AFAIK heavy front end loading is the only current option and may have limited effectiveness, although empirically I can say that supplementation appears to reduce markers of oxidative stress in my bloodstream and is similar but less effective for my brother, and it seemed effective for my father. I have a suspicion that absorption might have a genetic component or may be dependant on other lifestyle factors, or perhaps dependant upon the generation mechanisms for oxidative stress itself.
IOTW YMMV and I’m not sure if supplemental CoQ10 is effective for everyone. It does seem to be safe, though, so there’s that.
But I wouldn’t call this a recommendation, more if a report of my choice and my reasoning.
I’m sure there are “better” options, but I don’t care if I have to ingest 200 mg of one brand to get the benefit I would get from 100mg of another brand, for 4x the price. In all I’d rather buy from a source that moves a lot of production and is less likely to be counterfeited or suffer from production inconsistencies.
But that’s just like, my unfounded and poorly considered opinion so…
There are some formulations that purport to have higher bioavailability on a gram-for-gram basis according to trials, but their price is often high enough that it’s cheaper to take more of a generic CoQ10 than to buy an expensive formulation.
CoQ10 supplementation has resulted in insomnia for some. I triggered it with higher doses (600-900mg per day) before I realized what was happening. Dropping down to 300mg alleviated the insomnia after about a week, which I interpreted as meaning the supplement was doing something.
I've suffered from Longcovid since last year, and this seems to be something safe that I can try, with a possibility of positive result.
I will try 200-300mg instead
I'm not as old as him nor trying to do anti aging. Being >50 has different requirements.
I'm just healthmaxxing
Isn't bioavailability ensured mainly by a liposomic form? Sinclair mentioned in podcasts that he is taking for example 1 gram of resveratrol with a pinch of jogurt (=fat) to increase bioavailability. If you take a powder form capsule with a pinch of olive oil, shouldn't it increase its bioavailability? (to cheaply emulate a liposomic form)
But like all FUD in the supplement industry, you do not need mega doses
For example, I can consume 200mg of K1 on a daily basis which has an RDA in the μg range with MnCl2 in 100's Mg, again another μg range RDA and if I were to believe the medical profession, my blood would have clotted in-vivo clogging up the vascular system in such a way, even Dyno-Rod or Mr Muscle wouldn't have been able to unblock it!
The blood would have been too thick to be pumped around the body, effectively clogging up the arteries in hours and days much hard and faster than atherosclerosis from a years worth of hedonism could have achieved!
But I also know about Prof Bruce Ames triage theory.
Anyway it just so happened, that I cut the end of a finger nearly off setting a cheap mole trap. Blood pouring everywhere, pissed off at the cheap trap prematurely going off when being placed in some warm moist soil in, I like to think, anticipation of catching a creature of darkness.
Anyway called the NHS 111 hotline, answered their banal questions, with the song Prodigy Omen (https://www.youtube.com/watch?v=xMVTKOoy1uk&t=84s) on a loop in my mind whilst talking to them, surprised I didnt have Prodigy Take me to the hospital ringing through my mind (https://www.youtube.com/watch?v=ncaNlxvTFzg) but anyway I hadnt eaten anything that evening and didnt want to spend fucking hours wasting away in the A&E dept waiting for someone to put a stich or two or a couple of butterfly stiches over the wound which I could have done myself anyway, so I told the 111 Hotline I'll look up on youtube if its serious or not and hung up!
Proceeded to put up with an unrecognised NHS 111 phone number phoning me back every 30minutes afterwards, like a nuisance caller until I added their number to the phone's block list.
An old surfers trick is to use superglue to seal up cuts from rocks and coral so I hunted around for some superglue and was going to use that, but whilst cleaning up the wound and then holding the skin together before squirting some superglue liberally over the skin, the blood did something amazing.
It formed its own clot much like you'd expect as if I had some burgundy superglue.
So I didnt bother using the superglue in the end, and over the following days, this blood clot turned out to be like a super clot, it wouldnt dissolve in the shower, it wouldnt dissolve when spending over an hour soaking in the bath.
It quite literally was a super blood clot, impervious to liquids and it could take an enormous amount of abuse, I never could get it to break off from the skin, so I was quite impressed with that and obviously full use of the finger was immediately available, I was only cautious using it to begin with.
You cant even see any scars today!
Now I would never have discovered these super blood clots had I not megadosed with K1 and MnCl2, so I dont need to put on copious amounts of adipose tissue in order to make me stab proof to all but the longest blades, but it got me thinking, if blood clots can be this good, why are these RDA's so low?
Well its quite likely the blood clotting like it did would make life much harder for the doctors and nurses in A&E and operating theatres to do their surgery.
If the blood can clot like this in under 20mins, they would not be able to perform surgery on people, they would be constantly fighting the blood clots, so this is the only explanation I can come up with as to why RDA's are so low for these two chemicals.
The medical profession want an easy life whilst dramatizing the dangers in some areas of human biology.
Ursolic acid is purported to increase the length of villi in the gut and thus absorption increases because of the increased surface area of the villi.
