CoQ4 is a functional substitute for CoQ10 and can be targeted to mitochondria

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by K0balt on Saturday July 22, 2023 @09:28PM (#36831726)

There are supplement formulations that are supposed to improve absorption, but I don’t know of their efficacy.

AFAIK heavy front end loading is the only current option and may have limited effectiveness, although empirically I can say that supplementation appears to reduce markers of oxidative stress in my bloodstream and is similar but less effective for my brother, and it seemed effective for my father. I have a suspicion that absorption might have a genetic component or may be dependant on other lifestyle factors, or perhaps dependant upon the generation mechanisms for oxidative stress itself.

IOTW YMMV and I’m not sure if supplemental CoQ10 is effective for everyone. It does seem to be safe, though, so there’s that.

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by wyldfire on Saturday July 22, 2023 @09:30PM (#36831741)

Are there any dietary sources that are CoQ<N>-rich?

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by K0balt on Saturday July 22, 2023 @09:35PM (#36831767)

I’m sure there are, but I lean on supplements because I’m lazy.

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by wyldfire on Saturday July 22, 2023 @09:37PM (#36831779)

Looked it up: "Primary dietary sources of CoQ10 include oily fish (such as salmon and tuna), organ meats (such as liver), and whole grains."

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by K0balt on Sunday July 23, 2023 @09:51AM (#36835276)

Oh yeah, I I remember salmon oil being a source now. Thanks!

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by jbotz on Sunday July 23, 2023 @06:48AM (#36834180)

Animal organ meats, especially hearts, have the highest level of CoQ10 of any common dietary sources. I suspect quite a few common modern dietary deficiences are the result most people no longer eating the "whole animal".

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by neeleshs on Saturday July 22, 2023 @10:18PM (#36831986)

Any brand recommendations?

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by K0balt on Saturday July 22, 2023 @10:51PM (#36832149)

I have no reason to believe that one brand is categorically better than another so I typically buy from someplace like puritans pride because of cost. Seems to work. From the website it’s cheaper than if you buy from their Amazon store.

But I wouldn’t call this a recommendation, more if a report of my choice and my reasoning.

I’m sure there are “better” options, but I don’t care if I have to ingest 200 mg of one brand to get the benefit I would get from 100mg of another brand, for 4x the price. In all I’d rather buy from a source that moves a lot of production and is less likely to be counterfeited or suffer from production inconsistencies.

But that’s just like, my unfounded and poorly considered opinion so…

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by cosmojg on Sunday July 23, 2023 @12:08AM (#36832484)

I've had great experiences with Nootropics Depot in terms of both product purity and customer service.

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by zer8k on Sunday July 23, 2023 @01:44AM (#36832833)

Solgar has been my go-to for a long time.

[ Parent | on HN ]

Re:CoQ4 is a functional substitute for CoQ10 and can be targ... by ar-jan on Sunday July 23, 2023 @03:56AM (#36833412)

I'll second the recommendation for Nootropics Depot. They're top notch with regard to testing (they run an ISO 17025 accreddited lab), and the owner frequently talks about the science of how various compounds work and interact on r/NootropicsDepot.

[ Parent | on HN ]