europe by far, yet never had overwhelmed hospitals despite very visibly turning its back on the policies supposedly required to avoid it. How can this be reconciled with there being genuine risk?

It's apparent when you look at what happened back then that there was no actual risk of anything except running out of ventilators, a problem that was in turn caused by the panic - doctors were told this was a very deadly disease so were putting people on ventilators unnecessarily, partly because ventilation ensures all the air a patient breathes out is filtered, so they thought it was a way to keep hospitals clean. Once doctors realised ventilation was doing more harm than good and the age skews of the patients started to become publicly known, they backed off the ventilator use and there was never any shortage, of either ventilators nor beds.

Re:Infection fatality rate of Covid-19 inferred from seropre... by thu2111 on Monday October 19, 2020 @08:55AM (#24825862)
We don’t regularly have hospital ITUs stuffed full of people with influenza, threatening to overwhelm capacity

Who/where is we, here? Because that's absolutely not true for many countries, where seasonal flu is routinely reported by the press as creating overloaded hospitals. Here are some examples:

https://www.healio.com/news/infectious-disease/20190205/bad-...

"Bad flu seasons test US hospitals: Hospitals in the United States have implemented new policies based on last year’s severe influenza season, but infectious disease experts agree that America’s health care systems would still be seriously challenged by another bad influenza season."

https://www.independent.co.uk/news/uk/home-news/nhs-winter-p...

"NHS winter pressure: Hospitals report 99 per cent capacity over festive period as flu season looms"

https://www.dailymail.co.uk/health/article-5279685/Californi...

"Flu drives hospitals into 'war zone' conditions: Tents on the street in California, 'state of emergency' in Alabama, and Boston is using GATORADE to plug shortage of IV drips"

https://www.thelocal.fr/20170111/french-hospitals-stretched-...

"Hospitals in France at breaking point as flu epidemic spreads"

etc. Reports like this are common across the world. Partly it's that the press like reporting crisis stories and in any large medical system they can always find health workers willing to give them dramatic quotes. Partly it's that surge capacity is always inherently limited.

every single post mentioning COVID is full of these shallow armchair analyses that seem to think rejecting all prevailing wisdom is an inherent good

I've not seen anyone claim that rejecting all prevailing wisdom is inherently good. That seems like a strawman. The posts arguing about COVID aren't rejecting panic just for the sake of it, they're arguing about it because they disagree that the severity of the problem supports the consequent social policies.

HN is also full of people posting comments decrying the awful people who double check what government officials are claiming against data, facts and logic. Those are equally aggravating to those of us who don't see a problem with critical thinking: especially when the "prevailing wisdom" is a subjective assessment of who thinks what. One that's being seriously distorted by media hype and censorship, to boot. The "wisdom" many governments are listening to is sadly very far from wise.

Re:Infection fatality rate of Covid-19 inferred from seropre... by tsimionescu on Monday October 19, 2020 @01:34PM (#24828687)
For the US 2018-2019 flu season ( https://www.cdc.gov/flu/about/burden/2018-2019.html ):

> CDC estimates that the burden of illness during the 2018–2019 season included an estimated 35.5 million people getting sick with influenza, 16.5 million people going to a health care provider for their illness, 490,600 hospitalizations, and 34,200 deaths from influenza

Covid19 has killed ~220,000 people so far in 2020 in the US.

From the same article you quoted about the epidemic in California (from 2018, mid-January):

> This year's outbreak is on track to becoming one of the worst flu seasons in recent history due to a deadly strand that has so far killed 85 adults and 20 children nationwide as the numbers continue to climb.

Covid19 has killed ~16,000 people so far in 2020 in California.

Related to the UK 2017-18 flu season that saw hospitals stretched ( https://www.theguardian.com/society/2018/jan/18/flu-outbreak... ):

> After 35 more deaths last week, 120 people across the country have died of flu-related symptoms since early October, compared with 45 in the same period in 2016-17.

Covid19 has killed ~43,000 people in the UK so far in 2020.

