I'd be honestly happy with my Rift as-is if they bumped up the resolution a bit, and had some way to see the real world with the headset on (even camera passthrough is fine!).
I've used virtual desktop apps in the Rift, and they aren't bad to use, and playing games like tabletop simulator is so intuitive and nice that I'm floored tht this hasn't been tried commercially yet.
I assume there are some pretty significant hurtles that I'm missing, or maybe the market is still hilariously small at this point, but it just seems so close!
Also the headsets are too hot and bulky to comfortably wear for a full workday.
I solve this by leaning forward or back. In VR/AR the same thing works.
No doubt 4-16x resolution would be nice, though. True "retina" screens are still at least a decade away.
And the rest already exists in other products!
Note,I am not claiming it won't succeed. Just that it will take a long time.
More, this will have less rigor than standard 2d graphical builders. And those don't exactly have a great track record. :(
I think that with the HL2, many of these are going to go away. I can't speak to the comfort, but I know that the first two are now non-issues for me.
It's only a few characters and you saving typing breaks my Ctrl+F and web search. :-)