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Re:High coffee consumption, brain volume and risk of dementi... by owlstuffing on Tuesday February 06, 2024 @04:12PM (#39280678)
> consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1–2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83)

6+ cups! That’s a cranial marinade.

Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @04:22PM (#39280824)
My mom, both of my sisters and I drink it by the pot. Each of us, every day.

6 cups? That doesn't sound like enough coffee to me.

Re:High coffee consumption, brain volume and risk of dementi... by FirmwareBurner on Tuesday February 06, 2024 @04:33PM (#39280958)
>My mom, both of my sisters and I drink it by the pot. Each of us, every day.

Can I ask how's your sleep?

Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @05:28PM (#39281683)
I seem to sleep as well as I always have.

I go to bed when I am tired. Usually 11pm-1am. I fall asleep in a few minutes. Then I wake up about 7am, feeling OK. Closer to 6 hours is more normal for me.

I’ve been like that since I was a teenager and I didn't drink coffee then.

Re:High coffee consumption, brain volume and risk of dementi... by 2OEH8eoCRo0 on Tuesday February 06, 2024 @05:26PM (#39281660)
Sleep was fine. I used to drink it by the pot but I cut back mainly because I'd have to piss too much.
Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @05:29PM (#39281701)
Yes, this is my main motivator when I cut back.

If I have to drive a long drive, as an example, I’ll skip coffee that day. I’d rather save stops.

Re:High coffee consumption, brain volume and risk of dementi... by op00to on Tuesday February 06, 2024 @04:24PM (#39280851)
I can’t even drink a single cup of coffee without shaking and getting intense anxiety.
Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @04:25PM (#39280870)
Perhaps someday we'll discover a coffee tolerance gene.
Re:High coffee consumption, brain volume and risk of dementi... by xcv123 on Tuesday February 06, 2024 @04:36PM (#39281006)
The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/

I have the rapid variant but could not sleep well on 6 cups.

Re:High coffee consumption, brain volume and risk of dementi... by JonChesterfield on Tuesday February 06, 2024 @05:10PM (#39281453)
That is interesting information. I note that the same enzyme breaks down melatonin. If a variant that is particularly efficient at caffeine is also particularly efficient at breaking down melatonin, the symptom would be difficulty getting to sleep independent of amount of caffeine, which is totally fixed by taking melatonin tablets.
Re:High coffee consumption, brain volume and risk of dementi... by b800h on Wednesday February 07, 2024 @01:49AM (#39285322)
Slow metaboliser here. If I drink a coffee at 11am my heart rate rises and doesn't return to normal until the following morning.

There are other genes for it too, like one that affects the degree to which coffee causes anxiety. And plenty of others that we haven't found, presumably.

Re:High coffee consumption, brain volume and risk of dementi... by op00to on Wednesday February 07, 2024 @07:46AM (#39287875)
I love love love love coffee. It took me years to realize that my high blood pressure was controlled almost immediately by cutting out a high-test canned “Draft Latte” drink. I can drink a single 8oz cup every few days. Decaf is fine.
Re:High coffee consumption, brain volume and risk of dementi... by PH95VuimJjqBqy on Tuesday February 06, 2024 @04:24PM (#39280854)
6 cups are scrub numbers, if you haven't done that by 10am you're behind the curve :P
Re:High coffee consumption, brain volume and risk of dementi... by lp4vn on Tuesday February 06, 2024 @04:44PM (#39281118)
I used to drink one liter of coffee a day, and I would prepare it in a measured cup by the way so it's not an exaggeration.
Re:High coffee consumption, brain volume and risk of dementi... by Kirby64 on Tuesday February 06, 2024 @04:29PM (#39280911)
The scientific definition of a 'cup' of coffee is important. Usually this is defined as 4 ounces of brewed coffee, which means a normal mug of coffee (which can fit something like 10 oz) would be 2.5 cups!

So, for most people's definition of a 'cup' of coffee, they really only mean 2.5 'mugs' of coffee.

