Your risk of myocarditis from COVID is 10x-20x your risk of myocarditis from a vaccine.
(One of many many sources: https://twitter.com/awong37/status/1444825498018795521)
One can't be expected to know what the credentials of some random doctor on twitter are and he doesn't reference any sources of his own.
It really bothers me that people are still touting such numbers around as obvious, indisputable facts given the poor quality of both covid and adverse effect statistical data.
1. What are the odds that you will experience symptoms if you get myocarditis?
2. What are the odds that vaccine induced myocarditis will be reported as such? There is a wealth of anecdotal evidence of people complaining about all manner of possible vaccine reactions to completely dismissive doctors, and filling out a VAERS report is time consuming and already overwhelmed medical practitioners are unlikely to spend 30+ minutes on a report.
3. Does vaccine (or covid) induced myocarditis have long term consequences, even if asymptomatic or mild? I've read repeatedly that myocarditis of any severity represents some degree of permanent damage but have not been able to conclusively verify this statement.
4. Why are we putting so much faith into the statements and research of pharmaceutical companies who stand to gain tens (hundreds?) of billions from vaccines+boosters, when we know that these same companies have been repeatedly sued in the past for dangerous/defective medications (and vaccines) as well as deliberately sociopathic business practices? We are talking about a massive conflict of interest from parties which have repeatedly demonstrated dishonesty in the past.
And then with respect to VAERS self reporting, the average person has been convinced that the vaccine is safe and is not likely to connect strange symptoms weeks after vaccination with the vaccine, if they even know about VAERS or the European equivalent. There's far too much uncertainty in the positive data to support such a rigid social orthodoxy around expression of negative sentiment toward the vaccine.
1. The sudden viral load is orders of magnitude larger than typical exposure and given the complexity of the immune system, may produce a different response. Also recall that unlike traditional vaccines this mRNA hijacks your cellular machinery to produce an inflammatory protein - so comparing it to past vaccines in this respect is invalid.
2. Again because of the complexity of the immune system, its possible that a sudden, massive injection of spike protein mRNA will not activate the immune system in the same way that a gradual infection by the full virus.
3. From what I've read, the spike protein when manufactured from snipped mRNA is then expressed on cell surfaces, in contrast to a true viral infection which releases the full viral particles into the bloodstream. This could induce autoimmune reactions which would explain many of the documented side effects.
My main point though is that many in the vocal pro-vaccine crowd are underestimating the borderline chaotic complexity of the finely tuned chemical soup that is our biology. And we are injecting an engineered substance which we know is biologically active in a novel way. It's hubris to casually presume that we got this right the first time.
Edit: for the programmers, think of it as a very clever and involved hack. And hacks can have unintended side effects, especially when the system is poorly understood.
No. It doesn't. This is completely ignorant misinformation. Your molecular machinery for creating proteins are doing so constantly. Introducing a bit of code that produces a protein that looks like the virus is in no way "hijacking" your molecular machinery. Your machinery happily chugs along with every other of the 10s of thousands of other proteins being produced at the same time. Nothing is hijacked.
And such an autoimmune disease, if caused by the vaccine, would possibly be difficult to detect, especially on short timescales, and/or if no one is looking for them. Add in the stigma/silencing of professionals who criticize the vaccines and you're unlikely to get such research done/published, and it is a very real possibility that we just dosed hundreds of millions of people with a substance that may cause long term issues.
There's plenty of room for uncertainty here. It is irresponsible to suggest otherwise, regardless of the media's manufactured consensus.
Next time you read something on the internet that sounds like something you would reasonably like to believe, please ask for a citation before you spread misinformation. The cell types that produce it and display it are exactly the same cell types that do it for every bit of foreign protein your immune system needs to protect against. There is nothing sneaky or take-over or unnatural about this process that happens all the time in your body.
Please stop.
This source[1] cites the following from a dead link to the cdc website:
>Upon entering the cell’s cytoplasm, the mRNA redirects some of the cell’s protein production machinery (of which ribosomes are the workhorse) to begin producing viral spike proteins. The produced spike proteins are then incorporated into and “displayed” on the host cell’s outer membrane surface
If you want something meatier, here's a detailed source[2] discussing this very point, that because the spike protein is not manufactured with the rest of the virus, at least some S protein expression is expected at the cell surface from the vaccine, in contrast to a true covid infection. And this source links to multiple others on the same subject.
People seem to presume that any information which reflects negatively on the vaccines is automatically misinformation and/or argued in bad faith. Its incredibly toxic to productive discussion.
>The cell types that produce it and display it are exactly the same cell types that do it for every bit of foreign protein your immune system needs to protect against.
