News for hackers. Stuff that matters.
Re:Malaria vaccine delivered by a mosquito bite by acyou on Wednesday November 27, 2024 @01:49PM (#42258595)
For those interested, I would suggest checking out Spillover by David Quammen. It goes into detail on why eradicating/eliminating zoonotic diseases isn't really feasible without also eradicating the host populations. I stumbled onto it and read it early on during SARS-CoV-2, it will give you a new perspective on the management of disease in general.

As for eradicating host populations/mosquitoes, it's not the greatest idea. Ecosystems are complicated and don't generally benefit from that sort of interference. Maybe if it's a recently invasive species, sure, as long as other species don't get inadvertently by-caught. Drastically simplifying - birds need to eat too, and they tried to do this style of ecosystem management in the past and it has had brutally adverse effects for ecosystem stability.

I think that this is an incredible development, but also seems kind of destabilizing. It's hard to say without seeming or being callous, that it seems good now, but we need to try to predict outcomes far into the future. That is to say - people think they are smart to have done it, and yeah it's doable, but is it really such a great idea to throw such a series of proverbial monkey wrenches into our proverbial biological engines?

Re:Malaria vaccine delivered by a mosquito bite by zamalek on Wednesday November 27, 2024 @02:19PM (#42258836)
As I understand the situation with mosquito eradication, there are highly specific places where mosquitos are a critical source of biomass (I think the Arctic tundra was one example). In all other places they are completely and utterly worthless. Blood-eating (never mind species that are parasite vectors) are also a tiny percentage of the overall biodiversity, the nectar species could easily fill the gap.
Re:Malaria vaccine delivered by a mosquito bite by soperj on Wednesday November 27, 2024 @02:29PM (#42258939)
Female mosquitoes bite to produce eggs, male mosquitoes feed on nectar and pollinate plants. Some orchids can only be pollinated by mosquitoes.
Re:Malaria vaccine delivered by a mosquito bite by jvanderbot on Wednesday November 27, 2024 @02:49PM (#42259100)
Fair trade.
Re:Malaria vaccine delivered by a mosquito bite by Modified3019 on Wednesday November 27, 2024 @04:45PM (#42260119)
So no one misunderstands, there are over 3000 species of mosquitos, but most biting species of mosquitos only go after birds/amphibians.

Only a small number of species (single digit percentage) go after mammals. And even less than have been found to be vectors for disease.

The basic point is that yes, we can wipe out selected mosquito species via eradication programs (like sterile mate release) with zero consequence outside of healthier people, because human hazardous mosquitos aren’t unique to the ecological niche they fill.

Re:Malaria vaccine delivered by a mosquito bite by smegger001 on Thursday November 28, 2024 @02:38AM (#42263319)
better than sterile male we could release fertile ones genetically modified to only have male offspring that in turn only have male offspring inside handful of generations there are no female mosquitos left.

https://pmc.ncbi.nlm.nih.gov/articles/PMC10795774/

Re:Malaria vaccine delivered by a mosquito bite by Modified3019 on Thursday November 28, 2024 @12:44PM (#42267205)
Oh that’s interesting, thanks.
Re:Malaria vaccine delivered by a mosquito bite by chpatrick on Wednesday November 27, 2024 @02:42PM (#42259044)
The problem is that you might only find out they're important after you wipe them out, at which point it will be too late.
Re:Malaria vaccine delivered by a mosquito bite by jvanderbot on Wednesday November 27, 2024 @02:50PM (#42259104)
Will it be too late? We could move region by region and give a few years to see any changes. It's a two-way door that way.
Re:Malaria vaccine delivered by a mosquito bite by chpatrick on Wednesday November 27, 2024 @03:03PM (#42259209)
I think collapsing the ecosystem of one region is already bad enough.
Re:Malaria vaccine delivered by a mosquito bite by satvikpendem on Wednesday November 27, 2024 @04:17PM (#42259870)
The point is that if an ecosystem needs to be "collapsed" to effect beneficial change for the humans living there in order to not die of illnesses, then so be it. Even referring to removing mosquitoes as "collapse" is not understanding the core argument, because not all collapse is bad and not all preservation is good; there is no value judgment in saying collapse but you are adding one there inherently.
Re:Malaria vaccine delivered by a mosquito bite by chpatrick on Wednesday November 27, 2024 @04:41PM (#42260076)
If the foodchain collapses it's much worse for humans living there than malaria.
Re:Malaria vaccine delivered by a mosquito bite by jvanderbot on Wednesday November 27, 2024 @05:00PM (#42260237)
What part of the food chain is foundational on mosquitos? These are hypotheticals not rooted in any concrete argument.

