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Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by temporalparts on Monday January 03, 2022 @12:25AM (#29777644)
Exciting! Now only if they can find the origins of the original virus.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by chrisco255 on Monday January 03, 2022 @12:52AM (#29777781)
It was in Wuhan, next to a BSL-4 virology institute that synthesizes and analyzes coronaviruses and other deadly diseases. But it most likely came from the seafood market down the road.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by pizza234 on Monday January 03, 2022 @04:40AM (#29778971)
There are at least two interpretations of "came from the seafood market down the road" (Hunan seafood market):

  - an infected animal at the market transmitted the virus to humans
  - an infected human at the market transmitted the virus to humans
The book "Viral" (Chan/Ridley), states, based on the official research performed on the matter:

> This China-WHO report revealed a different picture from that given by media reports. The market was called a seafood market for a reason: most of the stalls were selling seafood and freshwater aquatic products. Crocodiles were being sold alive. Snakes and salamanders were being slaughtered on the spot for sale. From sales records in December 2019, just ten stalls were selling meat or products from birds and mammals, including chickens, ducks, geese, pheasants and doves; and deer, badgers, rabbits, bamboo rats, porcupines and hedgehogs. According to the market authorities, all of these animals were from licensed farms and no illegal trade in wildlife was detected.

> The authorities tested 457 samples from 188 animals spanning 18 species. They all proved negative for SARS-CoV-2 genetic material. This included 27 stray cats (a species that is susceptible to the virus), which were presumably living free in or around the market, as well as 52 rabbits and hares, 16 hedgehogs, ten mice, seven dogs, six muntjac deer, six badgers, six bamboo rats, a number of pigs, five chickens, three giant salamanders, two wild boar, two crocodiles, two soft-shelled turtles, two fish, one sheep and one weasel. They tested 616 animals of ten species from the suppliers to the market and found no sign of SARS-CoV-2 genetic material.

Note that this doesn't imply the lab-leak hypothesis, as the human in the second case may have contracted the virus from an animal elsewhere.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by kuhewa on Monday January 03, 2022 @05:16AM (#29779185)
Well, yes. Wuhan is the largest city in central China which is why there is a large science lab there, and one that studies viruses in bats in caves in the sand province. But that's the same reason- that it is a large urban hub for the region- that there is significant amount of wildlife trade and The population densities to foster a pandemic arising from a zoonotic spillover. No coincidence need be invoked.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by captainmuon on Monday January 03, 2022 @07:08AM (#29779940)
> No coincidence need be invoked.

It is not just a coincidence, but a plausible hypothesis, just like the hypothesis that it is a zoonosis from an exotic animal market.

I think we have to take all possible causes seriously. Act as if it was a zoonosis and act as if it was a lab leak, in order to prevent another pandemic.

(Actually, I think the lab leak is both the more scary and the easier to prevent cause, so no matter what actually happened we should try to shut down this possibility as much as possible in the future.)

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by code_biologist on Monday January 03, 2022 @10:38AM (#29781774)
The book Viral suggests that the wildlife trade, especially the intermediate species under consideration, is significantly more prevalent in southern China. Further, wildlife trade is seasonal and Oct/Nov (when the virus emerged) is the beginning of the winter slow season, with most trade occurring in summer months.

Again, if it's zoonotic it's surprising that it would emerge in a city with much less animal trade than somewhere like Guangdong, and in the slow months of that trade.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by kuhewa on Monday January 03, 2022 @06:00PM (#29788304)
There may be more wildlife trade to the south, but Wuhan has a substantial amount of wildlife trade, along with being the trading and transport hub in a region with lots of Rhinolophid bat habitat in rural areas (and areas where the human population has a considerable (several %) background prevelance of bat virus antibodies. Appearance in autumn could easily fit with infection from a traded animal a couple months earlier and perhaps a couple of host jumps to gain mutations that conferred pandemic potential. We won't know just how much of a long shot - or just how parsimonious a Wuhan emergence was unless we actually identified early hosts and the likely chain of events that occurred, but depending on the details, even despite the points you raise Wuhan could end up the 'likeliest' spot.

