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Re:Brains on Drugs: How tinkering with consciousness became ... by thr_msc on Thursday June 22, 2023 @06:48AM (#36430233)
Ironically enough this is exactly what the tone for drugs was in the early mid sixties. Then the summer of love happened and people couldn't ignore tweens whoring themselves out for smack because they expanded their consciousness first.

Look at the size of the average American. They can't handle cheese responsibly. But we're supposed to think that now they'll manage acid?

Re:Brains on Drugs: How tinkering with consciousness became ... by silveraxe93 on Thursday June 22, 2023 @07:11AM (#36430382)
Have you ever done acid? If you want to reduce drug use, you should legalise LSD and make it easy to buy.

Your average American that "can't handle cheese responsibly" will try it once, have a terrible 12h and swear off drugs for life. With no long term health effects from one dose.

Re:Brains on Drugs: How tinkering with consciousness became ... by rocketbop on Thursday June 22, 2023 @07:42AM (#36430620)
Yea for sure. Mushrooms and LSD are not really popular and not drugs drug addicts gravitate towards.

I don’t thin legalisation would hugely increase use.

Re:Brains on Drugs: How tinkering with consciousness became ... by spoiler on Thursday June 22, 2023 @08:12AM (#36430929)
Not to mention that due to tolerance build up, you can't take LSD/psilocybin too often. And also, they don't "make you" wanna take them often either.

This might be anecdotal, but even though they can be fun, but they're also very exhausting and make you introspective and also kinda encourage you to think about improving different aspec of your life. Sure, there's some bad trips that make people psychotic, but I think that legalisation and regulations would help protect those peope, rather than harm them, because there's usually an underlying condition that triggers such an episode. On the flip side, I've had bad trips a few times and they usually taught me a lot about myself, the people around me, and how I lived life at the, which in turn pushed me to change for the better, and improve some aspects of my life.

Re:Brains on Drugs: How tinkering with consciousness became ... by bryanrasmussen on Thursday June 22, 2023 @08:29AM (#36431112)
>Not to mention that due to tolerance build up, you can't take LSD/psilocybin too often. And also, they don't "make you" wanna take them often either.

these arguments never seem to have a separate addictive from non-addictive drugs component.

Re:Brains on Drugs: How tinkering with consciousness became ... by sowbug on Thursday June 22, 2023 @11:08AM (#36433306)
Not that I have any data to back up this anecdote, but you don't see people in rehab for tryptamines. But you do for alcohol, coke, heroin, and meth.
Re:Brains on Drugs: How tinkering with consciousness became ... by BasedAnon on Thursday June 22, 2023 @07:39AM (#36430592)
>Your average American that "can't handle cheese responsibly" will try it once, have a terrible 12h and swear off drugs for life

You severely underestimate how much most people want to escape their lives, even if the experience is negative. It's silly to act like people don't self-harm.

Re:Brains on Drugs: How tinkering with consciousness became ... by silveraxe93 on Thursday June 22, 2023 @08:43AM (#36431274)
If they want to escape their lives they'll just become an alcoholic.

I'm not denying that people will self-harm. But the argument that people will self-harm with LSD needs to ignore that there's plenty of better drugs legalised already

Re:Brains on Drugs: How tinkering with consciousness became ... by BasedAnon on Thursday June 22, 2023 @10:28AM (#36432683)
Alcohol is much worse than LSD
Re:Brains on Drugs: How tinkering with consciousness became ... by soligern on Thursday June 22, 2023 @11:34AM (#36433759)
In a way. It has much worse physical outcomes over the long term especially if you’re drinking humongous amounts. However, alcohol/nicotine etc. don’t change your modality of thought processes or your underlying perspectives on life. Anecdotally from that perspective LSD is way, way more destructive. It can reconstruct you as a shell of the person you were, and very quickly. I’ve seen it happen so many times and anyone arguing the alcohol is worse than LSD is missing the forest for the tree.
Re:Brains on Drugs: How tinkering with consciousness became ... by skyyler on Thursday June 22, 2023 @12:37PM (#36434797)
>However, alcohol/nicotine etc. don’t change your modality of thought processes or your underlying perspectives on life.

Go to a couple of AA meetings and say that again.

Re:Brains on Drugs: How tinkering with consciousness became ... by pixl97 on Thursday June 22, 2023 @10:56AM (#36433108)
>You severely underestimate how much most people want to escape their lives

Hey, lets optimize society for human happiness and enjoyment without escapism then...