I'm not sure what you're implying here - that its normal for your cells to absorb foreign RNA and manufacture inflammatory proteins that are then expressed on cell walls and used to induce what is effectively an autoimmune response?
>There is nothing sneaky or take-over or unnatural about this process that happens all the time in your body.
I'm not saying anything about this is "sneaky" but injecting mRNA with the purpose of manufacturing inflammatory proteins is hardly "natural".
1. https://www.acepnow.com/article/how-the-covid-19-mrna-vaccin...
If you are going to cite literature at least understand what you're citing.
> Antigen-presenting cells (APC) are cells that can process a protein antigen, break it into peptides, and present it in conjunction with class II MHC molecules on the cell surface where it may interact with appropriate T cell receptors.
APCs do not hoover up random mRNA to translate. They hoover up remnants after a carnage.
The vaccine is jabbed into the muscle, the spikes are (likely) expresses from the muscle cells, most definitely not only APC cells. Even if they were, it is not normal for APCs to be producing the proteins.
[1] https://www.sciencedirect.com/topics/veterinary-science-and-...
It's normal for Antigen Presenting Cells to present antigens on the surface of their cell membrane. It's what they do all day.
So, yes. Every bit of the process is completely natural and normal.
The claims seem incorrect.
Please stop.
The vaccine is not and purposefully does not act like normal mRNA. It's not even made of the same 4 building blocks.
Yes; that's why it has to be stored at such a cold temperature, to stave off that degradation.
The "engineered quasi-mRNA" aspect of things isn't to evade degradation, but initial immune response so it can avoid being broken down before it can express itself. https://www.science.org/content/article/mysterious-2-billion...
> Assembling mRNA using pseudouridine, a nucleoside variant that occurs naturally in the body, greatly reduced the tendency of immune sentinels called dendritic cells to shoot out inflammatory molecules in response, they reported in 2005.
> When a vaccinated cell dies, the debris will contain many spike proteins and protein fragments, which can then be taken up by a type of immune cell called an antigen-presenting cell. [1]
Is it true that host cells need to die for the vaccine to take effect?
I'm not entirely sure and couldn't find good sources to verify or disprove OPs claim, but I recall some claims that the vaccine kills cells.
> it will lead to the cells death because it produces the foreign protein as instructed until it is killed by your immune system.
Different sites have different descriptions, but even [2] mentions:
> The priming of CD8 T cells can induce the formation of cytotoxic T lymphocytes (5b) which are capable of directly killing infected cells.
Which likely means killing cells presenting the vaccine spikes? Most sites mention some form of cytotoxic action or reponse, which I do not understand, but I take it to mean that some cells are killed.
[1] https://www.irishtimes.com/life-and-style/health-family/expl...
> ... but I recall some claims that the vaccine kills cells.
You are spreading your own ignorance.
I would especially be interested in a source claiming APCs transcribe RNA to present antigens; that antigens enter the cells; and that they (rather than you) are full of it.
Note, I think both you and OP presented false claims and misconception. OP probably more, but it is you that will help spread and affirm more anti-vaxers with the - you're wrong, here's what I think, now shut up and take the jab - attitude towards their concerns.
Especially when viruses are commonly described in the same way, since the mechanism and outcome is the same: an entity other than the human cell is controlling the output of the organelles.
In any case this is a pedantic argument and changes absolutely nothing about any of my points, nor is it misinformation.
It is simply presenting the information in the language of your immune system.
That history of research says this: If "symptoms" don't show up within 6 weeks, they don't really show up at all.
That is to say, with ALL other vaccines in existence, issues have shown up within 6 weeks.
Here is an article which explains it, but this is like common knowledge amongst epidemiologists: https://www.nationalgeographic.com/science/article/vaccines-...
Autoimmune disorders in particular are not necessarily going to appear in 6 weeks. Especially when the data is so noisy and there's a clear, career risking stigma against reporting anything.
Nobody is.
Regulators are largely looking at facts on the ground before making decisions.
But since the vaccines are proven to be safe given hundreds of millions of doses there is a lot more willingness to trust them.
My point is that the "facts on the ground" are extremely noisy and in large part coming from the pharmaceutical companies themselves. This proof is overstated, ignoring the fact that there hasn't been enough time to detect mid-long term effects, its own can of worms.
All of this doubly so given the chilling effect of the stigma associated with what has seemingly been decided to be "misinformation". Clinicians, researchers, nurses are less willing to stick their necks out to criticize the research/data, and so the problem is dangerously self-reinforcing.
