like thats not something I’m deriding its just news to me
makes me wonder what this drug actually does, flush gut bacteria? just the right ones?
To answer your question, yeah turns out it was never about will power. Some people just had hormone drive to be healthier than others and finally we can pharmacologically start to level the field.
I’m lean but dont do that and can recognize the benefits. It would be cool if we could pharmacologically make that appealing too.
What if we could just continually swap in states.
Executive work mode, ah it feels so good to think and focus.
Empath mode, ah it feels so good to build relationships.
Brolic mode, ah it feels so good to think about working out, and actually work out!
In the meantime I would like that choice from a purely self preservation interest in being good at other bodily health and resource appropriations
Shouldn't take more than a bit of caffeine to get you moving at that point.
As to empath mode, you've just described MDMA. But it'd be nice if there were something a little less intense. That you could take weekly without frying your brain & was mild enough for family/work social situations. (And no, alcohol doesn't fit the bill).
appreciate the perspective but I want to be like the people that feel pulled to "find" it at all.
The high can be way better than you'd believe possible before you try. Or if you don't believe personal anecdote.. /something/ must be keeping all those people coming back to it at considerable expense, hassle and time.
but its pretty clear what I'm asking I don't have to keep re-explaining that, for thanks for chiming in.
- aim to either meet or exceed the previous workout, and consider that a success
- count reps so you can increase them 1 at a time until you're ready to increase weight
- for cardio, increase difficulty (incline/speed) until you're ready to increase distance
- set a longer term goal, too, like a body weight bench press or a 10 minute mile
- after doing this for a while, you might notice some differences in your appearance, which can be its own motivator
What a completely silly take away. It's like nature vs nurture it's not 100% one thing only.
As a very young child, my family was probably on the upper end of poor. "Treats" were rare and food was not anything to be wasted at all. I'm almost 50 now, and it's virtually impossible for me to throw away food. I have to have an inner monologue conversation with myself about whether I really need to finish my portion and whether it's OK to discard it. Needless to say, despite being very physically active, my weight has challenged me my entire life.
As a parent, I'm irrationally proud of my child for being able to stop eating when they're full, even if it's ice cream or a treat. That's actually helped me get over throwing food away (a little bit, at least)
- GLP-1 (semaglutide)
- optionally, that and also GIP (tirzepatide)
- optionally, both of those and also glucagon receptor (retatrutide)
But these hormones directly make you not hungry, among other things. They are probably some of the things that your gut bacteria manipulate to commandeer your behavior.
This can lead to the body to break down muscle tissue to obtain protein for energy which could lead to a loss of lean muscle mass
However, maintaining regular exercise and consuming sufficient protein can help to minimize the impact of lean muscle mass loss
The problem is apparently that studies only use change in weight instead of body composition, so doctors have to be aware of that and get the patient measured themselves to make sure they're actually getting leaner instead of losing weight but getting "more obese".
Misinformation. Many of the studies track total fat, lean body mass, visceral fat, and literally dozens of other secondary outcomes/endpoints. See an example of such results here: https://clinicaltrials.gov/ct2/show/results/NCT03548935
This has already been covered yesterday in sibling comments about the NCT03548935 study and Peter Attia being in general a source of misinformation.
Here are some other semaglutide studies which track lean body mass specifically: https://clinicaltrials.gov/ct2/results?cond=Semaglutide&term...
Semaglutide users lost 16% bodyweight overall but only 3.4% of their lean mass.
This is study NCT03548935 if you’d like to look it up, there are other statistics of interest in it as well.
I used to lift and be real fit till about 40. Like bulky-lean looking, bench 400 10x with a 6pack. Had a lot to do with being on the road for work all over the world, and you sit at the gym at the hotel for an hour every night because of nothing else to do, and there are girls there also on business who you'll never see again. I drank A Lot, ate anything I wanted, and did lots of blo on weekends.
It was getting out of control, so I did months of google-foo, went to a pharmacy in eastern europe, got like a thousand 150mg disulfiram pills under the counter for fifty bucks, and took one pill every morning for 2 years. You don't drink, you can't drink or you die, you forget drinking exists and after a couple of months don't even think about it, yet still do all the same stuff you used to - like dancing and clubs if that's your thing. And it's even more fun. There were no side effects.