For the France 2016-2017 flu epidemic ( https://www.researchgate.net/publication/321906828_Influenza... ):

> During the epidemic wave, a marked excess mortality estimate at 14,400 deaths attributable to influenza was observed.

Covid19 has killed ~34,000 people in France in 2020 so far.

Point being, perhaps it is the old news that were a bit exaggerated; either way, Covid19 is measurably worse than then any recent flu, and this is after extreme lockdown measures compared to any flu pandemic in living memory.

Note: I am fully aware that some of the lower numbers are partial numbers from about the middle of the flu season. Feel free to look up the final numbers for that season as well - they will be at worst half the Covid19 numbers.

Re:Infection fatality rate of Covid-19 inferred from seropre... by thu2111 on Tuesday October 20, 2020 @04:02AM (#24834918)
But there are two problems here:

1. That isn't the point that was being made. Matthew McCleod argued that "we don't regularly have ICUs stuffed full of people with influenza", and that HN is full of people who reject the "prevailing wisdom" just for the sake of it. Neither is the case, and my post provides plenty of evidence to reject the belief about hospitals (which is driven by media stories not actual overload - in the UK hospitals are being reported as about to overflow although they have normal load for this time of year, i.e. the reports are misleading).

2. Your data is comparing apples and oranges. Nowhere has ever made the kind of testing effort being made for COVID. We really have no idea how many people catch or die from flu because it's not really tracked to the same level of effort. Meanwhile COVID reporting has been hopelessly inflated by a medical establishment that takes every option to increase reported numbers. People are "COVID hospitalisations" if they're admitted with a broken arm and happen to test positive even though they don't seem to be sick, they are "COVID deaths" if they get shot and test positive at time of death. They have "COVID" the disease even if no doctor ever diagnosed them based purely on fragments of RNA found in a blood sample, using a test with unknown and it seems wildly varying false positive rates, that's been ramped up well beyond the max sensitivity many PCR experts actually recommend.

Reported COVID numbers really can't be compared numerically to anything historical at this point. They are "meaningful" only when compared against each other and even then there are difficulties as countries report things differently. For instance the numbers were inflated in the UK by at least 5000 deaths because the health agency defined COVID as a terminal disease. Once you tested positive, for the rest of your life your death would be marked a COVID death regardless of how much later you died or what of. They "fixed" this by changing forever to 28 days, which is still not a valid way to measure who died of what. That's how you get the New York Times reporting a list of people who died of COVID in which the sixth person on the list was a homicide victim.

Fundamentally, if you look at excess death numbers in a lot of countries, they look like flu season. Reported IFRs have continuously fallen and even the establishment figures are now in range of a strong flu season, not anything more. That's why people keep comparing it to flu.

Re:Infection fatality rate of Covid-19 inferred from seropre... by watwut on Saturday October 17, 2020 @04:39PM (#24813147)
Influenza mortality rates are subject to exactly same problems as covid rates. The same caveats apply. And, influenza deaths are estimated - we assume that some percentage of pneumonia deaths are flu deaths without ever doing test.

You debunked nothing. All the per age IFR comparisons of flu vs covid I had seen has covid killing more people for 30 years old too.

Re:Infection fatality rate of Covid-19 inferred from seropre... by dougk16 on Saturday October 17, 2020 @04:29PM (#24813031)
Thanks for all your comments in this thread. I looked at your profile to try and find an email address to say this personally but I figure it's good to say this in public too. You're writing all the things I would if I had a bit more time and inclination. I know it takes a good chunk of time and courage and mindspace to go against the current like you are, but just know there are a lot of people reading comments like yours and nodding their head but just don't want to join the fray. There are also a lot of people waking up from the virus fear only to confront the way scarier danger of the agendas driving things. Your comments are helpful to them too. Anyway keep it up!
Re:Infection fatality rate of Covid-19 inferred from seropre... by ImaCake on Saturday October 17, 2020 @08:04PM (#24814505)
Your linked study is much better than Ionnadis' one! This one actually followed the proper protocol for a meta-analysis for one. The results here are better stratified, the data more solid (because they did their meta-analysis properly), and the justifications better.