These are the same circles that gave us the opioid crisis. And suddenly we've all forgotten about regulatory capture? None of these criticisms deserve this rabid bullying. This is supposed to be science, not religious dogma.
Edit: and let's not forget that these pharmaceutical companies are legally not liable for any adverse effects. Informed consent requires freedom of discussion.
> Please, get vaccinated.
> I will respect your decision, but I would also like to have you on the team the next 3 seasons. Here is the data, consider getting a vaccine.
The comparison isn't moderna vs no vaccine (in which case moderna would win the risk trade-off). The comparison is moderna vs pfizer.
EDIT: The alternative is not stopping vaccinations. Men under 30 are given Pfizer.
https://www.cdc.gov/mmwr/volumes/70/wr/mm7035e5.htm
> During March 2020–January 2021, the risk for myocarditis was 0.146% among patients with COVID-19 and 0.009% among patients without COVID-19. Among patients with COVID-19, the risk for myocarditis was higher among males (0.187%) than among females (0.109%) and was highest among adults aged ≥75 years (0.238%), 65–74 years (0.186%), and 50–64 years (0.155%) and among children aged <16 years (0.133%).
Later
Another thing to consider is that the myocarditis rate from C19 itself may exceed that of the vaccine, which would basically refute the argument against vaccination.
(By all means, pick vaccines strategically.)
For children and healthy young people below the age of 30, Covid is mostly harmless (https://www.bbc.com/news/health-57766717). The risk of vaccination may actually be higher since the vaccines currently used aren't fully researched nor fully approved yet. The situation is not black or white. Vaccination may be very useful for people aged 50 and above but at the same time counterproductive for children.
If this young person below 30 gets a side effect from the vaccine, is that side effect worse than what they'd get by having the virus?
It should be clear that we aren't going to suppress or eradicate covid, so you shouldn't be comparing getting the vaccine or nothing happening, but getting covid with or without the vaccine
Furthermore, there is no guarantee that Covid won't mutate so that you will have to refill your vaccination every year to stay immune like with vaccines against the flu. If so, mass vaccinations probably won't be employed again and we'll only vaccinate at risk groups.
With an endemic Covid, how often will people get an infection on average?
It isn't a too trivial calculation at all.
You could easily argue for vaccinating everyone with comorbidities <30, without arguing for vaccinating everyone.
Also, even in apparently benign myocarditis, there may be heart damage which will not become apparent for many years.
The alternative is not stopping vaccinations. Men under 30 are given Pfizer.
An even higher number has a very poor idea of the state of their health. Never assume you're healthy.
People keep throwing this statement out as though somehow the risk of vaccination is higher then the risks due to viral infection. It is not.
The risks of adverse reactions to COVID infection is reduced across the board if you are fully vaccinated regardless of your health status.
Also worth noting: plenty of young people have comorbidities they don't know about yet, because they haven't found them. It is actually quite difficult to exclude yourself from the "has comorbidities" risk group apriori. A common one is in fact undiscovered heart conditions for people in their 30s, since they usually only become an issue later in life when symptoms are more likely to present.
If you’re going to disagree with me at least disagree with me.
No, because you need to consider not just the odds of getting myocarditis from covid vs vaccine (Pc:Pv), but the bayesian probabilities of getting infected (Pi) or vaccinated (1) and then getting myocarditis, such that the full risk analysis would look more like Pi*Pc:Pv[1]. Point being when you are talking about vaccinating the entire population, you can easily end up in a position where there are more cases of heart inflammation from fully vaccinating the population than simply letting the virus run its course. I believe the term is relative risk reduction but don't quote me.
1. This isn't quite right, there should be a 1-x term or two in there somewhere to account for the probabilities of getting vaccinated/infected and not developing myocarditis, but its been a few years since my probability course...In any case the point still stands, that the vaccine may be less likely to cause heart inflammation does not imply that it would produce fewer cases overall if a sizeable proportion is vaccinated. To properly estimate that you need an accurate estimate for the myocarditis rate from both covid and vaccine, which I don't think anyone has.
There is also this fact that myocarditis has high prevalence among teenage boys (even CDC might underestimate it) and it looks like it is caused by some form of immune reaction and its occurrence is immune reaction size dependent (Moderna causes more myocarditis than Pfizer that causes more than AstraZeneca). It allows to postulate that it might be that the people who get myocarditis after vaccination have high risk of getting it after infection.
Just make it so you can't use a hospital bed in that case. It's only fair to people who are actually forced to go to the hospital, as opposed to gambling for it.
