LSD is not so dangerous per se if you are in good hands. It does leave you discombobulated for 12 hours or so and put somebody into a strange and sketchy city like Amsterdam and some of them will get into trouble. Mushrooms are a little better because the duration is shorter but they still didn't find the problems acceptable. They tried the stimulating and hallucinatory 2C-T2 which is somehow entirely non-cosmic but I think even that failed market testing.

After all these years a pastor I know is providing psilocybin therapy for the terminally ill which they are doing in a tightly controlled

https://en.wikipedia.org/wiki/Ganzfeld_effect

environment and of course accompanying people for the whole tip.