That said, wanted to share that super glue was used in Vietnam War to close wounds. Also dermabond RX is krazy glue [1].
Also, this month I’ve caught and killed 12 raccoons. Not sure if you have them over there but they are vile disgusting disease vectors but very cute looking.
View it however you like, the saying "you can lead a horse to water, but you cant make it drink" springs to mind, but do these two aforementioned chemicals only do blood clotting, or do they take part in other chemical reactions which may be good or bad for human health?
> Also, this month I’ve caught and killed 12 raccoons. Not sure if you have them over there but they are vile disgusting disease vectors
Dont know if you noticed but living on an island has meant alot of the dangerous animals and vectors were eradicated hundreds of years ago in the UK, and yet in a schadenfreude like manner, the UK and royals like Prince Philip and King Charles attempt to lead the world in animal conservation elsewhere in the world. The Frenchie called William The Conqueror had his uses!
That must annoy the Aussies amongst others, considering how many dangerous animals they have over there, but they do put up a good Monty Python Black Knight attitude to the situation. https://www.youtube.com/watch?v=SI5nL8vZcl8
The body's ability to recover is underrated.
Most of the body’s daily requirement for CoQ10 is produced within the body. Some CoQ10 is ingested from food (typically 5 mg/day [5]). It is estimated that the daily requirement for CoQ10, from both endogenous bio-synthesis and food sources, is about 500 mg; this estimate is based on a total body quantity of about 2 mg of CoQ10 and based on an average turnover time of 4 days in tissue [5]. This estimate serves as the justification for the size of the dosage (typically 300 mg/day) that is used in many clinical trial studies.
As people mature into adulthood and begin to increase in age, the ability of the body to synthesise its own CoQ10 decreases; optimal human bio-synthesis occurs in the mid-twenties, with a continual gradual decline in tissue levels thereafter [6]. In addition to the normal aging process, CoQ10 levels have also been shown to be depleted in a number of disorders, particularly heart disease [7]. The synthesis of CoQ10 is a complex multistage process (governed by at least 13 genes), requiring a number of amino acids, vitamins, and trace element precursors and cofactors, deficiency of any of which can adversely affect normal CoQ10 production [8]. Nutritional supplementation with CoQ10 therefore provides a mechanism to maintain adequate levels within the body.
...The CoQ10 raw material comes in the structural form of polymorphic crystals [9]. CoQ10 in polymorphic crystalline forms will not be absorbed in the gastro-intestinal tract. CoQ10 can be absorbed only as individual molecules, as described in Section 4 of this article below [10]. The CoQ10 crystals must therefore be dissociated first into individual CoQ10 molecules.
...The first point of note is the difference in bioavailability between samples 01 and 02 of the study. Both samples contained 100 mg CoQ10 in identical ubiquinone form, in a soy carrier oil with identical excipient content and capsule specification; sample 01 (Myoqinon, Pharma Nord, Vejle, Denmark) had been subject to a patented thermal crystal dispersion process whilst sample 02 (from the same manufacturer) had not undergone this procedure. The respective mean AUC and Cmax values in the Lopez-Lluch study were 28.0 mg/L/48 h and 1.07 mg/L for sample 01, and 6.89 mg/L/48 h and 0.33 mg/L for sample 2. Failure to subject crystalline CoQ10 to crystal dispersion therefore reduced bioavailability by approximately 75%.
...Thus, the AUC for CoQ10 in ubiquinol form was approximately twice of that for ubiquinone, which had not been subjected to thermal crystal dispersion (sample 02), but was only 52% of that for ubiquinone that had been subjected to thermal crystal dispersion (sample 01). It should be noted that it is not possible to subject ubiquinol to the same crystal dispersion process as that described for sample 01; this is because of the differential stability of ubiquinone and ubiquinol. These data therefore demonstrate (i) the importance of CoQ10 crystal dispersion, the absence of which reduces bioavailability by some 75%; (ii) the fact that the relative bioavailability of ubiquinone and ubiquinol forms of CoQ10 depends on CoQ10 crystal dispersion status and carrier oil/excipient composition.
... The study therefore concluded that intestinal absorption of CoQ10 is highly variable among individuals, and is independent of the form of CoQ10 (ubiquinone/ubiquinol) administered. This is because the body is limited in how much CoQ10 it can absorb at a given time, and thus if an individual takes several 100 mg capsules together, some of the CoQ10 tends to be wasted CoQ10 is a lipid soluble substance; therefore, the highest quality CoQ10 preparations have the CoQ10 dissolved in a well-suited carrier lipid (e.g., soy oil or palm oil).
The KISEL-10 study was a clinical trial that enrolled 443 senior citizens living in south-eastern Sweden. The study was designed as a randomized, double-blind, placebo-controlled clinical trial. The elderly study participants—average age of 78 years—took either 200 milligrams of coenzyme Q10 together with 200 micrograms of an organic high-selenium yeast preparation or matching placebos daily for 4 years
The cardio-protective effect of the combined daily supplementation with CoQ10 and selenium endure for several years beyond the period of intervention. A follow-up analysis showed that the significantly reduced risk of death from heart disease still held 12 years after the intervention