Moloch: "Now just hold the fuck up, I have some corporations to run"

Re:Brains on Drugs: How tinkering with consciousness became ... by Communitivity on Thursday June 22, 2023 @08:38AM (#36431214)
"no long term health effects from one dose" does not account for the possibility of persistent flashbacks, or for bad trips that can cause lasting psychological trauma.

LSD bonds with something in the brain, such that it causes persistent flashbacks more than any other hallucinogen, sometimes years later. Taking it just once to try it might not have any effect, or might cause flashbacks for the rest of your life. Depends on your personal neurochemistry, the dosage, form of dosing, and your mental state. A friend who had taken LSD described it to me once something like this: LSD sometimes takes any cracks (neurosis or psychosis) in your mind and expands them wide open, forcing you to look into them. If you're aware of them already and they're minor, it can be helpful, sometimes expanding your mind to new capabilities. If you've been unaware or worse, in denial, or they're major, then you get a bad trip that may come back to haunt you over and over again over the years.

Flashbacks that continue to occur after the original drug effects have worn off are a medically recognized phenomenon, which is documented in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as hallucinogen persisting perception disorder.

Flashbacks typically happen in the days or weeks following ingestion of the drug but can happen months or even years after the drug use has been discontinued.

Re:Brains on Drugs: How tinkering with consciousness became ... by silveraxe93 on Thursday June 22, 2023 @08:53AM (#36431387)
Eh... fine. People won't come out unscathed in literally all cases.

However the risk from one dose is minimal. If your risk threshold is so close to 0 then we should be banning way more things today.

Re:Brains on Drugs: How tinkering with consciousness became ... by scrozart on Thursday June 22, 2023 @10:30AM (#36432727)
I've done LSD numerous times, including "heroic" doses, as have many of my friends, starting 30 years ago (I haven't in a while as i no longer feel the need to blow open those doors).

Not one of us has ever had a single flashback, let alone "persistent" flashbacks. If they were ever really an issue, it was long ago with different/absurdly strong formulations.

Re:Brains on Drugs: How tinkering with consciousness became ... by GuB-42 on Thursday June 22, 2023 @12:42PM (#36434902)
I don't believe in the "LSD binds to something in the brain and this causes flashbacks". LSD obviously binds to something in the brain during the trip, like all psychoactive substances, but after that, it is gone. LSD degrades relatively easily, you only get micrograms of it and there are known metabolic pathways.

A more convincing theory for flashbacks is that they are similar to PTSD. LSD can give really intense and memorable experiences, and in the case of a bad trip, they can be considered traumatic. Symptoms show similarities too. Essentially, flashbacks are just memories, good or bad, and in the worst cases, so bad as to haunt you for years.

Hallucinogen Persisting Perception Disorder (HPPD) is not like flashbacks. As the name suggests, it affects perception, i.e. senses, commonly in the form of visual noise, distinct from what is experienced during a trip. Think something like tinnitus. We know it exists, but the details are unclear.

Re:Brains on Drugs: How tinkering with consciousness became ... by PaulHoule on Thursday June 22, 2023 @09:49AM (#36432140)
The Netherlands has struggled to commercialize a safe psychedelic.

LSD is not so dangerous per se if you are in good hands. It does leave you discombobulated for 12 hours or so and put somebody into a strange and sketchy city like Amsterdam and some of them will get into trouble. Mushrooms are a little better because the duration is shorter but they still didn't find the problems acceptable. They tried the stimulating and hallucinatory 2C-T2 which is somehow entirely non-cosmic but I think even that failed market testing.

After all these years a pastor I know is providing psilocybin therapy for the terminally ill which they are doing in a tightly controlled

https://en.wikipedia.org/wiki/Ganzfeld_effect

environment and of course accompanying people for the whole tip.

Re:Brains on Drugs: How tinkering with consciousness became ... by cmh89 on Thursday June 22, 2023 @10:38AM (#36432825)
Amsterdam already has a problem with alcohol getting people in trouble. Millions of people take mushrooms every year with no issues.

The problem is we have such a high bar for pyschedelics that isn't applied to other recreational drugs.

Re:Brains on Drugs: How tinkering with consciousness became ... by totallywrong on Thursday June 22, 2023 @12:36PM (#36434753)
> put somebody into a strange and sketchy city like Amsterdam and some of them will get into trouble

Funny you say that because I couldn't have wished for a better trip than roaming Amsterdam with my friends when I tried mushrooms all those years ago. The canals, the architecture.. it was a fairy tale and I remember it dearly.