For those not familiar with biostatistics and meta-analysis. There is a standard and well defined pathway for doing a meta-analysis. It exists for a reason. Namely that it is really easy to misinterpret the results of aggregated studies if you do it wrong. The fact that the Ionnadis' article does not follow these procedures is enough to disregard it and instead focus on understand the studies that have done proper meta-analysis.

Re:Infection fatality rate of Covid-19 inferred from seropre... by jeffbee on Saturday October 17, 2020 @07:50PM (#24814411)
Bt it's great news for people who want some turnover in the US Senate.
Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @11:17AM (#24810595)
> > reaching 0.4% at age 55 > This isn't good news, really, not for middle-aged-adults anyway.

Overall mortality at age 55 is about 0.5%: https://www.statista.com/statistics/241572/death-rate-by-age...

In general, COVID-19's IFR by age is pretty close to overall mortality. So even in unrestricted spread, limited by only herd immunity, at worst direct deaths from it would less than double your chances of dying in a year.

Re:Infection fatality rate of Covid-19 inferred from seropre... by seanbecker on Saturday October 17, 2020 @11:32AM (#24810713)
> less than double your chances of dying in a year.

The way this is phrased makes it sound like it's not a big deal. Doubling every individual's chance of dying within an entire generation is not something we should say lightly. Imagine if the base fatality rate was 50% rather than .5%.

Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @03:51PM (#24812665)
Maybe I’m crazy, but I view doubling a chance of dying in a year, and then returning to normal mortality for the next year, as far preferable to mass business closures, suspension of civil liberties, pulling kids out of school without evidence, mandating everyone wear masks, etc.

I guess I never realized how risk averse people apparently are. I imagine these same people never drive a car since those things are deathtraps by comparisons.

Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @04:29PM (#24813030)
I was quite amused early on when people were talking about how brave truck drivers were for risking a COVID-19 infection. The per-year-worked fatal injury rate for truck drivers(1) is 0.024%. Meanwhile, a COVID-19 infection for the 20-49 age group has just a 0.02% fatality rate. Logging is even worse, at 0.14%/year-worked.

More than just risk adverse, I think a lot of people don't understand how risky life in general is.

edit: ...and I'll point out, those truck drivers may still have been brave! If you mistakenly think the risk is higher than it actually is, you're still brave for taking it on.

1) https://www.trucks.com/2017/12/26/trucking-deadliest-jobs/

Re:Infection fatality rate of Covid-19 inferred from seropre... by morsch on Saturday October 17, 2020 @04:05PM (#24812798)
[A]n English person aged 55–64 years who gets infected with SARS-CoV-2 faces a fatality risk that is more than 200 times higher than the annual risk of dying in a fatal car accident.

Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications https://www.medrxiv.org/content/10.1101/2020.07.23.20160895v...

Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @04:12PM (#24812866)
I glanced at the study and the fatality rates they use are absurdly high. They estimate .7% IFR for that age range which is way too high.

Anyway, my point was simply that if we took the same attitude towards risk that you all do with COVID and applied that elsewhere, we’d all be rolling around in hermetically sealed hamster balls until we died of boredom.

Re:Infection fatality rate of Covid-19 inferred from seropre... by morsch on Saturday October 17, 2020 @04:17PM (#24812922)
How convenient.
Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @05:05PM (#24813363)
The study linked in the OP estimates a median .27% IFR across all populations.

The following numbers are from several month old seroprevalence studies so take them with a grain of salt but:

https://www.ryankemper.io/post/2020-04-29-the_case_for_endin...

Pegs the 50-59 age range around the median IFR. Whereas the >70 mortality is where things really start falling off of a cliff.

BTW my point was never “your chance of dying in a car crash is >= COVID”...although that statement would be very true for <40 age populations. My point was more broadly that people have a risk aversion to COVID that is unmatched by their attitudes towards risk in all other areas of life.

Re:Infection fatality rate of Covid-19 inferred from seropre... by tsimionescu on Saturday October 17, 2020 @05:25PM (#24813513)
> BTW my point was never “your chance of dying in a car crash is >= COVID”...although that statement would be very true for <40 age populations. My point was more broadly that people have a risk aversion to COVID that is unmatched by their attitudes towards risk in all other areas of life.

