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Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by radiofreeeuropa on Tuesday August 05, 2025 @05:39PM (#44804720)
There's anecdotes, and there's science.

Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)".

Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss.

It also very much appears to be the case that weight gain and loss are heavily influenced by environmental factors. Skinnier countries aren't skinnier because the people there have more willpower, it seems, but because they live in a skinnier country and are surrounded by the culture, laws, physical layouts of the created world, et c., that come with that. It'd be kinda weird if we expected "just try harder" to work very well when that's evidently not the mechanism by which skinny countries are skinny. Alternatively, if it is willpower doing it, we're just adding a step, because then it appears that environment strongly influences willpower, instead, since the same observations hold.

Sure, sometimes it works for individuals. In fact, it often works temporarily, causing a yo-yo effect. It can work for long periods (many years without a slip) but that's rare.

If your solution to the obesity crisis is "people need to try harder" your solution is demonstrably not helpful. Can it work for one person? Yes. Over a population, will it? No, it won't, it's amazingly ineffective, even very expensive high-touch interventions involving multiple experts aimed at weight loss and lifestyle change and such are wildly less effective than "inject GLP-1 agonists" or "move somewhere skinnier".

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by throwawaylaptop on Tuesday August 05, 2025 @06:08PM (#44805039)
My dad was never told by a single doctor to cut out all processed carbs/grains, and even potatoes, by a single doctor in his life.

So "try harder" isn't going to work when the doctors don't even know what they're talking about.

I'm losing faith in this forum. People would prefer to give people pharma bs because no processed carbs is too much of an ask. Pathetic.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by radiofreeeuropa on Tuesday August 05, 2025 @06:11PM (#44805072)
Run a study of your approach and show good results over a cohort for 2+ years and you'll make an entire sub-field of medical scientists very happy.

[EDIT] It's not that your approach can't work, it's that if (for example) people had as hard a time following the directions for condoms as they do following diet & workout plans, we'd never allow condoms to be sold as contraceptives, they'd not even be close to being OK to promote as useful for that purpose. It wouldn't matter if a few people could follow the directions and it worked 100% of the time for them.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by throwawaylaptop on Tuesday August 05, 2025 @06:28PM (#44805246)
I assure you, not buying bread and pastries for your family is a lot easier than correctly using a condom in the heat of the moment. Which is why most people don't use them and use pull out instead. Because even that is easier and better if done right. (I know when to pullout, I don't know if a condom broke before it's too late).

Anyway, it does work, people just aren't told to do it firmly. Doctors dance around it.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by op00to on Tuesday August 05, 2025 @07:07PM (#44805635)
You’re a fool. “Pull out” does not protect against pregnancy or STDs. Pre-ejaculate can have viable sperm in it.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by throwawaylaptop on Tuesday August 05, 2025 @08:19PM (#44806172)
It only has sperm if you have a medical problem.

I have been using pullout method for 25 years, very consistently with basically 50 women at this point, and not one pregnancy scare (other than one girl trying to pass off her pregnancy as mine once). Same for many of my friends.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by bluGill on Wednesday August 06, 2025 @02:32AM (#44808442)
You reduce the odds. It is good for those who want kids but not 20 - which is likely the result with nothing at all.

does nothing about stds though.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by backscratches on Wednesday August 06, 2025 @05:50AM (#44809934)
pre ejaculate contains zero sperm if you havent fully ejaculated previously. there is no mechanism for sperm to be released during preejaculation.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by komali2 on Wednesday August 06, 2025 @07:03AM (#44810431)
Pull out method is a less viable method of preventing pregnancy, and especially less viable at preventing STDs. However, it's still considered a contraceptive strategy.

https://www.plannedparenthood.org/learn/birth-control/withdr...

For every 100 people who use pull out method perfectly, within a year, 4 will get pregnant. Since not everyone does a great job doing it, in reality 22 get pregnant every year.

Here's a great overview page: https://www.plannedparenthood.org/learn/birth-control in summary, condoms are 87% effective at preventing pregnancy, and withdrawal is 78% effective.