Then things changed with age, testosterone went to crap, joints hurt. I got married and settled down. Can't work out too much now - just a couple of hours per week, and no heavy weights. Within 2 years I couldn't fit into my clothes and had high blood pressure and high cholesterol.
I realized I don't eat because I'm hungry, but because it keeps away sadness. So I changed my diet so I could eat however much I want. I now have a 4-pack instead of 6, fit into my pants, and eat however much I want.
I cut out fat completely. No oil when I cook besides a light spray on the frying pan. No nuts. Tuna - not salmon. Real expensive lean filet if I want cow in my mouth. Only white meat from birds. All the pasta, rice, and potatoes I want, but zero sugar added to anything. Lots of splenda and sweet n low. Fat free fairlife milk (lactose filtered out = less sugar calories). I eat normal sized meals.
Then, I have fruit and berries, and I eat as much of that as I want. I'm stuffing my face the whole day. Today, I had a pint of blueberries, 5 medium apples, 2 mangoes, and a pound of grapes.
Speaking of gastrointestinal issues, my poo is now soft and gentle, and smells delicious.
With regards to cutting out fat, if you are advocating for a weight management plan for the general person, it is really too prescriptive and doesn't take into account that someone following your diet should not be accidentally increasing your carbohydrate intake (fruit sugars are still sugars!), resulting in the diet being a total wash. The gold standard for diet-based weight management is food journaling, and not cutting out an entire group of macronutrients without holistic consideration of your diet.
people who have to take last-measure medication usually don't stop eating when they are full. i know, it's weird to tell someone who doesn't stop eating when they're full, how to still maintain weight if they... don't stop eating when they're full. i'm a weird guy with all these offtopic anecdotes.
and yes, a doctor will not tell you diet tricks. if you are asking your doctor for diet tricks, we need to step back a minute. when you're done grocery shopping at jiffy lube, drive home, sit down, and carefully read this link.
this is what a doctor is. a doctor will give you general health guidelines, but knows very little about diets. https://en.wikipedia.org/wiki/Physician
And again, you are being far too presumptuous about OP’s interventions. And I certainly don’t know what this business about ADD appointments at the florist or grocery shopping at Jiffy Lube you’re talking about is.
so, would you say a solution to the problem that lets you eat as much as you want, so you don't have to use your willpower, be an appropriate solution to suggest? There is a difference between taking last-resort medication for the rest of your life, and eating apples.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764193/ (2019)
Substantial weight loss is possible across a range of treatment modalities, but long-term sustenance of lost weight is much more challenging, and weight regain is typical1–3. In a meta-analysis of 29 long-term weight loss studies, more than half of the lost weight was regained within two years, and by five years more than 80% of lost weight was regained (Figure 1)4. Indeed, previous failed attempts at achieving durable weight loss may have contributed to the recent decrease in the percentage of people with obesity who are trying to lose weight5 and many now believe that weight loss is a futile endeavor6.
I had to reconfigure my entire life around it. I kept barely enough food in the house to meet my calorie target for the week. I once fell asleep while driving home from work and ran off the road because my blood sugar was so low. I spent 9 hours a week doing intense exercise and pretty much any time I wasn't doing that or working I was just sleeping. I basically had to have no social life, because socialization around here pretty much mandates large quantities of food.
Is something physically wrong with me? Probably, but good luck getting an American doctor to give a flying fuck. My thyroid stopped working when I was a child and it went undiagnosed for two years because doctors just keep telling my mother I was lazy. Ultimately a toll booth attendant diagnosed it because her dog had similar symptoms and my mother had to go full Karen to get the simple blood test to happen. American physicians are fucking useless.
Even treated, to this day I have to eat well under the caloric requirement that I "should" be eating and constantly feel like shit in order to lose weight, which makes me perform worse at work and apparently require 3-4 hours extra sleep every day.
I can guarantee you "willpower" people aren't doing that. Your body isn't fucked up and constantly demanding more calories than you need, so it comes easy to you and you probably just take any excuse to feel like you are better than other people.
It is people like you who are the absolute worst to deal with. You take a specific example which probably does not not apply to your body, completely and completely twisted what was said so you can both be a victim and feel superior.