My point here is assuming zoonotic origin, it isn't a one in a trillion coincidence that Wuhan has a coronavirus lab. It has a coronavirus lab for the same reasons a zoonotic origin appears likely - it is within trading/sampling expedition distance to bat caves and is an urban hub. Perhaps Guangdong still was the more likely candidate for a pandemic emergence, but based on what we know today Wuhan appears to be 1-in-100 betting favourite, plus or minus an order of magnitude.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by dangrossman on Monday January 03, 2022 @01:08AM (#29777862)
Wuhan is also home to bat caves where we've identified dozens of SARS/COVID-like viruses to date. They're the same caves three of that lab's researchers went into before becoming hospitalized with a flu-like illness in December of 2019. Even if you could trace this pandemic to those three researchers, it would not be evidence of SARS-COV-2 being a manufactured virus.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by xyzzy123 on Monday January 03, 2022 @01:49AM (#29778073)
This is plausible sounding but wrong, in fact it's in Alina Chan's top 10 myths:

"(4) (FALSE) Wuhan is a place where SARS transmits from animals into humans frequently. That's why the Wuhan Institute of Virology was built there.

Actually, Wuhan is ~1000km away from SARS spillover zones. Its human population was even used as a negative (no SARS) control group."

https://twitter.com/ayjchan/status/1394327680456220672?s=12

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by bawolff on Monday January 03, 2022 @02:19AM (#29778224)
That doesn't really seem to contradict the important part of the parent's argument: that the researchers went into the caves in question. I have no idea if that's true, but how far away the caves are seems like a quibble that's fairly irrelevant.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by xyzzy123 on Monday January 03, 2022 @03:21AM (#29778519)
There are 3 sentences in OP's post, the first two are wrong or misleading. The third (conclusion) is OK only insofar as it doesn't depend on the (false) premises.

1. Wuhan is not known for spillover.

2. Cave visits did happen but this has never been connected to the 3 "sick researchers" reported by US intel.

3. Sure, lab origin, zoonosis, engineering or not, all still on the table, just factually what OP wrote was inaccurate or misleading.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by mytailorisrich on Monday January 03, 2022 @04:25AM (#29778886)
Wuhan is a very large city in Central China and a transport hub. So it at least sounds plausible that the virus might have been carried there by someone, though I don't know how plausible it is that (if that's what occured) it did not seem to have left a trail of contamination (or perhaps it did but we don't know...)

Also, I believe that the first recorded outbreak of SARS was in Guangdong while the origin of the virus was eventually found to be in Yunnan, 1000+km away.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by timr on Monday January 03, 2022 @01:14AM (#29777885)
> Wuhan is also home to bat caves where we've identified dozens of SARS/COVID-like viruses to date.

The closest related natural viruses to SARS-CoV2 were not found in Wuhan. They were found in caves in Yunnan, and possibly Laos.

> The same caves three of that lab's researchers went into before becoming hospitalized with a flu-like illness in December of 2019

Again, Yunnan, not Wuhan. The researchers worked at the Wuhan Institute of Virology.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by petre on Monday January 03, 2022 @01:16AM (#29777898)
The bat caves are mostly in the region of Yunnan, a mountainous region famous for the tea with the same name. It directly borders Myanmar and Laos.

Noted, about "nearby", edited.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by wk_end on Monday January 03, 2022 @01:37AM (#29778021)
Not really "nearby" - they're something like 1500km away. Unless you'd refer to Warsaw as a nearby city of Paris, or Atlanta as nearby to New York, or Vancouver, BC as nearby to San Jose.

