Every story and comment from the Hacker News API, in a layout borrowed from 2001.
A comment on Finland joins Sweden and Denmark in limiting Moderna Covid-19 vaccine. Parent comment
Yes; that's why it has to be stored at such a cold temperature, to stave off that degradation.
The "engineered quasi-mRNA" aspect of things isn't to evade degradation, but initial immune response so it can avoid being broken down before it can express itself. https://www.science.org/content/article/mysterious-2-billion...
> Assembling mRNA using pseudouridine, a nucleoside variant that occurs naturally in the body, greatly reduced the tendency of immune sentinels called dendritic cells to shoot out inflammatory molecules in response, they reported in 2005.
There are no comments on this comment yet.
Yes; that's why it has to be stored at such a cold temperature, to stave off that degradation.
The "engineered quasi-mRNA" aspect of things isn't to evade degradation, but initial immune response so it can avoid being broken down before it can express itself. https://www.science.org/content/article/mysterious-2-billion...
> Assembling mRNA using pseudouridine, a nucleoside variant that occurs naturally in the body, greatly reduced the tendency of immune sentinels called dendritic cells to shoot out inflammatory molecules in response, they reported in 2005.