For a going-steady couple that isn't worried about STDs, keeps an emergency contraceptive ('morning after pill') ready for oopsie mistakes, and live in a country that grants women bodily autonomy (or have discussed and accepted that a mistake might lead to a child), pullout is a perfectly valid contraceptive mechanism. There are better, but considering that basically every method except a condom/internal condom can cause extreme discomfort or bad side effects to the woman in the relationship, I think it's totally fine to choose pull-out.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by liveoneggs on Wednesday August 06, 2025 @09:09AM (#44811477)
87% of people in this study reversed t2d or prediabetes with diet and exercise: https://bmcmedicine.biomedcentral.com/articles/10.1186/s1291...
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by radiofreeeuropa on Wednesday August 06, 2025 @10:48AM (#44812768)
... and drugs.

And they had 86% adherence for a year. If they'd studied this farther out and it went the same way as basically any study that's done that, adherence would be a lot worse in another couple years. And that's in a group that's exceptionally motivated vs. the general population—has an actual illness they're trying to treat, and has opted in to the study knowing what it's asking of them and for how long.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by c4ptnjack on Tuesday August 05, 2025 @07:56PM (#44805997)
The zeitgeist has pushed the idea carbs/grains and sugar are terrible over the last 40 years on and off, so that seems to say more about the medical industrial complex, than anything. That's fair, but if that message has been pushed so consistently, why didn't we see a real decrease in the consumption of those things and the associated weight loss?
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by ses1984 on Wednesday August 06, 2025 @01:03AM (#44807861)
Because carbs taste great.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by rkomorn on Wednesday August 06, 2025 @03:45AM (#44808941)
I can confirm.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by satyrun on Wednesday August 06, 2025 @07:41AM (#44810676)
It is really more than just taste though.

I am on a GLP-1 level calorie restricted diet right now without a GLP-1 and of course it is just miserable.

I love eating a giant sandwich at night that is more calories than what I am eating all day now but it isn't the taste it is the brain chemical release.

It is an addiction like any other addiction. I have never felt that same craving for chicken breast.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by rockemsockem on Tuesday August 05, 2025 @07:09PM (#44805653)
I find that almost all doctors give useless advice. On multiple occasions I've been advised that there was nothing wrong but they can run a scan "if I insist" and then bam, the exact problem I expected shows up clear as day.

They're morons for the most part.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by throwawaylaptop on Tuesday August 05, 2025 @08:36PM (#44806304)
A doctor at their best, really focusing on a problem as if their spouses life depended on it, might pull out some decent advice after really thinking about something.

In their 8 minute session with you, they are worse than chatgpt basically.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by fossuser on Wednesday August 06, 2025 @12:51AM (#44807764)
It’s like any other field, most suck and it requires effort to find the smart ones.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by rockemsockem on Thursday August 07, 2025 @08:07PM (#44831933)
Yep, 100%. It just feels worse with doctors imo because it feels like the culture treats them like some monolith of skill and wisdom.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by fossuser on Thursday August 07, 2025 @11:04PM (#44832972)
Yeah and the dumber ones think they’re smart because they did the grindy schooling. My dad is a physician and did EE undergrad - he says EE is much harder and med school is (mostly) low complexity but high volume, high memorization.

If anything it’s somewhat of a lemon market that’s worse than average because it’s not a great career generally to leverage skill into wealth (relatively compared to other options), but it lets risk averse people on rails get a decent outcome.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by op00to on Tuesday August 05, 2025 @07:06PM (#44805620)
Oh no, a throwaway troll is tired of this “forum”. What ever will we do without this throwaway account contributing conspiracy theories and whining? I hope we will survive, but maybe dang should just shut things down right now.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by aydyn on Tuesday August 05, 2025 @07:54PM (#44805977)
Maybe dont take it personally bro. Unless your identity is tied to posting on HN.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by throwawaylaptop on Tuesday August 05, 2025 @08:21PM (#44806188)
I've been on here for 10+ years I think at this point. New throwaway, named throwaway to not even lie, every few months. I tweet with Paul G every now and then positively, because I'm nicer on there. But sorry you dont think I provide value.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by maest on Tuesday August 05, 2025 @11:13PM (#44807200)
For someone as clever as you, I'm sure it's obvious why using a throwaway greatly diminishes the value of what you're saying.