ETA: parent comment (to their credit!) edited the above to remove the world "nearby" either while I was replying or right after. Still leaving this comment up because it's worth pointing out just how far those caves are from Wuhan.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by kennywinker on Monday January 03, 2022 @05:21AM (#29779222)
Since you called it out, and I live in Vancouver, BC - before the pandemic put a damper on travel I would say that Vancouver, BC and San Jose are pretty close - not geographically but for virus transmission. More important than physical distance, for a virus, is how often and how many potential carriers move between the locations.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by jml7c5 on Monday January 03, 2022 @01:03AM (#29777837)
The BSL-4 lab is ~14 km away from the market.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by sockfish on Monday January 03, 2022 @02:19AM (#29778226)
Yeah but one of the BSL2 labs (coronavirus research was being done in BSL2/3 labs, not BSL4) is not. It is a couple of hundred meters down the street https://www.google.com/maps/d/u/0/viewer?mid=1D12qtMmmH_qrb5...
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by slenk on Monday January 03, 2022 @01:18AM (#29777903)
Correlation does not mean causation.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by _heimdall on Monday January 03, 2022 @02:47AM (#29778350)
A lack of correlation definitely does not mean causation, and they never found any relevant evidence of CoV-2 transmission in the wet market. They also never found cases of Covid prior to November 2019, which would mean this virus somehow became an extremely good for for human transmission within weeks of making the jump.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by Flankk on Monday January 03, 2022 @04:18AM (#29778846)
If two variables are correlated that means they share a relationship. If you are stating that the relationship is coincidental then you should have a basis for that rationale. This can easily be estimated. There are 59 BSL4 labs in the world. The wet market is 14 km away from the lab. The Earth's land surface area is 148,326,000 km2.

    14^2 * pi * 59 = 36,329 km2
    36,329 / 148,326,000 = 0.000245
There is a 0.02% chance that a random disease will outbreak within 14 km of a BSL4 lab.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by notahacker on Monday January 03, 2022 @05:23AM (#29779239)
The problem with this sort of crude statistical analysis is that it assumes humans and coronaviruses are evenly distributed across the earth's surface. This obviously isn't the case. Wuhan is a densely populated major population centre and transit/commerce hub with a population larger than the Bay Area, and the [large] surrounding region supplying produce to Wuhan's markets includes rural areas noted for animal coronaviruses, including the suspected origin of SARS. Which isn't to say there's no statistical reason to consider the lab and the outbreak might be linked, but back of the envelope maths which ignores the existence of cities is the opposite of a compelling case.

No to mention that the outbreak is the first known one, not the origin which - if not spread from a lab - is likely somewhere considerably more rural and less likely to attract attention. Took 15 years to trace the probable natural origin of SARS in China (1000km away from the first city outbreak, 1km from a neighbouring village) which wasn't as highly politicised. The subsequent lab-originated local SARS outbreaks were traced to people associated with the labs more easily (though again, they weren't as highly politicised).

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by Flankk on Monday January 03, 2022 @06:12AM (#29779586)
These viruses come from animals, not humans. The probability of rural infection is probably much higher, as you said. So cut it in half, it's more like a 0.01% chance.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by notahacker on Monday January 03, 2022 @07:15AM (#29779990)
Yes, if you completely ignore the probability of detection being much higher when the virus reaches an urban area, and the reference in my post to the original SARS virus being traced to an "origin" in an urban area 1000 miles from its animal source, much like the MERS virus was identified in Jeddah and not amongst camel herders in the desert, you can make up new estimates which also bear no resemblance to the actual underlying probabilities.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by Flankk on Monday January 03, 2022 @08:12AM (#29780418)
No to mention that the outbreak is the first known one, not the origin

Epidemiologists conducted an extensive investigation to trace the origin. The probability of detection is not higher in the city. So I'm afraid that's incorrect. You're not making any sense here. You're disputing both the lab leak theory and the wet market theory? You're just shifting the goalposts to fit your argument.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by notahacker on Monday January 03, 2022 @08:55AM (#29780768)
Epidemiologists conducted an extensive investigation to trace the origin and also didn't find any connection whatsoever with the lab. I'm not sure why every theory that doesn't involve the lab is forced to conform to the assumption that epidemiologists know everything there is to know about the source of COVID, something epidemiologists themselves didn't claim when identifying the wet market as the initial superspreader event, most likely from animals or traders originating from unknown regions outside the city.