Re:Brains on Drugs: How tinkering with consciousness became ... by PaulHoule on Thursday June 22, 2023 @02:27PM (#36436593)
I remember getting bitched out for wandering around stoned in Het Vondelpark.
Re:Brains on Drugs: How tinkering with consciousness became ... by andelink on Saturday June 24, 2023 @04:36AM (#36456750)
Was just about to say this. My shrooms trip in Amsterdam was nothing short of magical. Such a colorful, vibrant city. It was beautiful
Re:Brains on Drugs: How tinkering with consciousness became ... by scruple on Thursday June 22, 2023 @11:26AM (#36433622)
> Have you ever done acid?

Yes, and a variety of other psychedelics in my early 20s. I remember spending time on erowid and then seeking out substances. Mescaline, peyote, ketamine, psylicobin, acid, GHB, DXM, others I'm forgetting.

I wish I had never done any of it.

Re:Brains on Drugs: How tinkering with consciousness became ... by novelwere on Friday June 23, 2023 @01:36AM (#36443203)
Can i ask why?
Re:Brains on Drugs: How tinkering with consciousness became ... by scruple on Friday June 23, 2023 @10:30AM (#36447293)
I had a few bad trips, one being very bad and which changed the direction of my life. It also made me realize that I was doing these things for the wrong reasons (mostly peer pressure, or a desire to fit in with certain crowds, etc.). In retrospect, it just wasn't very fun, and certainly wasn't a useful way (for me) to live my life.
Re:Brains on Drugs: How tinkering with consciousness became ... by davidguetta on Thursday June 22, 2023 @08:10AM (#36430908)
Best comment ever. And also true. I do drugs what i feels is responsable (5 times a year) and i always feel im the only one doing it responsibly among people i know who do drugs.
Re:Brains on Drugs: How tinkering with consciousness became ... by randomNumber7 on Thursday June 22, 2023 @01:19PM (#36435533)
> I do drugs what i feels is responsable (5 times a year)

One problem is that you can't get honest information about what is responsable, besides the "all drugs are evil" propaganda. Like you can defenitley smoke weed more often and call it responsable, but for MDMA 5 times is already quite at the edge imo. And people don't realize that easily.

Re:Brains on Drugs: How tinkering with consciousness became ... by davidguetta on Thursday June 22, 2023 @08:50PM (#36441309)
> for MDMA 5 times is already quite at the edge imo

Indeed, but I was speaking of 5 times like 1 LSD 1 mushroom, 1 coke and 1 mdma a year or something, with extremely cautious dosing..

> you can't get honest information about what is responsable

This is really debatable or even not true. There are several website (erowid, r/drugs) with literally thousands of not tens of thousands of reports and experiences of various people, including thoughts on multi-year / multi-decade drug experiences. If you sincerely look for the information there's everything you need

Re:Brains on Drugs: How tinkering with consciousness became ... by scotty79 on Thursday June 22, 2023 @08:36AM (#36431199)
"I handle cheese responsibly" is a great thing to put on a t-shirt.
Re:Brains on Drugs: How tinkering with consciousness became ... by mrguyorama on Thursday June 22, 2023 @12:13PM (#36434409)
But then I'd be a liar
Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Thursday June 22, 2023 @08:37AM (#36431213)
We aren't all average Americans.

Individual responsibility should apply here. I don't want my rights restricted because other people are fools.

If it's considered acceptable to tell people what they can and cannot put into their bodies because "average" people can't handle it, there's no limiting principle in place to stop our bodies from being controlled by others.

Re:Brains on Drugs: How tinkering with consciousness became ... by circlefavshape on Thursday June 22, 2023 @09:05AM (#36431534)
It actually is considered acceptable to tell people what they can and cannot put into their bodies. Legal restrictions on medicines and intoxicants are in place all over the world, and that hasn't led to "others" taking control of my body.
Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Thursday June 22, 2023 @09:55AM (#36432222)
>Legal restrictions on medicines and intoxicants are in place all over the world, and that hasn't led to "others" taking control of my body.

If you say so. I believe prohibition exerts substantial control over our bodies, and also corrodes other aspects of personal freedom (such as the Fourth Amendment in the US).