To spell it out for you: there is value to having some notion of persistent identity even on pseudonymous forums. Anyone can use a throwaway and say anything - and valiantly admitting you're using a throwaway doesn't change this fact.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by unethical_ban on Tuesday August 05, 2025 @11:47PM (#44807397)
It should not be surprising as to why someone would be suspicious in 2025, if someone is insulting anyone who got success from a drug by saying "my dad's dirt worked for him" and then complaining about declining quality on the forums.

Use throwaway identity, pay the price.

I'm glad your dad is healthy and yes, carbs cause issues.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by ranger_danger on Tuesday August 05, 2025 @11:16PM (#44807228)
I've been told many doctors don't offer "free" solutions specifically because there's no monetary benefit to them.

Maybe if the anti-carb society offered some payola, the story would be different.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @12:20AM (#44807600)
Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything.

At most a drug rep comes by and brings donuts or something to talk about their new drugs.

Source wife is a doctor.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by mensetmanusman on Wednesday August 06, 2025 @01:44AM (#44808123)
They get paid in lower risk deductibles. If a patient demands a drug they saw on commercials, the doctor can reduce liability by prescribing it in many cases.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by jalk on Wednesday August 06, 2025 @05:22AM (#44809734)
Wonder how the "online star-rating economy" affects US doctors.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @03:51PM (#44816856)
That 100% impacts doctors. It’s well known that doctors who prescribe unnecessary antibiotics get higher ratings.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @08:36AM (#44811149)
Doctors don’t have less liability if they give the patient something they ask for.

It’s certainly not enough of an effect that doctors make decisions on what to prescribe based on their malpractice insurance premiums.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by mensetmanusman on Wednesday August 06, 2025 @12:09PM (#44813933)
Sure they do, it’s why doctors these days prescribe pills versus recommending healthy habits.

There are no healthy habit recommendations anymore in many practices due to anti shame culture etc.

This is different to other parts of the world with healthier citizens.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @03:37PM (#44816660)
Anti-shame culture is not what we’re talking about. What we were talking about was doctors prescribing pills that patients asked for to lower their liability, which is nonsense.

Doctors are humans though and if people repeatedly ask for a specific treatment some percentage of them will offer it. That’s how drug advertising impacts prescriptions. Nothing to do with liability.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by _345 on Wednesday August 06, 2025 @01:08AM (#44807888)
My dad got box seats to a hockey game when I was a wee lad so theyll sometimes throw money at docs
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by HWR_14 on Wednesday August 06, 2025 @01:32AM (#44808040)
The rules changed around a decade ago to limit the amount of gifts a doctor could receive from pharmaceutical companies.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by KPGv2 on Wednesday August 06, 2025 @01:32AM (#44808037)
Thanks to Obama and the Sunshine Act, this basically never happens anymore.

https://www.mdlinx.com/article/a-physician-s-guide-to-accept...

Increased reporting requirements and a cap on the value of these gifts that is far too low for box seats.

My wife's a physician, and I've seen these things change dramatically. Sometimes some food for the whole office will get dropped off. Or donuts. No one's getting box seats to a pro sports game anymore.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by Spooky23 on Wednesday August 06, 2025 @01:27AM (#44808012)
Huh? Drug reps have scorecards for the doctors they call on and throw perks at the top performers or influencers. It also depends on the speciality - dermatologists working for price equity mills are almost evaluated like salespeople. Source: girlfriend is a rep.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @08:30AM (#44811094)
Yeah and what are those perks? Pens, t-shirts, backpacks, posters for patient rooms?
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by Spooky23 on Wednesday August 06, 2025 @01:35PM (#44815091)
Steak dinners and briefings at the beach.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @03:49PM (#44816829)
Each one of those has to be reported and the information is publicly available.