I realize this is a dumb starting point, but ... Cows don't eat mosquitos, Feed corn is not pollinated by mosquitos, Orange groves do not require mosquitos. What, specifically, are we afraid of?

Re:Malaria vaccine delivered by a mosquito bite by satvikpendem on Wednesday November 27, 2024 @04:43PM (#42260100)
Sure, but it's unknown whether it will or not, that is what is being discussed.
Re:Malaria vaccine delivered by a mosquito bite by jvanderbot on Wednesday November 27, 2024 @04:54PM (#42260198)
I mean that certainly sounds unequivocally true.

But "collapse" is not what I'm saying. If you were to remove mosquitos in a localized region and observe the effects on the region's ecology, you could witness the problems, reintroduce the bugs, and revitalize the region (probably it'd recover anyway).

Mosquitos are fairly localized. Their range upperbound is 7 miles. Some just fly 300 feet and breed around your house. There are plenty of ecological phenomena that are managed in "a few miles" ranges, like fish populations, forests, etc.

I haven't heard a compelling reason in any of these threads to believe that it's actually dangerous to remove them from a few sq mile area.

There's no reason to be absolutist about problems we can manage, just based on unobserved worst case solutions with no risk profile attached.

Re:Malaria vaccine delivered by a mosquito bite by imtringued on Thursday November 28, 2024 @01:33PM (#42267540)
You're making arguments based on pure faith. There is no substance to anything you're saying.
Re:Malaria vaccine delivered by a mosquito bite by chpatrick on Friday November 29, 2024 @11:52AM (#42275114)
I'm sure they thought they had everything figured out when they introduced the cane toad in Australia as well.
Re:Malaria vaccine delivered by a mosquito bite by Steven420 on Monday December 02, 2024 @10:17AM (#42297010)
Mosquitos are an extremely important food source for countless animals especially aquatic species. The gap won't be filled. The animals that rely on them for food will just die off
Re:Malaria vaccine delivered by a mosquito bite by waveBidder on Wednesday November 27, 2024 @03:35PM (#42259465)
I've yet to hear a single ecologist equivocate on eliminating aedes aegypti, the primary vector for the worst vector borne diseases, and have heard many endorse the idea. Even so, things like Wolbachia give a means of effectively inoculating the vector.
Re:Malaria vaccine delivered by a mosquito bite by taosx on Wednesday November 27, 2024 @04:37PM (#42260043)
I also endorse that, they've somehow made way in Europe. They are active during the day and are very aggressive.
Re:Malaria vaccine delivered by a mosquito bite by duskwuff on Wednesday November 27, 2024 @05:09PM (#42260301)
The sheer amount of human and animal* suffering caused by mosquito-borne diseases speaks strongly in favor of mosquito eradication. Over half a million people died of malaria in 2022 alone, over three quarters of them children - even if there are ecological risks, they need to be weighed against allowing that suffering to continue.