"Heart and lung transplant candidates must be free of nicotine and tobacco use, including chewing tobacco, for six months prior to an initial listing."
https://www.osotc.org/resources/tobacco-abstinence-criteria/
Should we refuse to treat any injury sustained by the Wright brothers during their experimental flights? Surely that's highly dangerous highly voluntary stuff. Should we refuse to rescue hikers if they become lost or trapped? Should the coast guard never help recreational sailors? Should we have to submit to a proscribed diet exactly to prove we deserve medical care? Should we forgo treatment for tendonitis if it can be shown we ignored known warnings about typing too much?
To me, people are precious, and they lead messy, imperfect lives. They make bad decisions and good ones, and decisions I don't understand. They'll take risks I never would in pursuit of goals I don't see as valuable. Sometimes, when you really get to know someone, a decision that didn't make sense from a distance really starts to. And sometimes people are being self-destructive and there's no more to the story, and sometimes it's something they go through and come out the other side of.
My conviction is to love and help them no matter what.
Sometimes I can't, and that's a different thing, but deciding that someone doesn't deserve help is a level of judgement I don't want and can't justify. Maybe what they were doing really was worth it. I don't know. Even if it's not, it's essential to let people try.
I would find someone else trying to exert this degree of control over my life - requiring me to comply with their particular take on what risks were worth it - suffocating and unbearable. I am sure others feel the same way, about control in areas in which I wouldn't mind it because I happen to already be normal. So I am against it on principle. People need to be people, in all their messy glory. And we should help them if we can, regardless of how they got there. I think the only case in which I would act differently was if I thought letting someone suffer natural consequences was for their best - and I would have to be incredibly sure.
Leaving people to a fatal condition when we could help them is incomprehensible and inhumane to me, and represents a dangerous level of escalating disagreement into dehumanization.
> Should we refuse to treat any injury sustained by ...
You break it you buy it. Should the state and society in general be expected to shoulder the burdeon for people who chose to put themselves in danger, should 10 people be sent into danger to save the sailor who makes the choice to take on a hurricane?
Who do we save if we can only save 1 person, the heroin addict with a fatal condition we can probably save or the child that would be a flip of a coin?
> My conviction is to love and help them no matter what.
What of the children of the helicopter crew flying into the hurricane to save the lone sailor? No love and help for them? Or the person who doesnt get a bed because it is take up by others?
> I would find someone else trying to exert this degree of control over my life - requiring me to comply with their particular take on what risks were worth it - suffocating and unbearable?
Your choices are other peoples consequences. As a functioning member of society, philosophically you comply with these things on a constant basis, and no doubt demand it of others. It is not a matter of principle, it is simply a question of where the line is. If you have ever complained about anything you have exerted your control over someone elses life.
You cannot rely on "being right this time" to avoid participating in tragedy. The liars are too good. But you can refuse to hate and dehumanize those you are told to.
If you truly believe that medical care is a human right, then you should extend it to every human, regardless of how they wound up in the situation they're in. While you sometimes do have to choose, it is abhorrent to choose the rich over the poor, the socially well-adjusted over the outcasts, ideological friends over ideological foes. The standard we actually use is to do the absolute best you can for everyone you can.
You're right that it doesn't make sense to cause greater harm to avoid lesser, but rationing too quickly, especially from a place of moral judgement rather than medical triage, seems much more likely to be coming from a place of spite than a place of tragic necessity. We take care of enemy soldiers. We take care of people on death row. We take care of people who would see us dead, because this is what civilized and humane people do. If you are quick to deny care to people you perceive as not doing their part, you're coming from a perspective much, much darker than the general thought and ethics of this civilization.
I know everyone is angry and has suffered in the last couple years, and I know everyone wants to fight. There are people running around right now stirring up that anger and trying to direct it at their ideological enemies. By all means, fight for what you think is right. But if you find yourself indifferent to the death of your fellow man or even cheering for it, beware - it may make sense to you right now, but that will be no comfort in five or ten or twenty years if what you wish for comes to pass and you have to remember cheering for it.
No: Absolutely not worth it to take that particular shot, as there are others available which don't have that side effect.
In that case, I'd expect all of the vaccines to have a similar risk, and it's only been spotted in one so far
It is fairly clear that adverse effect is dose dependent and it may be the reason why we do not see that many with vector vaccines - immune system creates some immunity against the vector virus and actual amount of vaccine entering cells is limited. It is also evident from the limited immune response from vector vaccines.
According to Finnish Institute for Health and Welfare, an additional 4 cases per 100k men under the age of 30.
They also note that having covid is a risk factor for myocarditis. So perhaps still worth it to take the shot.
Possibly they are doing this to put out the antivax wildfires in social media by reacting to statistical information about risks. So as to show that when there are scientifically established risks, there will be reaction to that as well.