Re:High coffee consumption, brain volume and risk of dementi... by OJFord on Tuesday February 06, 2024 @04:38PM (#39281025)
And surely the amount of water is inconsequential, why can't we just use grams of actual coffee? Then we don't have to worry about how many espressos are in a 10oz mug. (Nevermind what that person's considering a standard dose for the espresso!)
Re:High coffee consumption, brain volume and risk of dementi... by Kirby64 on Tuesday February 06, 2024 @05:20PM (#39281588)
Measuring extraction ratio on coffee is difficult and wildly varies based on preparation method. The standard “cup” assumes 4oz of coffee, using 5oz of brew water (so, 1oz stays in the coffee grounds as waste). I believe there’s also a standard amount of coffee grounds used as well, though.
Re:High coffee consumption, brain volume and risk of dementi... by jna_sh on Tuesday February 06, 2024 @05:23PM (#39281618)
Different brew methods extract differing amounts from the coffee, so the amount of water is indeed consequential. Same grams of coffee in to a pour-over vs espresso would result in different amounts of extracted coffee material consumed.
Re:High coffee consumption, brain volume and risk of dementi... by OJFord on Tuesday February 06, 2024 @05:35PM (#39281785)
True. I'm inclined to think it would be closer than 'do whatever you want in order to end up with an Xoz drink' though!
Re:High coffee consumption, brain volume and risk of dementi... by Kirby64 on Tuesday February 06, 2024 @05:56PM (#39282028)
Prep method matters so much though. For comparison, a standard double shot of espresso is typically 18g of coffee. This would yield approximately 110mg of caffeine.

By comparison, the same 18g brewed using a pour over method should yield an 8oz cup of coffee with … likely around 170mg of caffeine.

Check out this James Hoffmann video specifically on this topic: https://youtube.com/watch?v=etnMr8oUSDo

Re:High coffee consumption, brain volume and risk of dementi... by chombier on Wednesday February 07, 2024 @04:00AM (#39286180)
I remember reading somewhere that the amount of caffeine in the cup is also proportional to the brewing time, therefore an espresso may not actually contain that much caffeine in the end (for the same initial amount of ground coffee, of course)
Re:High coffee consumption, brain volume and risk of dementi... by zaphar on Wednesday February 07, 2024 @07:42AM (#39287842)
When I was in Organic Chemistry in College we demonstrated this experimentally. A cup of drip coffee had more caffeine than a shot of espresso. We were college kids so I'm not sure how consistent our how methodology was but the result was pretty consistent across all of us.
Re:High coffee consumption, brain volume and risk of dementi... by porknubbins on Wednesday February 07, 2024 @01:16AM (#39285142)
True but I think the coffee machine definition of 4-5oz per coffee “cup” usually also assumes a stronger European strength of coffee which is quite concentrated. Most Americans seem to make coffee larger but more watered down, so it could be back to a 10oz mug is 1 or 1.5 cup equivalents.
Re:High coffee consumption, brain volume and risk of dementi... by elzbardico on Wednesday February 07, 2024 @04:59AM (#39286589)
Americans drink very watered coffee though compared to most of the rest of the world. For us that came from abroad, it is basically tea.
Re:High coffee consumption, brain volume and risk of dementi... by troydavis on Wednesday February 07, 2024 @06:31PM (#39295759)
This survey is using self-assessed cups - without providing a cup size or any guidance. Specifically, a survey asks users "How many cups of coffee do you drink a day?" with no other context.

So, "cups" for this study is whatever the respondent considers a cup. For most people, that's going to be at least 8 ounces and probably 8-12 oz.

From the full text (https://ore.exeter.ac.uk/repository/bitstream/handle/10871/1...), here's how the intake is described:

> Habitual coffee intake was self-reported as cups per day, as part of the touchscreen questionnaire at baseline with the question “How many cups of coffee do you drink a day?” (38). Participants were asked to include decaffeinated (decaf) coffee intake in their response. Decaffeinated consumers were identified from response to the question “What type of coffee do you usually drink?”. Coffee consumption was grouped in seven categories, including non- drinkers, decaffeinated coffee drinkers, and caffeinated coffee drinkers consuming <1 cup/day, 1-2 cups/day, 3-4 cups/day, 5-6 cups/day and >6 cups/day. “Coffee drinkers” in the text refer to participants who report intake of caffeinated coffee. For sensitivity analyses we constructed separate indicators restricting the data to decaffeinated coffee drinkers and according to tea consumption, using intake categories as above"

Re:High coffee consumption, brain volume and risk of dementi... by op00to on Tuesday February 06, 2024 @04:24PM (#39280841)
That’s like a little more than 2 venti Starbucks.
Re:High coffee consumption, brain volume and risk of dementi... by FirmwareBurner on Tuesday February 06, 2024 @04:31PM (#39280933)
> more than 2 venti

Americans will do anything to not use the metric system :)

Re:High coffee consumption, brain volume and risk of dementi... by zdragnar on Tuesday February 06, 2024 @05:05PM (#39281397)
Venti is the Starbucks name for their largest size cup, which holds 20 ounces.