Perks for prescriptions is illegal.

If your GF is really keeping score and rewarding doctors for performance, she’s breaking anti kickback laws. All that has to happen is for prosecutor to make the connection.

I know a guy who spent 3 years in prison for something very very close to what you just described. He was just a rep and he said he was just doing what his company told him to do, but they threw him under the bus and now he’s a felon.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by liveoneggs on Wednesday August 06, 2025 @09:13AM (#44811519)
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by sarchertech on Wednesday August 06, 2025 @03:33PM (#44816605)
Now go drill down into what those payments are for. The vast majority is for running trials. Each payment is tracked, and you can drill down into each one.

If you don’t want a doctor who takes money to run clinical trials, use this database to avoid them. It’s not hard.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by _345 on Wednesday August 06, 2025 @01:03AM (#44807862)
Then what should I do :(
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by toomuchtodo on Wednesday August 06, 2025 @01:44AM (#44808119)
Get a GLP-1 under the supervision of a doctor or other licensed medial provider.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by ykonstant on Wednesday August 06, 2025 @04:02AM (#44809101)
As a chronically obese, non-diabetic individual, here in Greece it is impossible to convince a doctor to prescribe anything close to that :(
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by siva7 on Wednesday August 06, 2025 @06:01AM (#44810009)
Get it simply over other legal channels instead of fighting with the stupidity of the local medical system.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by mghfreud on Wednesday August 06, 2025 @06:14AM (#44810109)
Visit Turkey for a couple weeks. Rules are the same, but behavior is the opposite. Weekly dose of 1mg is sold over the counter for around 150$.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by jart on Wednesday August 06, 2025 @08:14AM (#44810940)
[delayed]
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by toomuchtodo on Wednesday August 06, 2025 @09:04AM (#44811419)
They’ve been rewarded enough (~$14.65B USD net profit 2024), and are lucky they’re allowed to capture any further economic benefit from the sale of a simple compound (imho).
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by radiofreeeuropa on Wednesday August 06, 2025 @12:10PM (#44813936)
... a simple compound that was already developed and in-use, so the current patent (the one that's made it a big, ongoing news story and a kind of social phenomenon) is rewarding only going through the approval process for using it for weight loss, specifically, not development of a new drug.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by jart on Monday August 11, 2025 @01:21PM (#44866840)
From https://en.wikipedia.org/wiki/Semaglutide

> In the 1970s, Jens Juul Holst and Joel Habener began research on the GLP-1 hormone [...] Research continued, and in 1993, Michael Nauck managed to infuse GLP-1 into people with type 2 diabetes, stimulating insulin while inhibiting glucagon and bringing blood glucose to normal levels. However, treating diabetes patients with GLP-1 hormones resulted in significant side effects, leading researchers financed by Novo Nordisk to start looking to develop a suitable compound for therapeutic use. In 1998, a team of researchers at Novo Nordisk led by the scientist Lotte Bjerre Knudsen developed liraglutide, a glucagon-like peptide-1 receptor agonist that could be used to treat diabetes.

GLP-1 is a hormone that naturally occurs in the human body. Novo Nordisk was responsible for turning it into a diabetes medication. They were responsible for turning it into a weight loss medication.

Where are you getting your facts from?

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by cthalupa on Wednesday August 06, 2025 @01:52PM (#44815312)
A huge chunk of Novo losing it's valuation is the fact that Eli Lilly is absolutely destroying them on the next generations of these. Tirzepatide is better than Semaglutide, and Retatrutide is better than Tirzepatide. Mazdutide looks to be a particularly good fit for Asia for a variety of reasons. And from Novo, Cagrilintide/CagriSema look to be a bust. Rybelsus is a bust.

Other "newcomers" in the GLP-1 space are also showing more promise than what Novo has in the pipeline. Boehringer Ingelheim has Survodutide in the pipeline as well, along with plenty of others.