Of course a novel coronavirus - especially one that does not produce severe or unusual symptoms in most infected people - is more likely to be identified when it becomes established in a city where it spreads quickly to many people with access to good healthcare, not a rural area where there are fewer people and more basic healthcare which infected people are less likely to use. This is why the outbreak of the original SARS novel coronavirus was identified in an urban area 1000 miles from the suspected zoonotic source of the virus, not in the neighbouring village whose unidentified inhabitants (or animal produce) most likely transmitted it to the city. It is not me "shifting the goalposts" that you continue to pretend I didn't point that out in my first post.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by kennywinker on Monday January 03, 2022 @05:12AM (#29779162)
Setting aside all the other evidence for and against the lab-leak hypothesis, I gotta argue with your numbers. Humans are not randomly distributed over the land-surface of the earth. Neither are virology labs. The first known starting point of a disease outbreak will almost definitely be in a densely populated area, since that's basically a requirement for an outbreak. So taking that into account we have to correlate densely populated areas with BSL4 labs. For a back-of-the-envelope estimate, let's use the assumption:

> "About 90% of the earth’s people live on only 10% of the land."

And let's assume that all of those 59 labs are in that 10% as well.

I'm sure it's actually smaller than that - since not all of that 10% of the land has enough density to be the epicenter of an outbreak, but... let's roll with that 10%

That'd put you off by a factor of 10.

14^2 * pi * 59 = 36,329 km2 148,326,000 * 10% = 14,832,600

36,329 / 14,832,600 = 0.00245 aka 0.2%

On top of that there have been multiple tries at this - in recent memory we've seen SARS classic, Covid-19, MERS-CoV, and Swine Flu. That's four chances at a target at least as big as 0.2%.

My probabilities are rusty, but I believe that's 99.8% * 99.8% * 99.8% * 99.8% = 99.2% chance of none of those appearing near a lab or an 0.8% chance it was near a lab. If we take that into account, it starts to seem a bit more likely that we'd see something like this...

And let's not even touch the > 1300 BLS3 labs that are out there.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by mandmandam on Monday January 03, 2022 @07:28AM (#29780088)
With all respect, how do you think this proves your point at all?

Do you not find it absurd in the extreme that the novel Coronavirus lab a few km from the outbreak of a novel coronavirus was barred from investigation?

Is it not a giant raging blinking neon clue that when Australia wanted an investigation China threatened them with economic apocalypse?

And in this context, you think a .8% chance that it would appear near a lab is high enough to discount the possibility??? My head is exploding.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by kennywinker on Monday January 03, 2022 @02:22PM (#29785102)
> With all respect, how do you think this proves your point at all?

I wasn’t trying to prove a point, I was trying to dis-prove a point: that you can’t prove the lab leaks based on geography alone. 0.02% chance is VERY unlikely - it’s not proof but it sure does suggest. A 0.2% chance or a 0.8% chance is… well it’s still rare, but not shockingly rare. Again I suspect the geographic odds are even higher, if you properly correlate outbreak-size population density and labs. Bsl3 labs brings the odds closer to 5% (or 19% if you count the four other novel disease incidents and I’m doing my probability math right).

Again, none of this disproves a lab leak. But it sure does tell us that we can’t prove it with geography, as the post I was responding to suggested.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by mytailorisrich on Monday January 03, 2022 @04:19AM (#29778850)
First known outbreak does not mean/imply origin.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by guilhas on Monday January 03, 2022 @03:17AM (#29778491)
With grants from the USA
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by cletus on Monday January 03, 2022 @12:56AM (#29777804)
This actually deserves to be talked about more.

Authorities seem to stand behind the Wuhan "wet market" theory but there's really no evidence of that, specifically if it came from an animal population, how come 2+ years later we haven't found that animal population? Also the bat coronavirus population is hundreds of miles away so how did this end up in Wuhan?

This brings us to the "lab leak" theory. There are lots of possibilities here. If this is true (and that's a mighty big IF) then my suspicion is that this was an accident and the CCP doesn't necessarily know what happened but there's absolutely incentivized not to find out. I find claims that this was a deliberate release to be unconvincing.

The key factors supporting this theory, or at least are open questions requiring further investigation are:

1. There's really no compelling alternative theory supported by substantial evidence;

2. The WHO has really lost a lot of credibility here. In early 2020, the WHO was bending over backwards not to upset China and not much has changed. In 2021 there was a joint investigation with the Chinese but the scope was pretty limited;

3. There used to be a database of coronaviruses that China had. In late 2019 this was taken offline. To date AFAIK this has never been examined by WHO investigators or any independent authority. Now this doesn't prove anything by itself but you'd think a thorough investigation would include examining it in its scope.