*: e.g. heartworm in dogs

Re:Malaria vaccine delivered by a mosquito bite by dietr1ch on Wednesday November 27, 2024 @05:56PM (#42260644)
It's crazy that eradicating missiles would do way better. It could even fund vaccination against mosquito-borne diseases without /figuring/ around and finding out if the chain reaction started by killing all the mosquitoes has big consequences or not.
Re:Malaria vaccine delivered by a mosquito bite by waveBidder on Wednesday November 27, 2024 @06:47PM (#42260995)
why are you bringing this up? It's irrelevant to the topic at hand
Re:Malaria vaccine delivered by a mosquito bite by dietr1ch on Wednesday November 27, 2024 @08:10PM (#42261416)
I agree it's sort of unrelated, but I think that people are getting nerd-snipped into thinking/discussing about a complicated improvement while there's easier ones right in front of us and it's kind of sad that while easy on theory, everyone seems already defeated by our apparent inability to do something about it.
Re:Malaria vaccine delivered by a mosquito bite by smegger001 on Thursday November 28, 2024 @02:31AM (#42263279)
only Malaria has killed far more people than missiles you brought up. According to estimates published in Nature, over 50 billion people have suffered from Malaria over the course of human history. (Whitfield, J. Portrait of a serial killer. Nature 2002) that nearly half of humanity lost to a single disease.

and unfortunately we are in warming planet where Malaria's host vector range is going to increase as temperatures continue to rise, destroying Malaria is one of the greatest possible morale goods we could pursue.

Re:Malaria vaccine delivered by a mosquito bite by dietr1ch on Thursday November 28, 2024 @07:56AM (#42264903)
> over 50 billion people have suffered from Malaria over the course of human history.

Those are long dead already, aren't they? I guess the right question to be asked when thinking about taking action is which one is going to kill more in the near future.

> unfortunately we are in warming planet where Malaria's host vector range is going to increase as temperatures continue to rise.

This is a fair point and should be accounted when thinking about the impact on malaria

> Destroying Malaria is one of the greatest possible morale goods we could pursue

It's great for sure, maybe among the greatest ones around health, but I don't think it'd go over peace.

Re:Malaria vaccine delivered by a mosquito bite by ashoeafoot on Thursday November 28, 2024 @02:28AM (#42263264)
its his/her job?
Re:Malaria vaccine delivered by a mosquito bite by bsimpson on Wednesday November 27, 2024 @05:22PM (#42260389)
See also, Debug:

https://verily.com/solutions/public-health/debug

It's a Verily project that causes population collapse in mosquitoes like aedes aegypti by rendering the males infertile.

> Aedes aegypti mosquitoes carry dengue, chikungunya, Zika and yellow fever diseases which have a large and growing impact on human health. They live almost exclusively in close association with humans, don’t fly very far compared to some mosquito species and are particularly difficult to attack using traditional methods, such as pesticides and source reduction of breeding sites.They’re also extensively studied in many labs around the world. We hope what we learn with the Aedes aegypti in the field will be helpful in developing new ways of tackling other mosquitoes and the diseases they transmit.

Re:Malaria vaccine delivered by a mosquito bite by acyou on Thursday November 28, 2024 @01:12AM (#42262870)
I bet those same ecologists that endorse eliminating Aedes aegypti have taken their fair share of mosquito bites, too. Not that it takes anything away from their credibility.

Wow, the Wikipedia article on Wolbachia is absolutely fascinating, thanks. I guess now they will push Wolbachia into Anopheles and use it as another control against malaria.

Re:Malaria vaccine delivered by a mosquito bite by BugsJustFindMe on Wednesday November 27, 2024 @02:02PM (#42258706)
> As for eradicating host populations/mosquitoes, it's not the greatest idea...birds need to eat too

This is a false dichotomy. Malaria is transmitted by only specific and very small subset of mosquitoes. There would still be plenty of mosquitoes if you eliminate the ones that cause unimaginably massive population harm.