They're the least interesting game in town when it comes to the incretin mimetics at this point.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by ponector on Wednesday August 06, 2025 @07:44PM (#44819145)
I always thought penicillin is the most successful and helpful drug. As well as vaccines against deadly diseases.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by jart on Friday August 08, 2025 @03:55PM (#44841011)
Can't argue with that.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by everfrustrated on Wednesday August 06, 2025 @07:24AM (#44810555)
I find this hard to believe. Wegovy is authorised for sale in the EU for weight loss (IE not Ozempic which is for diabetes. Yes I know it's the same drug). If you can't find someone to prescribe it, that's on you. Find a better doctor or pharmacist. In all seriousness, please do - obesity is no joke and taking ownership of this by at the very least finding a doctor who will support you might be one of the most important and life changing decisions you make.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by ponector on Wednesday August 06, 2025 @07:42PM (#44819129)
Hard to believe. Always can try the same kind of doctors who issue prescription for medical marijuana.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by verisimi on Wednesday August 06, 2025 @02:19AM (#44808350)
> There's anecdotes, and there's science.

> If your solution to the obesity crisis is "people need to try harder" your solution is demonstrably not helpful. Can it work for one person? Yes. Over a population, will it? No

Are you an individual or a population though? Take off the telescopes (and data, and science), and look at the world through your own eyes.

No one needs (or can) to address the obesity crisis in the population. The only crises that can be solved are the ones individuals find in themselves.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by vidarh on Wednesday August 06, 2025 @02:31AM (#44808434)
And odds are very firmly that you'll fail. That's what the science shows us.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by gmadsen on Wednesday August 06, 2025 @04:49AM (#44809489)
having the understanding of the science and self motivated enough to make lifestyle changes already puts you a couple standard deviations out of the population average, such that I don't really think its helpful as a comparison or something to model after
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by vidarh on Wednesday August 06, 2025 @09:02AM (#44811397)
The science is clear that people who do make changes and achieve initial results are still overwhelmingly likely to fail at maintaining the results.

Lots of people successfully make changes and lose weight, but exceedingly few manage to keep it low over time.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by gmadsen on Wednesday August 06, 2025 @12:53PM (#44814534)
you are misunderstanding my point. There is a selection bias. Those with the reading comprehension and scientific aptitude to make a statement like "the science is clear" with accuracy and confidence is already exceedingly rare.

My assertion is that the success of long term weight changes is not independent from that variable.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by vidarh on Wednesday August 06, 2025 @01:53PM (#44815347)
That's an assertion there is to my knowledge no evidence for.

There's no evidence to suggest that reading comprehension or scientific aptitude has any link whatsoever to ability to maintain the willpower to stick to a diet. It seems distinctly non-obvious to think it would matter.

And all the evidence is that diets works soo poorly that the effect would need to be astronomical for it to counter-act just how unlikely they are to effect lasting change.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by randomNumber7 on Wednesday August 06, 2025 @04:34AM (#44809361)
I think it's mainly the food that makes skinnier countries skinnier.

People in the US eat absolute shit. Even the bread is full with sugar.

Good for capitalism if you can feed that to the people and then give them an injection to be healthy again I guess.

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by eru on Wednesday August 06, 2025 @05:29AM (#44809790)
> Skinnier countries aren't skinnier because the people there have more willpower, it seems, but because they live in a skinnier country and are surrounded by the culture, laws, physical layouts of the created world, et c., that come with that.

Do we have data on that?

I guess you could look at natural experiments, like people who lost and won H1B lotteries, and see if only the ones actually making it to the US get fat?

Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by radiofreeeuropa on Wednesday August 06, 2025 @08:44AM (#44811232)
Yes, it’s a google away.
Re:Ozempic Shows Anti-Aging Effects in Trial, Reversing Biol... by skeezyboy on Wednesday August 06, 2025 @06:57AM (#44810388)
you are taking in more calories than you are burning off, for whatever reason. its that simple