4. A long time (over a year) passed between the start of the outbreak and the investigation. This is a long time for evidence to go cold or "missing".

To compare, the origins of two previous coronavirus outbreaks (ie SARS and MERS) were relatively quickly identified.

No lab worker or official wants to be responsible for a leak (if there was one). No one wants to find out they were responsible. The CCP also doesn't want to set the precedent they're answerable or accountable to international authorities. This is what I mean when I say I suspect the CCP doesn't know and doesn't want to know.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by ggm on Monday January 03, 2022 @01:08AM (#29777861)
Your argument is functionally a syllogism. You assert the argument for an animal host is weak and dismiss it in one sentence but it has been repeatedly observed finding the origin host of viral infection can take years and years.

Secondly you discuss the lab leak theory at length and construct the state of being that because not A it must be B but there is no dichotomy here, there are many choices, including the fantastical which break Occam's razor but alas may turn out to be true. Simply because we have not found a wild host does not make lableak "true" or even more likely.

I have no idea what the origin is. I'm not in the field, I'm not competent to judge. What I read suggests most people who are competent to judge want more evidence.

If your point is that the CCPs exclusion of external verification of theories is proof, I'm sorry but it's just not proof: there are many reasons why the Chinese government does this, guilt is not a given although fear of guilt is plausible. Shaming the state is not easy or wise for people in this political system and "Strong China" Plays inside the government and the party (they are different things btw) as well as differences between ministries, departments, provinces, external parties make this a very complex problem.

Power struggles often have nothing to do with the ostensible reasons they are fought over.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by hattmall on Monday January 03, 2022 @01:20AM (#29777916)
You can judge. You can get all the evidence available to you and make an assessment. You can update that assessment as you gain more evidence, and you can share that with other people. No one has to defer to your authority if you don't make a good case. Stop waiting for "experts" to tell you how to use your judgement. Listening to supposed experts is why we have had such a prolonged battle with COVID with so much non-disease related societal harm.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by tempestn on Monday January 03, 2022 @01:55AM (#29778101)
The problem with this argument is that in a complex field, a layperson does not have the baseline expertise needed to evaluate cases made by experts. Try reading a novel mathematical proof published in a journal paper and see if you can weigh the available evidence and make an assessment as to whether it's correct. The only reasonable way to do so as a layperson would be to acknowledge the fact that the proof was peer reviewed by experts, and so is likely correct, and assume that to be the case unless it is later disproven by experts. (A fact you'd also be unable to independently verify.)

In a field like mathematics it's obvious that we don't have the necessary tools to evaluate expert evidence, but the same is true in most complex fields, of which epidemiology is certainly one. The experts of course won't always be right, and their best guesses will evolve as more evidence is gathered, as they should. But asking people without specific domain knowledge, even intelligent generalists, to independently weight expert evidence without resorting to trust of experts is likely to result in less informed decision making, not more.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by larryflint on Monday January 03, 2022 @04:20AM (#29778856)
et Voila, Animal Farm.

We can't let the sheep make up their own minds, we have to make up their minds for them; for they are only sheep of course, and we are the pigs.

I mean, what would happen in one of those stupid sheep had a thought to themselves? They might think

    Hey isn't that a coronavirus reasearch lab right down the street? Maybe
    they know something about this new coronavirus?
I mean, if they starting thinking...we might have a real problem on our hands. Better lock it all down.

....

Human beings are built to defer to *legitamite* authority, its a principle of how we organize ourselves. Doesn't matter if its mathematics or goverment. But that legitamacy must be demonstrated. If a mathematician fails to answer basic mathematical questions, then his authority on the subject comes into question. When the authorities fail to answer basic questions (like where did this virus come from? Why aren't we investigating the wuhan lab? Why was Fauci funding it? Why was the man in charge of the WHO investigation the man who was in charge of funding it?), they are failing to demonstrate *legitamite* authority. In a functioning democracy, that failure would be met with replacement.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by tempestn on Monday January 03, 2022 @06:56PM (#29788879)
I should also point out than when I refer to experts, I'm talking about a consensus of the majority of experts. You can always find an expert to take any position on anything. But when most of the experts in a field agree, they're probably largely right.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by ggm on Monday January 03, 2022 @01:27AM (#29777958)
My judgement such as it is, says we need a lot more time to be confident about the root cause and its premature to judge based solely on what is known at present from primary sources.