Re:Brains on Drugs: How tinkering with consciousness became ... by MichaelZuo on Thursday June 22, 2023 @11:37AM (#36433806)
Well if you don't believe in any medicine prohibitions, then you'd be arguing against literally every government in the world (except maybe Somalia) plus the UN and hundreds of other IGOs, NGOs, etc...
Re:Brains on Drugs: How tinkering with consciousness became ... by Mordisquitos on Thursday June 22, 2023 @12:43PM (#36434916)
Spain for instance does not impose any legal restriction as to what you knowingly choose to put into your own body.

Not only is possession of any drug for personal use without an intent to distribute not a criminal offence in Spain, neither is consuming said drugs in the privacy of your own home. There is also no legal restriction on growing cannabis or psychedelic mushrooms on private property outside of public view, as long as the amounts are small enough that there is no reason to suspect an intent to distribute it.

Re:Brains on Drugs: How tinkering with consciousness became ... by randomNumber7 on Thursday June 22, 2023 @01:06PM (#36435343)
> then you'd be arguing against literally every government in the world

I'd like to do that^^.

1. Imagine what would happen to the mafia etc... No more war in mexico for example.

2. Normal people wouldn't just start taking heroine for example

3. Imagine what happens to jails

4. You could use some of the new tax money (which goes to the mafia currently) to hire some medical professionals. That way you could help the really addicted.

5. 100% pure heroin would not destroy the body (it was developed as painkiller). Those junkies are that f*ed up because of the other stuff they pump in their veins. How is that a win for society?

Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Thursday June 22, 2023 @01:55PM (#36436108)
Yes I believe every government in the world has made a mistake by implementing prohibition.

I also believe they were all in error when slavery was legal everywhere.

This is a combination of appeal to authority and appeal to majority.

Re:Brains on Drugs: How tinkering with consciousness became ... by MichaelZuo on Thursday June 22, 2023 @09:30PM (#36441680)
Why would anyone take you seriously? (Anymore so then the fringe groups that call for disbanding the UN, all central banks, etc...)
Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Friday June 23, 2023 @12:37AM (#36442824)
Ideas should be judged on their merit, not their popularity.

I don't care if my views are fringe and others choose to not take them seriously as a result. That's outside my control.

People accepting beliefs uncritically is the problem, and that applies equally to nutjob conspiracy theorists as well as people who accept the whatever the current groupthink believes.

A cursory examination of history is all that's needed to know that, at any given point in time, there are many beliefs across society which are just flat out wrong. To think that in 2023 somehow we've finally got it figured out is arrogance.

Re:Brains on Drugs: How tinkering with consciousness became ... by MichaelZuo on Friday June 23, 2023 @08:05AM (#36445700)
> Ideas should be judged on their merit, not their popularity.

No, ideas that need to be applied broadly should be judged on a combination of their merits and demerits, and popularity, as there are enforcement and political costs associated with any proposal (as long as the government needs to do make any changes whatsoever).

It would be different if it was a private proposal that will only affect you and immediate family.

To be entirely honest, it seems like you need to rethink this more thoroughly instead of just repeating memorable slogans.

Re:Brains on Drugs: How tinkering with consciousness became ... by misja111 on Thursday June 22, 2023 @10:13AM (#36432474)
I see what you mean and on the one hand I agree.

On the other hand, what to do if some people don't act responsibly and get addicted; and then for instance ruin their health or neglect their children. Who should be responsible for helping them go to rehab, fixing their health problems or helping their children? If it means the society has to take care of this, then isn't it also fair that society tries to prevent people from getting addicted in the first place? And prohibiting drugs is one way of trying to do that.

Re:Brains on Drugs: How tinkering with consciousness became ... by di456 on Thursday June 22, 2023 @11:16AM (#36433436)
> And prohibiting drugs is one way of trying to do that.

The war on drugs had tried and failed for decades. All it's done is enrich the cartels, fill prisons with minorities, create an oxycodone epidemic, flood the streets with cheap and deadly fentanyl, and countless other problems.

While the same government "protecting" citizens from harm is corrupt the point of the CIA becomeing drug traffickers on the side [1], making the problem even worse like throwing petrol on a fire.

[1] https://www.ojp.gov/ncjrs/virtual-library/abstracts/big-whit...

Prohibition has nothing to do with prevention.

Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Thursday June 22, 2023 @02:08PM (#36436301)
Prohibiting drugs is one way of trying to do that.

Has it succeeded? No.