I specifically stated a diet that for a person who is working out a couple of hours per week, there is a way to constantly eat and minimize the caloric intake despite large amounts of food. I did not remotely suggest stuffing your face all day is a willpower-based solution to a thyroid problem.
I'm 5'11. In my early 30s, I was a 31 waist, 170lb, benched a full set of 400lb, ran cross country, and had 6% body fat. In my late 30s, I was a 34 waist with high blood pressure. I made the change in my diet, and a few years later, I'm a 31 waist, 170lb, normal blood pressure, and 10% bodyfat, and I eat as much as I feel like, just not whatever I feel like.
This is a solution for maintaining a healthy weight in an active lifestyle, that uses zero willpower, because my willpower is bad. This is not a solution for someone with a thyroid problem who needs to lose almost the weight of my whole body.
I don't know what it is with you and this other guy. You read very simple basic text, and you reply to something you've completely made up. It's like your brain paints a virtual world for yourself where you can feel constantly offended. No one's out to get you. No one's making fun of you. People are talking about something that clearly wasn't for you, so you inject yourself into the conversation so you can feel attacked. Stop that.
They talk about how if you want success, you need to treat it like the air you breathe, that once you want something as bad as you want to breathe, then you'll finally get there.
Huge respect for your personal transformation, and the insane willpower you channeled to lose 3 inches of your waistline over the course of a few years.
I tried this a few years before going with my "apple diet." It works, but my bloodwork after a few years said I need to stop. There is a catch. The first year, you Cannot pass gas. That clumped oil that comes out, comes out very easily, and unfortunately Alli makes you gassy too. This side-effect goes away in about a year if you power through it.
Not a dietician or a doctor, but perhaps your mounjaro treatment can be cycled with Alli (cheap, OTC) every few years to save some cash. Invest in a large bottle of Dawn dishsoap. Put it in a spray bottle and spray the bowl after you do your stuff. You'll have to, just trust me.
Elsewhere in this thread it was stated that food journaling was the gold standard in weight loss, which also I’d expect to increase mindfulness around eating.
And then when you go off the diet (either intentionally, or more likely, by just slowly drifting back to the norm), you'll return to eating what you were before, and will return to your original weight. Which is why the only diet that works is one you can stick to indefinitely. So, if the parent can stick to a no fat, high complex carbs diet for life, it will probably work for them.
I don't do high carbs - fruit are not high in carbs you actually process. I eat normal portions of complex carbs like bread and pasta, normal sized meals. I eat a ridiculous amount of fruit, and that has some sugar in it, but it's actually not that much. What that does is increase my fiber intake to ridiculous levels - and that has many benefits.
My issue was that I use food as an anti-depressant, and to deal with stress. The solution had to involve eating a lot, but minimizing calories. That's why the fat had to go - I can eat twice as many carbs as fat for the same weight. When you look at things like fruit - a lot of those "carb" calories you don't even metabolize since it's fiber.
I don't think I have discovered some magical solution, but it works for people like myself, who have what I consider a minor mental illness called 'self-medication with food.' Mental problems are a lot harder to fix than just not using oil and replacing nuts and chips with fruit. My solution to win the war was not to fight it and learn to live w/ the fact that I'm not perfect, and adjust the lifestyle to that.
High carb diets are a bad idea. I eat normal balanced meals, just with no fat. Long-term high fat diets are for people who want liver damage, and stop eating when they're full. A little bit of fat makes you full, unlike carbs. But keto is terrible for your health if you do it for decades.
The tiny amount of fat I do get, is from things like red tuna and other low-fat fish. It's amazing how little good fat you actually need in your diet, if you look that up. Literally one can of chunk light canned tuna is all you need for the day.
Now here's something groundbreaking that's pretty good - thin and wide no sugar no fat pancakes: 1 cup flour, 3/4 cup fat free fairlife milk, 2 packets splenda, 1/2 cup Egg Beaters. mix real well so it's runny with no flour chunks. no need for baking powder. real short spray of oil to just get some drops on a teflon pan. no need to spray when you flip.