I also judge most people's opinions are being formed from at best secondary and probably tertiary sources.

I personally think your clarion call isn't helping.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by _heimdall on Monday January 03, 2022 @02:53AM (#29778378)
The irony Herr is that its likely been so long that we won't find enough evidence to determine cause with high confidence.

The fact that a lab leak was even possible but it took over a year to get any researchers into the lab is a serious issue for data collection, not to mention the fact that the CCP got to pick those researchers and didn't share any lab records.

Its important that we learn from how this played out, but seems very unrealistic to think we could pinpoint the initial transmission event now.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by okaram on Monday January 03, 2022 @01:07AM (#29777853)
I think this is mostly asking how many angels can dance on the head of a pin ...

What definitive evidence can we provide of an animal host now? What definitive evidence can we provide of a lab leak? Of a deliberate release?

I don't think we can provide definitive evidence for any of the options, that proponents of another theory, even the reasonable ones, will accept, so ... I believe it is exactly 3 angels.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by wott on Monday January 03, 2022 @02:29AM (#29778274)
There cannot be evidence of the first, but there can be evidence of the other two (supposing one of the latter options happened). The problem is that there cannot be evidence that those two didn't happen. So if the first option happened, we can never be sure of it; the only way of being sure of something is if one of the other options happened and it is revealed.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by seattle_spring on Monday January 03, 2022 @02:06AM (#29778155)
> This actually deserves to be talked about more

Does it? It's brought up in nearly every covid related thread both here and on Reddit. I couldn't avoid talking about it or reading about it even if I tried.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by mandmandam on Monday January 03, 2022 @07:31AM (#29780107)
Have we had an independent investigation? No? Then let's talk about it more.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by david_draco on Monday January 03, 2022 @07:29AM (#29780094)
The animal population has been known for decades, it is bats in rural Wuhan. People catch the bats and sell them at the Wuhan wet market. Mystery solved.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by AlbertoGP on Monday January 03, 2022 @04:59AM (#29779080)
For those interested in the evidence, this has been researched and documented by Charles Rixey, retired Marine and WMD expert.:

https://www.researchgate.net/publication/352536433_Prometheu...

His research is ongoing: https://prometheusshrugged.substack.com/

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by sneak on Monday January 03, 2022 @01:35AM (#29778012)
Aside from being unable to be researched, to the point of being effectively unknowable: it's actually completely irrelevant. Where covid came from is meaningless now. Take any hypothesis you may have about its origins: you can't explain why it might matter today, in any way whatsoever.

Covid is here and we have to cope with it. It's just our stupid monkey brains that thrive on x did y to z narratives that are demanding answers, as if they were in any way relevant.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by _heimdall on Monday January 03, 2022 @02:56AM (#29778394)
Its only irrelevant if that information wouldn't help avoid a future pandemic.

If it was a lab accident that's extremely important to know as we could easily mitigate (or eliminate) that risk. If it was zoological, there may be changes that could make that less likely. If it was a third cause that no one is even thinking about, that's even more important because it somehow was missed by everyone looking for the most likely cause.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by jackdaniel on Monday January 03, 2022 @01:57AM (#29778108)
What was the source doesn't matter for fighting COVID but certainly matters for people who work on gain of function research. If the virus leaked from the laboratory then it will be a strong argument against funding this kind of science.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by gugagore on Monday January 03, 2022 @01:53AM (#29778089)
While it may be irrelevant to how we address this current pandemic, whether covid came from a lab leak holds relevance because of the possibility of future lab leaks.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by em500 on Monday January 03, 2022 @03:27AM (#29778553)
But that possibility (as well as animal origin possibility) is there, regardless of the actual origin of the current pandemic.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by gugagore on Monday January 03, 2022 @04:17AM (#29778834)
That's the same as saying that the possibility of a plane crash is there regardless of the reason of the current plane crash. There could be something worth learning in the details...
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by justinclift on Monday January 03, 2022 @06:29AM (#29779689)
> it's actually completely irrelevant. Where covid came from is meaningless now.