Criminalizing it often makes it even more difficult to deal with the societal damage of addiction. Dealing with an addict is difficult, but dealing with an addict who is now a criminal is that much harder.

Society has all sorts of tools to help people who are struggling. Our criminal justice system is one of the least effective.

An addict is harming their family whether drugs are legal or not, and it's obvious from our current situation that their legal status doesn't prevent people from using drugs.

Re:Brains on Drugs: How tinkering with consciousness became ... by seanmcdirmid on Thursday June 22, 2023 @02:13PM (#36436376)
Not even Western Europe, especially Western Europe, has tried "decriminalizing drugs" yet. They might offer treatment as an alternative to incarceration for users, but they definitely don't allow police to ignore the problem (like we seem to do here in Seattle).

An addict who is now a criminal can be forced into treatment at least. An addict who can freely buy their drugs (because we aren't prosecuting dealers either) and do them on the street anywhere will just die faster (especially with fentanyl).

Re:Brains on Drugs: How tinkering with consciousness became ... by leetcrew on Friday June 23, 2023 @06:08PM (#36452826)
putting people in jail for doing drugs doesn't do much for their children or their health either.

I also don't see why it has to be all one way or the other. I agree that people with dependent children have no business taking risks with drugs. like you say, this creates a mess other people are compelled to clean up.

but what if a person doesn't have children (or successfully raised them to be independent adults)? as long as they pay whatever taxes they owe, why care what they do with their time?

Re:Brains on Drugs: How tinkering with consciousness became ... by pixl97 on Thursday June 22, 2023 @11:07AM (#36433297)
This is messy...

Lets imagine a hypothetical drug so we don't have to argue about the effects of real ones. This drug removes the idea of responsibility from your mind when your on it. This drug creates a paradox in your framework. You dictate that individuals have ultimate responsibility. This drug removes any internal idea of responsibility as a concept leading to bizzare and potential dangerous actions from the user.

Would you agree this drug should be banned then?

Re:Brains on Drugs: How tinkering with consciousness became ... by amanaplanacanal on Thursday June 22, 2023 @11:34AM (#36433750)
You’re talking about ethanol aren’t you.
Re:Brains on Drugs: How tinkering with consciousness became ... by pixl97 on Thursday June 22, 2023 @11:46AM (#36433988)
Nope. Was talking about something hypothetical with a 100% responsibility removal rate.

But with ethanol we tried that once, didn't work out well as you tend to create a police state to prevent it as it's easy to make.

Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Thursday June 22, 2023 @02:19PM (#36436481)
No, it should not be banned. The drug itself isn't the issue. If a person took precautions to ensure they couldn't harm others while using the drug (consenting trip sitter who can physically handle them, proper set and setting) then they should be able to do that.

However they must also bear the cost of any harm done in that state. The problem isn't that someone took a drug, it's that they did X thing to hurt others. Punish X thing, not the drug use.

I acknowledge that this has serious problems because not everyone acts responsibly. But the alternative is to implement a system which removes the basic freedom to control what goes into your own body... and still have people acting irresponsibly anyway.

Re:Brains on Drugs: How tinkering with consciousness became ... by refurb on Thursday June 22, 2023 @01:48PM (#36435984)
Not going to happen. People aren't even responsible enough to read their mortgage documents.
Re:Brains on Drugs: How tinkering with consciousness became ... by SamPatt on Thursday June 22, 2023 @01:57PM (#36436134)
Those people should bear the costs of acting irresponsibly.

The alternative is worse.

Re:Brains on Drugs: How tinkering with consciousness became ... by refurb on Thursday June 22, 2023 @08:05PM (#36440979)
We're already doing the opposite with most instances of personal responsibility.

I agree it's unfortunate.

Re:Brains on Drugs: How tinkering with consciousness became ... by thelastparadise on Thursday June 22, 2023 @10:08AM (#36432412)
The point of laws isn't to protect people from themselves.
Re:Brains on Drugs: How tinkering with consciousness became ... by mrguyorama on Thursday June 22, 2023 @12:13PM (#36434404)
Ah yes, the government requires I wear a seatbelt because they think it's fun
Re:Brains on Drugs: How tinkering with consciousness became ... by scrozart on Thursday June 22, 2023 @10:32AM (#36432746)
Your comment indicates you can't differentiate between LSD and dangerous opioids. Cheese is the opioid supplying immediate gratification. LSD, and other hallucinogens, work much, much differently.