Re:Malaria vaccine delivered by a mosquito bite by blastro on Wednesday November 27, 2024 @02:05PM (#42258732)
False equivalency, perhaps? Big assumption that all mosquito sub-species affect their environment in the same way.
Re:Malaria vaccine delivered by a mosquito bite by BugsJustFindMe on Wednesday November 27, 2024 @02:08PM (#42258748)
We know that they share predators. We know that they share environments. We know that they share impact patterns. We also know that more than half a million people die from malaria every year.
Re:Malaria vaccine delivered by a mosquito bite by blastro on Wednesday November 27, 2024 @03:57PM (#42259695)
Certainly we must be missing some factor from this analysis
Re:Malaria vaccine delivered by a mosquito bite by BugsJustFindMe on Wednesday November 27, 2024 @05:51PM (#42260608)
> Certainly we must be missing some factor from this analysis

This is like saying nobody should ever take any medicine ever, even after years of study and analysis, because there might be some unknown harm that we haven't yet identified from it because we aren't looking in the right places. And yet we have collectively decided that taking medicine when we are sick is actually a good thing to do, because being sick in known catastrophic ways is objective and true while the unknown unknown is purely hypothetical and unfounded.

Well millions upon millions of people are dying, objectively and truly, and we can stop it. And what you have to say against a proposal that has had substantial risk analysis already done, where the harms have been determined to be nil, is something completely unfounded without a basis in any known mechanism in the real world.

It has been analyzed to death. At some point it becomes important to recognize that further objection on the same basis that has already been rebutted time and again is no longer clever and is just obstructionism with a willfully catastrophic cost.

Re:Malaria vaccine delivered by a mosquito bite by danparsonson on Wednesday November 27, 2024 @06:40PM (#42260940)
> This is like saying nobody should ever take any medicine ever, even after years of study and analysis

Surely no-one would argue against the benefits of antibiotics, and yet after decades of successful use we're only now discovering that in using them, we're breeding resistant bacteria that we have no way to deal with. We're clever monkeys but we should remember that however hard we think, we can always miss something important, especially when we're talking about large complex biological systems.

If we can develop effective vaccines then I personally don't see the need to start deliberately exterminating species, even the truly loathesome ones.

Re:Malaria vaccine delivered by a mosquito bite by wat10000 on Wednesday November 27, 2024 @07:16PM (#42261154)
Antibiotic resistance was foreseen pretty much from the start. And this is hardly a cautionary tale. Antibiotic resistance just makes antibiotics less effective, and you’re still better off than you were without antibiotics.

A better example would be something like tetraethyl lead, which poisoned (indeed continues to poison) huge numbers of people for relatively minor gain. Even then, the problems were known, the profit motive just won out over the don’t-poison-everyone motive.

Re:Malaria vaccine delivered by a mosquito bite by JumpCrisscross on Wednesday November 27, 2024 @07:00PM (#42261057)
> Surely no-one would argue against the benefits of antibiotics, and yet after decades of successful use we're only now discovering that in using them, we're breeding resistant bacteria that we have no way to deal with

People have been constantly arguing against all kinds of medicine, including antibiotics. And we have solutions to resistant bacteria. It's a social problem of developing expensive new antibiotics while restricting their market to the last line of defence. And finally, the analogy breaks down: we did develop and deploy antibiotics, and have been able to see the consequences and adapt as a result.

We're mindlessly eradicting species all the time. There might be a trolley problem in intentionally nuking one. But that's, again, socio-philosophical. If the first ecosystem we eradicate in collapses, against the predictions of practically every expert in the field, we can stop. In the meantime, we avoid a useless debate that costs millions their lives.

> If we can develop effective vaccines then I personally don't see the need to start deliberately exterminating species, even the truly loathesome ones

Again, a social problem. It's easier to get rid of the diseasse by taking out mosquitoes than it is to continuously convince populations to get vaccinated into perpetuity. (To say nothing of vaccines' adverse effects.)

Re:Malaria vaccine delivered by a mosquito bite by danparsonson on Thursday November 28, 2024 @12:19AM (#42262678)
> ... the analogy breaks down: we did develop and deploy antibiotics, and have been able to see the consequences and adapt as a result.

Not sure what you mean here; I was replying to this:

> Certainly we must be missing some factor from this analysis

> ---

> This is like saying nobody should ever take any medicine ever, even after years of study and analysis, because there might be some unknown harm that we haven't yet identified from it because we aren't looking in the right places.

