Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by sufehmi on Sunday July 23, 2023 @04:52AM
(#36833644)
One question - in your case, how long does it take for you to start noticing its (good or bad) effect?
I've suffered from Longcovid since last year, and this seems to be something safe that I can try, with a possibility of positive result.
Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by loa_in_ on Sunday July 23, 2023 @09:57AM
(#36835345)
It's as long as it takes to be sure it's not other things that inadvertently happen to one in life
Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by dmix on Sunday July 23, 2023 @09:09AM
(#36834972)
I've bought a bunch of stuff of Bryan Johnsons supplement list (a reasonable amount, 8-9/day) and he recommends 100mg, not sure if he's researched that one properly but he's usually pretty open about it https://blueprint.bryanjohnson.co/#step-2-supplements
I will try 200-300mg instead
Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by pstanger on Sunday July 23, 2023 @10:22AM
(#36835553)
how do you choose what to take? I think he listed every supplement in the aisle
Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by dmix on Sunday July 23, 2023 @10:30AM
(#36835644)
I researched each and chose the ones that sounded relevant to me
I'm not as old as him nor trying to do anti aging. Being >50 has different requirements.
I'm just healthmaxxing
Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by amts on Sunday July 23, 2023 @01:10PM
(#36837356)
Strangely enough he is taking NR (nicotineamid riboside) rather than NMN, probably as there was recent evidence (including on HN) that NMN can evoke cancer (in those who are prone to cancer or already have it).
Re:CoQ4 is a functional substitute for CoQ10 and can be targ...
by amts on Sunday July 23, 2023 @01:07PM
(#36837324)
>> There are some formulations that purport to have higher bioavailability on a gram-for-gram basis according to trials, but their price is often high enough that it’s cheaper to take more of a generic CoQ10 than to buy an expensive formulation.
Isn't bioavailability ensured mainly by a liposomic form? Sinclair mentioned in podcasts that he is taking for example 1 gram of resveratrol with a pinch of jogurt (=fat) to increase bioavailability. If you take a powder form capsule with a pinch of olive oil, shouldn't it increase its bioavailability? (to cheaply emulate a liposomic form)
There are some formulations that purport to have higher bioavailability on a gram-for-gram basis according to trials, but their price is often high enough that it’s cheaper to take more of a generic CoQ10 than to buy an expensive formulation.
CoQ10 supplementation has resulted in insomnia for some. I triggered it with higher doses (600-900mg per day) before I realized what was happening. Dropping down to 300mg alleviated the insomnia after about a week, which I interpreted as meaning the supplement was doing something.