Most people don't really care about the exact, specific volume of fluid, they just go by whatever the cup size happens to be called.

At least it is more descriptive than the grande or short cups, or the small / medium / large at other places (even if you have to know that venti is 20 in Italian to make the connection).

Re:High coffee consumption, brain volume and risk of dementi... by Uinchuling on Tuesday February 06, 2024 @06:14PM (#39282218)
I doubt I'm the only obnoxious country dude who rolls into Starbucks and orders a "large". You can ignore their pretentious names, they're very accommodating.
Re:High coffee consumption, brain volume and risk of dementi... by datavirtue on Tuesday February 06, 2024 @09:31PM (#39283765)
Too insecure to use the size names. That's how it plays...fyi
Re:High coffee consumption, brain volume and risk of dementi... by yanellena on Wednesday February 07, 2024 @05:18AM (#39286735)
It's probably more that you don't want a corporation to dictate how you describe (brand) the sizes of a drink where we have near universal language for that purpose already.
Re:High coffee consumption, brain volume and risk of dementi... by the_third_wave on Wednesday February 07, 2024 @07:55AM (#39287961)
Too much experience with cattle and thus not longing to resemble them. One of 'm says 'moo' and soon the rest follows. Now just imagine a ${city_equivalent_of_field} full of city folk where one of 'm says 'venti' and you understand what I mean.
Re:High coffee consumption, brain volume and risk of dementi... by jemmyw on Wednesday February 07, 2024 @02:29AM (#39285619)
They don't usually advertise it, but you can get a smaller cups than on the menu too. I prefer an 8oz size.
Re:High coffee consumption, brain volume and risk of dementi... by op00to on Wednesday February 07, 2024 @07:48AM (#39287901)
I order from the app, I think both the barista and I prefer to reduce talking. :)
Re:High coffee consumption, brain volume and risk of dementi... by PortiaBerries on Tuesday February 06, 2024 @05:09PM (#39281448)
Hell Yeah!!
Re:High coffee consumption, brain volume and risk of dementi... by op00to on Wednesday February 07, 2024 @07:48AM (#39287889)
Haha! I was just thinking that I see people drink like 3-4 of those huge coffees a day. I am a true American Metric Patriot.
Re:High coffee consumption, brain volume and risk of dementi... by Jcampuzano2 on Tuesday February 06, 2024 @04:50PM (#39281172)
I used to drink along the lines of this much coffee or more. I was travelling very often and often working 12+ hour days for weeks on end. I look back on those days and just thinking about it reminds me of my constantly tweaking eyes, lack of sleep, constant hyperactivity, anxiousness, stress etc.

I stopped cold turkey for a while but nowadays have settled on more like 1-2 a day and never after a specific time of day (for me I hard stop at 3pm). Having any more than this or after this time kills my sleep immediately.

Re:High coffee consumption, brain volume and risk of dementi... by SOLAR_FIELDS on Tuesday February 06, 2024 @10:13PM (#39284010)
Decaf is something I’ve really started to enjoy over the last couple of years. I’ll have one mug of actual coffee in the morning to start my day and then anywhere from 1-3 mugs of decaf. Back in the day it was not an equivalent option due to the chemical extraction process making it taste inferior. Now with water processed beans being offered with my local roaster it’s just about the same level of taste
Re:High coffee consumption, brain volume and risk of dementi... by euroderf on Tuesday February 06, 2024 @11:35PM (#39284536)
Great album title, Cranial Marinade.
Re:High coffee consumption, brain volume and risk of dementi... by TyrianPurple on Wednesday February 07, 2024 @05:32AM (#39286831)
Coffee & Tea are both stimulants. So I wouldn't be wrong by coming to the same conclusion about tea drinkers. Guess my cranium has been marinated real good.