High coffee consumption, brain volume and risk of dementia and stroke

Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @04:22PM (#39280824)

My mom, both of my sisters and I drink it by the pot. Each of us, every day.

6 cups? That doesn't sound like enough coffee to me.

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Re:High coffee consumption, brain volume and risk of dementi... by FirmwareBurner on Tuesday February 06, 2024 @04:33PM (#39280958)

>My mom, both of my sisters and I drink it by the pot. Each of us, every day.

Can I ask how's your sleep?

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Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @05:28PM (#39281683)

I seem to sleep as well as I always have.

I go to bed when I am tired. Usually 11pm-1am. I fall asleep in a few minutes. Then I wake up about 7am, feeling OK. Closer to 6 hours is more normal for me.

I’ve been like that since I was a teenager and I didn't drink coffee then.

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Re:High coffee consumption, brain volume and risk of dementi... by 2OEH8eoCRo0 on Tuesday February 06, 2024 @05:26PM (#39281660)

Sleep was fine. I used to drink it by the pot but I cut back mainly because I'd have to piss too much.

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Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @05:29PM (#39281701)

Yes, this is my main motivator when I cut back.

If I have to drive a long drive, as an example, I’ll skip coffee that day. I’d rather save stops.

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Re:High coffee consumption, brain volume and risk of dementi... by op00to on Tuesday February 06, 2024 @04:24PM (#39280851)

I can’t even drink a single cup of coffee without shaking and getting intense anxiety.

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Re:High coffee consumption, brain volume and risk of dementi... by doubled112 on Tuesday February 06, 2024 @04:25PM (#39280870)

Perhaps someday we'll discover a coffee tolerance gene.

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Re:High coffee consumption, brain volume and risk of dementi... by xcv123 on Tuesday February 06, 2024 @04:36PM (#39281006)

The gene is called CYP1A2 with two variants. One variant is a rapid caffeine metabolizer. The other is a slow caffeine metabolizer. https://www.geneticlifehacks.com/liver-detox-genes-cyp1a2/

I have the rapid variant but could not sleep well on 6 cups.

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Re:High coffee consumption, brain volume and risk of dementi... by JonChesterfield on Tuesday February 06, 2024 @05:10PM (#39281453)

That is interesting information. I note that the same enzyme breaks down melatonin. If a variant that is particularly efficient at caffeine is also particularly efficient at breaking down melatonin, the symptom would be difficulty getting to sleep independent of amount of caffeine, which is totally fixed by taking melatonin tablets.

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Re:High coffee consumption, brain volume and risk of dementi... by b800h on Wednesday February 07, 2024 @01:49AM (#39285322)

Slow metaboliser here. If I drink a coffee at 11am my heart rate rises and doesn't return to normal until the following morning.

There are other genes for it too, like one that affects the degree to which coffee causes anxiety. And plenty of others that we haven't found, presumably.

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Re:High coffee consumption, brain volume and risk of dementi... by op00to on Wednesday February 07, 2024 @07:46AM (#39287875)

I love love love love coffee. It took me years to realize that my high blood pressure was controlled almost immediately by cutting out a high-test canned “Draft Latte” drink. I can drink a single 8oz cup every few days. Decaf is fine.

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Re:High coffee consumption, brain volume and risk of dementi... by PH95VuimJjqBqy on Tuesday February 06, 2024 @04:24PM (#39280854)

6 cups are scrub numbers, if you haven't done that by 10am you're behind the curve :P

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