...my point being that we are now facing previously unknown harms despite the best research available at the time (maybe antibiotic resistance itself was foreseen, but did anybody warn about hospital run-off and agricultural usage creating reservoirs of resistance-breeding via competition and horizontal gene transfer inside sewage systems? This is the sort of unforeseen consequence I'm talking about).

> We're mindlessly eradicting species all the time. There might be a trolley problem in intentionally nuking one. But that's, again, socio-philosophical. If the first ecosystem we eradicate in collapses, against the predictions of practically every expert in the field, we can stop. In the meantime, we avoid a useless debate that costs millions their lives.

This is exactly the kind of hubris I'm arguing against.

The fact that we're doing it all the time anyway is not an argument to do more of it. It's a compelling reason to do less.

Ecosystems don't generally exist in total isolation from each other, and don't just collapse when we poke them. Far more likely is that we will cause a problem that takes years or more to manifest, by which time it's out of our control and much more difficult or impossible to fix.

The debate is not useless when we're meddling with things that we don't fully understand, with unknown consequences for the environment that we live in. This is the trolley problem - do we save people from malaria now at the cost of potentially worse problems in the future? Since we don't know for sure what effect our intervention will have on a grander scale, what can't know what if any damage we're doing further down the line. I think it's OK to consider that carefully; in the meantime, vaccines are still our best option, and social problems are generally easier to quantify and address; we're pretty good at human psychology these days.

Re:Malaria vaccine delivered by a mosquito bite by throwaway2037 on Thursday November 28, 2024 @07:57AM (#42264909)

    > To say nothing of vaccines' adverse effects.
I don't follow this part. Can you provide some examples?
Re:Malaria vaccine delivered by a mosquito bite by JumpCrisscross on Thursday November 28, 2024 @09:43AM (#42265603)
> Can you provide some examples

Every vaccine has some fraction of the population is affects adversely. We’re super strict about that hazard. But it exists. Eradicating a mosquito isn’t risk free, but it’s (a) one and done and (b) strikes me as less risky.

Re:Malaria vaccine delivered by a mosquito bite by throwaway2037 on Sunday December 01, 2024 @01:58AM (#42286761)
That is true of all medicines. So what is really being said here? Is there a hint of anti-vax in that comment? I cannot tell.
Re:Malaria vaccine delivered by a mosquito bite by diggernet on Thursday November 28, 2024 @10:34PM (#42270574)
The factor you are missing is that aedes aegypti is an invasive species in most countries. Eradicating it isn't harming the environment, it's restoring the environment.
Re:Malaria vaccine delivered by a mosquito bite by bryanlarsen on Wednesday November 27, 2024 @02:05PM (#42258727)
> birds need to eat too

There's a big difference between eliminating all mosquitoes and eliminating just malaria-carrying mosquito species. IIRC studies show that if you eliminate malaria-carrying mosquito species that other mosquito species very quickly take over this ecological niche.

Re:Malaria vaccine delivered by a mosquito bite by exabrial on Wednesday November 27, 2024 @02:14PM (#42258788)
I don't believe mosquitoes are a keystone species in any ecosystem... I remember hearing this, not sure if it's true.
Re:Malaria vaccine delivered by a mosquito bite by equestria on Wednesday November 27, 2024 @03:30PM (#42259421)
We have already thrown and will throw a lot of wrenches into the works. We have extensively reshaped the planet to the benefit of some species and the detriment of many others.

It's a risk, but it's not worse than the thousands of other risks we've already taken. Given the absolutely insane amount of death and suffering caused by mosquito-borne diseases, it's probably also a justifiable one.

Re:Malaria vaccine delivered by a mosquito bite by lifeformed on Wednesday November 27, 2024 @08:34PM (#42261543)
But could the potential disruption to the ecosystem be as bad as the 600,000 deaths per year from malaria?
Re:Malaria vaccine delivered by a mosquito bite by directevolve on Thursday November 28, 2024 @11:33AM (#42266561)
In response to that, I say “600,000 deaths per year, mostly of African children.”