It's really strange how you and a few other people just keep making up weird scenarios, then attacking those to make yourself feel superior. I don't get it. It was 1/4 book page of simple text. How is it possible to read something that simple, that short, and then make up something completely different in your head. This explains a lot of politics, but I don't get what people with that mental illness are on HN. Please stop. You are not superior - you have reading comprehension problems.
Do you find other pleasures (non food and drink) as enjoyable? Interesting to hear if it’s selective or dampens everything.
I'd say that's a pretty huge deal. Did you report that?
> In a 2-year trial among patients with type 2 diabetes and high cardiovascular risk, patients treated with this drug experienced a great incidence of diabetic retinopathy complications (3% vs 1.8%). The absolute risk was greater in patients with a history of diabetic retinopathy at baseline (8.2%[drug] vs 5.2%[placebo]) than those without (0.7%[drug] vs 0.4%[placebo]).
https://www.drugs.com/sfx/semaglutide-side-effects.html
Would be very interested in knowing the commenter’s diabetes status.
The no apparent reason was a bit of hyperbole, since my vitreous was pulling away from the retina and brought some pieces with it during the process. But as to why that was happening at my current age is unknown. Second was likely related to stress in the eye from healing from the first surgery. But the point was I didn’t take any blows to the head or eye, or any other common cause of retinal detachments.
>but my untreated ADHD seems to be getting worse.
I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done.
I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily).
Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?
don't make unsubstantiated leaps :-)
I’m not making unsubstantiated claims. Don’t accuse me of that, because you don’t like my answer.
So what? Ketamine is a treatment, not a cure.
Would you apply the same logic to insulin for T1 diabetes?
We don't know of any cure for depression, but with ketamine we have an effective rapid treatment.
Ketamine has a great therapeutic range, a well-understood side effect profile, and can bring a patient back from the brink of suicide in a matter of hours. It's also incredibly inexpensive to produce, on par with aspirin. Why shouldn't we use it?
Ketamine or suffering & death? Ketamine no question. I agree, but it’s not so black and white how you may perceive it. It might be ketamine or death for you, I don’t know. For me it was certainly. So sorry, if it is for you now. I’m not telling you it’s bad or that you shouldn’t do it. Do whatever you think is the best for you. I went through all of that and found other methods of treatment actually effective of solving the root causes of my suffering and not just the symptoms. Meditation, somatic experiencing and mdma therapy[1] are the main methods I found the most effective, in no particular order.
I’m not looking to argue about your choice of treatment. If you want to share your experience or hear mine, give me a way to contact you. Have a good night/day. [1]https://www.nature.com/articles/s41591-021-01336-3
In my case, MDMA would not have been the appropriate treatment.
All of the things we are discussing have a role in mental health care. It doesn't have to be a contest.
>Neurotoxicity
unclear. on the onehand, unpublished studies in gorillas show no lesions. on the other, retroactive studies of heavy polydrug abusers show lesions. not super high-quality evidence either way. there's also rat studies showing lesions, but rats are unusually sensitive to neurotoxicity from dissociatives. they get similar lesions from nitrous oxide while humans get no such thing. honestly the potential bladder toxicity is more concerning imo.
>relapse rate
still much better success rates than SSRIs.
not saying ketamine is perfect --- would be better to have a purpose-built drug, and a lot of the clinics are kind of scummy and charge exorbitant prices. but this + non-psychedelic 5ht2a plastinogens are the most promising things to come out of depression research in the past 45 years.
If anything, the after-effects of ketamine treatment alleviate my lifelong dissociation and other symptoms depression and PTSD.
Have you ever had ketamine treatment? Where are you getting these conclusions?
Ketamine didn’t heal me, my perspective just changed, which can be valuable though.
I thought that was the entire point of the treatment. Is that not the case?
> Weeks after the second treatment ... I stopped getting treatments
This sounds like an unusual, very sparse schedule. Most ketamine treatment routines have many more than two doses, and nothing resembling multi-week intervals between doses at the start.
My wife has undergone ketamine treatment, and as part of it, I read up on the literature. Typical ramp-up schedules (like hers was) would be one or twice per week for one or two months, and then less frequently until you stop or go into "as-needed" maintenance dosing.
I'm glad you found other things that worked for you, but what you describe doesn't sound like a normal course of ketamine treatment.
Work also seems more interesting, but my untreated ADHD seems to be getting worse.