Wonder if insurance companies would generally have the same opinion.

If there was an actually provable origin, do you reckon insurance companies _wouldn't_ give them the bill? ;)

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by umanwizard on Monday January 03, 2022 @07:01AM (#29779895)
I don’t think foreign insurance companies would have any luck making the Chinese state pay for the worldwide cost of Covid, even if there were ironclad proof the pandemic was their fault.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by fredestine on Monday January 03, 2022 @03:57AM (#29778722)
it is relevant because people need to be accountable for this and governments too. if it comes from a lab funded by usa and china they need to be held accountable and show us that they can change security and safety protocols so that it doesnt happen again. I don't understand why it's even up for debate.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by sneak on Monday January 03, 2022 @04:35PM (#29787266)
There is no meaningful way for any other country to hold any global superpower "accountable" unless they consent to such treatement. Nuclear weapons are a thing.

China has closed the book on this discussion. There's no further steps to take on the matter, even if you had unassailable proof, unless you wish to go to war.

Nobody wants to go to war (like that, anyway - the CIA may well wish to step up the trade war, based on how much anti-China sentiment is being stoked in the US population over the last dozen years).

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by evv555 on Monday January 03, 2022 @01:13PM (#29784065)
It's relevant in that there might be a huge conflict of interest at the NIH that has undermined the pandemic response.[1]

1. https://www.youtube.com/watch?v=lRCowOPL5Vc&t=229s

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by jessaustin on Monday January 03, 2022 @12:28AM (#29777655)
It's possible that several scientists in the relevant fields already have well-founded suspicions regarding this. As soon as political developments allow them to share their knowledge without endangering their funding, we might hear about it.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by wesleywt on Monday January 03, 2022 @12:51AM (#29777772)
Comments like these are frustrating. This pandemic was predicted for many years by scientist. I don't understand why the public wants to believe in the fantasy that this was deliberate action. No, this pandemic was caused by deliberate inaction.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by pizza234 on Monday January 03, 2022 @06:13AM (#29779592)
> I don't understand why the public wants to believe in the fantasy that this was deliberate action

This is gross oversimplification. The fact that some scientists may know doesn't imply that the only possibility is deliberate action.

Since there have been a lot of money poured on Coronaviruses research in the last decade, it's reasonable that, (important!) even not assuming a lab leak (/important!), scientists working on it, don't want to disclose it.

Even those who didn't work on it are disincentived to talk about it, as their reputation is on the line (in particular, because of the misguided opinion that lab leak equals bioengineerd virus). A few co-subscribers of the Lancet letter changed their mind on the topic. It doesn't surprise me that they did it only recently - precisely because their position is now less endangered.

> This pandemic was predicted for many years by scientist

It's hard to extract any value from this, especially without a very serious analysis, because at any point in time, there will be people predicting that events of any kind will happen.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by halpert on Monday January 03, 2022 @12:54AM (#29777791)
How can you be so sure. The first outbreak was literally a few feet from a lab studying this exact virus. Biden called for U.S. intelligence to figure out if the original virus came from a lab: https://www.nytimes.com/2021/05/27/briefing/lab-leak-theory-...

What do you know that the U.S. president and U.S. intelligence doesn't?

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by stirfish on Monday January 03, 2022 @01:13AM (#29777880)
I think USA intelligence only decided that it isn't a bioweapon

https://www.washingtonpost.com/national-security/wuhan-coron...

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by halpert on Monday January 03, 2022 @01:52AM (#29778086)
I didn't say it was a bioweapon, just that it very well could have originated in a lab. From your article:

> The two main hypotheses — that the virus jumped from animals to humans in a natural process, or that it escaped from a research laboratory in China — remain on the table, ODNI said. Both theories are plausible, the agencies concluded.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by stirfish on Monday January 03, 2022 @08:34AM (#29780607)
I know, I was just providing some context. You sent me down a bit of a rabbit hole :)
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by jcranmer on Monday January 03, 2022 @01:28AM (#29777975)
> The first outbreak was literally a few feet from a lab studying this exact virus.