Which was based on your observation of driving VS Covid19 mortality, or at least it appeared to be from the comment.

People have a very natural risk aversion for a new disease that is extremely likely to kill their parents or grandparents, that has unknown long-term effects, that has no known treatment, and that risks becoming endemic if not contained soon (and that has already killed more people than malaria).

Re:Infection fatality rate of Covid-19 inferred from seropre... by __blockcipher__ on Saturday October 17, 2020 @11:52PM (#24815412)
You fundamentally misunderstand SARS-2 if you think it “risks becoming endemic”. It already is endemic and it would be regardless of whatever measures we took. It’s a zoonotic virus that is great at spreading. It is functionally impossible to eradicate.
Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Sunday October 18, 2020 @12:29AM (#24815556)
...and it may have animal reservoirs: https://www.sciencemag.org/news/2020/08/covid-19-hits-us-min...

"The Dutch government reported multiple cases of transmission from mink to farm staff"

If it can happen in a farm, there's a reasonable chance it can happen in the wild too. Cats also seem to be able to get it: https://www.webmd.com/lung/news/20200911/covid-19-may-strike...

Animal reservoirs make the flu pretty much impossible to eradicate.

Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @04:16PM (#24812917)
The US has a mortality rate from car accidents per capita of 0.01%/year(1). The CDC's best guess infection fatality rate estimate(2) for the 20-49 age group is 0.02%/infection.

With a conservative herd immunity threshold of 50%, that'd put an uncontrolled COVID-19 pandemic and random car accidents about equal for that age group. For the 50-69 age group, the CDC estimates a 0.5% IFR, so COVID-19 would be 25x higher mortality than random car crashes.

1) https://en.wikipedia.org/wiki/List_of_countries_by_traffic-r... 2) https://www.cdc.gov/coronavirus/2019-ncov/hcp/planning-scena...

Re:Infection fatality rate of Covid-19 inferred from seropre... by morsch on Saturday October 17, 2020 @04:34PM (#24813085)
a) IFR is in fact higher according to that research, and b) US roads are far more dangerous than UK roads.
Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @05:00PM (#24813331)
> IFR is in fact higher according to that research,

By "that research" you mean https://www.medrxiv.org/content/10.1101/2020.07.23.20160895v... right?

Because it actually gives a slightly lower IFR than the CDC at age 55 (0.4% vs 0.5%), not higher. So I'm not sure what you mean.

> US roads are far more dangerous than UK roads.

Yes, according to the WHO(1) the US has a 3.6x higher mortality rate from car accidents than the UK, which gets us to 90x higher for the age group I quoted.

Anyway, I didn't want to contradict that figure. Just give perspective.

1)https://www.who.int/violence_injury_prevention/road_safety_s...

Re:Infection fatality rate of Covid-19 inferred from seropre... by tsimionescu on Saturday October 17, 2020 @05:21PM (#24813479)
Why are you assuming that you would return to normality for the next year? If this becomes endemic, the mortality rate doubles forever, especially since there doesn't seem to be long-lasting immunity to this virus.
Re:Infection fatality rate of Covid-19 inferred from seropre... by christophilus on Saturday October 17, 2020 @02:01PM (#24811837)
Double 0.5% is 1%. Where'd you get 50%?
Re:Infection fatality rate of Covid-19 inferred from seropre... by csnover on Saturday October 17, 2020 @03:26PM (#24812462)
I believe the parent was making a rhetorical point: if your base fatality rate were 50%, then doubling it would mean you’d be guaranteed to die. Therefore, saying something “only” doubles your risk of death can understate the impact of what that doubling means in practice.
Re:Infection fatality rate of Covid-19 inferred from seropre... by petertodd on Saturday October 17, 2020 @04:08PM (#24812824)
It's pretty simple: at my age randomly dying isn't something I'm concerned about at all. So doubling those chances is still not something I'm concerned about.

It's certainly not an existential threat to society.