Fact check: false. The early cases in Wuhan almost all cluster near the wet market, not the virology lab, which is on the outskirts of town on the other side of the river some ~30km from the market. (And to the extent they don't cluster near that market, they do favor quite strongly the market's side of the river, not the virology lab's side of the river.)

> Biden called for U.S. intelligence to figure out if the original virus came from a lab

Because a government has never, ever called for an investigation or an action to be taken because of political pressure despite its internal knowledge bases saying there is no need to investigate it.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by pizza234 on Monday January 03, 2022 @06:25AM (#29779661)
> Fact check: false. The early cases in Wuhan almost all cluster near the wet market, not the virology lab, which is on the outskirts of town on the other side of the river some ~30km from the market. (And to the extent they don't cluster near that market, they do favor quite strongly the market's side of the river, not the virology lab's side of the river.)

To be considered:

> the Wuhan CDC ‘hosted animals in laboratories for research purpose, one of which was specialized in pathogens collection and identification’. Moreover, the Xiaos described how a lead researcher at this laboratory who collected bats had featured in articles and at least one broadcast video revealing that ‘he was once attacked by bats and the blood of a bat shot on his skin. He knew the extreme danger of the infection so he quarantined himself for 14 days. In another accident, he quarantined himself again because bats peed on him.’ Given that ‘surgery was performed on the caged animals and the tissue samples were collected for DNA and RNA extraction and sequencing’, relatively close to the Huanan seafood market where clusters of Covid-19 cases had been detected, it was reasonable to ask whether an accident had occurred, the two scientists argued.

If a case like this was hypothetically true, it would sit on a line between zoonotic origin and lab leak. Remember that lab leak doesn't imply bioengineering.

> the virology lab, which is [...] some ~30km from the market.

Independently of lab leak or not, this is wrong. You can check on google maps that by car (and even more in a straight line), is less than 15 km.

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by adolph on Monday January 03, 2022 @02:09AM (#29778173)
The Wuchang campus is closer, 17k away.

Crucially, however, the now famous “earliest” COVID-19 case (1), a 41-year-old male accountant, who lived 30 km south of Huanan Market and had no connection to it—illness onset reported as 8 December—may have become ill with COVID-19 considerably later. . . . This suggests that he may have been infected through community transmission after the virus had begun spreading from Huanan Market.

[C]onclusive evidence of a Huanan Market origin from infected wildlife may nonetheless be obtainable through analysis of spatial patterns of early cases and from additional genomic data, including SARS-CoV-2–positive samples from Huanan Market, as well as through integration of additional epidemiologic data. Preventing future pandemics depends on this effort.

https://www.science.org/doi/10.1126/science.abm4454

Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by jcranmer on Monday January 03, 2022 @02:24AM (#29778249)
The Wuchang campus may be closer, but the image of the case clusters still shows strong clustering near the markets and not particularly near either campus.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by tptacek on Monday January 03, 2022 @03:45PM (#29786603)
That's the distance from the Mission to SFO, or from the Freedom Tower all the way across Manhattan to Harlem. Seems like a hike.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by todd3834 on Monday January 03, 2022 @12:54AM (#29777790)
If it came from a lab then it was caused by overaction. If it came from the wild then you are right. That’s the reason people want to know
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by petre on Monday January 03, 2022 @01:10AM (#29777870)
It could have come from guano miners just as easily, but bringing it to a 50M population center was a recipe for disaster. Ebola and AIDS did not come from a lab but from tampering with wild animals.
Re:Evidence for a mouse origin of the SARS-CoV-2 Omicron var... by jessaustin on Monday January 03, 2022 @01:03AM (#29777835)
You have oversimplified. It isn't necessary to believe that any researcher is capable of designing a sophisticated new virus. (Although, since this is all hooked to computers, just wait a decade...) It's just plausible that some researchers could be sloppy enough with inherently dangerous research to cause serious harm. Further, many have observed how those researchers have been at least partially funded by the same well-endowed funding entities that also fund major portions of most other research in virology.

[EDIT:] But you're right about the "deliberate inaction". The obvious way to fight pandemics (as opposed to less contagious health threats) is to make sure everyone in society has access to relevant health care and other vital resources. This came naturally to many societies that earned much lower covid death rates than USA earned.